Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance.

Abstract:

BACKGROUND & AIMS:Significant improvements in management of hepatocellular carcinoma (HCC) have occurred in the last years, but their impact on surveillance outcome is unknown. To clarify this, we compared survival of HCC patients identified along 3 consecutive quinquennia of surveillance. METHODS:A cohort of 417 HCC-free outpatients with compensated cirrhosis was prospectively followed for 148 months (range, 1-213 months) with periodic ultrasound examinations. RESULTS:HCC developed in 112 patients, at a 3.4% rate per year, and was the prime cause of death (n = 54). Forty-six (41%) patients had a single tumor, with a mean size of 3.7 cm, 3.0 cm, and 2.2 cm in the 3 quinquennia (first vs. second: ns; first vs. third: P = 0.017; second vs. third: P = 0.02), and 38 (44%) underwent radical therapy. Mortality rates in HCC patients fell from 45% in the first quinquennium to 37% in the second and 10% in the third (first vs. second: ns; first vs. third: P = 0.0009; second vs. third: P = 0.018) in parallel with a reduction in yearly mortality of treated patients (34%, 28%, and 5%, respectively; first vs. second: ns; second vs. third: P = 0.036; first vs. third: P = 0.0024). After stratification for quinquennium, tumor staging, according to Cancer of the Liver Italian Program (CLIP), was the only independent predictor of survival (P = 0.015). CONCLUSIONS:Cirrhotic patients developing a HCC during the last 5 years of surveillance survived longer than previously, as a consequence of improved management of the tumor and complications of cirrhosis.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Sangiovanni A,Del Ninno E,Fasani P,De Fazio C,Ronchi G,Romeo R,Morabito A,De Franchis R,Colombo M

doi

10.1053/j.gastro.2003.12.049

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

1005-14

issue

4

eissn

0016-5085

issn

1528-0012

pii

S0016508503021498

journal_volume

126

pub_type

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