当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients.

Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients.

Abstract：

BACKGROUND & AIMS:To elucidate the survival of the patients with unresectable hepatocellular carcinoma (HCC) who underwent transcatheter arterial lipiodol chemoembolization (TACE) and to analyze the factors affecting the survivals. METHODS:During the last 8 years, a nationwide prospective cohort study was performed in 8510 patients with unresectable HCC who underwent TACE using emulsion of lipiodol and anticancer agents followed by gelatin sponge particles as an initial treatment. Exclusion criteria were extrahepatic metastases and/or any previous treatment prior to the present TACE. The primary end point was survival. The survival rates were calculated by the Kaplan-Meier method. The multivariate analyses for the factors affecting survival were evaluated by the Cox proportional hazard model. The mean follow-up period was 1.77 years. RESULTS:For overall survival rates by TACE, median and 1-, 3-, 5-, and 7-year survivals were 34 months, 82%, 47%, 26%, and 16%, respectively. Both the degree of liver damage and the tumor-node-metastasis (TNM) system proposed by the Liver Cancer Study Group of Japan demonstrated good stratification of survivals (P = .0001). The multivariate analyses showed significant difference in degree of liver damage (P = .0001), alpha-fetoprotein value (P = .0001), maximum tumor size (P = .0001), number of lesions (P = .0001), and portal vein invasion (P = .0001). The last 3 factors could be replaced by TNM stage. The TACE-related mortality rate after the initial therapy was .5%. CONCLUSIONS:TACE showed safe therapeutic modality with a 5-year survival of 26% for unresectable HCC patients. The degrees of liver damage, TNM stage, and alpha-fetoprotein values were independent risk factors for patient survival.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Takayasu K,Arii S,Ikai I,Omata M,Okita K,Ichida T,Matsuyama Y,Nakanuma Y,Kojiro M,Makuuchi M,Yamaoka Y,Liver Cancer Study Group of Japan.

doi

10.1053/j.gastro.2006.05.021

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

461-9

issue

2

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(06)01075-4

journal_volume

131

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Prospective study of dietary fiber, whole grain foods, and small intestinal cancer.

    abstract：BACKGROUND & AIMS:Although a number of epidemiologic studies have found dietary fiber and whole grains to be inversely associated with colorectal cancer incidence, studies of dietary and other risk factors for small intestinal cancer have been sparse and all of a case-control design. We conducted a prospective cohort s...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2008.07.015

    authors： Schatzkin A,Park Y,Leitzmann MF,Hollenbeck AR,Cross AJ

    更新日期：2008-10-01 00:00:00

  • Diarrhea caused by enterotoxigenic Escherichia coli infection of humans is inhibited by dietary calcium.

    abstract：BACKGROUND & AIMS:In several rat infection experiments, we have shown that dietary calcium inhibits intestinal colonization and translocation of invasive salmonella. The aim of the present study was to find out whether calcium is also protective against enterotoxigenic Escherichia coli (ETEC) infection. This was first ...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0016-5085(03)00884-9

    authors： Bovee-Oudenhoven IM,Lettink-Wissink ML,Van Doesburg W,Witteman BJ,Van Der Meer R

    更新日期：2003-08-01 00:00:00

  • DDIT4 Licenses Only Healthy Cells to Proliferate During Injury-induced Metaplasia.

    abstract：BACKGROUND AND AIMS:In stomach, metaplasia can arise from differentiated chief cells that become mitotic via paligenosis, a stepwise program. In paligenosis, mitosis initiation requires reactivation of the cellular energy hub mTORC1 after initial mTORC1 suppression by DNA damage induced transcript 4 (DDIT4 aka REDD1). ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2020.09.016

    authors： Miao ZF,Sun JX,Adkins-Threats M,Pang MJ,Zhao JH,Wang X,Tang KW,Wang ZN,Mills JC

    更新日期：2021-01-01 00:00:00

  • Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair.

    abstract：BACKGROUND & AIMS:The lipocalin superfamily, including the mouse and human homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin, show great functional diversity including roles in olfaction, transportation, and prostaglandin synthesis in mammals. Their potential role in maintaining gastrointestinal mucos...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2006.05.051

    authors： Playford RJ,Belo A,Poulsom R,Fitzgerald AJ,Harris K,Pawluczyk I,Ryon J,Darby T,Nilsen-Hamilton M,Ghosh S,Marchbank T

    更新日期：2006-09-01 00:00:00

  • Serum tumor markers for the diagnosis of cholangiocarcinoma in primary sclerosing cholangitis.

    abstract：BACKGROUND/AIMS:The diagnosis of cholangiocarcinoma in primary sclerosing cholangitis (PSC), even with the use of current imaging techniques and brush cytology, is difficult and particularly important in patients being assessed for liver transplantation. This study investigated the accuracy of serum levels of a combina...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90462-x

    authors： Ramage JK,Donaghy A,Farrant JM,Iorns R,Williams R

    更新日期：1995-03-01 00:00:00

  • Hyperplasia of histamine-depleted enterochromaffinlike cells in rat stomach using omeprazole and alpha-fluoromethylhistidine.

    abstract：:In the rat, gastric histamine is stored mainly in the enterochromaffinlike cells. Gastrin releases histamine from these cells, and long-term hypergastrinemia results in hyperplasia. The effect of sustained hypergastrinemia on histamine-depleted enterochromaffinlike cells was studied by measuring histidine decarboxylas...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(92)90023-r

    authors： Andersson K,Håkanson R,Mattsson H,Ryberg B,Sundler F

    更新日期：1992-09-01 00:00:00

  • Food, immunity, and the microbiome.

    abstract：:There is increasing evidence that ingested diet-borne components are involved in the pathogenesis of disorders such as inflammatory bowel diseases, atherosclerosis, and type 2 diabetes. Nutrients can have short- and long-term effects in shaping the composition of the microbiota. Western diets (enriched in fat, phospha...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2014.12.036

    authors： Tilg H,Moschen AR

    更新日期：2015-05-01 00:00:00

  • Gastric mucosal alpha(4)beta(7)-integrin-positive CD4 T lymphocytes and immune protection against helicobacter infection in mice.

    abstract：BACKGROUND & AIMS:The integrin alpha(4)beta(7) mediates homing of effector/memory lymphocytes to the intestine and the mucosa-associated lymphoid tissue. This study examined the ability of alpha(4)beta(7)(hi) CD4(+) T lymphocytes to home to the stomach and their role in immunization-mediated protection against Helicoba...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2000.8548

    authors： Michetti M,Kelly CP,Kraehenbuhl JP,Bouzourene H,Michetti P

    更新日期：2000-07-01 00:00:00

  • Ileal distention relaxes the canine colon: a model of megacolon?

    abstract：BACKGROUND/AIMS:Reflex relaxation is a mechanism whereby the colon can show short-term dilatation in the absence of mechanical obstruction. This study investigated the tonic response of the canine colon to ileal distention and its pharmacological control. METHODS:In four dogs, the tone of the proximal colon was record...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(94)90692-0

    authors： Basilisco G,Phillips SF

    更新日期：1994-03-01 00:00:00

  • Changes in protein kinase C isoforms in association with vascular hyporeactivity in cirrhotic rat aortas.

    abstract：BACKGROUND & AIMS:Although protein kinase C (PKC) alterations may play a role in the abnormal reactivity of cirrhotic rat aortas, its isoforms and cellular distribution are unknown. We therefore studied the protein expression and cellular distribution of PKC isoforms and their activation in cirrhotic rat aortas. METHO...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2000.8522

    authors： Tazi KA,Moreau R,Heller J,Poirel O,Lebrec D

    更新日期：2000-07-01 00:00:00

  • Effects of extracellular Ca2+ and HCO3- on epidermal growth factor-induced DNA synthesis in cultured rat hepatocytes.

    abstract：BACKGROUND/AIMS:The elevation of cytosolic free calcium concentration ([Ca2+]i) and intracellular pH mediate the growth factor-initiated proliferation of many cells, but it is not known if they trigger mitosis in resting hepatocytes. The maintenance of [Ca2+]i and intracellular pH depends partly on extracellular calciu...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90077-2

    authors： Zhang BH,Farrell GC

    更新日期：1995-02-01 00:00:00

  • Degradative intracellular transport of antisecretory component in cultured hepatocytes. An alternate pathway for the immunoglobulin A receptor.

    abstract：:The liver efficiently transports dimeric immunoglobulin A (dIgA) from blood to bile in a direct, nonlysosomal pathway involving smooth-surfaced vesicles. Secretory component (SC), the plasma membrane receptor for dIgA, is released into bile still bound to its ligand by disulfide bridges. Rabbit IgG antirat SC binds sp...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(85)90002-2

    authors： Kim E,Hradek GT,Jones AL

    更新日期：1985-06-01 00:00:00

  • Intestinal absorption of the octapeptide SMS 201-995 visualized by fluorescence derivatization.

    abstract：:The absorption of an intact oligopeptide was investigated in rat and dog small intestine using the metabolically stable somatostatin analogue SMS 201-995. The synthetic octapeptide was coupled to 4-nitrobenzo-2-oxa-1,3-diazol to have a fluorescent label for the direct visualization. The 4-nitrobenzo-2-oxa-1,3-diazol-l...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90651-z

    authors： Fricker G,Bruns C,Munzer J,Briner U,Albert R,Kissel T,Vonderscher J

    更新日期：1991-06-01 00:00:00

  • Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients.

    abstract：BACKGROUND & AIMS:Few data are available concerning the long-term prognosis of chronic liver disease associated with hepatitis C virus infection. This study examined the morbidity and survival of patients with compensated cirrhosis type C. METHODS:A cohort of 384 European cirrhotic patients was enrolled at seven terti...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v112.pm9024300

    authors： Fattovich G,Giustina G,Degos F,Tremolada F,Diodati G,Almasio P,Nevens F,Solinas A,Mura D,Brouwer JT,Thomas H,Njapoum C,Casarin C,Bonetti P,Fuschi P,Basho J,Tocco A,Bhalla A,Galassini R,Noventa F,Schalm SW,Realdi

    更新日期：1997-02-01 00:00:00

  • Effects of chlorpromazine on bilirubin metabolism and biliary secretion in the rat.

    abstract：:Chlorpromazine (CPZ) is a long recognized cause of jaundice, but the mechanism by which this agent produces icteric liver disease is not well defined. This study examined some effects of CPZ administration on bilirubin metabolism and biliary secretion in the rat. Acute CPZ treatment (25 mg per kg intravenously) produc...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Knodell RG

    更新日期：1975-10-01 00:00:00

  • Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-Associated Colorectal Cancer.

    abstract：BACKGROUND & AIMS:A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted vs random biopsies in patients with UC. METHODS:W...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1053/j.gastro.2016.08.002

    authors： Watanabe T,Ajioka Y,Mitsuyama K,Watanabe K,Hanai H,Nakase H,Kunisaki R,Matsuda K,Iwakiri R,Hida N,Tanaka S,Takeuchi Y,Ohtsuka K,Murakami K,Kobayashi K,Iwao Y,Nagahori M,Iizuka B,Hata K,Igarashi M,Hirata I,Kudo S

    更新日期：2016-12-01 00:00:00

  • The importance of local acid production in the distribution of Helicobacter felis in the mouse stomach.

    abstract：BACKGROUND/AIMS:Helicobacter felis colonizes the gastric mucosa of rodents. Preliminary studies showed differences in the distribution of the organism in different parts of the stomach that seemed related to the secretory capacity of the mucosa. The aim of this study was to determine the localization of H. felis in the...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90686-x

    authors： Danon SJ,O'Rourke JL,Moss ND,Lee A

    更新日期：1995-05-01 00:00:00

  • Implementation of on-site screening sigmoidoscopy positively influences utilization by primary care providers.

    abstract：BACKGROUND & AIMS:Sigmoidoscopy is an effective screening strategy for colorectal cancer that is not widely used by primary care providers. The aim of this study was to assess the impact of "academic detailing" in the form of an outreach educational seminar combined with implementation of on-site sigmoidoscopy services...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1053/gast.1999.0029900304

    authors： Schroy PC,Heeren T,Bliss CM,Pincus J,Wilson S,Prout M

    更新日期：1999-08-01 00:00:00

  • CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice.

    abstract：BACKGROUND & AIMS:Adenosine mediates immune suppression and is generated by the ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial cells and regulatory T cells (Tregs). Although tumor-infiltrating immune cells include Foxp3(+) Tregs, it is not clear whether local adenosine generation by...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.05.007

    authors： Sun X,Wu Y,Gao W,Enjyoji K,Csizmadia E,Müller CE,Murakami T,Robson SC

    更新日期：2010-09-01 00:00:00

  • The protective effect of gamma-hydroxybutyrate in regional intestinal ischemia in the hamster.

    abstract：:The purpose of this study was to determine whether gamma-hydroxybutyrate provides protection against intestinal ischemia/reperfusion injury and to compare its effect with that of allopurinol and vitamin E. Thirty minutes of total regional ischemia, followed by 3 hours of reperfusion, produced intestinal damage that wa...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)90982-7

    authors： Boyd AJ,Sherman IA,Saibil FG,Mamelak M

    更新日期：1990-09-01 00:00:00

  • Lack of association between oral contraceptive use and Crohn's disease: a community-based matched case-control study.

    abstract：:Previous epidemiologic studies have suggested a weak association between oral contraceptive use and Crohn's disease, specifically Crohn's colitis. To measure a possible etiologic association, 51 women with Crohn's disease who were 18-50 yr old were studied and compared with peer-nominated age- and sex-matched controls...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)90388-0

    authors： Lashner BA,Kane SV,Hanauer SB

    更新日期：1989-12-01 00:00:00

  • STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.

    abstract：BACKGROUND:The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) has proposed treatment-targets in 2015 for adult IBD patients. We aimed to update the original STRIDE statements for incorporating treatme...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2020.12.031

    authors： Turner D,Ricciuto A,Lewis A,D'Amico F,Dhaliwal J,Griffiths AM,Bettenworth D,Sandborn WJ,Sands BE,Reinisch W,Schölmerich J,Bemelman W,Danese S,Mary JY,Rubin D,Colombel JF,Peyrin-Biroulet L,Dotan I,Abreu MT,Dignass A

    更新日期：2020-12-21 00:00:00

  • Admission volume determines outcome for patients with acute pancreatitis.

    abstract：BACKGROUND & AIMS:There is controversy over the optimal management strategy for patients with acute pancreatitis (AP). Studies have shown a hospital volume benefit for in-hospital mortality after surgery, and we examined whether a similar mortality benefit exists for patients admitted with AP. METHODS:Using the Nation...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2009.08.056

    authors： Singla A,Simons J,Li Y,Csikesz NG,Ng SC,Tseng JF,Shah SA

    更新日期：2009-12-01 00:00:00

  • Human intestinal intraepithelial lymphocytes have potent chemotactic activity.

    abstract：BACKGROUND & AIMS:Inflammation is created by the movement of leukocytes toward soluble attractants (chemokines). The aim of this study was to identify the chemokines that attract intestinal lymphocytes. METHODS:Intraepithelial and lamina propria lymphocytes were isolated from human jejunal mucosa of healthy individual...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90573-1

    authors： Ebert EC

    更新日期：1995-10-01 00:00:00

  • A circulating ligand for galectin-3 is a haptoglobin-related glycoprotein elevated in individuals with colon cancer.

    abstract：BACKGROUND & AIMS:Galectin-3 is a beta-galactoside-binding protein implicated in tumor progression and metastasis of colorectal cancers. To determine whether circulating galectin-3 ligands are related to the presence of colon cancer, we sought to identify and quantify ligands in serum that bind to galectin-3. METHODS:...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2004.06.016

    authors： Bresalier RS,Byrd JC,Tessler D,Lebel J,Koomen J,Hawke D,Half E,Liu KF,Mazurek N,Great Lakes-New England Clinical and Epidemiology Center of the Early Detection Research Network.

    更新日期：2004-09-01 00:00:00

  • AGA Clinical Practice Update: Coagulation in Cirrhosis.

    abstract：DESCRIPTION:This expert review was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership. The intent is to evaluate the current data on mechanism of altered coagulation in pat...

    journal_title：Gastroenterology

    pub_type： 杂志文章,实务指引,评审

    doi：10.1053/j.gastro.2019.03.070

    authors： O'Leary JG,Greenberg CS,Patton HM,Caldwell SH

    更新日期：2019-07-01 00:00:00

  • Immunogenicity of biliary epithelium: study of the adhesive interaction with lymphocytes.

    abstract：BACKGROUND & AIMS:Intrahepatic bile ducts express a range of lymphocyte adhesion molecules during episodes of inflammation. This may contribute to the susceptibility of biliary epithelium to immunologic damage during liver allograft rejection, graft-versus-host disease, and primary biliary cirrhosis. However, no previo...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v112.pm9041260

    authors： Leon MP,Bassendine MF,Gibbs P,Thick M,Kirby JA

    更新日期：1997-03-01 00:00:00

  • YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling.

    abstract：BACKGROUND & AIMS:Pancreatitis is the most important risk factor for pancreatic ductal adenocarcinoma (PDAC). Pancreatitis predisposes to PDAC because it induces a process of acinar cell reprogramming known as acinar-to-ductal metaplasia (ADM)-a precursor of pancreatic intraepithelial neoplasia lesions that can progres...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2016.05.006

    authors： Gruber R,Panayiotou R,Nye E,Spencer-Dene B,Stamp G,Behrens A

    更新日期：2016-09-01 00:00:00

  • Mucosal expression by B7-positive cells of the 60-kilodalton heat-shock protein in inflammatory bowel disease.

    abstract：BACKGROUND/AIMS:Heat-shock protein (Hsp) 60 is an immunodominant antigen of mycobacteria and other microorganisms that is highly homologous to its human counterpart. Hsp60 may provide a link between immunity to invading microorganisms and autoimmune diseases. METHODS:Expression of Hsp60 was studied by immunohistochemi...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90010-1

    authors： Peetermans WE,D'Haens GR,Ceuppens JL,Rutgeerts P,Geboes K

    更新日期：1995-01-01 00:00:00

  • Pathophysiology of Shigella diarrhea in the rhesus monkey: intestinal transport, morphological, and bacteriological studies.

    abstract：:In contrast to the "toxigenic diarrheas" caused by Vibrio cholerae and Escherichia coli, the site and mechanism of fluid loss in shigellosis are unknown. The occurrence of watery diarrhea in shigellosis suggests involvement of the small bowel. Therefore, jejunal, ileal, and colonic water and electrolyte transport was ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Rout WR,Formal SB,Giannella RA,Dammin GJ

    更新日期：1975-02-01 00:00:00