Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients.

abstract：:Eleven infants born to mothers with acute hepatitis B during the third trimester of pregnancy who were hepatitis B surface antigen-positive at delivery were treated with hepatitis B immune globulin within 24-48 h of birth. Five infants received one dose of hepatitis B immune globulin and 6 infants received a second do...

journal_title：Gastroenterology

authors： Tong MJ,Nair PV,Thursby M,Schweitzer IL

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND & AIMS:Caspases are critical mediators of apoptosis and proliferation of peripheral blood T cells (PBT), but their role in lamina propria T cells (LPT), a cell population highly susceptible to apoptosis, has not been explored. METHODS:RA(+), RO(+) PBT, and LPT were activated with CD3, CD2, and CD28 antibodi...

journal_title：Gastroenterology

authors： Sturm A,Mohr S,Fiocchi C

更新日期：2002-05-01 00:00:00

abstract：:Acute self-limited liver disease has been associated with tetracycline use. However, severe prolonged cholestatic hepatitis and bile duct paucity have not been previously attributed to tetracyclines. Hepatitis, characterized by prolonged jaundice, severe pruritus, and moderate increased transaminase values, occurred w...

journal_title：Gastroenterology

authors： Hunt CM,Washington K

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Mutant hepatitis B virus is often associated with severe liver damage. The purpose of this study is to elucidate the relationship between mutations in hepatitis B precore/core gene and the severity of liver damage. METHODS:The hepatitis B precore/core gene from 20 patients with chronic hepatitis B virus inf...

journal_title：Gastroenterology

authors： Chuang WL,Omata M,Ehata T,Yokosuka O,Ito Y,Imazeki F,Lu SN,Chang WY,Ohto M

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND & AIMS:We assessed the influence of genetic variants in the hepatitis B virus (HBV) core, which is a principal immunologic target, on the progression to hepatocellular carcinoma (HCC) in a cohort of 4841 male HBV carriers followed up for 16 years. METHODS:First, baseline sera from 116 HCC cases and 154 cont...

journal_title：Gastroenterology

authors： Sung FY,Jung CM,Wu CF,Lin CL,Liu CJ,Liaw YF,Tsai KS,Yu MW

更新日期：2009-11-01 00:00:00

abstract：:The appropriate treatment of patients with fistulas in the setting of Crohn's disease requires a knowledge of the specific medical and surgical literature of fistulizing Crohn's. The patient with symptomatic fistulizing Crohn's disease may respond differently to specific medical therapy than a patient with symptomatic...

journal_title：Gastroenterology

authors： Lichtenstein GR

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Current information concerning endothelin in cirrhosis is conflicting. Plasma endothelin concentration has been found to be increased in some studies and normal or reduced in others. The present study was aimed to investigate the plasma levels of endothelin in cirrhosis and to assess whether it is involved i...

journal_title：Gastroenterology

authors： Asbert M,Ginès A,Ginès P,Jiménez W,Clària J,Saló J,Arroyo V,Rivera F,Rodés J

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND & AIMS:We aimed to characterize offers of organs to candidates awaiting liver transplantation (LT). METHODS:We analyzed data from the United Network for Organ Sharing registry on all US LT candidates with nonfulminant disease who were offered livers from February 1, 2005, to January 31, 2010, and ultimately...

journal_title：Gastroenterology

authors： Lai JC,Feng S,Roberts JP

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND & AIMS:Entecavir demonstrated superior benefit to lamivudine at 48 weeks in nucleoside-naive patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB). We evaluated continued entecavir and lamivudine treatment through 96 weeks. METHODS:709 HBeAg-positive CHB patients were randomized to ...

journal_title：Gastroenterology

authors： Gish RG,Lok AS,Chang TT,de Man RA,Gadano A,Sollano J,Han KH,Chao YC,Lee SD,Harris M,Yang J,Colonno R,Brett-Smith H

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND & AIMS:Mutations in the APC gene result in an increased propensity to develop intestinal neoplasia; however, a complete understanding of the mechanisms resulting in tumor formation has remained elusive. Min mice possess a mutation in the APC gene and display a neoplastic phenotype similar to that observed in...

journal_title：Gastroenterology

authors： Williams CS,Luongo C,Radhika A,Zhang T,Lamps LW,Nanney LB,Beauchamp RD,DuBois RN

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND & AIMS:Numerous studies have linked the proliferation of liver progenitor cells (LPCs) during chronic liver disease to the risk for development of hepatocellular carcinoma. Thus, selective inhibition of LPC growth during preneoplastic injury may prevent or delay the onset of liver cancer. Rats carrying a ger...

journal_title：Gastroenterology

authors： Knight B,Tirnitz-Parker JE,Olynyk JK

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND/AIMS:We have identified several clones specifically expressed during malignant cell proliferation by screening a complementary DNA library constructed from a human primary liver cancer with subtractive probes. One clone was identified as the glutamine synthetase (GS) transcript. Its expression is tightly reg...

journal_title：Gastroenterology

authors： Christa L,Simon MT,Flinois JP,Gebhardt R,Brechot C,Lasserre C

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic myelopathy is a rare complication of chronic liver disease, causing progressive spastic paraparesis. Today, no therapy of this disorder has been established. Commonly used therapeutic strategies for hepatic encephalopathy aiming at the reduction of plasma ammonia levels such as protein restric...

journal_title：Gastroenterology

authors： Weissenborn K,Tietge UJ,Bokemeyer M,Mohammadi B,Bode U,Manns MP,Caselitz M

更新日期：2003-02-01 00:00:00

abstract：:The study of cholesterol gallstone disease would be facilitated if the nucleation time of cholesterol crystals could be measured in duodenal bile and was correlated with nucleation occurring in vivo. Therefore, our aims were to determine (a) if nucleation time could be measured in duodenal bile, (b) the effect of bact...

journal_title：Gastroenterology

authors： Marks JW,Broomfield P,Bonorris GG,Schoenfield LJ

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:Few studies, even those with cohort designs, test the mediating effects of infant gut microbes and metabolites on the onset of disease. We undertook such a study. METHODS:Using structural equation modeling path analysis, we tested directional relationships between first pregnancy, birth mode, prolong...

journal_title：Gastroenterology

authors： Vu K,Lou W,Tun HM,Konya TB,Morales-Lizcano N,Chari RS,Field CJ,Guttman DS,Mandal R,Wishart DS,Azad MB,Becker AB,Mandhane PJ,Moraes TJ,Lefebvre DL,Sears MR,Turvey SE,Subbarao P,Scott JA,Kozyrskyj AL

更新日期：2021-01-01 00:00:00

abstract：:Identification of physiologic factors that predict response to fecal incontinence therapy would be helpful in choosing the optimal treatment and advising patients on the likelihood of a successful outcome. However, few physiologic parameters have been consistently identified as important in predicting response to eith...

journal_title：Gastroenterology

authors： Prather CM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND & AIMS:Endoscopic and Histologic remission are important goals in the treatment of ulcerative colitis (UC). We investigated the correlation of the recently developed Paddington International Virtual ChromoendoScopy ScOre( PICaSSO) and other established endoscopic scores against multiple histological indices ...

journal_title：Gastroenterology

authors： Iacucci M,Smith SC,Bazarova A,Shivaji UN,Bhandari P,Cannatelli R,Daperno M,Ferraz J,Goetz M,Gui X,Hayee B,De Hertogh G,Lazarev M,Li J,Nardone OM,Parra-Blanco A,Pastorelli L,Panaccione R,Occhipinti V,Rath T,Tontini

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p...

journal_title：Gastroenterology

authors： Almeida MI,Nicoloso MS,Zeng L,Ivan C,Spizzo R,Gafà R,Xiao L,Zhang X,Vannini I,Fanini F,Fabbri M,Lanza G,Reis RM,Zweidler-McKay PA,Calin GA

更新日期：2012-04-01 00:00:00

abstract：:Prior animal models of cholesterol gallstone formation have been criticized for their dissimilarity to the conditions of humans with gallstones. We present a new hamster model of cholesterol cholelithiasis that more closely approximates the human situation. Sixty female Golden Syrian hamsters (average weight 83.2 +/- ...

journal_title：Gastroenterology

authors： Pearlman BJ,Bonorris GG,Phillips MJ,Chung A,Vimadalal S,Marks JW,Schoenfield LJ

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Celiac disease is a prevalent disorder characterized by a chronic intestinal inflammation driven by HLA-DQ2 or -DQ8-restricted T cells specific for ingested wheat gluten peptides. The dominant T-cell responses are to epitopes that cluster within a stable 33mer fragment formed by physiologic digestio...

journal_title：Gastroenterology

authors： Molberg O,Uhlen AK,Jensen T,Flaete NS,Fleckenstein B,Arentz-Hansen H,Raki M,Lundin KE,Sollid LM

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND & AIMS:We aimed to identify the incidence and predictors of de novo gastroesophageal variceal formation and progression in a large cohort of patients with chronic hepatitis C and advanced fibrosis. METHODS:All participants in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis Trial were offered...

journal_title：Gastroenterology

authors： Fontana RJ,Sanyal AJ,Ghany MG,Lee WM,Reid AE,Naishadham D,Everson GT,Kahn JA,Di Bisceglie AM,Szabo G,Morgan TR,Everhart JE,HALT-C Trial Group.

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND/AIMS:A double-blind, placebo-controlled trial of ursodeoxycholic acid (UDCA) was conducted in 180 patients with primary biliary cirrhosis (PBC) to define the efficacy and safety of UDCA. Efficacy was assessed by time to treatment failure defined as death; liver transplantation; histological progression; deve...

journal_title：Gastroenterology

authors： Lindor KD,Dickson ER,Baldus WP,Jorgensen RA,Ludwig J,Murtaugh PA,Harrison JM,Wiesner RH,Anderson ML,Lange SM

更新日期：1994-05-01 00:00:00

abstract：:Receptor-dependent and -independent regulation of gastrin secretion from cultured human antral G cells was investigated. Human antral mucosal cell preparations that were enriched for G cells were obtained by sequential incubations with collagenase and ethylenediaminetetraacetic acid, centrifugal elutriation, and short...

journal_title：Gastroenterology

authors： Campos RV,Buchan AM,Meloche RM,Pederson RA,Kwok YN,Coy DH

更新日期：1990-07-01 00:00:00

abstract：:Characteristics of a macroamylase that was considered not to be formed by the binding of normal amylase to immunoglobulins were studied. The macroamylase was reversibly dissociated into apparently normal amylase by treating the macroamylasemic serum with guanidine hydrochloride. Concanavalin A precipitated a large por...

journal_title：Gastroenterology

authors： Kitamura T,Yoshioka K,Ehara M,Akedo H

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regula...

journal_title：Gastroenterology

authors： Garuti C,Tian Y,Montosi G,Sabelli M,Corradini E,Graf R,Ventura P,Vegetti A,Clavien PA,Pietrangelo A

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:It is uncertain whether peptide YY (PYY) inhibits human intestinal secretion directly through enterocyte receptors or via indirect neural mechanisms. Thus, the effect of PYY on prostaglandin E2 (PGE2)-induced jejunal secretion in normal volunteers was measured, and it was determined whether a dopamine...

journal_title：Gastroenterology

authors： Rozé C,Molis C,Xiaomei FC,Ropert A,Genève J,Galmiche JP

更新日期：1997-05-01 00:00:00

abstract：:Chenodeoxycholic acid (CDC) and ursodeoxycholic acid (UDC) have distinct physicochemical and metabolic properties which, being complementary, should favor more rapid removal of cholesterol from gallstones when both bile acids are administered together. To see if the combination is more effective and well tolerated, we...

journal_title：Gastroenterology

authors： Podda M,Zuin M,Battezzati PM,Ghezzi C,de Fazio C,Dioguardi ML

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND & AIMS:Studies on the early steps in the life cycle of hepatitis B virus have been hampered by the lack of readily available target cells. In this study, we mapped a defined virus attachment site to primary hepatocytes that is essential for infection. METHODS:We used purified virus particles from human carr...

journal_title：Gastroenterology

authors： Glebe D,Urban S,Knoop EV,Cag N,Krass P,Grün S,Bulavaite A,Sasnauskas K,Gerlich WH

更新日期：2005-07-01 00:00:00

abstract：:Basal and pentagastrin-stimulated gastric acid secretion, fasting serum gastrin concentrations, and the gastric output of prostaglandin E and its major metabolite 13,14-dihydro 15-keto prostaglandin E2 were measured in 9 normal subjects before and after 14-20 days of dietary supplementation with linoleic acid. Mean ma...

journal_title：Gastroenterology

authors： Grant HW,Palmer KR,Kelly RW,Wilson NH,Misiewicz JJ

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND & AIMS:Common germline genetic variation in the 3' region of myosin IXB (MYO9B) has been associated recently with susceptibility to celiac disease, with a hypothesis that MYO9B variants might influence intestinal permeability. These findings suggested the current study investigating a possible further role f...

journal_title：Gastroenterology

authors： van Bodegraven AA,Curley CR,Hunt KA,Monsuur AJ,Linskens RK,Onnie CM,Crusius JB,Annese V,Latiano A,Silverberg MS,Bitton A,Fisher SA,Steinhart AH,Forbes A,Sanderson J,Prescott NJ,Strachan DP,Playford RJ,Mathew CG,Wijm

更新日期：2006-12-01 00:00:00