Abstract:
BACKGROUND & AIMS:Hepatic myelopathy is a rare complication of chronic liver disease, causing progressive spastic paraparesis. Today, no therapy of this disorder has been established. Commonly used therapeutic strategies for hepatic encephalopathy aiming at the reduction of plasma ammonia levels such as protein restriction, oral neomycin, lactulose, or ornithine aspartate fail to improve the symptoms of hepatic myelopathy. The aim of this study was to find out whether orthotopic liver transplantation (OLT) may improve hepatic myelopathy. METHODS:Follow-up examinations of 3 patients with severe hepatic myelopathy before and after OLT. RESULTS:In all 3 patients, the neurologic status improved significantly after liver transplantation. The grade of improvement was related to the time interval between onset of the first symptoms of hepatic myelopathy and liver transplantation. CONCLUSIONS:Early recognition of hepatic myelopathy is important because timely liver transplantation as an established therapy for end-stage liver disease offers the chance of complete recovery from hepatic paraparesis.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Weissenborn K,Tietge UJ,Bokemeyer M,Mohammadi B,Bode U,Manns MP,Caselitz Mdoi
10.1053/gast.2003.50062keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
346-51issue
2eissn
0016-5085issn
1528-0012pii
S0016508502159130journal_volume
124pub_type
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