Abstract:
BACKGROUND/AIMS:Cytokines are thought to be important in mediating tissue damage in inflammatory bowel disease (IBD). Many of the in vivo activities of tumor necrosis factor alpha (TNF-alpha) match the changes found in IBD, but its importance is controversial. METHODS:A sensitive, reverse hemolytic plaque assay was used to determine the frequency of TNF-alpha secreting cells isolated from mucosal biopsy specimens of children with Crohn's disease or ulcerative colitis (UC) and non-IBD controls before and after medical treatment. RESULTS:Frequency of TNF-alpha secreting cells was significantly increased in biopsy specimens from children with mild, nonspecific inflammation compared with those with histologically normal intestine. Frequency did not increase in UC compared with children with nonspecific inflammation but was significantly greater in Crohn's disease than in UC. After treatment, the frequency of TNF-alpha secreting cells was reduced in patients receiving cyclosporin A, not reduced in patients with steroids or enteral nutrition, and not changed with treatment in UC. CONCLUSIONS:TNF-alpha secreting cells are increased in the mucosa of inflamed intestine, regardless of pathogenesis. In patients with IBD, higher levels are seen in Crohn's disease than in UC, probably reflecting the extensive T-cell activation in Crohn's disease. No relation existed between histological healing and the frequency of TNF-alpha-secreting cells.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Breese EJ,Michie CA,Nicholls SW,Murch SH,Williams CB,Domizio P,Walker-Smith JA,MacDonald TTdoi
10.1016/0016-5085(94)90398-0subject
Has Abstractpub_date
1994-06-01 00:00:00pages
1455-66issue
6eissn
0016-5085issn
1528-0012pii
0016-5085(94)90398-0journal_volume
106pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND & AIMS:We recently identified a polymorphism upstream of interleukin (IL)-28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to pegylated interferon-alfa and ribavirin therapy in a large cohort of treatment-naive, adherent patients with chronic hepatitis C virus genotyp...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.04.013
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND & AIMS:This study aimed to determine if hiatal hernia influences vulnerability to reflux and transient lower esophageal sphincter relaxation (tLESR) during gastric distention in patients with gastroesophageal reflux disease (GERD). METHODS:Eight normal subjects and 15 patients with GERD were studied. A meta...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(00)70138-7
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND & AIMS:Metaplasias often have characteristics of developmentally related tissues. Pancreatic metaplastic ducts are usually associated with pancreatitis and pancreatic ductal adenocarcinoma. The tuft cell is a chemosensory cell that responds to signals in the extracellular environment via effector molecules. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.08.053
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND & AIMS:Sjögren's syndrome and autoimmune pancreatitis are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. Nonobese diabetic/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren's syndrome and chronic pancreatitis and MRL/Mp mice are models of autoi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.06.011
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND & AIMS:Gastroesophageal reflux is common among patients with postnasal drainage. We investigated whether proton pump inhibitor therapy improved symptoms in patients with postnasal drainage without sinusitis or allergies. METHODS:In a parallel-group, double-blind, multi-specialty trial, we randomly assigned ...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2010.08.039
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND & AIMS:Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regula...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.03.043
更新日期:2010-07-01 00:00:00
abstract::Basal and pentagastrin-stimulated gastric acid secretion, fasting serum gastrin concentrations, and the gastric output of prostaglandin E and its major metabolite 13,14-dihydro 15-keto prostaglandin E2 were measured in 9 normal subjects before and after 14-20 days of dietary supplementation with linoleic acid. Mean ma...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90553-7
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND & AIMS:Noninvasive methods are needed to identify clinically significant portal hypertension (CSPH) and esophageal varices (EVs) in patients with compensated cirrhosis. We looked for markers of the presence of CSPH and EVs in patients with cirrhosis. METHODS:We performed a cross-sectional study that include...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.10.001
更新日期:2013-01-01 00:00:00
abstract::We studied the response of lymphocytes from 43 patients with inflammatory bowel disease to allogeneic stimulation in one-way mixed-lymphocyte cultures. We found that 53% of patients with inflammatory bowel disease, in contrast to 4% of normal and disease controls, had significant depression of mixed-lymphocyte culture...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1980-10-01 00:00:00
abstract:BACKGROUND & AIMS:Host genetic factors are likely to contribute to the variable course of hepatic fibrosis in response to chronic liver injury. Similarly, the fibrotic response differs among inbred mouse strains after challenge with CCl(4). Our aim was to identify unknown susceptibility loci for hepatic fibrosis in a c...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.37069
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND & AIMS:In searching for effects of acetaminophen (APAP) on hepatocytes downstream of its metabolism that may participate in hepatotoxicity, we examined the role of stress kinases. METHODS:Mouse hepatocytes and C57BL/6 mice were administered a toxic dose of APAP with or without SP600125, a chemical c-jun N-t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.03.045
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND AND AIMS:The peptidyl prolyl isomerase Pin1 frequently is overexpressed in hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1. The role of Pin1 in hepatocarcino...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.12.030
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND & AIMS:Alterations in the gastrointestinal microbiota have been associated with metabolic diseases. However, little is known about host factors that induce changes in gastrointestinal bacterial populations. We investigated the role of bile acids in this process because of their strong antimicrobial activitie...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.07.046
更新日期:2011-11-01 00:00:00
abstract::Thyrotropin-releasing hormone transiently increased resting tension and spontaneous contraction amplitude more potently in longitudinal muscle than in circular muscle. The frequency of the contraction did not change. Excitation was enhanced by eserine, and blocked by atropine and tetrodotoxin; this excitation was, the...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(85)80070-6
更新日期:1985-05-01 00:00:00
abstract::Secretin, substance P, and vasoactive intestinal peptide (VIP) were studied from the immunological point of view using synthetic hormones and their related peptides which were prepared by the conventional method for peptide synthesis. Immunological properties of these hormones were characterized by radioimmunoassays s...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract::The burden of disease consequent to hepatitis C virus (HCV) infection has been well described and is expected to increase dramatically over the next decade. Current approved antiviral therapies are effective in eradicating the virus in approximately 50% of infected patients. However, pegylated interferon and ribavirin...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2007.03.116
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:There is a significant interobserver and intraobserver variation in grading dysplasia in Barrett's metaplasia. New markers are needed to optimize the assessment of potential risk of cancer development in these patients. The aim of this study is to explore the use of p53 as a marker of neoplastic progression ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)91058-p
更新日期:1993-12-01 00:00:00
abstract::To evaluate the effect of aging upon the small intestine, the distribution, content, and concentration of epithelial cell enzymes at different levels along the crypt-villus column were measured in aging and young adult, male, Fisher 344 rats. Specific activities of sucrase, maltase, lactase, and adenosine deaminase in...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90204-5
更新日期:1985-11-01 00:00:00
abstract::A 76-yr-old male presented with Guillain-Barré syndrome after acute hepatitis B virus infection. Main immunologic features were: (a) high levels of circulating hepatitis B surface antigen-containing immune complexes in serum and cerebrospinal fluid during the acute neurologic syndrome, and (b) clearance of immune-comp...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
abstract::Circulating precursors of mucosal immunoglobulin A plasma cells and T-cell immunoblasts migrate selectively into mucosal sites from the blood, but the mechanisms controlling this selective trafficking have not been determined. One possibility is that the site-specific extravasation of circulating effector cell populat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90226-0
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND & AIMS:Patients with Barrett's esophagus (BE) have a risk of esophageal adenocarcinoma of approximately 0.5% per year. Patients may have difficulty understanding this risk. This study assessed the perceived risk of cancer in patients with BE, and correlated their risk estimates with their health care use beh...
journal_title:Gastroenterology
pub_type: 评论,杂志文章
doi:10.1016/j.gastro.2005.05.055
更新日期:2005-08-01 00:00:00
abstract::Cholylglycylhistamine, a derivative of cholic acid, has been synthesized and characterized. This derivative has been iodinated using Na125I and chloramine-T and purified free from unlabeled cholylglycylhistamine. Application of this iodinated bile salt derivative to radioimmunoassay of bile salts in human serum is rep...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-02-01 00:00:00
abstract::A case of primary undifferentiated sarcoma of the liver in a 66-year-old woman is reported. The similarity of the presenting symptoms to those of a hepatic abscess is emphasized. The patient's response to palliative treatment by means of hepatic artery ligation and chemotherapy was excellent. We believe that this is t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::Serum gastrin and gastric endocrine cell numerical densities were examined in 22 patients with long-standing Zollinger-Ellison syndrome who were receiving either ranitidine, omeprazole, or other antisecretory drugs (SMS 201-995 or pirenzepine with or without ranitidine) for long periods of time. Fifteen patients had i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)91620-x
更新日期:1989-04-01 00:00:00
abstract::Although long-term parenteral nutrition is lifesaving in patients with intestinal failure, it is expensive and associated with serious complications such as catheter sepsis, venous occlusions, and liver failure and severely impairs the quality of life in the short bowel patients. Therefore, treatments that increase th...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2005.09.068
更新日期:2006-02-01 00:00:00
abstract::A new experimental model, the isolated perfused antrectomized pig stomach with intact vagal innervation, was shown to produce pepsinogen and gastric acid upon electrical stimulation of the vagus nerves and by intravascular administration of carbachol (from a basal value of 111 +/- 24 units of pepsin per minute and 0.0...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90353-8
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND & AIMS:Omeprazole is metabolized by cytochrome P450 (CYP2C19). The activity of this enzyme is polymorphic, with incidences of poor metabolizers (PMs), heterozygous extensive metabolizers (EMs), and homozygous EMs in white populations of 3%, 30%, and 67%, respectively. The importance of the CYP2C19 polymorphi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.16515
更新日期:2000-09-01 00:00:00
abstract::Rising trends in the incidence and mortality of early-onset CRC in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2020.12.068
更新日期:2021-01-05 00:00:00
abstract::In addition to the previously described molecular forms of gastrin, a new component has been found in high concentrations in the serum of 6 patients with Zollinger-Ellison syndrome. Serum was fractionated by gel filtration, and ion exchange chromatography, and the new component was identified in eluates by radioimmuno...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-02-01 00:00:00
abstract::The effects of chronic mild restraint on the susceptibility of the rat gastric mucosa to ethanol or cold-restraint injury were studied. Gastric mucosas of animals subjected to chronic mild restraint exhibited less damage when bathed with 40% ethanol than those of control animals. This reduced damage was observed with ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00