Thyrotropin-releasing hormone effects on guinea pig antrum.

abstract：BACKGROUND & AIMS:Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive human disorder characterized by reduced activities of the brush border enzyme sucrase-isomaltase (SI). Here, we elucidate the pathogenesis of a new variant of CSID at the cellular and molecular level. METHODS:Assessment of the ...

journal_title：Gastroenterology

authors： Ritz V,Alfalah M,Zimmer KP,Schmitz J,Jacob R,Naim HY

更新日期：2003-12-01 00:00:00

abstract：:Helicobacter pylori infects the stomach of half of the human population worldwide and causes chronic active gastritis, which can lead to peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The host immune response to the infection is ineffective, because the bacterium persists...

journal_title：Gastroenterology

authors： Wilson KT,Crabtree JE

更新日期：2007-07-01 00:00:00

abstract：:We describe 2 siblings with multiple gastrointestinal stromal tumors (GISTs) and cutaneous hyperpigmentation. Both had a point mutation of the c-kit gene. The patients were sisters who had exhibited cutaneous hyperpigmentation since their late teens, but the diagnosis of multiple gastrointestinal submucosal tumors was...

journal_title：Gastroenterology

authors： Maeyama H,Hidaka E,Ota H,Minami S,Kajiyama M,Kuraishi A,Mori H,Matsuda Y,Wada S,Sodeyama H,Nakata S,Kawamura N,Hata S,Watanabe M,Iijima Y,Katsuyama T

更新日期：2001-01-01 00:00:00

abstract：:We have examined the possibility that the 33- and 39-amino acid forms of cholecystokinin (CCK) are cleaved to produce CCK-octapeptide (CCK-8) during circulation in humans. When a mixture of the 33- and 39-amino acid forms of porcine CCK was infused at 0.1-2.5 pmol/kg.min into normal subjects, material indistinguishabl...

journal_title：Gastroenterology

authors： Springer CJ,Calam J

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic hepatitis C virus infection activates an intrahepatic immune response, leading to increased expression of interferon (IFN)-stimulated genes and activation of natural killer (NK) cells-the most prevalent innate immune cell in the liver. We investigated whether the elimination of hepatitis C vir...

journal_title：Gastroenterology

authors： Serti E,Chepa-Lotrea X,Kim YJ,Keane M,Fryzek N,Liang TJ,Ghany M,Rehermann B

更新日期：2015-07-01 00:00:00

abstract：:Hepatic morphology and immunocytology were evaluated in 4 children with clinical and immunologic characteristics of the acquired immune deficiency syndrome or acquired immune deficiency syndrome related complex. All 4 children had hepatomegaly and increased serum alanine and aspartate aminotransferase activity. Both l...

journal_title：Gastroenterology

authors： Duffy LF,Daum F,Kahn E,Teichberg S,Pahwa R,Fagin J,Kenigsberg K,Kaplan M,Fisher SE,Pahwa S

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:Black patients with chronic hepatitis C have lower response rates than white patients to interferon monotherapy. The factors responsible for these differences are unknown, as is the impact of combination antiviral therapy on responsiveness among ethnic groups. We evaluated the impact of race on respon...

journal_title：Gastroenterology

authors： McHutchison JG,Poynard T,Pianko S,Gordon SC,Reid AE,Dienstag J,Morgan T,Yao R,Albrecht J

更新日期：2000-11-01 00:00:00

abstract：:Two patients developed local gangrene after subcutaneous infiltration of vasopressin (Pitressin, Parke, Davis & Company, Detroit, Mich.) utilized for the control of bleeding from esophageal varices. In the 1st patient, ischemic gangrene resulted in transmetatarsal amputation and also necessitated skin grafts on the fo...

journal_title：Gastroenterology

authors： Greenwald RA,Rheingold OJ,Chiprut RO,Rogers AI

更新日期：1978-04-01 00:00:00

abstract：:A new experimental model, the isolated perfused antrectomized pig stomach with intact vagal innervation, was shown to produce pepsinogen and gastric acid upon electrical stimulation of the vagus nerves and by intravascular administration of carbachol (from a basal value of 111 +/- 24 units of pepsin per minute and 0.0...

journal_title：Gastroenterology

authors： Skak-Nielsen T,Holst JJ,Nielsen OV

更新日期：1988-11-01 00:00:00

abstract：:The hemodynamic effects of octreotide were studied in 20 patients with hepatitis B-related cirrhosis. In patients receiving a 100-micrograms bolus and a 100-micrograms/h infusion, heart rate, cardiac index, and systemic vascular resistance showed no significant changes, whereas right atrial pressure, pulmonary capilla...

journal_title：Gastroenterology

authors： Lin HC,Tsai YT,Lee FY,Lee SD,Hsia HC,Lin WJ,Lo KJ

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND & AIMS:Because alterations of integrin expression in cancers contribute to cancer cell biology, we analyzed the association between the potential for peritoneal dissemination and integrin expression. METHODS:The dissemination potential of 10 human gastric cancer cell lines in mice with severe combined immun...

journal_title：Gastroenterology

authors： Ishii Y,Ochiai A,Yamada T,Akimoto S,Yanagihara K,Kitajima M,Hirohashi S

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND & AIMS:Gastric histology is not well studied in patients with Crohn's disease. The aim of this study was to analyze the histological appearance of gastric mucosa in patients with Crohn's disease. METHODS:In a prospective study, biopsy specimens taken from the antrum and body of 75 patients with known Crohn'...

journal_title：Gastroenterology

authors： Oberhuber G,Püspök A,Oesterreicher C,Novacek G,Zauner C,Burghuber M,Vogelsang H,Pötzi R,Stolte M,Wrba F

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND & AIMS:Mutational inactivation of adenomatous polyposis coli (APC) is an early event in colorectal cancer (CRC) progression that affects the stability and increases the activity of β-catenin, a mediator of Wnt signaling. Progression of CRC also involves inactivation of signaling via transforming growth facto...

journal_title：Gastroenterology

authors： Freeman TJ,Smith JJ,Chen X,Washington MK,Roland JT,Means AL,Eschrich SA,Yeatman TJ,Deane NG,Beauchamp RD

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND & AIMS:Postprandial glycemia excursions increase after gastric bypass surgery; this effect is even greater among patients with recurrent hypoglycemia. These patients also have increased postprandial levels of insulin and glucagon-like peptide 1 (GLP-1). We performed a clinical trial to determine the role of ...

journal_title：Gastroenterology

authors： Salehi M,Gastaldelli A,D'Alessio DA

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND & AIMS:Refractory gastroesophageal reflux disease (GERD) reduces quality of life and creates significant financial burden on the health care system. Approximately 30% of patients with GERD who receive label-dose proton pump inhibitors (PPIs) still have symptoms. We performed a trial to evaluate the efficacy ...

journal_title：Gastroenterology

authors： Vaezi MF,Fass R,Vakil N,Reasner DS,Mittleman RS,Hall M,Shao JZ,Chen Y,Lane L,Gates AM,Currie MG

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND & AIMS:The pregnane X receptor (PXR) regulates an array of genes involved in the response to xenobiotics. Evidence from several studies suggests that xenobiotic metabolism may play a role in inflammatory bowel disease (IBD) and that low levels of PXR may be associated with disease expression. The aim of this...

journal_title：Gastroenterology

authors： Dring MM,Goulding CA,Trimble VI,Keegan D,Ryan AW,Brophy KM,Smyth CM,Keeling PW,O'Donoghue D,O'Sullivan M,O'Morain C,Mahmud N,Wikström AC,Kelleher D,McManus R

更新日期：2006-02-01 00:00:00

abstract：:A pancreatic somatostatinoma metastatized to the liver was detected in a 70-yr-old woman presenting with chronic diarrhea, steatorrhea, pancreatic insufficiency, diabetes mellitus, and achlorhydria. At immunocytochemistry, most tumor cells stored both somatostatin and calcitoninlike substances. Chromatography of acid ...

journal_title：Gastroenterology

authors： Galmiche JP,Chayvialle JA,Dubois PM,David L,Descos F,Paulin C,Ducastelle T,Colin R,Geffroy Y

更新日期：1980-06-01 00:00:00

abstract：:Serum gastrin and gastric endocrine cell numerical densities were examined in 22 patients with long-standing Zollinger-Ellison syndrome who were receiving either ranitidine, omeprazole, or other antisecretory drugs (SMS 201-995 or pirenzepine with or without ranitidine) for long periods of time. Fifteen patients had i...

journal_title：Gastroenterology

authors： Lehy T,Mignon M,Cadiot G,Elouaer-Blanc L,Ruszniewski P,Lewin MJ,Bonfils S

更新日期：1989-04-01 00:00:00

abstract：:In the TMC435-C101 study, 6 patients infected with hepatitis C virus genotype 1 were treated with the protease inhibitor TMC435 (200 mg once daily) as monotherapy for 5 days. Approximately 1.5 years later, 5 of these patients were re-treated with TMC435 (200 mg once daily) plus pegylated interferon alfa-2a and ribavir...

journal_title：Gastroenterology

authors： Lenz O,de Bruijne J,Vijgen L,Verbinnen T,Weegink C,Van Marck H,Vandenbroucke I,Peeters M,Simmen K,Fanning G,Verloes R,Picchio G,Reesink H

更新日期：2012-11-01 00:00:00

abstract：:An animal model suitable for in vivo studies of interferon-mediated suppression of hepatic oxidative drug metabolism has been developed. Rats were injected with either recombinant human interferon alpha A, recombinant human interferon gamma, recombinant rat interferon gamma, or vehicle and experiments were performed 2...

journal_title：Gastroenterology

authors： Craig PI,Williams SJ,Cantrill E,Farrell GC

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Defects in the epithelial tight junction (TJ) barrier contribute to development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) increases intestinal permeability in mice. We investigated microRNAs that are regulated by IL1B and their effects on expression of TJ proteins ...

journal_title：Gastroenterology

authors： Rawat M,Nighot M,Al-Sadi R,Gupta Y,Viszwapriya D,Yochum G,Koltun W,Ma TY

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND/AIMS:Platelet-activating factor (PAF) is involved in the pathophysiology of motility changes induced by intestinal inflammation. The aim of this study was to evaluate a possible desensitization of PAF receptors in guinea pig intestinal smooth muscle cells after experimental inflammation induced by trinitrobe...

journal_title：Gastroenterology

authors： Jeanneton O,Delvaux M,Frexinos J,Bueno L

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND & AIMS:Alcohol abuse causes half of all deaths from cirrhosis in the West, but few tools are available for noninvasive diagnosis of alcoholic liver disease. We evaluated 2 elastography techniques for diagnosis of alcoholic fibrosis and cirrhosis; liver biopsy with Ishak score and collagen-proportionate area ...

journal_title：Gastroenterology

authors： Thiele M,Detlefsen S,Sevelsted Møller L,Madsen BS,Fuglsang Hansen J,Fialla AD,Trebicka J,Krag A

更新日期：2016-01-01 00:00:00

abstract：:We investigated whether intrapancreatic coagulation, with deposition of the fibrinogen-γ dimer (Fib-γD) and hypoxia, affect the severity of acute pancreatitis (AP) in mice. Pancreata of mice with AP induced by administration of cerulein or by L-arginine, or from patients with pancreatitis, had increased deposition of ...

journal_title：Gastroenterology

authors： Park MJ,Iyer S,Xue X,Bragazzi Cunha J,Gu S,Moons D,Pipe SW,Williams JA,Simeone DM,Shah YM,Omary MB

更新日期：2018-05-01 00:00:00

abstract：:Several areas regarding Helicobacter pylori that need improvement or clarification in the United States include treatment of dyspepsia, physician education on disease associations with H. pylori, and evidence from U.S. studies that 7-day H. pylori eradication regimens are more effective than current regimens. Dyspepsi...

journal_title：Gastroenterology

authors： Freston JW

更新日期：1997-12-01 00:00:00

abstract：:To clarify the role of fat maldigestion in the pathogenesis of steatorrhea in patients with ileal resection the total and aqueous phase concentrations of bile acid and fatty acid were characterized in 8 such patients (5 patients with small ileal resection, bile acid diarrhea, and steatorrhea less than 20 g per day; 3 ...

journal_title：Gastroenterology

authors： Poley JR,Hofmann AF

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND & AIMS:: At least half of patients with chronic hepatitis C virus (HCV) fail to respond to interferon or interferon/ribavirin therapy. Histological improvement is observed in some nonresponders. We conducted a randomized, controlled trial to determine if maintenance interferon therapy could prevent histologi...

journal_title：Gastroenterology

authors： Shiffman ML,Hofmann CM,Contos MJ,Luketic VA,Sanyal AJ,Sterling RK,Ferreira-Gonzalez A,Mills AS,Garret C

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND AIMS:To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. We therefore aimed to characterize the genetic potential of the gut microbiome in PSC compared to ...

journal_title：Gastroenterology

authors： Kummen M,Thingholm LB,Rühlemann MC,Holm K,Hansen SH,Moitinho-Silva L,Liwinski T,Zenouzi R,Storm-Larsen C,Midttun Ø,McCann A,Ueland PM,Høivik ML,Vesterhus M,Trøseid M,Laudes M,Lieb W,Karlsen TH,Bang C,Schramm C,Fra

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p...

journal_title：Gastroenterology

authors： Almeida MI,Nicoloso MS,Zeng L,Ivan C,Spizzo R,Gafà R,Xiao L,Zhang X,Vannini I,Fanini F,Fabbri M,Lanza G,Reis RM,Zweidler-McKay PA,Calin GA

更新日期：2012-04-01 00:00:00

abstract：:Phlebotomy constitutes the established treatment for HFE-related hemochromatosis. Retrospective studies have suggested proton pump inhibitors (PPIs) reduce the need for phlebotomy in this population. We conducted a randomized controlled trial to prove this. Thirty p.C282Y homozygous patients were randomly allocated to...

journal_title：Gastroenterology

authors： Vanclooster A,van Deursen C,Jaspers R,Cassiman D,Koek G

更新日期：2017-09-01 00:00:00