Role of gastrin-releasing peptide in the neural control of pepsinogen secretion from the pig stomach.

abstract：BACKGROUND & AIMS:Persons infected with Helicobacter pylori show an enhanced meal-stimulated gastrin release compared with uninfected controls. The aim of this study was to determine in animal models whether this gastrin release could be related to chronic gastric inflammation, elevated luminal ammonia level, or a comb...

journal_title：Gastroenterology

authors： Dial EJ,Hall LR,Romero JJ,Lichtenberger LM

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND & AIMS:Men have a higher incidence of hepatocellular carcinoma (HCC) than women, which is believed to partly be because of protective effects of estrogen. We sought to determine whether there were differences in levels of microRNA (miRNA) molecules between male and female HCC samples. METHODS:The expression...

journal_title：Gastroenterology

authors： Liu WH,Yeh SH,Lu CC,Yu SL,Chen HY,Lin CY,Chen DS,Chen PJ

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND & AIMS:Clearance of hepatitis C virus (HCV) via antiviral treatment changes the course of liver disease. We evaluated the benefit of sustained virologic response (SVR) in patients with HCV and cirrhosis without (stage 1) and with (stage 2) esophageal varices (EV). METHODS:We performed a prospective cohort s...

journal_title：Gastroenterology

authors： Di Marco V,Calvaruso V,Ferraro D,Bavetta MG,Cabibbo G,Conte E,Cammà C,Grimaudo S,Pipitone RM,Simone F,Peralta S,Arini A,Craxì A

更新日期：2016-07-01 00:00:00

abstract：:The conventional method of ascitic fluid culture detects bacteria in only 42%-65% of patients who have neutrocytic ascites and suspected spontaneous bacterial peritonitis. In this study ascitic fluid was cultured by the conventional method as well as by a new method consisting of bedside inoculation of blood culture b...

journal_title：Gastroenterology

authors： Runyon BA,Canawati HN,Akriviadis EA

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND & AIMS:The disruption of homeostasis between proliferation and apoptosis in the colonic epithelium contributes to the pathogenesis of human ulcerative colitis. Mice lacking the transcriptional corepressor myeloid translocation gene related-1 (Mtgr1) display impaired secretory cell lineage development in the ...

journal_title：Gastroenterology

authors： Martinez JA,Williams CS,Amann JM,Ellis TC,Moreno-Miralles I,Washington MK,Gregoli P,Hiebert SW

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND & AIMS:Host cell lipid rafts form a scaffold required for replication of hepatitis C virus (HCV). Serine palmitoyltransferases (SPTs) produce sphingolipids, which are essential components of the lipid rafts that associate with HCV nonstructural proteins. Prevention of the de novo synthesis of sphingolipids b...

journal_title：Gastroenterology

authors： Katsume A,Tokunaga Y,Hirata Y,Munakata T,Saito M,Hayashi H,Okamoto K,Ohmori Y,Kusanagi I,Fujiwara S,Tsukuda T,Aoki Y,Klumpp K,Tsukiyama-Kohara K,El-Gohary A,Sudoh M,Kohara M

更新日期：2013-10-01 00:00:00

abstract：:In the rat, gastric histamine is stored mainly in the enterochromaffinlike cells. Gastrin releases histamine from these cells, and long-term hypergastrinemia results in hyperplasia. The effect of sustained hypergastrinemia on histamine-depleted enterochromaffinlike cells was studied by measuring histidine decarboxylas...

journal_title：Gastroenterology

authors： Andersson K,Håkanson R,Mattsson H,Ryberg B,Sundler F

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND & AIMS:The emergence of oxyntic atrophy and metaplastic cell lineages in response to chronic Helicobacter pylori infection predisposes to gastric neoplasia. We have described a trefoil factor family 2 (TFF2; spasmolytic polypeptide) expressing metaplasia (SPEM) associated with gastric neoplasia in both roden...

journal_title：Gastroenterology

authors： Nomura S,Baxter T,Yamaguchi H,Leys C,Vartapetian AB,Fox JG,Lee JR,Wang TC,Goldenring JR

更新日期：2004-08-01 00:00:00

abstract：:The purpose of the study was to determine (a) the frequency and cause of mortality in patients with chronic pancreatitis; (b) the cumulative survival rates corrected by comparison of patients with a matched French population; and (c) the factors associated with mortality by a unidimensional and multidimensional analys...

journal_title：Gastroenterology

authors： Levy P,Milan C,Pignon JP,Baetz A,Bernades P

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND & AIMS:Caco-2 cells have been used extensively to elucidate events involved in intestinal cell proliferation and differentiation. Because individual isoforms of protein kinase C (PKC) and p21waf1, a cyclin-dependent kinase inhibitor, may regulate these processes, their role(s) on the growth and differentiati...

journal_title：Gastroenterology

authors： Abraham C,Scaglione-Sewell B,Skarosi SF,Qin W,Bissonnette M,Brasitus TA

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND & AIMS:Ethanol causes both tolerance and sensitization of Kupffer cells. This study was designed to evaluate temporal effects of ethanol in an attempt to understand this paradox. METHODS:Rats were given ethanol (4 g/kg body wt) intragastrically, and Kupffer cells were isolated 0-48 hours later. After additi...

journal_title：Gastroenterology

authors： Enomoto N,Ikejima K,Bradford B,Rivera C,Kono H,Brenner DA,Thurman RG

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND & AIMS:Most colon cancers arise from polypoid adenomas, but how these benign lesions develop into malignant neoplasms is not understood. This study examined the migration of epithelial cells within human adenomatous polyps by determining the distribution of proliferating and apoptotic cells and immunoreactiv...

journal_title：Gastroenterology

authors： Moss SF,Liu TC,Petrotos A,Hsu TM,Gold LI,Holt PR

更新日期：1996-12-01 00:00:00

abstract：:The courses of 38 patients with severe, uncomplicated acute colitis (16 with Crohn's colitis and 22 with ulcerative colitis) were analyzed retrospectively. The patients were placed on total parenteral nutrition and treated concomitantly with corticosteroids, antibiotics (often metronidazole), sulfasalazine, and/or aza...

journal_title：Gastroenterology

authors： Sitzmann JV,Converse RL Jr,Bayless TM

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive and metastatic disease for which conventional treatments are of limited efficacy. A number of agents in development are potential anti-invasive and antimetastatic agents, including the Src kinase inhibitor dasatinib. The aim of this study wa...

journal_title：Gastroenterology

authors： Morton JP,Karim SA,Graham K,Timpson P,Jamieson N,Athineos D,Doyle B,McKay C,Heung MY,Oien KA,Frame MC,Evans TR,Sansom OJ,Brunton VG

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Current information concerning endothelin in cirrhosis is conflicting. Plasma endothelin concentration has been found to be increased in some studies and normal or reduced in others. The present study was aimed to investigate the plasma levels of endothelin in cirrhosis and to assess whether it is involved i...

journal_title：Gastroenterology

authors： Asbert M,Ginès A,Ginès P,Jiménez W,Clària J,Saló J,Arroyo V,Rivera F,Rodés J

更新日期：1993-05-01 00:00:00

abstract：:Using an in vivo canine chambered stomach preparation, the clearance of [14C]aminopyrine across mucosa when intravenously infused and the back-diffusion of this substance from gastric lumen to mucosa when topically applied to gastric epithelium were evaluated in aspirin-damaged gastric epithelium. In mucosa damaged by...

journal_title：Gastroenterology

authors： Miller TA,Henagan JM,Loy TM

更新日期：1983-09-01 00:00:00

abstract：:We are delighted to introduce a new and simple format in the references section of the articles we publish in Gastroenterology that highlights joint first authors of citations. We believe this is an important step to acknowledging equal contribution to published work as research becomes increasingly team-oriented and ...

journal_title：Gastroenterology

authors： Dubnansky E,Omary MB

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanism by which sulindac causes regression of adenomas in patients with familial adenomatous polyposis (FAP) is unclear. Conflicting data on the drug's effects on colorectal epithelial proliferation have been reported. An alternative mechanism, and one not previously studied, is via induction o...

journal_title：Gastroenterology

authors： Pasricha PJ,Bedi A,O'Connor K,Rashid A,Akhtar AJ,Zahurak ML,Piantadosi S,Hamilton SR,Giardiello FM

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND & AIMS:A variety of gastrointestinal motility disorders have been attributed to alterations of interstitial cells of Cajal and malformations of the enteric nervous system. This study evaluates both the distribution of interstitial cells of Cajal and the pathohistology of the enteric nervous system in 2 sever...

journal_title：Gastroenterology

authors： Wedel T,Spiegler J,Soellner S,Roblick UJ,Schiedeck TH,Bruch HP,Krammer HJ

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND/AIMS:Antifungal therapy cures esophageal candidiasis in most patients with acquired immunodeficiency syndrome, but the subsequent course of these patients is not established. This study examines the natural history of esophageal candidiasis after successful treatment. METHODS:Patients with endoscopic and cl...

journal_title：Gastroenterology

authors： Laine L

更新日期：1994-09-01 00:00:00

abstract：:Water and electrolyte transport were determined in rat ileum and colon using the single-pass perfusion technique. Intraperitoneal dopamine caused prompt stimulation of both ileal and colonic water absorption. The dopamine effect was mediated by both specific dopamine and alpha 2-adrenergic receptors. Haloperidol, a sp...

journal_title：Gastroenterology

authors： Donowitz M,Elta G,Battisti L,Fogel R,Label-Schwartz E

更新日期：1983-03-01 00:00:00

abstract：:Studies on the natural history of chronic type B hepatitis have shown that loss of hepatitis B e antigen and seroconversion to antibody to hepatitis B e antigen are usually accompanied by remission of disease activity and improvement in serum aminotransferase levels. Twenty-five symptomatic patients with biopsy-docume...

journal_title：Gastroenterology

authors： Davis GL,Hoofnagle JH,Waggoner JG

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND & AIMS:Leptin production has been reported in the rat and in human stomach. It initiates intestinal nutrient absorption. In this study, we analyzed the effect of vagal stimulation on leptin release in the human stomach. METHODS:We studied the secretion of gastric acid and leptin on stimulation with insulin ...

journal_title：Gastroenterology

authors： Sobhani I,Buyse M,Goïot H,Weber N,Laigneau JP,Henin D,Soul JC,Bado A

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND & AIMS:Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis. Although highly expressed in liver, several studies have reported TfR2 expression in other tissues. To determine the contribution of liver expressed...

journal_title：Gastroenterology

authors： Wallace DF,Summerville L,Subramaniam VN

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND & AIMS:Abdominal pain is the main symptom in patients with irritable bowel syndrome (IBS). Glycerol is an irritant of colonic mucosa. The aim of this study was to evaluate the effects of an intraluminal injection of glycerol on colonic motility and tone in patients with IBS and their modulation by drugs. ME...

journal_title：Gastroenterology

authors： Louvel D,Delvaux M,Staumont G,Camman F,Fioramonti J,Bueno L,Frexinos J

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND & AIMS:The secretion and function of antral histamine are not known. The aims of this study were to characterize the mechanisms of histamine release from the gastric antrum of humans, dogs, and rats and to determine whether histamine can influence the secretion of somatostatin and gastrin. METHODS:Somatosta...

journal_title：Gastroenterology

authors： Vuyyuru L,Schubert ML,Harrington L,Arimura A,Makhlouf GM

更新日期：1995-11-01 00:00:00

abstract：:The fibrinolytic activity of blood draining from the stomachs of patients with gastroduodenal disease has been compared with the fibrinolytic activity of blood in the systemic venous circulation and with the blood draining from normal stomachs. Gastric venous blood from normal and diseased stomachs contains greater am...

journal_title：Gastroenterology

authors： O'Brien TE,Hadley H,Irving MH

更新日期：1979-03-01 00:00:00

abstract：:Heterogeneity of colonic mucin glycoprotein was examined in rectal mucosal biopsy specimens from a variety of primate species (Saguinus oedipus, n = 18; Macaca mulatta, n = 2; Macaca fascicularis, n = 2; Aotus trivirgatus, n = 2; Saimiri sciureus, n = 2; and Callithrix jacchus, n = 2). After initial separation of radi...

journal_title：Gastroenterology

authors： Podolsky DK,Madara JL,King N,Sehgal P,Moore R,Winter HS

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND & AIMS:The vagus nerve negatively regulates macrophage cytokine production via the release of acetylcholine (ACh) and activation of nicotinic acetylcholine receptors (nAChR). In various models of intestinal inflammation, vagus nerve efferent stimulation ameliorates disease. Given the actively constrained cyt...

journal_title：Gastroenterology

authors： van der Zanden EP,Snoek SA,Heinsbroek SE,Stanisor OI,Verseijden C,Boeckxstaens GE,Peppelenbosch MP,Greaves DR,Gordon S,De Jonge WJ

更新日期：2009-09-01 00:00:00

abstract：:From 1979 to 1984, we followed the cases of 3 men (aged 13, 31, and 75 yr) and 2 women (aged 38 and 45 yr who had never used oral contraceptives) suffering from liver adenomatosis, an uncommon lesion consisting of numerous benign adenomas in an otherwise normal hepatic parenchyma. During the same period, we observed 2...

journal_title：Gastroenterology

authors： Flejou JF,Barge J,Menu Y,Degott C,Bismuth H,Potet F,Benhamou JP

更新日期：1985-11-01 00:00:00