Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2.

abstract：:Vascular casts of human oxyntic mucosa, examined by scanning electron microscopy, revealed that (a) arterial breakup occurs only at the submucosal aspect of the mucosa, there being no arterial vessels further into the mucosa and (b) mucosal capillaries drain into the infrequent mucosal venules only in the most luminal...

journal_title：Gastroenterology

authors： Gannon B,Browning J,O'Brien P,Rogers P

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with colorectal tumors with microsatellite instability (MSI) have better prognoses than patients with tumors without MSI, but have a poor response to 5-fluorouracil–based chemotherapy. A dominant-negative form of heat shock protein (HSP)110 (HSP110DE9) expressed by cancer cells with MSI, via ...

journal_title：Gastroenterology

authors： Collura A,Lagrange A,Svrcek M,Marisa L,Buhard O,Guilloux A,Wanherdrick K,Dorard C,Taieb A,Saget A,Loh M,Soong R,Zeps N,Platell C,Mews A,Iacopetta B,De Thonel A,Seigneuric R,Marcion G,Chapusot C,Lepage C,Bouvier

更新日期：2014-02-01 00:00:00

abstract：:Microsatellite instability (MSI) caused by mismatch repair deficiency (dMMR) is detected in a small proportion of pancreatic ductal adenocarcinomas (PDACs). dMMR and MSI have been associated with responses of metastatic tumors, including PDACs, to immune checkpoint inhibitor therapy. We performed immunohistochemical a...

journal_title：Gastroenterology

authors： Lupinacci RM,Goloudina A,Buhard O,Bachet JB,Maréchal R,Demetter P,Cros J,Bardier-Dupas A,Collura A,Cervera P,Scriva A,Dumont S,Hammel P,Sauvanet A,Louvet C,Delpéro JR,Paye F,Vaillant JC,André T,Closset J,Emile JF

更新日期：2018-03-01 00:00:00

abstract：:Numerous epidemiologic studies suggest a relationship between lung cancer and peptic ulcer disease. Furthermore, various lung cancers synthesize and release a number of peptides such as gastrin and gastrin-releasing peptide that could cause acid hypersecretion; however, Zollinger-Ellison syndrome (ZES), because of a l...

journal_title：Gastroenterology

authors： Abou-Saif A,Lei J,McDonald TJ,Chakrabarti S,Waxman IF,Shojamanesh H,Schrump DS,Kleiner DE,Gibril F,Jensen RT

更新日期：2001-04-01 00:00:00

abstract：:The case of a 21-yr-old man, who died in cachexia after 2 yr of intermittent abdominal pain, bouts of diarrhea, and anorexia, is reported. Laboratory tests performed shortly before death disclosed signs of malabsorption. Radiologic examination of the gastrointestinal tract showed a coarse mucosal relief in the upper j...

journal_title：Gastroenterology

authors： Jacobs E,Ardichvili D,Perissino A,Gottignies P,Hanssens JF

更新日期：1979-10-01 00:00:00

abstract：:The presence of autoimmune gastritis was investigated in 54 women with postpartum thyroiditis. Parietal cell antibodies (PCA) specific against H+, K(+)-adenosine triphosphatase (EC 3.6.1.36) were found in 18 women during pregnancy; in 10 of them, a 2-9-fold increase in the PCA level was observed in the postpartum peri...

journal_title：Gastroenterology

authors： Burman P,Kämpe O,Kraaz W,Lööf L,Smolka A,Karlsson A,Karlsson-Parra A

更新日期：1992-09-01 00:00:00

abstract：:We are delighted to introduce a new and simple format in the references section of the articles we publish in Gastroenterology that highlights joint first authors of citations. We believe this is an important step to acknowledging equal contribution to published work as research becomes increasingly team-oriented and ...

journal_title：Gastroenterology

authors： Dubnansky E,Omary MB

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND & AIMS:We have shown that addition of gum arabic (GA) to a 90 mmol/L sodium-111 mmol/L glucose oral rehydration solution (ORS) enhances its effectiveness for water and electrolyte absorption in normal rats. The present study extends these observations on GA in ORS to two rat models of diarrheal disease. MET...

journal_title：Gastroenterology

authors： Wapnir RA,Wingertzahn MA,Moyse J,Teichberg S

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND & AIMS:Mechanisms of diarrhea in ulcerative colitis (UC) are still unknown. Functional and structural characterization of epithelial barrier and transport properties in ulcerative colitis (UC) was performed. METHODS:Inflamed sigmoid colon epithelium from UC patients was studied by alternating current impeda...

journal_title：Gastroenterology

authors： Schmitz H,Barmeyer C,Fromm M,Runkel N,Foss HD,Bentzel CJ,Riecken EO,Schulzke JD

更新日期：1999-02-01 00:00:00

abstract：:Intestinal mucin and goblet cells were examined in streptozotocin-diabetic rats and age-matched controls. Mucin (tissue content and secretion) was measured using a highly specific enzyme-linked immunoassay. In contrast to the increased protein to deoxyribonucleic acid ratio, an absolute decrease was observed in the mu...

journal_title：Gastroenterology

authors： Mantle M,Thakore E,Atkins E,Mathison R,Davison JS

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND & AIMS:We evaluated etanercept, a human soluble tumor necrosis factor receptor: Fc fusion protein, for the treatment of active Crohn's disease. METHODS:Forty-three patients with moderate to severe Crohn's disease were enrolled in an 8-week placebo-controlled trial. Patients were randomized to subcutaneous e...

journal_title：Gastroenterology

authors： Sandborn WJ,Hanauer SB,Katz S,Safdi M,Wolf DG,Baerg RD,Tremaine WJ,Johnson T,Diehl NN,Zinsmeister AR

更新日期：2001-11-01 00:00:00

abstract：:Ketoconazole has only recently been recognized as a cause of hepatic injury, with most reports coming from outside the United States. In order to characterize more fully the U.S. experience, we undertook an analysis of 54 reports of alleged ketoconazole-induced liver injury submitted to the Food and Drug Administratio...

journal_title：Gastroenterology

authors： Lewis JH,Zimmerman HJ,Benson GD,Ishak KG

更新日期：1984-03-01 00:00:00

abstract：:Sweden has one of the highest incidences of gallstone disease in the Western world. It is therefore important to characterize the mechanisms responsible for the formation of cholesterol gallstones in this population. In the present study, we have determined the kinetics of the two primary bile acids, cholic acid and c...

journal_title：Gastroenterology

authors： Nilsell K,Angelin B,Liljeqvist L,Einarsson K

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND & AIMS:Gastroenteropancreatic neuroendocrine cells secrete chemical messengers in a calcium-dependent fashion. So far, other second messenger systems involved in regulated secretion have gained little attention. The aim of this study was to characterize guanosine 3',5'-cyclic monophosphate (cGMP)-mediated ve...

journal_title：Gastroenterology

authors： John M,Wiedenmann B,Kruhøffer M,Adermann K,Ankorina-Stark I,Schlatter E,Ahnert-Hilger G,Forssmann WG,Kuhn M

更新日期：1998-04-01 00:00:00

abstract：:Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). The mean half-life of the sensitized erythrocytes was significantly prolonged in patients with...

journal_title：Gastroenterology

authors： Ekdahl KN,Lööf L,Nyberg A,Nilsson UR,Nilsson B

更新日期：1991-10-01 00:00:00

abstract：:We have examined the receptor binding of radio-iodinated murine epidermal growth factor and the effects of epidermal growth factor on both amylase release and incorporation of [3H]leucine into protein in isolated adult mouse pancreatic acini in primary culture. Binding of radioiodinated murine epidermal growth factor ...

journal_title：Gastroenterology

authors： Logsdon CD,Williams JA

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Hepatic lymphocytes are composed mainly of natural killer (NK) cells and NKT cells, which play key roles in innate immune responses against pathogens and tumors in the liver. This report analyzes the effects of activation of innate immunity by viral infection or the toll-like receptor 3 (TLR3) ligan...

journal_title：Gastroenterology

authors： Sun R,Gao B

更新日期：2004-11-01 00:00:00

abstract：:The prevalence of marginal zinc nutriture in several populations of people in this country and the lack of reports on the effect of marginal zinc nutriture in experimental animals prompted us to look at pancreatic acinar cell function and morphology in rats fed a zinc-deficient diet ad libitum: 4 and 50 ppm zinc-suppl...

journal_title：Gastroenterology

authors： Perez-Jimenez F,Bockman DE,Singh M

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND & AIMS:Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Elevated 5-HT levels are associated with diarrheal conditions such as irritable bowel syndrome and enteric infections. Whether alteration in SERT activity contributes to the...

journal_title：Gastroenterology

authors： Esmaili A,Nazir SF,Borthakur A,Yu D,Turner JR,Saksena S,Singla A,Hecht GA,Alrefai WA,Gill RK

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND & AIMS:Fully covered self-expanding metal stents (FCSEMS) are gaining acceptance for the treatment of benign biliary strictures. We performed a large prospective multinational study to study the ability to remove these stents after extended indwell and the frequency and durability of stricture resolution. M...

journal_title：Gastroenterology

authors： Devière J,Nageshwar Reddy D,Püspök A,Ponchon T,Bruno MJ,Bourke MJ,Neuhaus H,Roy A,González-Huix Lladó F,Barkun AN,Kortan PP,Navarrete C,Peetermans J,Blero D,Lakhtakia S,Dolak W,Lepilliez V,Poley JW,Tringali A,Costam

更新日期：2014-08-01 00:00:00

abstract：:To determine the long-term efficacy, safety, and toxicity of omeprazole, we studied 40 patients with Zollinger-Ellison syndrome given omeprazole for 6-51 mo (median 29). The mean daily dose of omeprazole required to control gastric acid secretion was 82 +/- 31 mg. Thirty-one patients required omeprazole once per day. ...

journal_title：Gastroenterology

authors： Maton PN,Vinayek R,Frucht H,McArthur KA,Miller LS,Saeed ZA,Gardner JD,Jensen RT

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Anemia is associated commonly with acute and chronic inflammation, but the mechanisms of their interaction are not clear. We investigated whether microRNA 122 (MIR122), which is generated in the liver and is secreted into the blood, is involved in the development of anemia associated with inflammation...

journal_title：Gastroenterology

authors： Rivkin M,Simerzin A,Zorde-Khvalevsky E,Chai C,Yuval JB,Rosenberg N,Harari-Steinfeld R,Schneider R,Amir G,Condiotti R,Heikenwalder M,Weber A,Schramm C,Wege H,Kluwe J,Galun E,Giladi H

更新日期：2016-11-01 00:00:00

abstract：:This study examines the effects of endotoxin on intestinal water and electrolyte transport in adult male rats. Endotoxin (1.55 mg/kg, intravenously) reduced in vivo colonic saline absorption 61% in 1 hour. In vitro unidirectional and net 22Na and 36Cl fluxes showed that endotoxin significantly decreased net colonic 22...

journal_title：Gastroenterology

authors： Ciancio MJ,Vitiritti L,Dhar A,Chang EB

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with Wilson's disease presenting with liver involvement, the correct diagnosis is often missed or delayed. The aim of this study was to find an algorithm for diagnosis of this difficult patient group. METHODS:Clinical and laboratory findings of 55 patients with Wilson's disease were evalu...

journal_title：Gastroenterology

authors： Steindl P,Ferenci P,Dienes HP,Grimm G,Pabinger I,Madl C,Maier-Dobersberger T,Herneth A,Dragosics B,Meryn S,Knoflach P,Granditsch G,Gangl A

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND & AIMS:We recently identified a polymorphism upstream of interleukin (IL)-28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to pegylated interferon-alfa and ribavirin therapy in a large cohort of treatment-naive, adherent patients with chronic hepatitis C virus genotyp...

journal_title：Gastroenterology

authors： Thompson AJ,Muir AJ,Sulkowski MS,Ge D,Fellay J,Shianna KV,Urban T,Afdhal NH,Jacobson IM,Esteban R,Poordad F,Lawitz EJ,McCone J,Shiffman ML,Galler GW,Lee WM,Reindollar R,King JW,Kwo PY,Ghalib RH,Freilich B,Nyberg

更新日期：2010-07-01 00:00:00

abstract：:Assessment of the influence of nutritional substrates on the disposition of ingested ethanol from the blood requires, first, an understanding of the influence that these may exert upon ethanol absorption from the gastrointestinal tract. In this report, the effects of various carbohydrates on the intestinal absorption ...

journal_title：Gastroenterology

authors： Broitman SA,Gottlieb LS,Vitale JJ

更新日期：1976-06-01 00:00:00

abstract：:To look for possible HLA linkage in familial Crohn's disease, HLA haplotype segregation patterns were determined in 70 members of five kindreds, each having 2 or more patients with Crohn's disease (total number: 13 with Crohn's disease, 1 with ulcerative colitis). Concordant segregation of HLA haplotypes and disease w...

journal_title：Gastroenterology

authors： Eade OE,Moulton C,MacPherson BR,Andre-Ukena SS,Albertini RJ,Beeken WL

更新日期：1980-08-01 00:00:00

abstract：:Antimitochondrial antibodies, serological hallmarks of primary biliary cirrhosis, recently were found to be directed against the E2 subunits of mitochondrial dehydrogenase complexes (pyruvate, branched-chain ketoacid, and alpha-ketoglutarate dehydrogenases). The objectives of this study were to extend these findings a...

journal_title：Gastroenterology

authors： Yoshida T,Bonkovsky H,Ansari A,Danner D

更新日期：1990-07-01 00:00:00

abstract：:The distribution of sigma and phencyclindine binding sites in the gastrointestinal tract of the guinea pig was studied by autoradiography after in vitro incubation of tissue slices with (+)3H-SKF 10,047 and 3H-1-1-[(2-thienyl)cyclohexyl] piperidine to locate sigma and phencyclidine receptors, respectively. A dense dis...

journal_title：Gastroenterology

authors： Roman F,Pascaud X,Chomette G,Bueno L,Junien JL

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND & AIMS:A common variant in the solute carrier family 39 member 6 gene (SLC39A6) has been associated with survival times of patients with esophageal squamous cell carcinoma (ESCC). We investigated the function of SLC39A6 and ways in which this variant affects tumor progression by studying ESCC samples and cel...

journal_title：Gastroenterology

authors： Cheng X,Wei L,Huang X,Zheng J,Shao M,Feng T,Li J,Han Y,Tan W,Tan W,Lin D,Wu C

更新日期：2017-06-01 00:00:00