Autoradiographic localization of sigma opioid receptors in the gastrointestinal tract of the guinea pig.

abstract：:In this study, quantitation of the epithelial proliferation status of gastric glands and duodenal crypts was performed using endoscopic biopsy specimens from patients with rheumatological conditions requiring long-term anti-inflammatory and analgesic therapy, testing the hypothesis that long-term administration of non...

journal_title：Gastroenterology

authors： Levi S,Goodlad RA,Lee CY,Walport MJ,Wright NA,Hodgson HJ

更新日期：1992-05-01 00:00:00

abstract：:In human cirrhosis, there is evidence that there are considerable alterations in fluid and solute exchange in the hepatic and intestinal microcirculations . Experimental cirrhosis was induced in rats by using oral phenobarbitone and carbon tetrachloride inhalation over an 8-wk period. Portal venous pressure, hepatic a...

journal_title：Gastroenterology

authors： Barrowman JA,Granger DN

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND AND AIMS:There has been much speculation about the potential impact on the use of conventional colonoscopy if "virtual" computed tomographic colonography (CTC) became a widely accepted modality for colorectal cancer (CRC) screening. However, no formal analysis of the impact of CTC on colonoscopy demand has b...

journal_title：Gastroenterology

authors： Hur C,Gazelle GS,Zalis ME,Podolsky DK

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND & AIMS:Gastrin stimulation of the type 2 cholecystokinin (CCK(2)) receptor results in ECL cell proliferation and histamine secretion. This report describes the effects of targeted disruption of the CCK(2) receptor gene on ECL cell morphology and function. METHODS:The ECL cells in the oxyntic mucosa of CCK(2...

journal_title：Gastroenterology

authors： Chen D,Zhao CM,Al-Haider W,Håkanson R,Rehfeld JF,Kopin AS

更新日期：2002-08-01 00:00:00

abstract：:The noninvasive assessment of intestinal permeability in humans has a 20-year history. Because the tests are increasingly used in clinical practice and research and because there is much controversy, we reviewed the literature and outlined the potential and possible shortcomings of these procedures. Data was obtained ...

journal_title：Gastroenterology

authors： Bjarnason I,MacPherson A,Hollander D

更新日期：1995-05-01 00:00:00

abstract：:This document presents the official recommendations of the American Gastroenterological Association (AGA) Institute on "Use of Gastrointestinal Medications in Pregnancy." It was approved by the Clinical Practice and Economics Committee on February 22, 2006, and by the AGA Institute Governing Board on April 20, 2006. ...

journal_title：Gastroenterology

authors： Mahadevan U,Kane S

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND & AIMS:Synchronous activation of the Wnt signaling pathway, mostly because of loss of function of the APC tumor suppressor, and of the oncogenic KRAS-signaling pathway is very frequent in colorectal cancer and is associated with poor prognosis. METHODS:We have generated a compound transgenic mouse model, KR...

journal_title：Gastroenterology

authors： Janssen KP,Alberici P,Fsihi H,Gaspar C,Breukel C,Franken P,Rosty C,Abal M,El Marjou F,Smits R,Louvard D,Fodde R,Robine S

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND & AIMS:Mucosal cell-mediated immune response is considered the central event in the pathogenesis of celiac disease. In cultured intestinal explants from celiacs in remission, we have characterized the early stages of gliadin-induced immune activation. METHODS:Intestinal biopsy specimens (15 treated celiacs ...

journal_title：Gastroenterology

authors： Maiuri L,Picarelli A,Boirivant M,Coletta S,Mazzilli MC,De Vincenzi M,Londei M,Auricchio S

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND & AIMS:Metaplasias often have characteristics of developmentally related tissues. Pancreatic metaplastic ducts are usually associated with pancreatitis and pancreatic ductal adenocarcinoma. The tuft cell is a chemosensory cell that responds to signals in the extracellular environment via effector molecules. ...

journal_title：Gastroenterology

authors： Delgiorno KE,Hall JC,Takeuchi KK,Pan FC,Halbrook CJ,Washington MK,Olive KP,Spence JR,Sipos B,Wright CV,Wells JM,Crawford HC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:During liver fibrosis, there is a putative pacemaker role of fibronectin. Fibrinogen is closely linked to fibronectin during clotting processes. The aim of this study was to show fibrinogen gene expression during liver damage. METHODS:Fibrinogen/fibrin deposition in damaged livers was studied by immuno...

journal_title：Gastroenterology

authors： Neubauer K,Knittel T,Armbrust T,Ramadori G

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND & AIMS:This longitudinal study investigated the interactions and roles of hepatitis B virus (HBV) genotypes, pre-S deletions, and core promoter and precore mutations on the progression of liver disease in hepatitis B e antigen (HBeAg)-negative patients. METHODS:A total of 141 HBeAg-negative patients without...

journal_title：Gastroenterology

authors： Chen CH,Hung CH,Lee CM,Hu TH,Wang JH,Wang JC,Lu SN,Changchien CS

更新日期：2007-11-01 00:00:00

abstract：:Antibodies to a membrane-bound antigen, localized to the canalicular structures of the parietal cell, are found in most sera of patients with chronic atrophic gastritis and pernicious anemia. In the present study immunoglobulins containing parietal cell antibodies were found to inhibit the activity of H+,K+-adenosine ...

journal_title：Gastroenterology

authors： Burman P,Mårdh S,Norberg L,Karlsson FA

更新日期：1989-06-01 00:00:00

abstract：:The mortality experienced by a cohort of 653 patients with celiac disease in Edinburgh and the Lothian region has been analyzed. Mortality overall was 1.9-fold (95% confidence limits, 1.5-2.2) that of the general population (115 deaths observed, 61.8 expected; p less than 0.0001). The increased mortality was greatest ...

journal_title：Gastroenterology

authors： Logan RF,Rifkind EA,Turner ID,Ferguson A

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND & AIMS:An increased duodenal expression of the iron transporters, divalent-metal-transporter-1, and ferroportin is observed in patients with iron deficiency or hereditary hemochromatosis. Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transpor...

journal_title：Gastroenterology

authors： Zoller H,Theurl I,Koch RO,McKie AT,Vogel W,Weiss G

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic vein thrombosis is thought to be manifested by ascites, abdominal pain, and hepatomegaly, with a uniformly poor prognosis. However, new imaging techniques allow for the diagnosis of hepatic vein thrombosis in asymptomatic cases. The aim of our study was to re-evaluate symptoms and prognosis in p...

journal_title：Gastroenterology

authors： Hadengue A,Poliquin M,Vilgrain V,Belghiti J,Degott C,Erlinger S,Benhamou JP

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND & AIMS:Intestinal epithelial cells release antigen-presenting vesicles (exosomes) bearing major histocompatibility complex class II/peptide complexes stimulating specific immune responses in vivo. To characterize further the role of human epithelial exosomes in antigen presentation, their capacity to load an...

journal_title：Gastroenterology

authors： Mallegol J,Van Niel G,Lebreton C,Lepelletier Y,Candalh C,Dugave C,Heath JK,Raposo G,Cerf-Bensussan N,Heyman M

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND & AIMS:Liver graft dysfunction is related to hypothermic preservation and may implicate altered cell volume homeostasis. The aim of this study was to evaluate how cold preservation and rewarming affect hepatocellular volume regulation and concentrative amino acid uptake. METHODS:Rat hepatocytes suspended fo...

journal_title：Gastroenterology

authors： Serrar H,Haddad P

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Nitric oxide acts as a neurotransmitter of nonadrenergic, noncholinergic pathways. The present study examined the role of the L-arginine/NO pathway on sphincter of Oddi motility. METHODS:In anesthetized guinea pigs and rabbits, intracholedochal pressure was recorded by a perfused catheter whose open tip was...

journal_title：Gastroenterology

authors： Mourelle M,Guarner F,Moncada S,Malagelada JR

更新日期：1993-11-01 00:00:00

abstract：:The role of the endothelium-derived vasodilator, nitric oxide, as a mediator of the increase in gastric mucosal blood flow and as a modulator of the acid secretory response induced by pentagastrin was investigated in the anesthetised rat. Intravenous administration of the selective inhibitor of endogenous nitric oxide...

journal_title：Gastroenterology

authors： Pique JM,Esplugues JV,Whittle BJ

更新日期：1992-01-01 00:00:00

abstract：:First, and most importantly, the standard of care for treating adenomatous polyps is polypectomy and not therapy with NSAIDs. The initial clinical observation by Waddell and Loughry in 1983 that sulindac treatment influenced rectal polyps in patients with FAP has led to a considerable amount of research, commentary, a...

journal_title：Gastroenterology

authors： DuBois RN

更新日期：1995-04-01 00:00:00

abstract：:Both high-resolution manometry (HRM) and impedance-pH/manometry monitoring have established themselves as research tools and both are now emerging in the clinical arena. Solid-state HRM capable of simultaneously monitoring the entire pressure profile from the pharynx to the stomach along with pressure topography plott...

journal_title：Gastroenterology

authors： Kahrilas PJ,Sifrim D

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND & AIMS:Congenital tufting enteropathy (CTE) is a rare autosomal recessive diarrheal disorder presenting in the neonatal period. CTE is characterized by intestinal epithelial cell dysplasia leading to severe malabsorption and significant morbidity and mortality. The pathogenesis and genetics of this disorder ...

journal_title：Gastroenterology

authors： Sivagnanam M,Mueller JL,Lee H,Chen Z,Nelson SF,Turner D,Zlotkin SH,Pencharz PB,Ngan BY,Libiger O,Schork NJ,Lavine JE,Taylor S,Newbury RO,Kolodner RD,Hoffman HM

更新日期：2008-08-01 00:00:00

abstract：:Spontaneous remission of gastric acid hypersecretion in the Zollinger-Ellison syndrome occurs rarely. This study shows the development of gastric secretory mucosal atrophy resulting in achlorhydria and loss of pepsin secretion in a 63-year-old woman with the Zollinger-Ellison syndrome. Reduced secretion began soon aft...

journal_title：Gastroenterology

authors： Griffith JL,Cummings OW,Hirschowitz BI

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hereditary colorectal cancer is associated most commonly with the hereditary nonpolyposis colorectal cancer or familial adenomatous polyposis syndromes. We investigated the prevalence of early onset colorectal cancer and the frequency of p53 germline mutations in 64 families from a Li-Fraumeni syndrom...

journal_title：Gastroenterology

authors： Wong P,Verselis SJ,Garber JE,Schneider K,DiGianni L,Stockwell DH,Li FP,Syngal S

更新日期：2006-01-01 00:00:00

abstract：:Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barret...

journal_title：Gastroenterology

authors： Garewal HS,Sampliner R,Gerner E,Steinbronn K,Alberts D,Kendall D

更新日期：1988-03-01 00:00:00

abstract：:Concern has arisen about the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection treated with direct-acting antivirals (DAAs). To identify patients at risk for HCC, we evaluated serum levels of immune mediators before, during, and after DAA treatment of HCV infection. Our s...

journal_title：Gastroenterology

authors： Debes JD,van Tilborg M,Groothuismink ZMA,Hansen BE,Schulze Zur Wiesch J,von Felden J,de Knegt RJ,Boonstra A

更新日期：2018-02-01 00:00:00

abstract：:We have studied the effect of short-term high-dose prednisone therapy on aminotransferase levels and hepatitis B virus markers in 6 patients with chronic type B hepatitis. All showed a decrease in amino transferase levels during treatment. This was followed by a transient increase in aminotransferase levels after pred...

journal_title：Gastroenterology

authors： Rakela J,Redeker AG,Weliky B

更新日期：1983-05-01 00:00:00

abstract：:We constructed ileocolonic loops of distal ileum, ileocolonic sphincter, and proximal colon in 5 dogs; neuromuscular continuity was maintained between loop and intact bowel by a bridge of tunica muscularis. To study ileocolonic sphincter function, we recorded myoelectric activity from subserosal electrodes and intralu...

journal_title：Gastroenterology

authors： Quigley EM,Phillips SF,Dent J,Taylor BM

更新日期：1983-11-01 00:00:00

abstract：:Approximately 10% of persons 70 years old or older are now diagnosed with pancreatic cysts, but it is not clear which ones require additional analysis, interventions, or follow-up. Primary care doctors rely on gastroenterologists for direction because no one wants to miss a diagnosis of pancreatic cancer, but meanwhil...

journal_title：Gastroenterology

authors： Farrell JJ,Fernández-del Castillo C

更新日期：2013-06-01 00:00:00

abstract：:Fifty-nine studies of gastrointestinal transit time were performed in 27 healthy women during pregnancy and postpartum. Gastrointestinal transit time was defined as the time of the first sustained rise in breath hydrogen concentration after ingestion of 10 g of lactulose. Gastrointestinal transit time was significantl...

journal_title：Gastroenterology

authors： Lawson M,Kern F Jr,Everson GT

更新日期：1985-11-01 00:00:00