Effects of cold preservation and rewarming on rat liver cell volume regulation and concentrative amino acid uptake.

abstract：BACKGROUND & AIMS:Ethanol causes both tolerance and sensitization of Kupffer cells. This study was designed to evaluate temporal effects of ethanol in an attempt to understand this paradox. METHODS:Rats were given ethanol (4 g/kg body wt) intragastrically, and Kupffer cells were isolated 0-48 hours later. After additi...

journal_title：Gastroenterology

authors： Enomoto N,Ikejima K,Bradford B,Rivera C,Kono H,Brenner DA,Thurman RG

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic iron toxicity may be mediated by free radical species and lipid peroxidation of biological membranes. The antioxidant property of silybin, a main constituent of natural flavonoids, was investigated in vivo during experimental iron overload. METHODS:Rats were fed a 2.5% carbonyl-iron diet and ...

journal_title：Gastroenterology

authors： Pietrangelo A,Borella F,Casalgrandi G,Montosi G,Ceccarelli D,Gallesi D,Giovannini F,Gasparetto A,Masini A

更新日期：1995-12-01 00:00:00

abstract：:Somatostatin-14 and somatostatin-28 are biologically active peptides derived from the posttranslational cleavage of prosomatostatin. Because both peptides are found in variable concentrations in the gastrointestinal (GI) tract and pancreas, it has been contended that somatostatin-28 is either an intermediate in the pr...

journal_title：Gastroenterology

authors： Francis BH,Baskin DG,Saunders DR,Ensinck JW

更新日期：1990-11-01 00:00:00

abstract：:We investigated the possibility that monocyte suppressor cells play a role in the peripheral lymphocyte hyporesponsiveness of chronic liver disease by utilizing assays of monocyte-mediated suppressor activity in 46 patients with chronic liver disease and 46 controls. The percent change achieved by the addition of indo...

journal_title：Gastroenterology

authors： Holdstock G,Chastenay BF,Krawitt EL

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND & AIMS:We assessed the influence of genetic variants in the hepatitis B virus (HBV) core, which is a principal immunologic target, on the progression to hepatocellular carcinoma (HCC) in a cohort of 4841 male HBV carriers followed up for 16 years. METHODS:First, baseline sera from 116 HCC cases and 154 cont...

journal_title：Gastroenterology

authors： Sung FY,Jung CM,Wu CF,Lin CL,Liu CJ,Liaw YF,Tsai KS,Yu MW

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND & AIMS:Intestinal microbes induce homeostatic mucosal immune responses, but can also cause inappropriate immune activation in genetically susceptible hosts. Although immune responses to bacterial products have been studied extensively, little is known about how intestinal inflammation affects functions of co...

journal_title：Gastroenterology

authors： Patwa LG,Fan TJ,Tchaptchet S,Liu Y,Lussier YA,Sartor RB,Hansen JJ

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND & AIMS:Three-dimensional (3D) ultrasound imaging of the total stomach volume has not yet been achieved. The aim of this study was to investigate whether a magnetic position sensor system for acquisition of 3D ultrasonograms could be used to determine gastric emptying rates and intragastric distribution. MET...

journal_title：Gastroenterology

authors： Gilja OH,Detmer PR,Jong JM,Leotta DF,Li XN,Beach KW,Martin R,Strandness DE Jr

更新日期：1997-07-01 00:00:00

abstract：:A multicenter study was conducted on 173 patients with active, endoscopically proven duodenal ulcers (158 men, 15 women). They were randomly assigned, in a double-blind manner, to two groups: those receiving placebo capsules (91 patients) and those receiving capsules containing 100 microgram of 15(R)-15-methyl prostag...

journal_title：Gastroenterology

authors： Vantrappen G,Janssens J,Popiela T,Kulig J,Tytgat GN,Huibregtse K,Lambert R,Pauchard JP,Robert A

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND & AIMS:Histamine-producing enterochromaffin-like (ECL) cells play an integrative role in the regulation of acid secretion. Decreased mucosal histamine concentrations and increased levels of interleukin (IL) 1 beta, IL-6, and IL-8 have been detected in the gastric mucosa inflamed with Helicobacter pylori. The...

journal_title：Gastroenterology

authors： Prinz C,Neumayer N,Mahr S,Classen M,Schepp W

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND & AIMS:Nuclear factor kappaB (NF-kappaB) is the master regulator of tumor necrosis factor (TNF) susceptibility. Although mitochondrial glutathione (mGSH) depletion was shown to sensitize hepatocytes to TNF despite NF-kappaB activation, the mechanisms involved, particularly the role of Bax oligomerization and...

journal_title：Gastroenterology

authors： Marí M,Colell A,Morales A,Caballero F,Moles A,Fernández A,Terrones O,Basañez G,Antonsson B,García-Ruiz C,Fernández-Checa JC

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND & AIMS:Serine proteases are postulated to influence gastrointestinal function by stimulating protease-activated receptors (PARs). This study identified the effects on myenteric neurons of activating PARs and investigated underlying mechanisms of action. METHODS:Intracellular electrophysiologic methods were ...

journal_title：Gastroenterology

authors： Gao C,Liu S,Hu HZ,Gao N,Kim GY,Xia Y,Wood JD

更新日期：2002-11-01 00:00:00

abstract：:Ileal Na+-dependent bile acid transport was quantified in vitro as the uptake of 3H-taurocholate into brush-border membrane vesicles. Vesicles were prepared from ileal biopsies of 158 patients placed in 10 diagnostic categories. Active bile acid transport (expressed as picomoles taurocholate uptake per milligram brush...

journal_title：Gastroenterology

authors： van Tilburg AJ,de Rooij FW,van Blankenstein M,van den Berg JW,Bosman-Jacobs EP

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Several studies suggest that statins prevent some cancers, with one study finding a 47% reduction in colorectal cancer risk after >or=5 years of regular use. METHODS:A nested case-control study was conducted within 454 general practices in the United Kingdom using the QRESEARCH database. Cases with...

journal_title：Gastroenterology

authors： Vinogradova Y,Hippisley-Cox J,Coupland C,Logan RF

更新日期：2007-08-01 00:00:00

abstract：:A 61-yr-old woman was found to have multicentric hepatocellular carcinoma associated with clinical hyperthyroidism. Marked elevations in serum thyroid-stimulating hormone, T4, T3, and free T4 were documented. These values increased with tumor progression. It is postulated that this patient's hepatoma produced a substa...

journal_title：Gastroenterology

authors： Helzberg JH,McPhee MS,Zarling EJ,Lukert BP

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND & AIMS:Most previous population-based studies of mortality in inflammatory bowel disease (IBD) did not account for medication use. We evaluated mortality by IBD medication use among members of the Kaiser Permanente Northern California IBD Registry. METHODS:The retrospective, population-based cohort study in...

journal_title：Gastroenterology

authors： Hutfless SM,Weng X,Liu L,Allison J,Herrinton LJ

更新日期：2007-12-01 00:00:00

abstract：:Hyperplasia of the oxyntic enterochromaffinlike cells in response to long-lasting blockade of acid secretion is closely related to hypergastrinemia. In the present study, the effect of a specific gastrin receptor antagonist on proton pump inhibitor-induced changes on serum gastrin levels, mucosal height, as well as ga...

journal_title：Gastroenterology

authors： Eissele R,Patberg H,Koop H,Krack W,Lorenz W,McKnight AT,Arnold R

更新日期：1992-11-01 00:00:00

abstract：:Ileocecal sphincter pressure was studied in the cat, using an open-tipped perfused catheter system. Ileocecal sphincter pressure was measured under basal conditions and in response to bethanechol or direct vagal nerve electrical stimulation. The pressure was 26.1 +/- 5.0 mmHg basally, and was unaltered by section of e...

journal_title：Gastroenterology

authors： Rubin MR,Cardwell BA,Ouyang A,Snape WJ Jr,Cohen S

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND & AIMS:Conflicting results have been published concerning the effects of different opioid-receptor agonists against visceral noxious stimulation. The introduction of colorectal distention facilitates research in this field. The aim of this study was to examine intrathecally administered opioid agonists again...

journal_title：Gastroenterology

authors： Borgbjerg FM,Frigast C,Madsen JB,Mikkelsen LF

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND & AIMS:The NOD2 gene, which is strongly associated with susceptibility to Crohn's disease (CD) of the terminal ileum, interacts with bacterial lipopolysaccharide (LPS), inducing cellular activation. However, the mechanisms by which NOD2 mutations cause terminal ileitis are unknown, and NOD2 is expressed most...

journal_title：Gastroenterology

authors： Lala S,Ogura Y,Osborne C,Hor SY,Bromfield A,Davies S,Ogunbiyi O,Nuñez G,Keshav S

更新日期：2003-07-01 00:00:00

abstract：:Interstitial pneumonitis is an uncommon complication of low-dose methotrexate therapy in patients with psoriasis but occurs in 3%-5% of patients with rheumatoid arthritis. We found a higher incidence of interstitial pneumonitis in patients with primary biliary cirrhosis (14%) and describe its clinical manifestations, ...

journal_title：Gastroenterology

authors： Sharma A,Provenzale D,McKusick A,Kaplan MM

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND & AIMS:Dilutional hyponatremia is a frequent complication of cirrhosis partly because of nonosmotic vasopressin release. No effective therapy exists for this complication. Therefore, we investigated the effects of VPA-985, an orally active vasopressin V2 receptor antagonist, in patients with cirrhosis and di...

journal_title：Gastroenterology

authors： Gerbes AL,Gülberg V,Ginès P,Decaux G,Gross P,Gandjini H,Djian J,VPA Study Group.

更新日期：2003-04-01 00:00:00

abstract：:We constructed ileocolonic loops of distal ileum, ileocolonic sphincter, and proximal colon in 5 dogs; neuromuscular continuity was maintained between loop and intact bowel by a bridge of tunica muscularis. To study ileocolonic sphincter function, we recorded myoelectric activity from subserosal electrodes and intralu...

journal_title：Gastroenterology

authors： Quigley EM,Phillips SF,Dent J,Taylor BM

更新日期：1983-11-01 00:00:00

abstract：:The results of this study show that lower esophageal sphincter contractions occur during phases 2 and 3 of the gastric interdigestive migratory motor complex in humans. In one series of studies, esophageal, gastric, and duodenal pressures were monitored overnight for 12 h in 7 healthy, fasting subjects. A second group...

journal_title：Gastroenterology

authors： Dent J,Dodds WJ,Sekiguchi T,Hogan WJ,Arndorfer RC

更新日期：1983-03-01 00:00:00

abstract：:Erythromycin has been shown to act as a motilin agonist by binding to motilin receptors on gastrointestinal smooth muscle and to improve the severely impaired gastric emptying in patients with diabetic gastroparesis. To elucidate the motor pattern that accounts for this accelerated emptying, the effect of 200 mg eryth...

journal_title：Gastroenterology

authors： Annese V,Janssens J,Vantrappen G,Tack J,Peeters TL,Willemse P,Van Cutsem E

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND & AIMS:Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We inve...

journal_title：Gastroenterology

authors： Ott SJ,Waetzig GH,Rehman A,Moltzau-Anderson J,Bharti R,Grasis JA,Cassidy L,Tholey A,Fickenscher H,Seegert D,Rosenstiel P,Schreiber S

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p...

journal_title：Gastroenterology

authors： Almeida MI,Nicoloso MS,Zeng L,Ivan C,Spizzo R,Gafà R,Xiao L,Zhang X,Vannini I,Fanini F,Fabbri M,Lanza G,Reis RM,Zweidler-McKay PA,Calin GA

更新日期：2012-04-01 00:00:00

abstract：:Twenty-seven carriers of the hepatitis B surface antigen who underwent liver transplantation in Italy and Belgium for terminal Hepatitis delta virus (HDV) cirrhosis were investigated. In 22 of the patients, HDV infection recurred. Two patients died of coexisting HDV and hepatitis B virus (HBV) reactivation. Four patie...

journal_title：Gastroenterology

authors： Ottobrelli A,Marzano A,Smedile A,Recchia S,Salizzoni M,Cornu C,Lamy ME,Otte JB,De Hemptinne B,Geubel A

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND & AIMS:Multiple molecular mechanisms are likely to contribute to the establishment of persistent infection by hepatitis C virus (HCV). The aim of this work was to study the evasion of cell-mediated antiviral immune responses in transgenic mice with liver-targeted expression of the hepatitis C viral genome. T...

journal_title：Gastroenterology

authors： Disson O,Haouzi D,Desagher S,Loesch K,Hahne M,Kremer EJ,Jacquet C,Lemon SM,Hibner U,Lerat H

更新日期：2004-03-01 00:00:00

abstract：:Increasing resistance to antibiotics worldwide has adverse effects on the effectiveness of standard therapies to eradicate Helicobacter pylori infection. We reviewed guidelines developed by expert groups in Europe, Canada, and the United States for the treatment of H pylori infection. We compared the recommendations o...

journal_title：Gastroenterology

authors： Fallone CA,Moss SF,Malfertheiner P

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:Persons infected with Helicobacter pylori show an enhanced meal-stimulated gastrin release compared with uninfected controls. The aim of this study was to determine in animal models whether this gastrin release could be related to chronic gastric inflammation, elevated luminal ammonia level, or a comb...

journal_title：Gastroenterology

authors： Dial EJ,Hall LR,Romero JJ,Lichtenberger LM

更新日期：1996-03-01 00:00:00