Abstract:
BACKGROUND AND AIMS:There has been much speculation about the potential impact on the use of conventional colonoscopy if "virtual" computed tomographic colonography (CTC) became a widely accepted modality for colorectal cancer (CRC) screening. However, no formal analysis of the impact of CTC on colonoscopy demand has been reported. METHODS:A mathematical model to predict colonoscopy demand based on several relevant input parameters was constructed. Current national colonoscopy practice, estimated using various published reports, was used as the foundation to project colonoscopy demand if CTC were implemented as the primary CRC screening modality. RESULTS:In the base-case analysis, if CTC were used as the primary modality for CRC screening, 1.78 million colonoscopies could be eliminated from the total 6.47 million in 2003. Depending on the polyp size threshold used to define a CTC study as positive (6 or 10 mm), this loss would be partially offset by 1.21 million (6 mm) or .34 million (10 mm) follow-up colonoscopies for CTC examinations with positive findings, resulting in a net loss of .57 million (8.8% decrease) (6 mm) or 1.44 million (22.3% decrease) (10 mm). Extensive sensitivity analyses showed that the findings of this model were robust and insensitive to most parameters tested but were sensitive to a few parameters, including the percentage of CTC examinations with positive findings. CONCLUSIONS:Wide-scale implementation of CTC for CRC screening would likely lead to a decrease in use of conventional colonoscopy. The percentage of CTC studies with positive findings seemed to be a pivotal variable, which would be determined in large part by the polyp size ultimately established to define a positive finding.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Hur C,Gazelle GS,Zalis ME,Podolsky DKdoi
10.1053/j.gastro.2004.07.018keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
1312-21issue
5eissn
0016-5085issn
1528-0012pii
S0016508504012429journal_volume
127pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract::Urokinase, the plasminogen activator from human urine, produces a dose-dependent increase in blood flow in the canine superior mesenteric artery when injected intraarterially at doses from 10(-1) to 10(3) units kg-1. This vasodilation persists despite blockade of beta-adrenergic and histamine H1 and H2 receptors as we...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract::In this study, quantitation of the epithelial proliferation status of gastric glands and duodenal crypts was performed using endoscopic biopsy specimens from patients with rheumatological conditions requiring long-term anti-inflammatory and analgesic therapy, testing the hypothesis that long-term administration of non...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1016/0016-5085(92)91720-o
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND & AIMS:Osteoporosis is common in patients with Crohn's disease, but less is known about their risk of actual fractures. METHODS:The medical records of all 238 Olmsted County, Minnesota, residents diagnosed with Crohn's disease between 1940 and 1993 were reviewed for evidence of subsequent fractures compared...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.34779
更新日期:2002-08-01 00:00:00
abstract::Liver copper concentration was studied in four groups of age-matched patients and in 9 patients with Wilson's disease of comparable age. Neutron activation analysis of hepatic copper concentration revealed markedly elevated hepatic copper levels, comparable with those in Wilson's disease, in 13 of 15 patients (P less ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Autoimmune responses against colonic epithelium may play a role in the development of colonic inflammation associated with ulcerative colitis (UC). In this study, we established and characterized B-cell lines and clones that produced anticolon antibody from inflamed colonic mucosa of UC subjects. M...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.25477
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND & AIMS:Chronic hepatitis C virus (HCV) infection is a major burden on individuals and health care systems. The Extension for Community Healthcare Outcomes (Project ECHO) enables primary care providers to deliver best-practice care for complex conditions to underserved populations. The US Congress passed the ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.10.016
更新日期:2017-12-01 00:00:00
abstract::Regional specific antibodies and gel permeation chromatography were used to analyze the molecular forms of motilin in the human gut and plasma and in the porcine gut. The same antibodies were also used for immunocytochemical localization of the cell of origin of motilin. Two main molecular forms of motilin were identi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
abstract::Histologic or ultrastructural evidence of the ability of sucralfate to protect the gastric mucosa against ethanol injury is lacking. Therefore we analyzed morphologic and functional changes in the mucosa of 120 rats receiving, intragastrically, 2 ml of either sucralfate 500 mg/kg body wt or a control solution and 1 h ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(85)80191-8
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND & AIMS:Leptin production has been reported in the rat and in human stomach. It initiates intestinal nutrient absorption. In this study, we analyzed the effect of vagal stimulation on leptin release in the human stomach. METHODS:We studied the secretion of gastric acid and leptin on stimulation with insulin ...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1053/gast.2002.31385
更新日期:2002-02-01 00:00:00
abstract::Hepatic morphology and immunocytology were evaluated in 4 children with clinical and immunologic characteristics of the acquired immune deficiency syndrome or acquired immune deficiency syndrome related complex. All 4 children had hepatomegaly and increased serum alanine and aspartate aminotransferase activity. Both l...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90090-9
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND/AIMS:Growth factors and their receptors play a role in healing ulcers of the rat. Somatostatin is a putative growth factor in the gastric mucosa with multiple functions mediated by specific receptors. Therefore, the distribution of somatostatin receptors was evaluated in the gastric mucosa of healing ulcers....
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90157-0
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatic steatosis is frequent in chronic hepatitis C. Several mechanisms might be implicated, including metabolic cofactors and direct viral effects on intracellular lipid pathways. In a transgenic mouse model, hepatitis C virus (HCV) was shown to inhibit microsomal triglyceride transfer protein (MTP)...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.02.035
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND & AIMS:Gastroesophageal reflux typically occurs after meals. During dual gastric and esophageal pH monitoring, we observed that postprandial refluxate was often more acidic than the gastric contents. This study aimed to investigate this phenomenon. METHODS:Dual gastric and esophageal pH tracings were analyz...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.27997
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND & AIMS:Thromboxane levels correlate with severity of liver injury in rats given alcohol. The aim of this study was to evaluate the effect of thromboxane inhibitors on pathological changes in experimental alcoholic liver disease. METHODS:Male Wistar rats were given a liquid diet and ethanol intragastrically ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70236-1
更新日期:1997-01-01 00:00:00
abstract::Acute, acute recurrent, and chronic forms of pancreatitis have been increasingly diagnosed in children in the past 2 decades. Risk factors in the pediatric group are broad and appear to be strikingly different compared with the adult cohort. However, the disease burden and impact on quality of life are surprisingly si...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2018.12.043
更新日期:2019-05-01 00:00:00
abstract::Basal lower esophageal sphincter (LES) pressure was measured in 6 patients with the Zollinger-Ellison syndrome (ZES) and hypergastrinemia, and in 6 patients with duodenal ulcer and normogastrinemia. Basal LES pressure in ZES patients, 17.0 +/- 3.7 (mean +/- SE) mm Hg was similar to basal LES pressure in duodenal ulcer...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::Hepatitis C virus (HCV) is the agent responsible for posttransfusion hepatitis. The incidence, timing, and clinical course of HCV positive hepatitis in liver transplant recipients are unknown. Three hundred and seventeen donor-recipient liver transplant pairs were grouped on the basis of their pretransplant HCV antibo...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)91130-v
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND & AIMS:Methionine adenosyltransferase (MAT) catalyzes S-adenosylmethionine biosynthesis. Two genes (MAT1A and MAT2A) encode for the catalytic subunit of MAT, while a third gene (MAT2beta) encodes for a regulatory subunit that modulates the activity of MAT2A-encoded isoenzyme. We uncovered multiple splicing v...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.10.027
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND & AIMS:Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and involvement in colorectal cancer progression. METHODS:Galectin 3 expression was examined immunohistochemically in 39 s...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70010-6
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND & AIMS:HCV nonstructural protein 5A (NS5A) has been implicated in regulating cell growth and interferon response. The NS5A protein contains proline-rich regions that are highly conserved among HCV genotypes and match Src homology 3 (SH3)-binding motifs (PxxP) found in various cellular signaling molecules. M...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.12.030
更新日期:2006-03-01 00:00:00
abstract::We have investigated the effect of oral cisapride (10 mg t.i.d.) in a double-blind, placebo-controlled trial in 26 patients with upper gut dysmotility: 11 with gastroparesis (8 diabetic, 3 idiopathic) and 15 with chronic idiopathic intestinal pseudoobstruction. Patients were evaluated at entry and at the end of the 6-...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND & AIMS:Neutrophils are generally thought to play an important proinflammatory role in the pathogenesis of inflammatory bowel disease. The objective of this study was to evaluate whether blocking the invasion of neutrophils by anti-L-selectin monoclonal antibodies modulates chemically induced colitis and how ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.08.073
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND & AIMS:In one-third of hepatocellular carcinomas (HCCs), cancer cells have mutations that activate β-catenin pathway. These cells have alterations in glutamine, bile, and lipid metabolism. We investigated whether positron emission tomography (PET) imaging allows identification of altered metabolic pathways t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2019.05.069
更新日期:2019-09-01 00:00:00
abstract::A method of measuring gastric secretions and emptying rates after ingestion of an ordinary (solid-liquid) meal has been developed and validated. The technique quantifies movements of volume across the pylorus using constant duodenal perfusion with a nonabsorbable marker, polyethylene glycol (PEG), which, in turn, quan...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-02-01 00:00:00
abstract::2-Camphanone is under clinical evaluation for alleviation of hemorrhoidal bleeding and inflammation. Reduced portal venous blood flow may distend, whereas improved portal venous blood flow may alleviate, hemorrhoidal vein distention. The effects of 2-camphanone on canine portal venous blood flow were investigated usin...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)90082-a
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND & AIMS:This study was undertaken to prospectively compare the clinical outcomes of small bowel radiographs with the wireless capsule endoscopy. METHODS:Twenty-two patients were selected consecutively because of suspected small bowel disease. Two patients were excluded owing to ileal stenosis. Thus, the resu...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1053/gast.2002.35988
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND & AIMS:Alcoholic patients with and without chronic liver disease have a high incidence of infection with hepatitis C virus (HCV). Long-term ethanol consumption in mice has been associated with a strikingly reduced CD8(+) cytotoxic T-lymphocyte (CTL) response to HCV nonstructural proteins following DNA-based ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.11.016
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND & AIMS:Infection with Tropheryma whipplei has a range of effects-some patients can be chronic carriers without developing any symptoms, whereas others can develop systemic Whipple disease, characterized by a lack a protective inflammatory immune response. Alterations in HLA-G function have been associated wi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2018.07.034
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND & AIMS:Gastric histology is not well studied in patients with Crohn's disease. The aim of this study was to analyze the histological appearance of gastric mucosa in patients with Crohn's disease. METHODS:In a prospective study, biopsy specimens taken from the antrum and body of 75 patients with known Crohn'...
journal_title:Gastroenterology
pub_type: 评论,杂志文章
doi:10.1053/gast.1997.v112.pm9041230
更新日期:1997-03-01 00:00:00
abstract::Excretion of hydrogen in breath commonly persists despite an overnight fast. Although elevation of hydrogen concentration above the fasting value after administration of a test sugar is evidence of malabsorption, the significance of the fasting value itself is unknown. We determined the normal limits of fasting breath...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00