Effect of six weeks of treatment with cisapride in gastroparesis and intestinal pseudoobstruction.

abstract：:Fifty-nine studies of gastrointestinal transit time were performed in 27 healthy women during pregnancy and postpartum. Gastrointestinal transit time was defined as the time of the first sustained rise in breath hydrogen concentration after ingestion of 10 g of lactulose. Gastrointestinal transit time was significantl...

journal_title：Gastroenterology

authors： Lawson M,Kern F Jr,Everson GT

更新日期：1985-11-01 00:00:00

abstract：:2-Camphanone is under clinical evaluation for alleviation of hemorrhoidal bleeding and inflammation. Reduced portal venous blood flow may distend, whereas improved portal venous blood flow may alleviate, hemorrhoidal vein distention. The effects of 2-camphanone on canine portal venous blood flow were investigated usin...

journal_title：Gastroenterology

authors： Xie JM,Greenberg SS,Longenecker G

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND & AIMS:Although bacterial bowel flora may be one of the contributing factors in the pathogenesis of chronic mucosal inflammation, antibiotic treatment has no established role in ulcerative colitis. The aim of the study was to evaluate the role of ciprofloxacin in the induction and maintenance of remission in...

journal_title：Gastroenterology

authors： Turunen UM,Färkkilä MA,Hakala K,Seppälä K,Sivonen A,Ogren M,Vuoristo M,Valtonen VV,Miettinen TA

更新日期：1998-11-01 00:00:00

abstract：:In this review, we speculate about future therapeutic approaches for inflammatory bowel diseases (IBDs), focusing on the need for better preclinical and clinical models and approaches beyond small molecules and systemically administered biologics. We offer ideas to change clinical trial programs and to use immunologic...

journal_title：Gastroenterology

authors： Plevy SE,Targan SR

更新日期：2011-05-01 00:00:00

abstract：:Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause 1.3 million deaths annually. To prevent more than 7 million deaths by 2030, the World Health Organization set goals to eliminate HBV and HCV, defined as a 90% reduction in new infections and a 65% reduction in deaths, and prevent more than 7 million related dea...

journal_title：Gastroenterology

authors： Ward JW,Hinman AR

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of Barrett's esophagus and esophageal adenocarcinoma has increased despite surveillance of patients with Barrett's esophagus. Limited data indicate that nonsteroidal anti-inflammatory drug (NSAID) and statin use reduce the risk for esophageal adenocarcinoma. We investigated whether NSAID...

journal_title：Gastroenterology

authors： Kastelein F,Spaander MC,Biermann K,Steyerberg EW,Kuipers EJ,Bruno MJ,Probar-study Group.

更新日期：2011-12-01 00:00:00

abstract：:Chronic liver diseases (CLDs), due to chronic hepatitis C; hepatitis B; nonalcoholic fatty liver diseases (NAFLD); and alcoholic liver disease, are a leading cause of morbidity and mortality globally. Early identification of patients with cirrhosis at high risk of progression to liver-related complications may facilit...

journal_title：Gastroenterology

authors： Singh S,Muir AJ,Dieterich DT,Falck-Ytter YT

更新日期：2017-05-01 00:00:00

abstract：:Jejunal absorption of acetate, propionate, and butyrate--the three predominant short chain fatty acids (SCFA's) in small and large intestinal contents--was studied in 5 volunteer subjects. A triple-lumen perfusion technique was employed; the test solutions were isotonic and contained 0, 5, 10, 25, 40, or 50 mM of a SC...

journal_title：Gastroenterology

authors： Schmitt MG Jr,Soergel KH,Wood CM

更新日期：1976-02-01 00:00:00

abstract：:A patient with post-traumatic seizure disorder developed lymphadenopathy, exfoliative dermatitis, and hepatic failure while on diphenylhydantoin therapy and died in hepatic coma. Autopsy disclosed massive hepatic necrosis. The clinical and pathological pictures are similar to the six previously reported cases of diphe...

journal_title：Gastroenterology

authors： Lee TJ,Carney CN,Lapis JL,Higgins T,Fallon HJ

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND & AIMS:The optimal strategy for the detection of hereditary nonpolyposis colorectal cancer (HNPCC) gene carriers remains uncertain. We evaluated whether microsatellite instability (MSI) analysis or MSH2 and MLH1 protein immunostaining of tumors will screen individuals efficiently for germline MSH2 and MLH1 t...

journal_title：Gastroenterology

authors： Terdiman JP,Gum JR Jr,Conrad PG,Miller GA,Weinberg V,Crawley SC,Levin TR,Reeves C,Schmitt A,Hepburn M,Sleisenger MH,Kim YS

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND & AIMS:The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS:Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structu...

journal_title：Gastroenterology

authors： Lerat H,Honda M,Beard MR,Loesch K,Sun J,Yang Y,Okuda M,Gosert R,Xiao SY,Weinman SA,Lemon SM

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND & AIMS:Hereditary colorectal cancer is associated most commonly with the hereditary nonpolyposis colorectal cancer or familial adenomatous polyposis syndromes. We investigated the prevalence of early onset colorectal cancer and the frequency of p53 germline mutations in 64 families from a Li-Fraumeni syndrom...

journal_title：Gastroenterology

authors： Wong P,Verselis SJ,Garber JE,Schneider K,DiGianni L,Stockwell DH,Li FP,Syngal S

更新日期：2006-01-01 00:00:00

abstract：:The emergence of new glycoprotein structures in colonic mucosa from patients with ulcerative colitis (UC) was assessed through the development of monoclonal antibodies (MAbs). Hybridomas were prepared from mice immunized with mucin glycoproteins purified from UC colonic tissue. Supernatants of 11 fusion products among...

journal_title：Gastroenterology

authors： Podolsky DK,Fournier DA

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND & AIMS:Capillarization of the sinusoids in cirrhosis is proposed to reduce oxygen availability to the hepatocyte, resulting in the patterns of altered drug metabolism observed in cirrhosis. If this were true, drug metabolism in cirrhotic livers would be expected to be more sensitive to reduced oxygen deliver...

journal_title：Gastroenterology

authors： Hickey PL,McLean AJ,Angus PW,Choo EF,Morgan DJ

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND/AIMS:Cirrhotic patients are predisposed to develop spontaneous bacteremias and/or peritonitis, mainly caused by enteric bacteria. The aim of this study was to investigate if bacterial translocation, which is the passage of bacteria from the intestinal lumen to regional lymph nodes and/or the systemic circula...

journal_title：Gastroenterology

authors： Garcia-Tsao G,Lee FY,Barden GE,Cartun R,West AB

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND & AIMS:The function of microRNA (miRNA) in liver development is unknown. To address this issue, we characterized miRNA expression in the embryonic mouse liver, performed functional miRNA analysis in zebrafish larvae, and identified novel hepatic miRNA targets. METHODS:Hepatic RNA isolated from mice at embry...

journal_title：Gastroenterology

authors： Hand NJ,Master ZR,Eauclaire SF,Weinblatt DE,Matthews RP,Friedman JR

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND & AIMS:Deoxycholate (DC) has proapoptotic and tumorigenic effects in different cell types of the gastrointestinal tract. Exposure of BHK-21 (stromal) cells to DC induces Ca(2+) entry at the plasma membrane, which affects intracellular Ca(2+) signaling. We assessed whether DC-induced increases in [Ca(2+)] can...

journal_title：Gastroenterology

authors： Gerbino A,Ranieri M,Lupo S,Caroppo R,Debellis L,Maiellaro I,Caratozzolo MF,Lopez F,Colella M

更新日期：2009-09-01 00:00:00

abstract：:A 61-yr-old woman was found to have multicentric hepatocellular carcinoma associated with clinical hyperthyroidism. Marked elevations in serum thyroid-stimulating hormone, T4, T3, and free T4 were documented. These values increased with tumor progression. It is postulated that this patient's hepatoma produced a substa...

journal_title：Gastroenterology

authors： Helzberg JH,McPhee MS,Zarling EJ,Lukert BP

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND & AIMS:We evaluated etanercept, a human soluble tumor necrosis factor receptor: Fc fusion protein, for the treatment of active Crohn's disease. METHODS:Forty-three patients with moderate to severe Crohn's disease were enrolled in an 8-week placebo-controlled trial. Patients were randomized to subcutaneous e...

journal_title：Gastroenterology

authors： Sandborn WJ,Hanauer SB,Katz S,Safdi M,Wolf DG,Baerg RD,Tremaine WJ,Johnson T,Diehl NN,Zinsmeister AR

更新日期：2001-11-01 00:00:00

abstract：:Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and pyroptosis, a form of phagocyte cell death induced by bacterial pathogens. Members of the Nod-like receptor family (including Nlrp1, Nlrp3, and...

journal_title：Gastroenterology

authors： Chen GY,Núñez G

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:Lactase is the intestinal disaccharidase responsible for digestion of lactose, the predominant carbohydrate in milk. Transcription of the lactase gene is activated during enterocyte differentiation. We have characterized the interaction between the lactase promoter and Cdx2, a homeodomain protein invo...

journal_title：Gastroenterology

authors： Fang R,Santiago NA,Olds LC,Sibley E

更新日期：2000-01-01 00:00:00

abstract：:Cellular protooncogenes such as c-myc and c-Ha-ras may play important roles in the control of regeneration of the stomach. In this study, in situ hybridization histochemistry and immunohistochemistry were used to determine how these protooncogenes and the corresponding oncoproteins are expressed at the cellular level ...

journal_title：Gastroenterology

authors： Ito T,Hayashi N,Sasaki Y,Morita Y,Kawano S,Fusamoto H,Sato N,Tohyama M,Kamada T

更新日期：1990-06-01 00:00:00

abstract：:Intragastric titration, introduced in 1973, has become more popular than in the past and is being applied to the study of gastric secretion under a variety of conditions using NaHCO3 and NaOH as titrant. Physical chemical and technical considerations point to limitations on the conditions under which quantitative resu...

journal_title：Gastroenterology

authors： Spenney JG

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND & AIMS:Gain-of-function mutations in the KIT receptor tyrosine kinase gene and rare mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene are important events in gastrointestinal stromal tumor (GIST) development. Different mutations are reportedly associated with distinctive phenotypes...

journal_title：Gastroenterology

authors： Andersson J,Bümming P,Meis-Kindblom JM,Sihto H,Nupponen N,Joensuu H,Odén A,Gustavsson B,Kindblom LG,Nilsson B

更新日期：2006-05-01 00:00:00

abstract：:We have recently demonstrated that ritanserin, a serotonin 5-hydroxytryptamine receptor antagonist void of systemic effects, caused a significant reduction of portal pressure in conscious cirrhotic dogs. The mechanism by which ritanserin lowers portal pressure is poorly defined. We investigated the splanchnic and syst...

journal_title：Gastroenterology

authors： Mastai R,Giroux L,Semret M,Huet PM

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIMS:The mechanisms of chemically induced injury are poorly understood. The purpose of this study was to develop a rapid method for isolation of gastric mucosal cells (GMCs) and sensitive tests for investigating cell damage and protection. METHODS:GMCs were prepared from rat glandular stomach with pronase a...

journal_title：Gastroenterology

authors： Nagy L,Szabo S,Morales RE,Plebani M,Jenkins JM

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND & AIMS:Although different brands of fecal immunochemical tests (FITs) are used for colorectal cancer (CRC) screening, few studies have compared their accuracy in detecting advanced neoplasia. METHODS:We performed a large prospective cohort study within the Dutch national CRC screening program to evaluate 2 ...

journal_title：Gastroenterology

authors： Wieten E,de Klerk CM,van der Steen A,Ramakers CR,Kuipers EJ,Hansen BE,Lansdorp-Vogelaar I,Bossuyt PM,Dekker E,Spaander MCW

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND & AIMS:High-level coffee consumption has been associated with reduced progression of pre-existing liver diseases and lower risk of hepatocellular carcinoma. However, its relationship with therapy for hepatitis C virus infection has not been evaluated. METHODS:Patients (n=885) from the lead-in phase of the H...

journal_title：Gastroenterology

authors： Freedman ND,Curto TM,Lindsay KL,Wright EC,Sinha R,Everhart JE,HALT-C TRIAL GROUP.

更新日期：2011-06-01 00:00:00

abstract：:The G-cell population in the pyloric antrum and proximal duodenum was studied quantitatively by immunofluorescence in specimens from 10 gastric and 12 duodenal ulcer patients. In both groups, G-cell density was highest in the pyloric antrum and much lower in the intermediate zone and proximal duodenum, and G-cell coun...

journal_title：Gastroenterology

authors： Takahashi T,Shimazu H,Yamagishi T,Tani M

更新日期：1980-03-01 00:00:00

abstract：:Serial studies of plasma lipids and lipoproteins were performed in 4 patients with acute alcoholic liver disease characterized by a massive fatty liver and laboratory evidence of intrahepatic cholestasis. There were striking alterations in the plasma lipoprotein electrophoretic patterns characterized by the absence of...

journal_title：Gastroenterology

authors： Sabesin SM,Hawkins HL,Kuiken L,Ragland JB

更新日期：1977-03-01 00:00:00