Sequential protooncogene expression during regeneration in rat stomach.

abstract：BACKGROUND & AIMS:Incidence of and mortality from pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, are almost equivalent, so better treatments are needed. We studied gene expression profiles of PDACs and the functions of genes with altered expression to identify new therapeutic target...

journal_title：Gastroenterology

authors： Jandaghi P,Najafabadi HS,Bauer AS,Papadakis AI,Fassan M,Hall A,Monast A,von Knebel Doeberitz M,Neoptolemos JP,Costello E,Greenhalf W,Scarpa A,Sipos B,Auld D,Lathrop M,Park M,Büchler MW,Strobel O,Hackert T,Giese NA,

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND & AIMS:Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with adverse events in observational studies. We aimed to confirm these findings in an adequately powered randomized trial. METHODS:...

journal_title：Gastroenterology

authors： Moayyedi P,Eikelboom JW,Bosch J,Connolly SJ,Dyal L,Shestakovska O,Leong D,Anand SS,Störk S,Branch KRH,Bhatt DL,Verhamme PB,O'Donnell M,Maggioni AP,Lonn EM,Piegas LS,Ertl G,Keltai M,Bruns NC,Muehlhofer E,Dagenais G

更新日期：2019-09-01 00:00:00

abstract：:Antigliadin antibodies have been widely used in the screening of celiac disease. Using this test, candidates for jejunal biopsy were selected from 328 first-degree relatives of 128 adult celiac patients. All relatives geographically available were willing to participate in the study. Twenty-one turned out to be positi...

journal_title：Gastroenterology

authors： Corazza G,Valentini RA,Frisoni M,Volta U,Corrao G,Bianchi FB,Gasbarrini G

更新日期：1992-11-01 00:00:00

abstract：:Much of what is currently accepted on the natural history of Helicobacter pylori-induced gastritis and its relationship with gastric adenocarcinoma rests on the assumption that atrophic gastritis can be correctly identified and reproducibly recognized. Recently, several studies have indicated that pathologists have a ...

journal_title：Gastroenterology

authors： Genta RM

更新日期：1997-12-01 00:00:00

abstract：:The purpose of this study was to develop an in vitro model of the proximal colon that would permit investigation of the function of colonic bacteria. Five continuous cultures of fecal bacteria were maintained anaerobically in steady state for at least 21 days in a medium simulating ileostomy effluent. The pH was maint...

journal_title：Gastroenterology

authors： Edwards CA,Duerden BI,Read NW

更新日期：1985-06-01 00:00:00

abstract：:Low residue, chemically defined diets containing all essential nutrients in a readily assimilated form, require minimal digestion and are almost entirely absorbed in the upper gastrointestinal tract. Within the past decade, these diets have been reported to provide nutritional support in a variety of clinical situatio...

journal_title：Gastroenterology

authors： Young EA,Heuler N,Russell P,Weser E

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND & AIMS:Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis. Although highly expressed in liver, several studies have reported TfR2 expression in other tissues. To determine the contribution of liver expressed...

journal_title：Gastroenterology

authors： Wallace DF,Summerville L,Subramaniam VN

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:The role of cholecystokinin (CCK) in the regulation of gastric acid secretion is still controversial. This study examined the effect of the CCK-A receptor antagonist loxiglumide (lox) on gastrin- or CCK-induced gastric acid secretion and meal-stimulated plasma gastrin levels in a placebo-controlled stud...

journal_title：Gastroenterology

authors： Schmidt WE,Schenk S,Nustede R,Holst JJ,Fölsch UR,Creutzfeldt W

更新日期：1994-12-01 00:00:00

abstract：:Because approximately 80% of reported patients with somatostatinomas have gallstones, this study was performed to determine the effects of exogenous somatostatin on gallbladder emptying responses to liquid and solid meals, direct cholinergic stimulation by bethanechol, indirect cholinergic stimulation by sham feeding,...

journal_title：Gastroenterology

authors： Fisher RS,Rock E,Levin G,Malmud L

更新日期：1987-04-01 00:00:00

abstract：:Motor abnormalities of the small bowel that occur only during the waking state have been reported in the irritable bowel syndrome (IBS), suggesting that central nervous system arousal is a necessary condition for expression of the disorder and that it may reflect inappropriate brain-gut interaction. This possible rela...

journal_title：Gastroenterology

authors： Kumar D,Thompson PD,Wingate DL,Vesselinova-Jenkins CK,Libby G

更新日期：1992-07-01 00:00:00

abstract：:Ceftriaxone, a semisynthetic third-generation cephalosporin, has recently been associated with biliary sludge formation. Analysis of the biliary concretions induced by this agent shows a calcium salt of ceftriaxone. The present in vitro studies were undertaken to provide insight into the pathogenesis of ceftriaxone-as...

journal_title：Gastroenterology

authors： Shiffman ML,Keith FB,Moore EW

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND & AIMS:Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair gene mutations that define this syndrome and result in microsatellite instability (MSI). The carcinogenic path...

journal_title：Gastroenterology

authors： Goel A,Xicola RM,Nguyen TP,Doyle BJ,Sohn VR,Bandipalliam P,Rozek LS,Reyes J,Cordero C,Balaguer F,Castells A,Jover R,Andreu M,Syngal S,Boland CR,Llor X

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND & AIMS:Current stool DNA tests identify about half of individuals with colorectal cancers and miss most individuals with advanced adenomas. We developed a digital melt curve (DMC) assay to quantify low-abundance mutations in stool samples for detection of colorectal neoplasms and compared this test with othe...

journal_title：Gastroenterology

authors： Zou H,Taylor WR,Harrington JJ,Hussain FT,Cao X,Loprinzi CL,Levine TR,Rex DK,Ahnen D,Knigge KL,Lance P,Jiang X,Smith DI,Ahlquist DA

更新日期：2009-02-01 00:00:00

abstract：:Hepatocellular carcinoma often affects blacks at an early age. The purpose of this study was to ascertain if the association between chronic hepatitis B virus infection and hepatocellular carcinoma is the same in young and older black patients. Serum markers of hepatitis B infection were measured by radioimmunoassay i...

journal_title：Gastroenterology

authors： Kew MC,Macerollo P

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND & AIMS:Parenteral methotrexate is an effective treatment for patients with Crohn's disease, but has never been adequately evaluated in patients with ulcerative colitis (UC). We conducted a randomized controlled trial to determine its safety and efficacy in patients with steroid-dependent UC. METHODS:We perf...

journal_title：Gastroenterology

authors： Carbonnel F,Colombel JF,Filippi J,Katsanos KH,Peyrin-Biroulet L,Allez M,Nachury M,Novacek G,Danese S,Abitbol V,Bossa F,Moreau J,Bommelaer G,Bourreille A,Fumery M,Roblin X,Reinisch W,Bouhnik Y,Brixi H,Seksik P,Mala

更新日期：2016-02-01 00:00:00

abstract：:We have conducted a double-blind controlled trial of colchicine in patients with primary biliary cirrhosis. Fifty-seven patients with biopsy-proven primary biliary cirrhosis were randomized to receive either 0.6 mg of colchicine twice daily or an identically appearing placebo. Patients underwent clinical and laborator...

journal_title：Gastroenterology

authors： Bodenheimer H Jr,Schaffner F,Pezzullo J

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND & AIMS:The secretion and function of antral histamine are not known. The aims of this study were to characterize the mechanisms of histamine release from the gastric antrum of humans, dogs, and rats and to determine whether histamine can influence the secretion of somatostatin and gastrin. METHODS:Somatosta...

journal_title：Gastroenterology

authors： Vuyyuru L,Schubert ML,Harrington L,Arimura A,Makhlouf GM

更新日期：1995-11-01 00:00:00

abstract：:The target appearance of grey scale ultrasound is thought to be a characteristic sign of gastrointestinal wall thickening. It consists of a strong echogenic center surrounded by a sonolucent rim. In a prospective controlled study, the sensitivity and specificity of the ultrasonic B-scan for Crohn's disease were invest...

journal_title：Gastroenterology

authors： Sonnenberg A,Erckenbrecht J,Peter P,Niederau C

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND & AIMS:Abnormal processing of visceral sensation at the level of the central nervous system is believed to be involved in functional dyspepsia. However, compared with studies of stimulation-related changes in brain activity, few studies have focused on resting brain activity, which also is important in patho...

journal_title：Gastroenterology

authors： Zeng F,Qin W,Liang F,Liu J,Tang Y,Liu X,Yuan K,Yu S,Song W,Liu M,Lan L,Gao X,Liu Y,Tian J

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND & AIMS:Idiopathic inflammatory bowel disease (IBD) is associated with bone loss in more than 30% of cases. Nevertheless, the pathogenesis of the bone loss is uncertain. The aim of this study was to investigate the bone loss and underlying mechanisms using an animal model of IBD. METHODS:Severe colitis was i...

journal_title：Gastroenterology

authors： Lin CL,Moniz C,Chambers TJ,Chow JW

更新日期：1996-11-01 00:00:00

abstract：:Helicobacter pylori infects the stomach of half of the human population worldwide and causes chronic active gastritis, which can lead to peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The host immune response to the infection is ineffective, because the bacterium persists...

journal_title：Gastroenterology

authors： Wilson KT,Crabtree JE

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND & AIMS:SPD476 (LIALDA in the US; MEZAVANT in the EU; otherwise known as MMX mesalamine; Shire Pharmaceuticals Inc., Wayne, PA, under license from Giuliani SpA, Milan, Italy) is a novel, once-daily, high-strength (1.2 g/tablet) formulation of mesalamine, utilizing MMX Multi Matrix System (MMX) technology desi...

journal_title：Gastroenterology

authors： Kamm MA,Sandborn WJ,Gassull M,Schreiber S,Jackowski L,Butler T,Lyne A,Stephenson D,Palmen M,Joseph RE

更新日期：2007-01-01 00:00:00

abstract：:The effects of vasopressin on blood flow in the superior mesenteric artery and on mean arterial pressure and portal venous pressure were measured in 7 rhesus monkeys. Vasopressin was injected, as either a bolus, or infused both intravenously and intraarterially to assess the influence of the route of administration up...

journal_title：Gastroenterology

authors： Freedman AR,Kerr JC,Swan KG,Hobson RW

更新日期：1978-05-01 00:00:00

abstract：:To determine the amount of lactose that could be tolerated in a meal, 59 lactase-deficient American Indians, ranging in age from 5 to 62, were given graded doses of lactose. The diagnosis of lactase deficiency had beeen documented previously by showing increased breath hydrogen after an oral lactose load (2 g per kg, ...

journal_title：Gastroenterology

authors： Newcomer AD,McGill DB,Thomas PJ,Hofmann AF

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hereditary hemochromatosis is a common disorder of iron homeostasis characterized by increased dietary iron absorption and progressive iron accumulation, mainly in the liver. Most patients are homozygous for the C282Y mutation in the HFE gene. However, not all individuals carrying the hemochromatosis-...

journal_title：Gastroenterology

authors： Bensaid M,Fruchon S,Mazères C,Bahram S,Roth MP,Coppin H

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND & AIMS:Gastric emptying plays an important role in regulating food intake. This study was designed to investigate whether intraperitoneally injected urocortin reduces gastric emptying, feeding, and body weight in lean and ob/ob obese mice. METHODS:Food intake and body weight were measured after intraperiton...

journal_title：Gastroenterology

authors： Asakawa A,Inui A,Ueno N,Makino S,Fujino MA,Kasuga M

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND & AIMS:Several studies have reported that low doses of interferon can delay the development of hepatocellular carcinoma (HCC) and progression of chronic hepatitis C. We investigated the incidence of clinical events among participants of the Evaluation of PegIntron in Control of Hepatitis C Cirrhosis (EPIC)3 ...

journal_title：Gastroenterology

authors： Bruix J,Poynard T,Colombo M,Schiff E,Burak K,Heathcote EJ,Berg T,Poo JL,Mello CB,Guenther R,Niederau C,Terg R,Bedossa P,Boparai N,Griffel LH,Burroughs M,Brass CA,Albrecht JK,EPIC3 Study Group.

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:During hepatic fibrogenesis, the hepatic extracellular matrix changes to fibrillar collagens types I and III, and cirrhosis is believed to produce an irreversible scar. In this study, we investigated whether gene delivery of human matrix metalloproteinase-1, which degrades collagens types I and type I...

journal_title：Gastroenterology

authors： Iimuro Y,Nishio T,Morimoto T,Nitta T,Stefanovic B,Choi SK,Brenner DA,Yamaoka Y

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND & AIMS:Postprandial glycemia excursions increase after gastric bypass surgery; this effect is even greater among patients with recurrent hypoglycemia. These patients also have increased postprandial levels of insulin and glucagon-like peptide 1 (GLP-1). We performed a clinical trial to determine the role of ...

journal_title：Gastroenterology

authors： Salehi M,Gastaldelli A,D'Alessio DA

更新日期：2014-03-01 00:00:00

abstract：:We are delighted to introduce a new and simple format in the references section of the articles we publish in Gastroenterology that highlights joint first authors of citations. We believe this is an important step to acknowledging equal contribution to published work as research becomes increasingly team-oriented and ...

journal_title：Gastroenterology

authors： Dubnansky E,Omary MB

更新日期：2012-10-01 00:00:00