Abstract:
:To determine the amount of lactose that could be tolerated in a meal, 59 lactase-deficient American Indians, ranging in age from 5 to 62, were given graded doses of lactose. The diagnosis of lactase deficiency had beeen documented previously by showing increased breath hydrogen after an oral lactose load (2 g per kg, maximum 50 g). With this load, 88% of the subjects had symptoms. On 6 consecutive mornings, each subject was given a breakfast that contained graded doses of lactose ranging from 0 to 18 g. The order of the breakfasts was randomized and the contents were double-blinded. Symptoms, which were assessed by a "blinded" observer, were present after 9% of the breakfasts at all dosage levels, including the lactose-free breakfast. Thus, under the conditions of this study, a modest amount of lactose, equivalent to that present in 1 to 1 1/2 glasses of milk, when taken with a meal, is well tolerated by the lactase-deficient American Indian.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Newcomer AD,McGill DB,Thomas PJ,Hofmann AFsubject
Has Abstractpub_date
1978-01-01 00:00:00pages
44-6issue
1eissn
0016-5085issn
1528-0012pii
S0016508578000013journal_volume
74pub_type
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