Gliadin immune reactivity is associated with overt and latent enteropathy in relatives of celiac patients.

abstract：:A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursor-product relationship betwe...

journal_title：Gastroenterology

authors： Schwartz CC,Vlahcevic ZR,Halloran LG,Gregory DH,Meek JB,Swell L

更新日期：1975-12-01 00:00:00

abstract：:The results of a clinical trial comparing slow-release 5-aminosalicylic acid tablets (Pentasa) and enteric-coated sulfasalazine tablets (Salazopyrin) with regard to the efficacy of maintaining ulcerative colitis patients in remission for 12 mo and with regard to safety of treatment are reported. Seventy-five patients ...

journal_title：Gastroenterology

authors： Mulder CJ,Tytgat GN,Weterman IT,Dekker W,Blok P,Schrijver M,van der Heide H

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND & AIMS:Endoscopic and Histologic remission are important goals in the treatment of ulcerative colitis (UC). We investigated the correlation of the recently developed Paddington International Virtual ChromoendoScopy ScOre( PICaSSO) and other established endoscopic scores against multiple histological indices ...

journal_title：Gastroenterology

authors： Iacucci M,Smith SC,Bazarova A,Shivaji UN,Bhandari P,Cannatelli R,Daperno M,Ferraz J,Goetz M,Gui X,Hayee B,De Hertogh G,Lazarev M,Li J,Nardone OM,Parra-Blanco A,Pastorelli L,Panaccione R,Occhipinti V,Rath T,Tontini

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND & AIMS:Despite inducing an inflammatory response, Helicobacter pylori can persist in the gastric mucosa for decades. H pylori expression of cholesterol-α-glucosyltransferase (encoded by cgt) is required for gastric colonization and T-cell activation. We investigated how cgt affects gastric epithelial cells a...

journal_title：Gastroenterology

authors： Morey P,Pfannkuch L,Pang E,Boccellato F,Sigal M,Imai-Matsushima A,Dyer V,Koch M,Mollenkopf HJ,Schlaermann P,Meyer TF

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with limited life expectancy, the risks of colorectal cancer screening may outweigh the benefits. The aim of this study was to quantify risks and benefits of different screening strategies in elderly patients with varying life expectancies. METHODS:We examined risks and benefits of screen...

journal_title：Gastroenterology

authors： Ko CW,Sonnenberg A

更新日期：2005-10-01 00:00:00

abstract：:Abdominal cramps and urgent defecation are common side effects of clinical doses of arginine vasopressin, indicating that the drug may have stimulating effects on colonic motor activity. Four strain-gauge transducers were implanted on the colon in six monkeys. A blood flow probe was fixed on the inferior mesenteric ar...

journal_title：Gastroenterology

authors： Zhu YR,Cowles VE,Herranz ES,Schulte WJ,Condon RE

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND & AIMS:Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated ...

journal_title：Gastroenterology

authors： Lo Sasso G,Bovenga F,Murzilli S,Salvatore L,Di Tullio G,Martelli N,D'Orazio A,Rainaldi S,Vacca M,Mangia A,Palasciano G,Moschetta A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND/AIMS:The effectiveness of ursodeoxycholic acid in treating biliary liver diseases is limited by low bioavailability and moderate activity. A new analogue of ursodeoxycholic acid was synthesized with a fluorine atom in position 6 because this should have resulted in an analogue more hydrophilic than ursodeoxy...

journal_title：Gastroenterology

authors： Roda A,Pellicciari R,Polimeni C,Cerrè C,Forti GC,Sadeghpour B,Sapigni E,Gioacchini AM,Natalini B

更新日期：1995-04-01 00:00:00

abstract：:Cholylglycylhistamine, a derivative of cholic acid, has been synthesized and characterized. This derivative has been iodinated using Na125I and chloramine-T and purified free from unlabeled cholylglycylhistamine. Application of this iodinated bile salt derivative to radioimmunoassay of bile salts in human serum is rep...

journal_title：Gastroenterology

authors： Spenney JG,Johnson BJ,Hirschowitz BI,Mihas AA,Gibson R

更新日期：1977-02-01 00:00:00

abstract：:The mechanism of acute ulceration and the nature of mucosal protective mechanisms were investigated in rabbit antrum, which is more resistant to injury than fundus of the same species, with particular reference to the relationship between H+ back diffusion, tissue acidification, and occurrence of ulceration. Exposure ...

journal_title：Gastroenterology

authors： Kivilaakso E,Barzilai A,Schiessel R,Fromm D,Silen W

更新日期：1981-01-01 00:00:00

abstract：:The effect of magnesium on calcium- and pentagastrin-induced gastric acid secretion and on calcium-induced gastrin secretion were studied in healthy volunteers. Intravenous infusion of calcium gluconate increased serum gastrin concentration as well as gastric volume secretion, acidity, and acid output. Addition of mag...

journal_title：Gastroenterology

authors： Christiansen J,Rehfeld JF,Stadil F

更新日期：1975-05-01 00:00:00

abstract：:The effect of experimental bypass on the intestinal epithelium of the rat was investigated from 2 to 360 days after creating a Thiry-Vella fistula. Within 7 to 14 days the number of cells per villus column and, to a lesser degree, the number of cells per crypt column decreased and subsequently these values remained co...

journal_title：Gastroenterology

authors： Rijke RP,Plaisier HM,de Ruiter H,Galjaard H

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND & AIMS:It is unclear whether genomic derangement precedes the histological development of dysplasia in ulcerative colitis (UC)-related neoplastic progression. The primary aim of this study was to determine if chromosomal alterations occur early in the progression pathway of UC-related neoplasia. METHODS:Flu...

journal_title：Gastroenterology

authors： Willenbucher RF,Zelman SJ,Ferrell LD,Moore DH 2nd,Waldman FM

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND & AIMS:Previous studies have indicated that serotonin-3-receptor antagonists might have a sex-specific effect in patients with irritable bowel syndrome with diarrhea (IBS-D). Alosetron has been approved for the treatment of only women, and ramosetron has been approved for the treatment for only men. We perfo...

journal_title：Gastroenterology

authors： Fukudo S,Kinoshita Y,Okumura T,Ida M,Akiho H,Nakashima Y,Nishida A,Haruma K

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND & AIMS:We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an optimal level of Wnt signaling. We and others subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total of 1-2 beta-catenin binding/deg...

journal_title：Gastroenterology

authors： Pollard P,Deheragoda M,Segditsas S,Lewis A,Rowan A,Howarth K,Willis L,Nye E,McCart A,Mandir N,Silver A,Goodlad R,Stamp G,Cockman M,East P,Spencer-Dene B,Poulsom R,Wright N,Tomlinson I

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND & AIMS:We investigated the transcriptome of esophageal squamous cell carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and the effects of blocking epigenetic regulatory proteins. METHODS:We performed chromatin immunoprecipitation sequencing with antibodies against H3K4me1,...

journal_title：Gastroenterology

authors： Jiang YY,Jiang Y,Li CQ,Zhang Y,Dakle P,Kaur H,Deng JW,Lin RY,Han L,Xie JJ,Yan Y,Doan N,Zheng Y,Mayakonda A,Hazawa M,Xu L,Li Y,Aswad L,Jeitany M,Kanojia D,Guan XY,Said JW,Yang W,Fullwood MJ,Lin DC,Koeffle

更新日期：2020-10-01 00:00:00

abstract：:The importance of various factors for dietary fiber effects on pancreatic enzyme activities was studied in vitro. Pectin of high methylic esterification and guar gum, which reduced enzyme activities, particularly lipase activity, increased the viscosity of duodenal juice. Increasing duodenal juice viscosity by polyeth...

journal_title：Gastroenterology

authors： Isaksson G,Lundquist I,Ihse I

更新日期：1982-05-01 00:00:00

abstract：BACKGROUND & AIMS:One approach to the development of targeted cancer chemotherapy exploits increased uptake of the agent into neoplastic cells. In this scenario, higher concentrations of the agent in cancer cells are responsible for differential killing, whereas the low concentration in normal human cells decreases sid...

journal_title：Gastroenterology

authors： Abe T,Unno M,Onogawa T,Tokui T,Kondo TN,Nakagomi R,Adachi H,Fujiwara K,Okabe M,Suzuki T,Nunoki K,Sato E,Kakyo M,Nishio T,Sugita J,Asano N,Tanemoto M,Seki M,Date F,Ono K,Kondo Y,Shiiba K,Suzuki M,Ohtani H,S

更新日期：2001-06-01 00:00:00

abstract：:Electromyogram of the submental muscles, esophageal manometry, and pH studies were simultaneously performed in an unselected group of 12 patients with subjective and objective evidence of gastroesophageal reflux (GER) disease to determine the frequency of transient relaxation of the lower esophageal sphincter (LES) an...

journal_title：Gastroenterology

authors： Mittal RK,McCallum RW

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND & AIMS:Epithelial cells of the small intestine migrate to the tip of the villus at which they are shed. It is not understood how the intestinal barrier is maintained during this high cell turnover. The aim of this study was to use high-resolution in vivo light microscopy to investigate the mechanism of epith...

journal_title：Gastroenterology

authors： Watson AJ,Chu S,Sieck L,Gerasimenko O,Bullen T,Campbell F,McKenna M,Rose T,Montrose MH

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND & AIMS:This study aimed to determine if hiatal hernia influences vulnerability to reflux and transient lower esophageal sphincter relaxation (tLESR) during gastric distention in patients with gastroesophageal reflux disease (GERD). METHODS:Eight normal subjects and 15 patients with GERD were studied. A meta...

journal_title：Gastroenterology

authors： Kahrilas PJ,Shi G,Manka M,Joehl RJ

更新日期：2000-04-01 00:00:00

abstract：:The prospect of a significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to be focused on the problem of growing obesity prevalence in these populations. Although these studies have shown that cardiometabolic complicatio...

journal_title：Gastroenterology

authors： Abate N,Chandalia M

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND & AIMS:Helicobacter pylori is an important etiologic factor in the development of gastric cancer. The aim of this study was to analyze the role of H. pylori infections in the induction of mutagenic events in gastric epithelial cells. The effect of a high-salt diet as a genotoxic risk factor was also investig...

journal_title：Gastroenterology

authors： Touati E,Michel V,Thiberge JM,Wuscher N,Huerre M,Labigne A

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND & AIMS:Long non-coding RNAs (lncRNAs) are expressed in tissue-specific pattern, but it is not clear how these are regulated. We aimed to identify squamous cell carcinoma (SCC)-specific lncRNAs and investigate mechanisms that control their expression and function. METHODS:We studied expression patterns and f...

journal_title：Gastroenterology

authors： Xie JJ,Jiang YY,Jiang Y,Li CQ,Lim MC,An O,Mayakonda A,Ding LW,Long L,Sun C,Lin LH,Chen L,Wu JY,Wu ZY,Cao Q,Fang WK,Yang W,Soukiasian H,Meltzer SJ,Yang H,Fullwood M,Xu LY,Li EM,Lin DC,Koeffler HP

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with chronic Helicobacter pylori (H pylori) infection, parietal and chief cell atrophy in the gastric corpus, a process known as spasmolytic polypeptide-expressing metaplasia (SPEM), increases the risk for progression to cancer. The relation between H pylori and these metaplastic changes i...

journal_title：Gastroenterology

authors： Sáenz JB,Vargas N,Mills JC

更新日期：2019-01-01 00:00:00

abstract：:Intramural pH of the gastric mucosa was measured using a microelectrode technique in rabbit gastric pouches under different secretory conditions and luminal acidity. Exposure of spontaneously secreting or metiamide-treated fundic pouches to a relatively high concentration of luminal acid. HCl 120 mM, for 60 min, led ...

journal_title：Gastroenterology

authors： Kivilaakso E,Fromm D,Silen W

更新日期：1978-10-01 00:00:00

abstract：:The clinical, functional, and histopathological effects of 18 g additional gluten intake daily for 4 wk was studied in 13 healthy siblings of Spanish children with celiac disease, including two pairs of discordant monozygotic twins. Five of the 13 children were HLA-DR identical to the celiac sibling, 5 shared only one...

journal_title：Gastroenterology

authors： Polanco I,Mearin ML,Larrauri J,Biemond I,Wipkink-Bakker A,Peña AS

更新日期：1987-03-01 00:00:00

abstract：:Prior studies confirm the increased incidence of carcinoma of the colon in chronic ulcerative colitis. The authors reviewed clinical and histologic data retrospectively in 23 patients with colon carcinoma and chronic ulcerative colitis. Twenty-two of these patients had dysplasia of colonic epithelium remote from the c...

journal_title：Gastroenterology

authors： Nugent FW,Haggit RC,Colcher H,Kutteruf GC

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND & AIMS:The relationship between the sensation of bloating, often ranked as the most bothersome symptom by patients with irritable bowel syndrome (IBS), and actual distention manifest as an increase in abdominal girth is controversial. Investigation of this problem has been hampered by the lack of a reliable ...

journal_title：Gastroenterology

authors： Houghton LA,Lea R,Agrawal A,Reilly B,Whorwell PJ

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Autoimmune responses against colonic epithelium may play a role in the development of colonic inflammation associated with ulcerative colitis (UC). In this study, we established and characterized B-cell lines and clones that produced anticolon antibody from inflamed colonic mucosa of UC subjects. M...

journal_title：Gastroenterology

authors： Inoue N,Watanabe M,Sato T,Okazawa A,Yamazaki M,Kanai T,Ogata H,Iwao Y,Ishii H,Hibi T

更新日期：2001-07-01 00:00:00