当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

Abstract：

BACKGROUND & AIMS:Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis. Although highly expressed in liver, several studies have reported TfR2 expression in other tissues. To determine the contribution of liver expressed TfR2 in iron homeostasis, we have generated and characterized a liver-specific TfR2-knockout (KO) mouse. METHODS:Liver-specific TfR2-KO mice were generated by crossing TfR2-floxed mice with transgenic albumin-Cre mice. Tissue and serum from homozygous TfR2-floxed mice with and without albumin-Cre were analyzed. Serum transferrin saturation, hepatic, and splenic iron concentrations were determined. The expression of iron-related mRNA transcripts was analyzed by real-time PCR. Levels of the iron-related proteins TfR1, TfR2, ferritin, and prohepcidin were analyzed by immunoblotting. RESULTS:Liver-specific TfR2-KO mice develop significant iron overload comparable to complete TfR2-KO mice. At all ages studied, transferrin saturation, hepatic iron concentration, and hepatic ferritin were significantly elevated. Hepatic TfR2 mRNA and protein were absent in the livers of liver-specific TfR2-KO mice, and TfR1 expression was reduced consistent with liver iron loading. At 5 weeks of age, hepcidin1 mRNA, and prohepcidin protein were decreased in liver-specific TfR2-KO compared to control mice. CONCLUSIONS:The significant iron loading and modulation of expression of iron-related genes in liver-specific TfR2-KO mice demonstrates that the liver is the primary site for TfR2 expression and activity and that liver-expressed TfR2 is required for the regulation of hepcidin1.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Wallace DF,Summerville L,Subramaniam VN

doi

10.1053/j.gastro.2006.11.028

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

301-10

issue

1

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(06)02483-8

journal_volume

132

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients.

    abstract：BACKGROUND & AIMS:Biliary atresia (BA) is a rare disease in infants, with unknown mechanisms of pathogenesis. It is characterized by hepatobiliary inflammatory, progressive destruction of the biliary system leading to liver fibrosis, and deterioration of liver function. Interleukin (IL) 17A promotes inflammatory and au...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2015.09.008

    authors： Klemann C,Schröder A,Dreier A,Möhn N,Dippel S,Winterberg T,Wilde A,Yu Y,Thorenz A,Gueler F,Jörns A,Tolosa E,Leonhardt J,Haas JD,Prinz I,Vieten G,Petersen C,Kuebler JF

    更新日期：2016-01-01 00:00:00

  • Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice.

    abstract：BACKGROUND & AIMS:Sjögren's syndrome and autoimmune pancreatitis are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. Nonobese diabetic/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren's syndrome and chronic pancreatitis and MRL/Mp mice are models of autoi...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2017.06.011

    authors： Zeng M,Szymczak M,Ahuja M,Zheng C,Yin H,Swaim W,Chiorini JA,Bridges RJ,Muallem S

    更新日期：2017-10-01 00:00:00

  • Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis.

    abstract：BACKGROUND & AIMS:We performed a prospective, randomized, controlled study to compare the combination of esomeprazole and clopidogrel vs clopidogrel alone in preventing recurrent peptic ulcers in patients with atherosclerosis and a history of peptic ulcers. We also investigated the effects of esomeprazole on the antipl...

    journal_title：Gastroenterology

    pub_type： 杂志文章,随机对照试验

    doi：10.1053/j.gastro.2010.11.056

    authors： Hsu PI,Lai KH,Liu CP

    更新日期：2011-03-01 00:00:00

  • Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

    abstract：BACKGROUND & AIMS:SMAD4 frequently is lost from colorectal cancers (CRCs), which is associated with the development of metastases and a poor prognosis. SMAD4 loss is believed to alter transforming growth factor β signaling to promote tumor progression. However, SMAD4 is also a central component of the bone morphogeneti...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2014.03.052

    authors： Voorneveld PW,Kodach LL,Jacobs RJ,Liv N,Zonnevylle AC,Hoogenboom JP,Biemond I,Verspaget HW,Hommes DW,de Rooij K,van Noesel CJ,Morreau H,van Wezel T,Offerhaus GJ,van den Brink GR,Peppelenbosch MP,Ten Dijke P,Hardwick JC

    更新日期：2014-07-01 00:00:00

  • Relapsing pancreatitis associated with duodenal wall cysts. Diagnostic approach and treatment.

    abstract：:A case of enterogenous cysts of the duodenum in a 44-yr-old man complicated by duodenal obstruction and relapsing pancreatitis is presented. The cystic duodenal lesions were visualized by endoscopic retrograde cholangiopancreatography and for the first time by computed tomography and abdominal sonography. Thus, the di...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(85)90157-x

    authors： Holstege A,Barner S,Brambs HJ,Wenz W,Gerok W,Farthmann EH

    更新日期：1985-03-01 00:00:00

  • Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals.

    abstract：BACKGROUND & AIMS:Little is known about substitutions that mediate resistance of hepatitis C virus (HCV) to direct-acting antivirals (DAAs), due to the small number of patients with treatment failure in approval studies. It is important to identify resistance patterns to select effective salvage treatments. METHODS:We...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1053/j.gastro.2017.11.007

    authors： Dietz J,Susser S,Vermehren J,Peiffer KH,Grammatikos G,Berger A,Ferenci P,Buti M,Müllhaupt B,Hunyady B,Hinrichsen H,Mauss S,Petersen J,Buggisch P,Felten G,Hüppe D,Knecht G,Lutz T,Schott E,Berg C,Spengler U,von Ha

    更新日期：2018-03-01 00:00:00

  • Effects of corticotropin-releasing factor on plasma motilin and somatostatin levels and gastrointestinal motility in dogs.

    abstract：:The effects of intracerebroventricular and intravenous administration of corticotropin-releasing factor (CRF) on gastrointestinal motility, motilin-induced gastric motor response, and plasma motilin and somatostatin levels were investigated in fasted dogs chronically prepared with strain gauge transducers on the antru...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)90690-6

    authors： Bueno L,Fargeas MJ,Gue M,Peeters TL,Bormans V,Fioramonti J

    更新日期：1986-10-01 00:00:00

  • Sucralfate suppresses Helicobacter pylori infection and reduces gastric acid secretion by 50% in patients with duodenal ulcer.

    abstract：BACKGROUND & AIMS:The mechanism(s) by which sucralfate heals duodenal ulcers remains unclear. The aim of this study was to determine the effect of sucralfate on Helicobacter pylori infection and on the accompanying hypersecretion of gastric acid the infection induces in patients with duodenal ulcer. METHODS:Basal and ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1996.v110.pm8608880

    authors： Banerjee S,El-Omar E,Mowat A,Ardill JE,Park RH,Watson W,Beattie AD,McColl KE

    更新日期：1996-03-01 00:00:00

  • Notch signaling is required for exocrine regeneration after acute pancreatitis.

    abstract：BACKGROUND & AIMS:The mechanisms for tissue regeneration and renewal after acute pancreatitis are not well understood but may involve activation of Notch signaling. To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling i...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2007.11.003

    authors： Siveke JT,Lubeseder-Martellato C,Lee M,Mazur PK,Nakhai H,Radtke F,Schmid RM

    更新日期：2008-02-01 00:00:00

  • Impaired mixed-lymphocyte culture reactions in patients with inflammatory bowel disease.

    abstract：:We studied the response of lymphocytes from 43 patients with inflammatory bowel disease to allogeneic stimulation in one-way mixed-lymphocyte cultures. We found that 53% of patients with inflammatory bowel disease, in contrast to 4% of normal and disease controls, had significant depression of mixed-lymphocyte culture...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Fiske SC,Falchuk ZM

    更新日期：1980-10-01 00:00:00

  • Cell wall-defective variants of pseudomonas-like (group Va) bacteria in Crohn's disease.

    abstract：:Several animal transmission studies have indicated that Crohn's disease may be caused by a filterable agent. Filtrates of homogenized tissues were prepared from 8 patients with Crohn's disease, 9 patients with chronic ulcerative colitis, and 20 control patients without inflammatory bowel disease. Conventional bacterio...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Parent K,Mitchell P

    更新日期：1978-09-01 00:00:00

  • Effect of oral dioctyl sodium sulfosuccinate on intake-output studies of human small and large intestine.

    abstract：:Dioctyl sodium sulfosuccinate (DSS) is an anionic detergent that is used widely as a laxative and promoted as a stool softener. Although many anecdotal reports attest to the laxative and stool softening efficacy of DSS, no controlled trials have been performed to document the effect of DSS on small or large bowel func...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0016-5085(85)90441-x

    authors： Chapman RW,Sillery J,Fontana DD,Matthys C,Saunders DR

    更新日期：1985-09-01 00:00:00

  • The protective effect of gamma-hydroxybutyrate in regional intestinal ischemia in the hamster.

    abstract：:The purpose of this study was to determine whether gamma-hydroxybutyrate provides protection against intestinal ischemia/reperfusion injury and to compare its effect with that of allopurinol and vitamin E. Thirty minutes of total regional ischemia, followed by 3 hours of reperfusion, produced intestinal damage that wa...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)90982-7

    authors： Boyd AJ,Sherman IA,Saibil FG,Mamelak M

    更新日期：1990-09-01 00:00:00

  • Decreasing risk of colorectal cancer in patients with inflammatory bowel disease over 30 years.

    abstract：BACKGROUND & AIMS:The risk for colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) could have changed over time, with changes in treatment options. We studied CRC risk in a nationwide cohort of 47,374 Danish patients with IBD over a 30-year period. METHODS:We determined relative risk (RR) values ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2012.04.016

    authors： Jess T,Simonsen J,Jørgensen KT,Pedersen BV,Nielsen NM,Frisch M

    更新日期：2012-08-01 00:00:00

  • Chronic liver disease after acute non-A, non-B viral hepatitis.

    abstract：:We have analyzed the frequency of chronicity and its distribution according to epidemiologic background following acute non-A, non-B hepatitis. Eighteen of 45 cases (40%) developed chronic liver disease. The incidence of chronicity was significantly higher following transfusion and among drug addicts (54% and 58%) tha...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Rakela J,Redeker AG

    更新日期：1979-12-01 00:00:00

  • Blockade of glucagon-like peptide 1 receptor corrects postprandial hypoglycemia after gastric bypass.

    abstract：BACKGROUND & AIMS:Postprandial glycemia excursions increase after gastric bypass surgery; this effect is even greater among patients with recurrent hypoglycemia. These patients also have increased postprandial levels of insulin and glucagon-like peptide 1 (GLP-1). We performed a clinical trial to determine the role of ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2013.11.044

    authors： Salehi M,Gastaldelli A,D'Alessio DA

    更新日期：2014-03-01 00:00:00

  • Functional gastroduodenal disorders.

    abstract：:A numerically important group of patients with functional gastrointestinal disorders have chronic symptoms that can be attributed to the gastroduodenal region. Based on the consensus opinion of an international panel of clinical investigators who reviewed the available evidence, a classification of the functional gast...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2005.11.059

    authors： Tack J,Talley NJ,Camilleri M,Holtmann G,Hu P,Malagelada JR,Stanghellini V

    更新日期：2006-04-01 00:00:00

  • 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.

    abstract：BACKGROUND & AIMS:Current therapy for primary sclerosing cholangitis is of limited efficacy. Multidrug resistance gene 2 knockout mice (Mdr2(-/-)) represent a well-characterized model for sclerosing cholangitis. Experiments were performed to test in such mice the therapeutic effects of 24-norUrsodeoxycholic acid, a C(2...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2005.10.018

    authors： Fickert P,Wagner M,Marschall HU,Fuchsbichler A,Zollner G,Tsybrovskyy O,Zatloukal K,Liu J,Waalkes MP,Cover C,Denk H,Hofmann AF,Jaeschke H,Trauner M

    更新日期：2006-02-01 00:00:00

  • Cimetidine in the treatment of duodenal ulcer: review and commentary.

    abstract：:The published world literature on the efficacy of cimetidine, a histamine H2-receptor antagonist, in the treatment of duodenal ulcer is reviewed. In eight prospective randomized double blind placebo-controlled studies, cimetidine was administered to 348 duodenal ulcer patients with an incidence of endoscopically verif...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Winship DH

    更新日期：1978-02-01 00:00:00

  • Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease.

    abstract：:Increasing evidence has emerged that supports an important intersection between 3 fundamental cell biologic pathways in the pathogenesis of inflammatory bowel disease. These include the intersection between autophagy, as revealed by the original identification of ATG16L1 and IRGM as major genetic risk factors for Croh...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2011.02.048

    authors： Kaser A,Blumberg RS

    更新日期：2011-05-01 00:00:00

  • Combined functional and positional gene information for the identification of susceptibility variants in celiac disease.

    abstract：BACKGROUND & AIMS:Celiac disease is a complex, immune-mediated disorder of the intestinal mucosa with a strong genetic component. HLA-DQ2 is the major determinant of risk, but other minor genes, still to be identified, also are involved. METHODS:We designed a strategy that combines gene expression profiling of intesti...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2007.11.041

    authors： Castellanos-Rubio A,Martin-Pagola A,Santín I,Hualde I,Aransay AM,Castaño L,Vitoria JC,Bilbao JR

    更新日期：2008-03-01 00:00:00

  • Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease.

    abstract：BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2000.8523

    authors： Tibble JA,Sigthorsson G,Bridger S,Fagerhol MK,Bjarnason I

    更新日期：2000-07-01 00:00:00

  • Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-Associated Colorectal Cancer.

    abstract：BACKGROUND & AIMS:A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted vs random biopsies in patients with UC. METHODS:W...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1053/j.gastro.2016.08.002

    authors： Watanabe T,Ajioka Y,Mitsuyama K,Watanabe K,Hanai H,Nakase H,Kunisaki R,Matsuda K,Iwakiri R,Hida N,Tanaka S,Takeuchi Y,Ohtsuka K,Murakami K,Kobayashi K,Iwao Y,Nagahori M,Iizuka B,Hata K,Igarashi M,Hirata I,Kudo S

    更新日期：2016-12-01 00:00:00

  • Predictive factors for reactivation of hepatitis B following hepatitis B e antigen seroconversion in chronic hepatitis B.

    abstract：BACKGROUND & AIMS:Predictors of reactivation of hepatitis B following hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B have rarely been reported before and deserve further study. METHODS:A total of 133 HBeAg-positive asymptomatic carriers who have undergone HBeAg seroconversion were studied. Reactiv...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2007.08.039

    authors： Chu CM,Liaw YF

    更新日期：2007-11-01 00:00:00

  • Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse.

    abstract：BACKGROUND & AIMS:Fatty acids are natural ligands of the peroxisome proliferator-activated receptor alpha (PPARalpha). Synthetic ligands of this nuclear receptor, i.e., fibrates, induce the hepatic expression of the multidrug resistance 2 gene (Mdr2), encoding the canalicular phospholipid translocator, and affect hepat...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2003.50007

    authors： Kok T,Wolters H,Bloks VW,Havinga R,Jansen PL,Staels B,Kuipers F

    更新日期：2003-01-01 00:00:00

  • The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin.

    abstract：BACKGROUND & AIMS:beta3 Adrenoceptor (beta3-AR) is expressed on adipocytes and enteric neurons. GW427353 is a human selective beta3-AR agonist with visceral analgesic effects. Some of its effects may involve release of somatostatin (SST) and actions on enteric neurons. The aim of this study was to investigate the mode ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2009.09.046

    authors： Schemann M,Hafsi N,Michel K,Kober OI,Wollmann J,Li Q,Zeller F,Langer R,Lee K,Cellek S

    更新日期：2010-01-01 00:00:00

  • Effect of colchicine on guinea pig intrinsic factor-vitamin B12 receptor.

    abstract：:Colchicine can induce the malabsorption of vitamin B12 and other nutrients. Previous investigations have suggested but not proved that this malabsorption was due to a lesion in the ileal mucosa. Employing the receptor assay of M. Katz and B. A. Cooper (J Clin Invest 54:733-739, 1974), the authors have observed a dose-...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Stopa EG,O'Brien R,Katz M

    更新日期：1979-02-01 00:00:00

  • Wilson's disease in patients presenting with liver disease: a diagnostic challenge.

    abstract：BACKGROUND & AIMS:In patients with Wilson's disease presenting with liver involvement, the correct diagnosis is often missed or delayed. The aim of this study was to find an algorithm for diagnosis of this difficult patient group. METHODS:Clinical and laboratory findings of 55 patients with Wilson's disease were evalu...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(97)70097-0

    authors： Steindl P,Ferenci P,Dienes HP,Grimm G,Pabinger I,Madl C,Maier-Dobersberger T,Herneth A,Dragosics B,Meryn S,Knoflach P,Granditsch G,Gangl A

    更新日期：1997-07-01 00:00:00

  • Distribution of somatostatin-14 and somatostatin-28 gastrointestinal-pancreatic cells of rats and humans.

    abstract：:Somatostatin-14 and somatostatin-28 are biologically active peptides derived from the posttranslational cleavage of prosomatostatin. Because both peptides are found in variable concentrations in the gastrointestinal (GI) tract and pancreas, it has been contended that somatostatin-28 is either an intermediate in the pr...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)91151-u

    authors： Francis BH,Baskin DG,Saunders DR,Ensinck JW

    更新日期：1990-11-01 00:00:00

  • Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression.

    abstract：BACKGROUND & AIMS:Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Elevated 5-HT levels are associated with diarrheal conditions such as irritable bowel syndrome and enteric infections. Whether alteration in SERT activity contributes to the...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2009.09.002

    authors： Esmaili A,Nazir SF,Borthakur A,Yu D,Turner JR,Saksena S,Singla A,Hecht GA,Alrefai WA,Gill RK

    更新日期：2009-12-01 00:00:00