Abstract:
:A numerically important group of patients with functional gastrointestinal disorders have chronic symptoms that can be attributed to the gastroduodenal region. Based on the consensus opinion of an international panel of clinical investigators who reviewed the available evidence, a classification of the functional gastroduodenal disorders is proposed. Four categories of functional gastroduodenal disorders are distinguished. The first category, functional dyspepsia, groups patients with symptoms thought to originate from the gastroduodenal region, specifically epigastric pain or burning, postprandial fullness, or early satiation. Based on recent evidence and clinical experience, a subgroup classification is proposed for postprandial distress syndrome (early satiation or postprandial fullness) and epigastric pain syndrome (pain or burning in the epigastrium). The second category, belching disorders, comprises aerophagia (troublesome repetitive belching with observed excessive air swallowing) and unspecified belching (no evidence of excessive air swallowing). The third category, nausea and vomiting disorders, comprises chronic idiopathic nausea (frequent bothersome nausea without vomiting), functional vomiting (recurrent vomiting in the absence of self-induced vomiting, or underlying eating disorders, metabolic disorders, drug intake, or psychiatric or central nervous system disorders), and cyclic vomiting syndrome (stereotypical episodes of vomiting with vomiting-free intervals). The rumination syndrome is a fourth category of functional gastroduodenal disorder characterized by effortless regurgitation of recently ingested food into the mouth followed by rechewing and reswallowing or expulsion. The proposed classification requires further research and careful validation but the criteria should be of value for clinical practice; for epidemiological, pathophysiological, and clinical management studies; and for drug development.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Tack J,Talley NJ,Camilleri M,Holtmann G,Hu P,Malagelada JR,Stanghellini Vdoi
10.1053/j.gastro.2005.11.059subject
Has Abstractpub_date
2006-04-01 00:00:00pages
1466-79issue
5eissn
0016-5085issn
1528-0012pii
S0016-5085(06)00508-7journal_volume
130pub_type
杂志文章,评审相关文献
GASTROENTEROLOGY文献大全abstract::With a worldwide prevalence of 15%, chronic constipation is one of the most frequent gastrointestinal diagnoses made in ambulatory medicine clinics, and is a common source cause for referrals to gastroenterologists and colorectal surgeons in the United States. Symptoms vary among patients; straining, incomplete evacua...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2019.12.034
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatic steatosis is frequent in chronic hepatitis C. Several mechanisms might be implicated, including metabolic cofactors and direct viral effects on intracellular lipid pathways. In a transgenic mouse model, hepatitis C virus (HCV) was shown to inhibit microsomal triglyceride transfer protein (MTP)...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.02.035
更新日期:2006-05-01 00:00:00
abstract::The efficacy of cimetidine (1.6 g per day) was evaluated using a double blind placebo-controlled trial in 24 patients with moderate or severe peptic reflux esophagitis. The results show that cimetidine is superior to placebo when using endoscopic and histological criteria. Improved patient symptomatology and lower ant...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND & AIMS:We have shown that intestinal manipulation leads to a significant inhibition of circular muscle contraction. We hypothesized that the inflammatory mediator inducible nitric oxide (NO) plays a role in surgically induced ileus. METHODS:Rats and inducible NO synthase (iNOS) knockout and wild-type mice u...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(00)70214-9
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND & AIMS:Circulating membrane-shed microparticles (MPs) participate in regulation of vascular tone. We investigated the cellular origins of MPs in plasma from patients with cirrhosis and assessed the contribution of MPs to arterial vasodilation, a mechanism that contributes to portal hypertension. METHODS:We ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.03.040
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND & AIMS:In intestinal inflammation the gut microbiota induces an innate immune response by activating epithelial and immune cells that initiate or maintain inflammation. We investigated whether the microbiota also can activate local microvascular cells and induce angiogenesis. METHODS:Human intestinal microv...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.11.005
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND & AIMS:Although long-term results of endoscopic sphincterotomy (ES) have been poorly estimated, extended indications of ES have been proposed, especially in young patients. The aim of this study was to assess late biliary complications of ES. METHODS:Between 1981 and 1986, 169 patients younger than age 70 (...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v110.pm8608900
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND & AIMS:Ethanol impairs the mitochondrial transport of reduced glutathione (GSH), resulting in lower mitochondrial GSH (mGSH) levels. Our purpose was to evaluate the role of acetaldehyde on the regulation of mGSH in HepG2 cells. METHODS:mGSH levels and transport, mitochondrial membrane microviscosity, and li...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2003.50089
更新日期:2003-03-01 00:00:00
abstract::Gastroenterologists frequently encounter pelvic floor disorders, which affect 10% to 15% of the population. The anorectum is a complex organ that collaborates with the pelvic floor muscles to preserve fecal continence and enable defecation. A careful clinical assessment is critical for the diagnosis and management of ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2013.10.062
更新日期:2014-01-01 00:00:00
abstract::We investigated the ability of isolated human colonic epithelial cells to express the common acute lymphoblastic leukemia antigen (CALLA), the transferrin receptor, and the 4F2 antigen in response to different types of stimuli. The expression of these markers was assessed by immunofluorescence using monoclonal antibod...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)90387-9
更新日期:1989-12-01 00:00:00
abstract::Based on in vitro experiments measuring daily secretion rates in the culture media of rat hepatocytes and in vivo experiments using pulse labeling of intracellular precursors, the present study examines the ontogenic expression of the polymeric immunoglobulin receptor and secretory component by hepatocytes during grow...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)90181-w
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND & AIMS:Retinoids inhibit growth and induce differentiation in a variety of pancreatic carcinoma cells. The goal of this study was to examine the molecular mechanisms responsible for retinoid sensitivity. METHODS:Anchorage-independent growth was examined in AR42J, DSL-6A/C1, and Capan-2 cells using a human t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(98)70269-0
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND & AIMS:The NOD2 gene, which is strongly associated with susceptibility to Crohn's disease (CD) of the terminal ileum, interacts with bacterial lipopolysaccharide (LPS), inducing cellular activation. However, the mechanisms by which NOD2 mutations cause terminal ileitis are unknown, and NOD2 is expressed most...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)00661-9
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND & AIMS:A 3-dimensional (3D) culture system for immortalized human hepatocytes (HuS-E/2 cells) recently was shown to support the lifecycle of blood-borne hepatitis C virus (HCV). We used this system to identify proteins that are active during the HCV lifecycle under 3D culture conditions. METHODS:We compared...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.05.014
更新日期:2013-09-01 00:00:00
abstract::A reliable method for studying lead absorption and excretion in rats is described. Lead absorption occurs primarily in theduodenum where lead enters the epithelial mucosal cells. There is a relative mucosal block for lead with increasing intraluminal doses. Certain substances which bind lead and increase its solubilit...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Although cholesterol is the most abundant sterol in animal tissues, oxidized products of cholesterol (oxysterols) also occur in mammalian organs and blood and are cytotoxic, atherogenic, and carcinogenic. However, the presence of oxysterols in bile or gallstones has never been reported. METHODS:Fre...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.25513
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND & AIMS:Peroxynitrite (PN), a potent oxidant, has been implicated in the pathogenesis of gut inflammation and epithelial cell apoptosis. The aim of this study was to investigate mesalamine, a standard therapy for inflammatory bowel disease, to see if it attenuates PN-induced cytotoxicity in human intestinal e...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1997.v113.pm9352850
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Nitric oxide acts as a neurotransmitter of nonadrenergic, noncholinergic pathways. The present study examined the role of the L-arginine/NO pathway on sphincter of Oddi motility. METHODS:In anesthetized guinea pigs and rabbits, intracholedochal pressure was recorded by a perfused catheter whose open tip was...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90132-v
更新日期:1993-11-01 00:00:00
abstract::In order to study the natural history of fundic gland polyposis, 23 patients with familial adenomatosis coli/Gardner's syndrome were examined over a follow-up period ranging from 17 mo to 13 yr (average 6 yr). Examinations included gastric radiography and endoscopy with biopsy. Fundic gland polyps were found in 10 ind...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90203-3
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND & AIMS:Activated recombinant factor VII (rFVIIa) has been shown to be effective in correcting prolonged prothrombin time (PT) in cirrhotic patients. The main objective of this study was to evaluate the effect of 4 (5, 20, 80, and 120 microg/kg) doses of rFVIIa on correction of PT and the time to achieve hemo...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/gast.2002.34164
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND & AIMS:Little is known about the prevalence of nonalcoholic fatty liver disease (NAFLD) among severely obese adolescents or factors that determine its development. We investigated the prevalence of NAFLD in a multicenter cohort of adolescents undergoing bariatric surgery and the factors associated with it. ...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1053/j.gastro.2015.05.039
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND & AIMS:Biomarkers are needed to risk stratify after chemoradiotherapy for localized esophageal cancer. These could improve identification of patients at risk for cancer progression and selection of additional therapy. METHODS:We performed deep sequencing (CAncer Personalized Profiling by deep Sequencing, [C...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2019.10.039
更新日期:2020-02-01 00:00:00
abstract::Sepsis, peritonitis, and gastroenteritis developed in a 45-yr-old homosexual man 1 day after ingestion of raw oysters. The patient had chronic active hepatitis and cirrhosis with hepatitis B virus and delta-infection. He also had persistent generalized lymphadenopathy associated with HTLV-III antibody positivity. Vibr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90035-7
更新日期:1987-03-01 00:00:00
abstract::Previous studies suggested that the food-containing canine stomach retains large, nondigestible spheres until all food has emptied; but it is not known whether there is a threshold size or a gradation of sizes that will empty along with food. Further, nothing is known of the effects of such parameters as density, shap...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90576-1
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND/AIMS:Hepatic glucuronidation is quantitatively the most important conjugation reaction by which an array of endogenous compounds and xenobiotics undergo biotransformation and detoxification. The active site of the uridine diphosphate (UDP) glucuronosyltransferases, which catalyze glucuronidation reactions, h...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90023-3
更新日期:1995-01-01 00:00:00
abstract::A 14-yr-old girl presented with long-standing symptoms of partial gastric outlet obstruction due to an antral mucosal diaphragm that had a central aperture of 4-5 mm. The literature of this congenital malformation is reviewed with respect to diagnostic criteria and feasibility of endoscopic transection. The procedure ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90222-7
更新日期:1985-11-01 00:00:00
abstract::This study examines restitution of the gastric surface epithelium at luminal pH 1 after damage to the gastric mucosa by instillation of 2 M NaCl for 10 min. After mucosal damage, potential difference decreased to zero and H+ back-diffusion increased. Gastric blood flow increased after exposure to 2 M NaCl, irrespectiv...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90437-9
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND & AIMS:We aimed to identify the incidence and predictors of de novo gastroesophageal variceal formation and progression in a large cohort of patients with chronic hepatitis C and advanced fibrosis. METHODS:All participants in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis Trial were offered...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2010.02.058
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND & AIMS:As life expectancy increases, there are greater numbers of patients with liver diseases who require surgery or transplantation. Livers of older patients have significantly less reparative capacity following ischemia and reperfusion (I/R) injury, which occurs during these operations. There are no strat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.08.005
更新日期:2011-12-01 00:00:00
abstract::The results of a clinical trial comparing slow-release 5-aminosalicylic acid tablets (Pentasa) and enteric-coated sulfasalazine tablets (Salazopyrin) with regard to the efficacy of maintaining ulcerative colitis patients in remission for 12 mo and with regard to safety of treatment are reported. Seventy-five patients ...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0016-5085(88)80061-1
更新日期:1988-12-01 00:00:00