Oral cimetidine in reflux esophagitis: a double blind controlled trial.

abstract：BACKGROUND & AIMS:Bile secretion is regulated in part by adenosine 3',5'-cyclic monophosphate (cAMP) and cytosolic Ca2+ (Ca2+i). Hormone receptors that link to these second messengers are not uniformly distributed across the hepatic lobule, but both cAMP and Ca2+i cross gap junctions, so we tested whether gap junctiona...

journal_title：Gastroenterology

authors： Nathanson MH,Rios-Velez L,Burgstahler AD,Mennone A

更新日期：1999-05-01 00:00:00

abstract：:Motor abnormalities of the small bowel that occur only during the waking state have been reported in the irritable bowel syndrome (IBS), suggesting that central nervous system arousal is a necessary condition for expression of the disorder and that it may reflect inappropriate brain-gut interaction. This possible rela...

journal_title：Gastroenterology

authors： Kumar D,Thompson PD,Wingate DL,Vesselinova-Jenkins CK,Libby G

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND & AIMS:In experimental animals, the indigenous microbiota modulates mucosal immunity. In humans, such direct evidence is scarce. The aim of this study was to examine the effect of intestinal bacteria on the local immunoglobulin (Ig) response. METHODS:The numbers of IgA-, IgM-, and IgG-producing immunocytes ...

journal_title：Gastroenterology

authors： Kett K,Baklien K,Bakken A,Kral JG,Fausa O,Brandtzaeg P

更新日期：1995-09-01 00:00:00

abstract：:Thirty-five 1-day-old Pekin-Aylesbury ducks were inoculated intravenously or intraperitoneally with duck hepatitis B virus, and the time-course of infection was examined by Southern-blot, dot-blot, and in situ hybridization and by immunohistochemistry. Randomly scattered single infected hepatocytes were first seen on ...

journal_title：Gastroenterology

authors： Jilbert AR,Freiman JS,Burrell CJ,Holmes M,Gowans EJ,Rowland R,Hall P,Cossart YE

更新日期：1988-11-01 00:00:00

abstract：:The effect of total-body ionizing radiation on the digestive tract is dose-dependent and time-dependent. At low doses (1.5 Gy), one observes only a short prodromal syndrome consisting of nausea, vomiting, and gastric suppression. At doses greater than 6 Gy, the prodromal syndrome is more marked, and it is followed aft...

journal_title：Gastroenterology

authors： Dubois A,Walker RI

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with colorectal tumors with microsatellite instability (MSI) have better prognoses than patients with tumors without MSI, but have a poor response to 5-fluorouracil–based chemotherapy. A dominant-negative form of heat shock protein (HSP)110 (HSP110DE9) expressed by cancer cells with MSI, via ...

journal_title：Gastroenterology

authors： Collura A,Lagrange A,Svrcek M,Marisa L,Buhard O,Guilloux A,Wanherdrick K,Dorard C,Taieb A,Saget A,Loh M,Soong R,Zeps N,Platell C,Mews A,Iacopetta B,De Thonel A,Seigneuric R,Marcion G,Chapusot C,Lepage C,Bouvier

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND & AIMS:It is unclear whether patients with diabetes are at an increased risk of developing acute liver failure (ALF). We performed a large cohort study to examine the occurrence of ALF by using the databases of the Department of Veterans Affairs. METHODS:We identified all patients with a hospital discharge ...

journal_title：Gastroenterology

authors： El-Serag HB,Everhart JE

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND & AIMS:Cost-effectiveness of colorectal cancer screening will be maximized by selecting the widest screening intervals that effectively prevent cancer mortality. However, data on the incidence of neoplasia in persons with no abnormal findings on initial examination are limited. The aim of this study was to d...

journal_title：Gastroenterology

authors： Rex DK,Cummings OW,Helper DJ,Nowak TV,McGill JM,Chiao GZ,Kwo PY,Gottlieb KT,Ikenberry SO,Gress FG,Lehman GA,Born LJ

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND & AIMS:This study examined the possible role of endotoxinemia (from increased gut permeability) as an additional trigger factor for overt pancreatic disease and as a promoter of chronic pancreatic injury in alcoholics by using a rat model of chronic alcohol feeding and in vitro experiments with cultured panc...

journal_title：Gastroenterology

authors： Vonlaufen A,Xu Z,Daniel B,Kumar RK,Pirola R,Wilson J,Apte MV

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND & AIMS:In the Active Ulcerative Colitis Trial (ACT)-1 and ACT-2, patients with ulcerative colitis treated with infliximab were more likely than those given placebo to have a clinical response, undergo remission, and have mucosal healing. We investigated the association between early improvement (based on end...

journal_title：Gastroenterology

authors： Colombel JF,Rutgeerts P,Reinisch W,Esser D,Wang Y,Lang Y,Marano CW,Strauss R,Oddens BJ,Feagan BG,Hanauer SB,Lichtenstein GR,Present D,Sands BE,Sandborn WJ

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND & AIMS:Barrett's esophagus-associated high-grade dysplasia is commonly treated by endoscopy. However, most guidelines offer no recommendations for endoscopic treatment of mucosal adenocarcinoma of the esophagus (mAC). We investigated the efficacy and safety of endoscopic resection in a large series of patien...

journal_title：Gastroenterology

authors： Pech O,May A,Manner H,Behrens A,Pohl J,Weferling M,Hartmann U,Manner N,Huijsmans J,Gossner L,Rabenstein T,Vieth M,Stolte M,Ell C

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatobiliary secretion is generally believed to be an integral step in the pathway of cholesterol excretion from the body. Here we have investigated the validity of this paradigm in mice. METHODS:Cholesterol balance was assessed by measuring intake, excretion, and biliary output in different mouse m...

journal_title：Gastroenterology

authors： van der Velde AE,Vrins CL,van den Oever K,Kunne C,Oude Elferink RP,Kuipers F,Groen AK

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND & AIMS:Liver injury leads to generation of reactive oxygen and nitrogen species, which can react to produce peroxynitrite (ONOO-). We investigated whether ONOO- and its metabolites modulate extracellular matrix remodeling. METHODS:Stellate cells (HSC) were incubated with pure ONOO- or SIN-1 (a ONOO- donor)....

journal_title：Gastroenterology

authors： Urtasun R,Cubero FJ,Vera M,Nieto N

更新日期：2009-04-01 00:00:00

abstract：:To determine the fate of exogenous epidermal growth factor (EGF) in regenerating liver, 125I-labeled EGF was injected into rat portal veins at various times after 70% hepatectomy. Epidermal growth factor was taken up by the liver remnant at all time points studied (0, 4, 8, 16, and 36 h), but at 8 h after hepatectomy ...

journal_title：Gastroenterology

authors： Raper SE,Burwen SJ,Barker ME,Jones AL

更新日期：1987-05-01 00:00:00

abstract：:Acute self-limited liver disease has been associated with tetracycline use. However, severe prolonged cholestatic hepatitis and bile duct paucity have not been previously attributed to tetracyclines. Hepatitis, characterized by prolonged jaundice, severe pruritus, and moderate increased transaminase values, occurred w...

journal_title：Gastroenterology

authors： Hunt CM,Washington K

更新日期：1994-12-01 00:00:00

abstract：:The effect of somatostatin 28, a noval intestinal peptide containing somatostatin in its C-terminal portion, was tested on basal exocrine pancreatic secretion on conscious dogs and after stimulation by secretin (1 CU x kg-1 x hr-1), caerulein (37.5 ng x kg-1 x hr-1) or secretin (2 CU x kg-1 x hr-1) caerulein (37.5 ng ...

journal_title：Gastroenterology

authors： Susini C,Esteve JP,Vaysse N,Pradayrol L,Ribet A

更新日期：1980-10-01 00:00:00

abstract：:This study examines the effects of endotoxin on intestinal water and electrolyte transport in adult male rats. Endotoxin (1.55 mg/kg, intravenously) reduced in vivo colonic saline absorption 61% in 1 hour. In vitro unidirectional and net 22Na and 36Cl fluxes showed that endotoxin significantly decreased net colonic 22...

journal_title：Gastroenterology

authors： Ciancio MJ,Vitiritti L,Dhar A,Chang EB

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND & AIMS:Activating transcription factor 4 (ATF4) regulates genes involved in the inflammatory response, amino acid metabolism, autophagy, and endoplasmic reticulum stress. We investigated whether its activity is altered in patients with inflammatory bowel diseases (IBDs) and mice with enterocolitis. METHODS:...

journal_title：Gastroenterology

authors： Hu X,Deng J,Yu T,Chen S,Ge Y,Zhou Z,Guo Y,Ying H,Zhai Q,Chen Y,Yuan F,Niu Y,Shu W,Chen H,Ma C,Liu Z,Guo F

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:The contribution of the crural diaphragm to the gastroesophageal high pressure zone (HPZ) may be important in prevention of gastroesophageal reflux. The purpose of this study was to investigate the manometric characteristics of the thoracoabdominal junction in patients after surgical removal of the lower eso...

journal_title：Gastroenterology

authors： Klein WA,Parkman HP,Dempsey DT,Fisher RS

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND & AIMS:The aim of this study was to evaluate the role of known colorectal adenoma and carcinoma susceptibility genes and to locate a novel susceptibility gene in an Ashkenazi family (SM1311) with dominantly inherited predisposition to colorectal adenomas and carcinomas. METHODS:Clinicopathologic and family ...

journal_title：Gastroenterology

authors： Tomlinson I,Rahman N,Frayling I,Mangion J,Barfoot R,Hamoudi R,Seal S,Northover J,Thomas HJ,Neale K,Hodgson S,Talbot I,Houlston R,Stratton MR

更新日期：1999-04-01 00:00:00

abstract：:Disordered gustatory acuity was demonstrated in 22 patients with acute viral hepatitis and in 16 patients with chronic liver disease utilizing subjective responses and objective measurements of detection and recognition thresholds and scaling for NaCl, sucrose, HCl, and urea. In patients with early hepatitis and those...

journal_title：Gastroenterology

authors： Smith FR,Henkin RI,Dell RB

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND & AIMS:The accurate identification of inactive (serum HBV-DNA persistently

journal_title：Gastroenterology

authors： Brunetto MR,Oliveri F,Colombatto P,Moriconi F,Ciccorossi P,Coco B,Romagnoli V,Cherubini B,Moscato G,Maina AM,Cavallone D,Bonino F

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND/AIMS:Antifungal therapy cures esophageal candidiasis in most patients with acquired immunodeficiency syndrome, but the subsequent course of these patients is not established. This study examines the natural history of esophageal candidiasis after successful treatment. METHODS:Patients with endoscopic and cl...

journal_title：Gastroenterology

authors： Laine L

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND & AIMS:Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair gene mutations that define this syndrome and result in microsatellite instability (MSI). The carcinogenic path...

journal_title：Gastroenterology

authors： Goel A,Xicola RM,Nguyen TP,Doyle BJ,Sohn VR,Bandipalliam P,Rozek LS,Reyes J,Cordero C,Balaguer F,Castells A,Jover R,Andreu M,Syngal S,Boland CR,Llor X

更新日期：2010-05-01 00:00:00

abstract：:The results of balloon dilatation of upper digestive tract stricture in 111 patients were evaluated. Eighty-eight patients had esophageal strictures and 23 had gastric or pyloric strictures. Thirty-six patients had strictures associated with previous operations. Twenty-two percent of the patients with esophageal stric...

journal_title：Gastroenterology

authors： Lindor KD,Ott BJ,Hughes RW Jr

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND/AIMS:In vivo hepatic 31P magnetic resonance spectroscopy (MRS) can provide information on hepatic energy metabolism, phospholipid substrates, and hepatocyte lipid bilayers. The aim of this study was to ascertain the effects of alcohol ingestion on hepatic 31P spectral variables. METHODS:Twenty-six chronic a...

journal_title：Gastroenterology

authors： Menon DK,Harris M,Sargentoni J,Taylor-Robinson SD,Cox IJ,Morgan MY

更新日期：1995-03-01 00:00:00

abstract：:The management of colon polyps has been completely revolutionized since the introduction of colonoscopic polypectomy. The reductions in patient time, cost, morbidity, and mortality are major advantages. Reported complications include primarily hemorrhage (1.7%) and frank clinical perforation (0.32%). This report descr...

journal_title：Gastroenterology

authors： Overholt BF,Hargrove RL,Farris RK,Wilson BM

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND/AIMS:Conventional flow-cytometric analysis of colorectal tumor DNA content includes both tumor and stromal cell DNA. To improve the method, we evaluated the DNA content of purified epithelial cells using the crypt-isolation technique. METHODS:Normal and neoplastic crypts were isolated from fresh resected co...

journal_title：Gastroenterology

authors： Nakamura S,Goto J,Kitayama M,Kino I

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND & AIMS:Epithelial stem cells in the stomach are responsible for constant renewal of the epithelium through generation of multiple gastric cell lineages that populate the gastric glands. However, gastric stem or progenitor cells have not been well-characterized because of the lack of specific markers that per...

journal_title：Gastroenterology

authors： Qiao XT,Ziel JW,McKimpson W,Madison BB,Todisco A,Merchant JL,Samuelson LC,Gumucio DL

更新日期：2007-12-01 00:00:00

abstract：:The role of leukotrienes in the pathogenesis of chronic colitis was investigated using a rat model. Ulceration and inflammation of the distal colon was initiated by the intracolonic administration of the hapten trinitrobenzene sulfonic acid in 50% ethanol. Leukotriene B4 synthesis increased significantly within 4 h af...

journal_title：Gastroenterology

authors： Wallace JL,MacNaughton WK,Morris GP,Beck PL

更新日期：1989-01-01 00:00:00