Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha.

Abstract:

BACKGROUND & AIMS:Liver injury leads to generation of reactive oxygen and nitrogen species, which can react to produce peroxynitrite (ONOO-). We investigated whether ONOO- and its metabolites modulate extracellular matrix remodeling. METHODS:Stellate cells (HSC) were incubated with pure ONOO- or SIN-1 (a ONOO- donor). Western blot, nuclear in vitro transcription, Northern blot, qPCR, and promoter transactivation analysis for COL1A1 and COL1A2 were carried out. Rats were fed alcohol or injected with CCl4 to cause alcohol-induced liver injury and an early fibrogenic response. RESULTS:HSC incubated with ONOO- or SIN-1 showed similar viability, proliferation, COL1A1 and COL1A2 transcription rates, and mRNA levels as controls. There was a time- and dose-dependent down-regulation of collagen I and alpha-Sma proteins and up-regulation of MMP1 and TNFalpha, indicating decreased HSC activation. These effects were blocked by ONOO- scavengers. SIN-1 or ONOO- increased nitrosylation of MMP1/MMP13 and transactivation of the MMP1, MMP13, and TNFalpha promoters. A TNFalpha neutralizing antibody or GSH-ethyl ester blocked MMP1 promoter transactivation; whereas TNFalpha or l-buthionine sulfoximine, which depletes GSH, further enhanced it. Pretreatment with SIN-1 or ONOO- reduced the TGFbeta pro-fibrogenic response in HSC. In vivo experiments validated the protective role of ONOO- on the early fibrogenic response. However, highly activated HSC, such as myofibroblasts and HSC from chronic alcohol-fed rats, were resistant to the anti-fibrogenic actions of ONOO- due to higher levels of GSH, a ONOO- scavenger, overproduction of pro-fibrogenic TGFbeta, and reactive oxygen species. CONCLUSION:ONOO- could induce a protective mechanism in HSC in early stages of liver injury.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Urtasun R,Cubero FJ,Vera M,Nieto N

doi

10.1053/j.gastro.2008.12.065

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

1410-22, e1-4

issue

4

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(09)00003-1

journal_volume

136

pub_type

杂志文章
  • Rectosigmoid motility and myoelectric activity in progressive systemic sclerosis.

    abstract::Colon motility and myoelectric slow wave activity were compared in 10 patients with progressive systemic sclerosis and 18 controls. Recordings were made in the rectosigmoid and rectum, 25-30 cm and 10-15 cm from the anal margin, respectively, during two 4-min baselines and in response to stepwise distention of the col...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(89)91567-9

    authors: Whitehead WE,Taitelbaum G,Wigley FM,Schuster MM

    更新日期:1989-02-01 00:00:00

  • Prior colorectal neoplasia is associated with increased risk of ileoanal pouch neoplasia in patients with inflammatory bowel disease.

    abstract:BACKGROUND & AIMS:Although restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) substantially reduces the risk of colorectal cancer in patients with inflammatory bowel disease (IBD), subsequent pouch neoplasia can develop. There are few data on the incidence of and risk factors for neoplasia, so there i...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2013.09.047

    authors: Derikx LA,Kievit W,Drenth JP,de Jong DJ,Ponsioen CY,Oldenburg B,van der Meulen-de Jong AE,Dijkstra G,Grubben MJ,van Laarhoven CJ,Nagtegaal ID,Hoentjen F,Dutch Initiative on Crohn and Colitis.

    更新日期:2014-01-01 00:00:00

  • Interleukin 10 reduces lethality and hepatic injury induced by lipopolysaccharide in galactosamine-sensitized mice.

    abstract:BACKGROUND & AIMS:Tumor necrosis factor alpha (TNF-alpha) release plays a pivotal role in the pathogenesis of liver injury induced by lipopolysaccharide (LPS) administration in D-galactosamine (GalN)-sensitized mice. Interleukin (IL) 10 is an anti-inflammatory cytokine that inhibits TNF-alpha synthesis and release both...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.1996.v111.pm8780580

    authors: Santucci L,Fiorucci S,Chiorean M,Brunori PM,Di Matteo FM,Sidoni A,Migliorati G,Morelli A

    更新日期:1996-09-01 00:00:00

  • Central nervous system effects of corticotropin-releasing factor on gastrointestinal transit in the rat.

    abstract::Corticotropin-releasing factor (CRF) administered into the lateral cerebral ventricle significantly inhibited gastric emptying and small bowel transit, but most markedly increased large bowel transit in a dose-related fashion in freely moving rats. Inhibition of gastric emptying induced by central administration of CR...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(88)90229-6

    authors: Lenz HJ,Burlage M,Raedler A,Greten H

    更新日期:1988-03-01 00:00:00

  • Intestinal permeability: an overview.

    abstract::The noninvasive assessment of intestinal permeability in humans has a 20-year history. Because the tests are increasingly used in clinical practice and research and because there is much controversy, we reviewed the literature and outlined the potential and possible shortcomings of these procedures. Data was obtained ...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1016/0016-5085(95)90708-4

    authors: Bjarnason I,MacPherson A,Hollander D

    更新日期:1995-05-01 00:00:00

  • Colorectal Cancer Screening With Repeated Fecal Immunochemical Test Versus Sigmoidoscopy: Baseline Results From a Randomized Trial.

    abstract:BACKGROUND & AIMS:The comparative effectiveness of sigmoidoscopy and fecal immunochemical testing (FIT) for colorectal cancer (CRC) screening is unknown. METHODS:Individuals aged 50-74 years living in Southeast Norway were randomly invited between 2012 and 2019 to either once-only flexible sigmoidoscopy or FIT screeni...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2020.11.037

    authors: Randel KR,Schult AL,Botteri E,Hoff G,Bretthauer M,Ursin G,Natvig E,Berstad P,Jørgensen A,Sandvei PK,Olsen ME,Frigstad SO,Darre-Næss O,Norvard ER,Bolstad N,Kørner H,Wibe A,Wensaas KA,de Lange T,Holme Ø

    更新日期:2020-11-21 00:00:00

  • Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics.

    abstract:BACKGROUND & AIMS:In 1988, we reported the first twin study in inflammatory bowel disease. The aim of the current study was to follow up these twins regarding new cases of inflammatory bowel disease and Crohn's disease characteristics using the Vienna classification. METHODS:The official Swedish population register an...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(03)00385-8

    authors: Halfvarson J,Bodin L,Tysk C,Lindberg E,Järnerot G

    更新日期:2003-06-01 00:00:00

  • Kinetics and risk of de novo hepatitis B infection in HBsAg-negative patients undergoing cytotoxic chemotherapy.

    abstract:BACKGROUND & AIMS:De novo hepatitis B virus (HBV)-related hepatitis after chemotherapy results in high morbidity and mortality. We evaluate the clinical course of de novo HBV-related hepatitis after chemotherapy. METHODS:Two hundred forty-four consecutive hepatitis B surface antigen (HBsAg)-negative lymphoma patients ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2006.04.015

    authors: Hui CK,Cheung WW,Zhang HY,Au WY,Yueng YH,Leung AY,Leung N,Luk JM,Lie AK,Kwong YL,Liang R,Lau GK

    更新日期:2006-07-01 00:00:00

  • Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement.

    abstract:BACKGROUND & AIMS:Activation of Fas or tumor necrosis factor receptor 1 (TNF-R1) on hepatocytes leads to apoptosis, which requires mitochondria activation. The pro-death Bcl-2 family protein, Bid, mediates this pathway by inducing mitochondrial releases of cytochrome c and other apoptotic factors. How Bid activates mit...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(03)01066-7

    authors: Zhao Y,Ding WX,Qian T,Watkins S,Lemasters JJ,Yin XM

    更新日期:2003-09-01 00:00:00

  • The effect of continuous enteral nutrition on gastric acidity in humans.

    abstract::The effect of continuous intraduodenal enteral nutrition on gastric pH was compared with the effects of fasting and of parenteral and standard nutrition control regimens containing equal amounts of carbohydrate, protein, and lipid. Eleven healthy volunteers underwent four 24-hour intragastric pH-metry studies; serum g...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(92)91708-c

    authors: Armstrong D,Castiglione F,Emde C,Cilluffo T,Duroux P,Koerfer J,Temler E,Lamers CB,Jansens JB,Blum AL

    更新日期:1992-05-01 00:00:00

  • Influence of endogenous prostaglandins on secretin-mediated inhibition of gastric acid secretion in dogs.

    abstract::The influence of endogenous prostaglandins on secretin-mediated inhibition of gastric acid secretion was examined in 6 mongrel dogs with Thomas gastric and Herrera pancreatic cannulas. The dogs were given intravenous pentagastrin (1 microgram/kg.h) during the 180-min experiment, and graded doses of secretin (0.3-1.5 m...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(88)80007-6

    authors: MacLellan DG,Upp JR Jr,Thompson JC

    更新日期:1988-09-01 00:00:00

  • Interleukin 10 reduces the incidence of pancreatitis after therapeutic endoscopic retrograde cholangiopancreatography.

    abstract:BACKGROUND & AIMS:Prophylactic administration of interleukin (IL)-10 decreases the severity of experimental pancreatitis. Prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in humans is a unique model to study the potential role of IL-10 in this setting. METHODS:In a single-center, d...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1053/gast.2001.21172

    authors: Devière J,Le Moine O,Van Laethem JL,Eisendrath P,Ghilain A,Severs N,Cohard M

    更新日期:2001-02-01 00:00:00

  • Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas.

    abstract:BACKGROUND & AIMS:Carcinomas of the extrahepatic bile ducts, ampulla of Vater, and duodenum are uncommon, and their epigenetic and genetic alterations are not well characterized. METHODS:We therefore compared the methylation profile and genetic alterations in 18 extrahepatic biliary, 9 ampullary, and 12 duodenal carci...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(03)00278-6

    authors: Kim SG,Chan AO,Wu TT,Issa JP,Hamilton SR,Rashid A

    更新日期:2003-05-01 00:00:00

  • Gastrin-producing ovarian cystadenocarcinoma: sensitivity to secretin and SMS 201-995.

    abstract::We report a patient with severe peptic ulcer disease and a right ovarian mass that was found to be a gastrin-producing cystadenocarcinoma. Gastrin production by the tumor was stimulated by secretin and inhibited by the long-acting somatostatin analogue SMS 201-995. Following resection of the tumor, serum gastrin level...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(89)90084-x

    authors: Heyd J,Livni N,Herbet D,Mor-Yosef S,Glaser B

    更新日期:1989-08-01 00:00:00

  • Defective Fc receptor-mediated clearance in patients with primary biliary cirrhosis.

    abstract::Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). The mean half-life of the sensitized erythrocytes was significantly prolonged in patients with...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(91)90736-5

    authors: Ekdahl KN,Lööf L,Nyberg A,Nilsson UR,Nilsson B

    更新日期:1991-10-01 00:00:00

  • Hepatic artery embolization for metastatic endocrine-secreting tumors of the pancreas. Report of two cases.

    abstract::Two patients with hormone-secreting metastatic tumors of the liver (carcinoid, islet cell) were treated with transcatheter arterial embolization. In both cases, occlusion of blood supply to the tumors was accomplished, resulting in cessation of the systemic symptoms. Arterial embolization provides another useful palli...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Clouse ME,Lee RG,Duszlak EJ,Lokich JJ,Alday MT

    更新日期:1983-11-01 00:00:00

  • Retinoids: effects on growth, differentiation, and nuclear receptor expression in human pancreatic carcinoma cell lines.

    abstract:BACKGROUND & AIMS:Advanced pancreatic carcinoma has a dismal prognosis despite extensive chemotherapeutic trials. The aim of this study was to evaluate the role of retinoids as an experimental therapeutic approach for pancreatic cancer. METHODS:Four ductal and one acinar pancreatic tumor cell lines were investigated. ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(95)90655-x

    authors: Rosewicz S,Stier U,Brembeck F,Kaiser A,Papadimitriou CA,Berdel WE,Wiedenmann B,Riecken EO

    更新日期:1995-11-01 00:00:00

  • Kappa opioid receptor agonists differentially inhibit two classes of rat spinal neurons excited by colorectal distention.

    abstract:BACKGROUND & AIMS:Quantitative neurophysiological studies have identified the presence of at least 2 spinal neuronal populations (abrupt and sustained) that are excited by the noxious visceral stimulus colorectal distention. This study examined the effects of the kappa opioid receptor agonists fedotozine and U50488H on...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.1999.0029900388

    authors: Ness TJ

    更新日期:1999-08-01 00:00:00

  • AGA Clinical Practice Update on Small Intestinal Bacterial Overgrowth: Expert Review.

    abstract:DESCRIPTION:Thanks to ready access to hydrogen breath testing, small intestinal bacterial overgrowth (SIBO) is now commonly diagnosed among individuals presenting with a variety of gastrointestinal and even nongastrointestinal symptoms and is increasingly implicated in lay press and media in the causation of a diverse ...

    journal_title:Gastroenterology

    pub_type: 实务指引

    doi:10.1053/j.gastro.2020.06.090

    authors: Quigley EMM,Murray JA,Pimentel M

    更新日期:2020-10-01 00:00:00

  • Feasibility and reliability of pancreatic cancer staging using fiberoptic confocal fluorescence microscopy in rats.

    abstract:BACKGROUND & AIMS:Surgical management of pancreatic cancer depends on tumor resectability and staging. This study evaluated a new in vivo technique, fiberoptic confocal fluorescence microscopy (FCFM), for detection and staging of pancreatic tumors in rats. METHODS:FCFM was used with a protease-activated fluorescent ma...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2009.07.045

    authors: Ignat M,Aprahamian M,Lindner V,Altmeyer A,Perretta S,Dallemagne B,Mutter D,Marescaux J

    更新日期:2009-11-01 00:00:00

  • Chemoprevention of colorectal neoplasia: the potential for personalized medicine.

    abstract::CRC development is a multi-step process that spans 10 to 15 years, thereby providing an opportunity for early detection and even prevention. The poor survival rate of advanced CRC has prompted the emphasis on prevention of this disease. CRC screening and removal of adenomas is an effective intervention, and is the cor...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2008.02.012

    authors: Arber N,Levin B

    更新日期:2008-04-01 00:00:00

  • Markers of fibrogenesis and basement membrane formation in alcoholic liver disease. Relation to severity, presence of hepatitis, and alcohol intake.

    abstract::This study investigated the relationships of the serum markers of fibrogenesis and basement membrane formation to the clinical and morphological severity of alcoholic liver disease and to the degree of alcohol abuse. The concentrations of the aminoterminal propeptide of type III collagen, type IV collagen, and laminin...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(90)91098-q

    authors: Niemelä O,Risteli J,Blake JE,Risteli L,Compton KV,Orrego H

    更新日期:1990-06-01 00:00:00

  • Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas.

    abstract::Microsatellite instability (MSI) caused by mismatch repair deficiency (dMMR) is detected in a small proportion of pancreatic ductal adenocarcinomas (PDACs). dMMR and MSI have been associated with responses of metastatic tumors, including PDACs, to immune checkpoint inhibitor therapy. We performed immunohistochemical a...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2017.11.009

    authors: Lupinacci RM,Goloudina A,Buhard O,Bachet JB,Maréchal R,Demetter P,Cros J,Bardier-Dupas A,Collura A,Cervera P,Scriva A,Dumont S,Hammel P,Sauvanet A,Louvet C,Delpéro JR,Paye F,Vaillant JC,André T,Closset J,Emile JF

    更新日期:2018-03-01 00:00:00

  • Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis.

    abstract:BACKGROUND & AIMS:Intestinal fibrosis and stricture formation are serious complications of Crohn's disease, often requiring surgical intervention. Unfortunately, the mechanisms underlying intestinal fibrosis development are poorly understood, in part because of the lack of relevant animal models. Here, we present a nov...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2007.12.043

    authors: Grassl GA,Valdez Y,Bergstrom KS,Vallance BA,Finlay BB

    更新日期:2008-03-01 00:00:00

  • Giardiasis with total villous atrophy.

    abstract::A patient who developed symptomatic giardiasis after a tour of the Soviet Union is presented. The diagnosis was established by duodenal aspiration. A small intestinal biopsy revealed total villous atrophy in the absence of celiac sprue or a gastrointestinal immunodeficiency syndrome, a finding not previously described...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Levinson JD,Nastro LJ

    更新日期:1978-02-01 00:00:00

  • Sustained remission after corticosteroid therapy of severe hepatitis B surface antigen-negative chronic active hepatitis.

    abstract::To determine the frequency of a sustained remission and to assess the long-term prognosis of relapse and retreatment, 66 patients with severe hepatitis B surface antigen-negative chronic active hepatitis and prolonged follow-up after initial corticosteroid withdrawal (mean, 10 +/- 0.4 yr) were evaluated. Selection of ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(87)90862-6

    authors: Czaja AJ,Beaver SJ,Shiels MT

    更新日期:1987-01-01 00:00:00

  • Fibrosing cytolytic liver failure secondary to recurrent hepatitis B after liver transplantation.

    abstract::Four patients who underwent transplantation for hepatitis B virus-related liver disease developed rapidly progressive liver failure attributable to recurrent hepatitis B disease typified by hyperbilirubinemia and distinctive hepatocyte ballooning and progressive fibrosis consistent with recently reported fibrosing cho...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(92)91521-5

    authors: Benner KG,Lee RG,Keeffe EB,Lopez RR,Sasaki AW,Pinson CW

    更新日期:1992-10-01 00:00:00

  • Mapping of the hepatitis B virus attachment site by use of infection-inhibiting preS1 lipopeptides and tupaia hepatocytes.

    abstract:BACKGROUND & AIMS:Studies on the early steps in the life cycle of hepatitis B virus have been hampered by the lack of readily available target cells. In this study, we mapped a defined virus attachment site to primary hepatocytes that is essential for infection. METHODS:We used purified virus particles from human carr...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2005.03.090

    authors: Glebe D,Urban S,Knoop EV,Cag N,Krass P,Grün S,Bulavaite A,Sasnauskas K,Gerlich WH

    更新日期:2005-07-01 00:00:00

  • Effect of bile acid synthesis rate on cholesterol secretion rate in the steady state.

    abstract::In order to discover the effect of bile acid synthesis on cholesterol secretion into the bile, 7 rhesus monkeys were studied at various stable interruptions of the enterohepatic circulation of bile acids. In 4 animals, 2.5 and 7.5% interruptions were compared; 2.5 and 15% interruptions were compared in 5 animals. Ther...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Strasberg SM,Petrunka CN,Ilson RG

    更新日期:1976-12-01 00:00:00

  • Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection.

    abstract:BACKGROUND & AIMS:We followed patients with ongoing hepatitis C virus (HCV) exposure following control of an initial HCV infection to determine whether primary control conferred protection against future persistent infections. METHODS:Twenty-two active injection drug users (IDU) who had cleared a primary hepatitis C v...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2009.09.017

    authors: Osburn WO,Fisher BE,Dowd KA,Urban G,Liu L,Ray SC,Thomas DL,Cox AL

    更新日期:2010-01-01 00:00:00