当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice.

Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice.

Abstract：

BACKGROUND & AIMS:Hepatobiliary secretion is generally believed to be an integral step in the pathway of cholesterol excretion from the body. Here we have investigated the validity of this paradigm in mice. METHODS:Cholesterol balance was assessed by measuring intake, excretion, and biliary output in different mouse models. Direct secretion of cholesterol from the luminal side of enterocytes was studied by perfusion of isolated segments of the small intestine in mice. RESULTS:Cholesterol input and output measurements in different mouse models revealed that fecal neutral sterol excretion was higher than the sum of dietary cholesterol intake and biliary cholesterol secretion indicating the existence of an alternative pathway. Here we show that substantial amounts of cholesterol can be secreted directly by enterocytes. Transintestinal cholesterol secretion is a specific process observed throughout the small intestine (proximal > medial > distal). Secretion depended on the presence of a cholesterol acceptor and was strongly stimulated by bile salts and phospholipids. The capacity of the pathway was sufficient to account for the missing cholesterol in the balance studies. The contribution of this pathway to cholesterol excretion in mice is approximately twice that of the biliary pathway. CONCLUSIONS:In mice, the intestine plays a significant role in removal of cholesterol from the body.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

van der Velde AE,Vrins CL,van den Oever K,Kunne C,Oude Elferink RP,Kuipers F,Groen AK

doi

10.1053/j.gastro.2007.06.019

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

967-75

issue

3

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(07)01160-2

journal_volume

133

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms.

    abstract：BACKGROUND & AIMS:Germline mutations in one of four mismatch repair genes have been found in the majority of families with hereditary nonpolyposis colorectal cancer (HNPCC), but only in a small part of families with atypical HNPCC. The recently cloned EXO1 gene might be involved in the pathogenesis of HNPCC because the...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.25117

    authors： Wu Y,Berends MJ,Post JG,Mensink RG,Verlind E,Van Der Sluis T,Kempinga C,Sijmons RH,van der Zee AG,Hollema H,Kleibeuker JH,Buys CH,Hofstra RM

    更新日期：2001-06-01 00:00:00

  • Estrogen rapidly modulates 5-hydroxytrytophan-induced visceral hypersensitivity via GPR30 in rats.

    abstract：BACKGROUND & AIMS:Sex hormones have been reported to modulate visceral hypersensitivity (VH). Estrogen regulates neurons not only by binding to estrogen receptors (ERalpha and ERbeta) to initiate transcription but also via the G-protein coupled receptor GPR30, which binds and rapidly mediates actions of estrogen. We ex...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2009.03.047

    authors： Lu CL,Hsieh JC,Dun NJ,Oprea TI,Wang PS,Luo JC,Lin HC,Chang FY,Lee SD

    更新日期：2009-09-01 00:00:00

  • Amino terminal gastrin fragment in serum of Zollinger-Ellison syndrome patients.

    abstract：:In addition to the previously described molecular forms of gastrin, a new component has been found in high concentrations in the serum of 6 patients with Zollinger-Ellison syndrome. Serum was fractionated by gel filtration, and ion exchange chromatography, and the new component was identified in eluates by radioimmuno...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Dockray GJ,Walsh JH

    更新日期：1975-02-01 00:00:00

  • Survival of patients identified as candidates for intestinal transplantation: a 3-year prospective follow-up.

    abstract：BACKGROUND & AIMS:The US Medicare indications for intestinal transplantation are based on failure of home parenteral nutrition. The American Society of Transplantation also includes patients at high risk of death from their primary disease or with high morbidity intestinal failure. A 3-year prospective study evaluated ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2008.03.043

    authors： Pironi L,Forbes A,Joly F,Colomb V,Lyszkowska M,Van Gossum A,Baxter J,Thul P,Hébuterne X,Gambarara M,Gottrand F,Moreno Villares JM,Messing B,Goulet O,Staun M,Home Artificial Nutrition Working Group of the European Society fo

    更新日期：2008-07-01 00:00:00

  • Long-term efficacy and safety of omeprazole in patients with Zollinger-Ellison syndrome: a prospective study.

    abstract：:To determine the long-term efficacy, safety, and toxicity of omeprazole, we studied 40 patients with Zollinger-Ellison syndrome given omeprazole for 6-51 mo (median 29). The mean daily dose of omeprazole required to control gastric acid secretion was 82 +/- 31 mg. Thirty-one patients required omeprazole once per day. ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)91485-6

    authors： Maton PN,Vinayek R,Frucht H,McArthur KA,Miller LS,Saeed ZA,Gardner JD,Jensen RT

    更新日期：1989-10-01 00:00:00

  • Effect of peptic digestion on emptying of cooked liver in dogs.

    abstract：:By speeding the fragmentation of meat, peptic digestion might accelerate gastric emptying. To examine this possibility, mongrel dogs prepared with chronic duodenal fistulas were fed steak and 99mTc-labeled chicken liver, measuring 99mTc in all chyme exiting from the stomach out the duodenal fistula allowed quantitatio...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Ohashi H,Meyer JH

    更新日期：1980-08-01 00:00:00

  • Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C.

    abstract：BACKGROUND & AIMS:Iron overload may cause or contribute to hepatic injury and fibrosis. Mutations in the HFE gene may influence development or progression of chronic liver disease by increasing iron stores or modulating immune responses. The aim of this work was to assess the influence of HFE mutations and serum and he...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1053/j.gastro.2006.08.036

    authors： Bonkovsky HL,Naishadham D,Lambrecht RW,Chung RT,Hoefs JC,Nash SR,Rogers TE,Banner BF,Sterling RK,Donovan JA,Fontana RJ,Di Bisceglie AM,Ghany MG,Morishima C,HALT-C Trial Group.

    更新日期：2006-11-01 00:00:00

  • Pancreatic bicarbonate response to food-bound hydrogen ion along the gut.

    abstract：:Recent reports suggest most solid food enters the duodenum as small particles. Our studies showed that small particles of liver were capable of binding hydrogen ions (H+), but there was slow equilibration of H+ between particulate and aqueous phases. We wondered whether titratable acid as H+ bound to meat particles co...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Meyer JH,Fink AS

    更新日期：1984-09-01 00:00:00

  • Approaches and Challenges to Management of Pediatric and Adult Patients With Eosinophilic Esophagitis.

    abstract：:Treatment of eosinophilic esophagitis has progressed from elemental formula for children and esophageal dilation for adults to selective exclusion of food triggers and swallowed topical corticosteroids. Management guidelines are available from the American Gastroenterological Association and the Joint Task Force on Al...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2019.09.052

    authors： Hirano I,Furuta GT

    更新日期：2020-03-01 00:00:00

  • Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types.

    abstract：BACKGROUND & AIMS:Human primary liver cancer is classified into biologically distinct subgroups based on cellular origin. Liver cancer stem cells (CSCs) have been recently described. We investigated the ability of distinct lineages of hepatic cells to become liver CSCs and the phenotypic and genetic heterogeneity of pr...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2013.03.013

    authors： Holczbauer Á,Factor VM,Andersen JB,Marquardt JU,Kleiner DE,Raggi C,Kitade M,Seo D,Akita H,Durkin ME,Thorgeirsson SS

    更新日期：2013-07-01 00:00:00

  • Communication via gap junctions modulates bile secretion in the isolated perfused rat liver.

    abstract：BACKGROUND & AIMS:Bile secretion is regulated in part by adenosine 3',5'-cyclic monophosphate (cAMP) and cytosolic Ca2+ (Ca2+i). Hormone receptors that link to these second messengers are not uniformly distributed across the hepatic lobule, but both cAMP and Ca2+i cross gap junctions, so we tested whether gap junctiona...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(99)70021-1

    authors： Nathanson MH,Rios-Velez L,Burgstahler AD,Mennone A

    更新日期：1999-05-01 00:00:00

  • Chronic Helicobacter pylori infections induce gastric mutations in mice.

    abstract：BACKGROUND & AIMS:Helicobacter pylori is an important etiologic factor in the development of gastric cancer. The aim of this study was to analyze the role of H. pylori infections in the induction of mutagenic events in gastric epithelial cells. The effect of a high-salt diet as a genotoxic risk factor was also investig...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(03)00266-x

    authors： Touati E,Michel V,Thiberge JM,Wuscher N,Huerre M,Labigne A

    更新日期：2003-05-01 00:00:00

  • c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.

    abstract：BACKGROUND & AIMS:In searching for effects of acetaminophen (APAP) on hepatocytes downstream of its metabolism that may participate in hepatotoxicity, we examined the role of stress kinases. METHODS:Mouse hepatocytes and C57BL/6 mice were administered a toxic dose of APAP with or without SP600125, a chemical c-jun N-t...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2006.03.045

    authors： Gunawan BK,Liu ZX,Han D,Hanawa N,Gaarde WA,Kaplowitz N

    更新日期：2006-07-01 00:00:00

  • Acetazolamide inhibits basal and stimulated HCO3- secretion in the human proximal duodenum.

    abstract：BACKGROUND/AIMS:Carbonic anhydrase activity plays a role in electrolyte transport in many tissues. This study examined the effect of the carbonic anhydrase inhibitor acetazolamide on human basal and prostaglandin E2- and acid-stimulated duodenal mucosal bicarbonate secretion and transmucosal electrical potential differ...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0016-5085(95)90013-6

    authors： Knutson TW,Koss MA,Hogan DL,Isenberg JI,Knutson L

    更新日期：1995-01-01 00:00:00

  • Inflammatory bowel disease in all three members of one family.

    abstract：:The occurrence of inflammatory bowel disease in all three members of one family is described. Studies of white blood cell chromosomes, histocompatibility antigens, and cellular and humoral immunity failed to explain this unusual phenomenon. However, the appearance of inflammatory bowel disease in an entire family reem...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Rosenberg JL,Kraft SC,Kirsner JB

    更新日期：1976-05-01 00:00:00

  • Isolation and characterization of normal and neoplastic colonic epithelial cell populations.

    abstract：:The aim of the present study was to characterize rat mucosal colonic cells harvested from the crypt continuum during differentiation and dimethylhydrazine-induced neoplasia. The collection of colonocytes was performed using a modified nonenzymatic isolation procedure based on Ca2+ chelation and gentle mechanical disso...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)80013-y

    authors： Schwartz B,Avivi C,Lamprecht SA

    更新日期：1991-03-01 00:00:00

  • The "mirroring" of gallstones: description of a novel silvering method to determine the surface area of an irregular object. In vitro demonstration that multiple gallstones from the same gallbladder dissolve in unsaturated "bile" at the same rate.

    abstract：:We describe a novel "silvering" method to determine the surface area of nonspherical objects and have applied this method to human cholesterol gallstones. A standard curve is first constructed, using data obtained from the dissolution rates of silver-coated plastic spheres of known dimensions in unstirred thiosulfate-...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Park YH,Igimi H,Carey MC

    更新日期：1982-11-01 00:00:00

  • Primary sarcoma of the liver. Report of a case with excellent response to hepatic artery ligation and infusion chemotherapy.

    abstract：:A case of primary undifferentiated sarcoma of the liver in a 66-year-old woman is reported. The similarity of the presenting symptoms to those of a hepatic abscess is emphasized. The patient's response to palliative treatment by means of hepatic artery ligation and chemotherapy was excellent. We believe that this is t...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Tanner AR,Bolton PM,Powell LW

    更新日期：1978-01-01 00:00:00

  • The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis.

    abstract：BACKGROUND & AIMS:Differences in genetic background may play a role in the development of ulcerative colitis (UC)-related neoplasia. Loss of heterozygosity (LOH) of APC has been reported in human UC-associated neoplasia. To investigate the role of genetic differences in UC-associated neoplasia, we compared differences ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.29609

    authors： Cooper HS,Everley L,Chang WC,Pfeiffer G,Lee B,Murthy S,Clapper ML

    更新日期：2001-12-01 00:00:00

  • Hepatic subcapsular biloma. An unusual complication of endoscopic retrograde cholangiopancreatography.

    abstract：:Development of an intraabdominal bile collection (biloma) usually occurs secondary to traumatic or iatrogenic injury including abdominal surgery, percutaneous catheter drainage, and transhepatic cholangiogram. We present a case of hepatic subcapsular biloma following endoscopic retrograde cholangiography and identifie...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Dupas JL,Mancheron H,Sevenet F,Delamarre J,Delcenserie R,Capron JP

    更新日期：1988-05-01 00:00:00

  • Bile-salt metabolism in the primate fetus.

    abstract：:Fetal bile salt metabolism was assessed by the intravenous infusion of e114C]cholate into 6 monkey fetuses. The placental transfer, fetal plasma clearance, and fetal hepatic excretion of the administered radiolabeled bile salt were measured. Placental transfer averaged 30% of the injected dose, while biliary excretion...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Little JM,Smallwood RA,Lester R,Piasecki GJ,Jackson BT

    更新日期：1975-12-01 00:00:00

  • Aggravation of different types of experimental colitis by depletion or adhesion blockade of neutrophils.

    abstract：BACKGROUND & AIMS:Neutrophils are generally thought to play an important proinflammatory role in the pathogenesis of inflammatory bowel disease. The objective of this study was to evaluate whether blocking the invasion of neutrophils by anti-L-selectin monoclonal antibodies modulates chemically induced colitis and how ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2007.08.073

    authors： Kühl AA,Kakirman H,Janotta M,Dreher S,Cremer P,Pawlowski NN,Loddenkemper C,Heimesaat MM,Grollich K,Zeitz M,Farkas S,Hoffmann JC

    更新日期：2007-12-01 00:00:00

  • Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells.

    abstract：BACKGROUND & AIMS:Activated pancreatic stellate cells have recently been implicated in pancreatic fibrogenesis. This study examined the role of pancreatic stellate cells in alcoholic pancreatic fibrosis by determining whether these cells are activated by ethanol itself and, if so, whether such activation is caused by t...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(00)70148-x

    authors： Apte MV,Phillips PA,Fahmy RG,Darby SJ,Rodgers SC,McCaughan GW,Korsten MA,Pirola RC,Naidoo D,Wilson JS

    更新日期：2000-04-01 00:00:00

  • Distribution of aneuploid cell populations in ulcerative colitis with dysplasia or cancer.

    abstract：:Flow cytometry was used to detect the presence and assess the distribution of aneuploid cell populations in eight proctocolectomy specimens from patients with ulcerative colitis. Mucosal samples were taken according to a systematic protocol for flow cytometry, the surrounding tissue was examined histologically, and th...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90068-v

    authors： Levine DS,Rabinovitch PS,Haggitt RC,Blount PL,Dean PJ,Rubin CE,Reid BJ

    更新日期：1991-11-01 00:00:00

  • Dietary linoleic acid, gastric acid, and prostaglandin secretion.

    abstract：:Basal and pentagastrin-stimulated gastric acid secretion, fasting serum gastrin concentrations, and the gastric output of prostaglandin E and its major metabolite 13,14-dihydro 15-keto prostaglandin E2 were measured in 9 normal subjects before and after 14-20 days of dietary supplementation with linoleic acid. Mean ma...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(88)90553-7

    authors： Grant HW,Palmer KR,Kelly RW,Wilson NH,Misiewicz JJ

    更新日期：1988-04-01 00:00:00

  • JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract.

    abstract：BACKGROUND & AIMS:JC virus (JCV), a human polyomavirus, has been found in a limited number of normal human tissues and cancers. The oncogenic potential of this virus is mediated by a transforming protein, the T antigen (TAg). We have previously demonstrated the presence of JCV-TAg in colorectal cancers, in adjacent nor...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2000.19269

    authors： Ricciardiello L,Laghi L,Ramamirtham P,Chang CL,Chang DK,Randolph AE,Boland CR

    更新日期：2000-11-01 00:00:00

  • Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells.

    abstract：BACKGROUND & AIMS:Helicobacter pylori infection causes inflammation, accumulation of reactive oxygen species, and oxidative DNA damage in the gastric mucosa. Apurinic/apyrimidinic endonuclease-1 (APE-1)/redox factor-1 (Ref-1) repairs damaged DNA and reductively activates transcription factors, including activator prote...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2004.06.017

    authors： Ding SZ,O'Hara AM,Denning TL,Dirden-Kramer B,Mifflin RC,Reyes VE,Ryan KA,Elliott SN,Izumi T,Boldogh I,Mitra S,Ernst PB,Crowe SE

    更新日期：2004-09-01 00:00:00

  • Na+-dependent bile acid transport in the ileum: the balance between diarrhea and constipation.

    abstract：:Ileal Na+-dependent bile acid transport was quantified in vitro as the uptake of 3H-taurocholate into brush-border membrane vesicles. Vesicles were prepared from ileal biopsies of 158 patients placed in 10 diagnostic categories. Active bile acid transport (expressed as picomoles taurocholate uptake per milligram brush...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)91286-f

    authors： van Tilburg AJ,de Rooij FW,van Blankenstein M,van den Berg JW,Bosman-Jacobs EP

    更新日期：1990-01-01 00:00:00

  • Gastric pepsin and acid secretion in patients with acute and healed duodenal ulcer.

    abstract：:The relationship between gastric pepsin, acid secretion, and duodenal ulcer activity was studied in 33 patients with an endoscopically proven carter, in 17 patients who were studied within 3 mo of an acute crater but who no longer had a crater endoscopically, and in 10 patients who had no duodenal ulcer symptoms for l...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Achord JL

    更新日期：1981-07-01 00:00:00

  • Monozygotic triplets with Crohn's disease of the colon.

    abstract：:Female monozygotic triplets all developed Crohn's disease within a period of 11 mo. The monozygosity was demonstrated by analysis of 24 genetic markers of different chromosomal localization. Crohn's disease was diagnosed using clinical, radiologic, and endoscopic findings. Histologic evaluation of bowel tissue was con...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)90215-5

    authors： Purrmann J,Bertrams J,Borchard F,Miller B,Cleveland S,Stolze T,Strohmeyer G

    更新日期：1986-12-01 00:00:00