Abstract：
:Fetal bile salt metabolism was assessed by the intravenous infusion of e114C]cholate into 6 monkey fetuses. The placental transfer, fetal plasma clearance, and fetal hepatic excretion of the administered radiolabeled bile salt were measured. Placental transfer averaged 30% of the injected dose, while biliary excretion averaged 36%. Of the amount excreted by the fetal liver, 78% was in the form of [14C]taurocholate. The findings suggest that bile salt metabolic and excretory mechanisms are undergoing developmental maturation at birth.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Little JM,Smallwood RA,Lester R,Piasecki GJ,Jackson BTkeywords:
subject
Has Abstractpub_date
1975-12-01 00:00:00pages
1315-20issue
6eissn
0016-5085issn
1528-0012pii
S0016508575002417journal_volume
69pub_type
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