Abstract:
:We describe a novel "silvering" method to determine the surface area of nonspherical objects and have applied this method to human cholesterol gallstones. A standard curve is first constructed, using data obtained from the dissolution rates of silver-coated plastic spheres of known dimensions in unstirred thiosulfate-ferricyanide solutions. Silver dissolution rates of silver-coated gallstones are then correlated with the standard curve so that the equivalent spherical surface area of the gallstones may be estimated. The technique has been applied to cholesterol dissolution rates of gallstones from the same patient and from different patients in unstirred bile salt (sodium chenodeoxycholate) solutions. The results demonstrate that cholesterol dissolution rates per unit surface area are identical for small stones as well as large ones, are identical for all stones from the same gallbladder, but are somewhat dissimilar for those originating from different gallbladders. The experimental results are in agreement with a priori theoretical predictions of mass transfer from spherical objects, and correlate satisfactorily with experimental dissolution rates of pure cholesterol monohydrate disks in unstirred bile salt solutions.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Park YH,Igimi H,Carey MCsubject
Has Abstractpub_date
1982-11-01 00:00:00pages
1071-8issue
5eissn
0016-5085issn
1528-0012pii
S0016508582002261journal_volume
83pub_type
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