Abstract:
:A case is presented of a 76-yr-old woman with primary biliary cirrhosis and adult polycystic liver disease who developed bone marrow toxicity associated with chronic low-dose colchicine therapy. Two months after starting colchicine therapy (0.6 mg b.i.d. p.o.), the patient developed hematologic toxicity as evidenced by transient but profound granulocytopenia which promptly reversed 4 days after the drug was stopped. Bone marrow examination revealed moderate hypocellularity of all cell lines and striking dysplastic changes in the late myeloid and erythroid series. There was no apparent toxicity involving other organ systems. The patient fully recovered. This case is compared with previous descriptions of colchicine toxicity.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Finklestein M,Goldman L,Grace ND,Foley M,Randall Ndoi
10.1016/0016-5085(87)90249-6subject
Has Abstractpub_date
1987-12-01 00:00:00pages
1231-5issue
6eissn
0016-5085issn
1528-0012pii
0016-5085(87)90249-6journal_volume
93pub_type
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