Abstract:
:An adult patient with chronic idiopathic intestinal pseudo-obstruction maintained on home parenteral nutrition for 6 consecutive years died from cardiomyopathy and ventricular fibrillation. Postmortem examination of the heart revealed widespread myocytolysis and replacement fibrosis similar to that seen in the selenium deficient cardiomyopathy in China (Keshan disease) and animal models. Selenium deficiency in this patient was documented with extremely low concentrations of selenium and decreased activity of the selenoprotein, glutathione peroxidase, in blood, heart, liver, and skeletal muscle. Reports of selenium deficient diets causing myocardial damage in humans and animals and the findings in our patient strongly suggest that his fatal cardiomyopathy was caused by selenium deficiency.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Fleming CR,Lie JT,McCall JT,O'Brien JF,Baillie EE,Thistle JLsubject
Has Abstractpub_date
1982-09-01 00:00:00pages
689-93issue
3eissn
0016-5085issn
1528-0012pii
S0016508582001772journal_volume
83pub_type
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