Abstract:
:The purpose of this study was to determine whether gamma-hydroxybutyrate provides protection against intestinal ischemia/reperfusion injury and to compare its effect with that of allopurinol and vitamin E. Thirty minutes of total regional ischemia, followed by 3 hours of reperfusion, produced intestinal damage that was completely prevented by gamma-hydroxybutyrate pretreatment. Naloxone partially blocked this protective effect. Allopurinol provided only partial protection against this injury, whereas vitamin E provided none. Treatment with gamma-hydroxybutyrate after ischemia but before reperfusion also provided significant protection. This study clearly demonstrates that gamma-hydroxybutyrate provides significant protection against intestinal ischemic injury and that it may do so via an opiate receptor-mediated mechanism.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Boyd AJ,Sherman IA,Saibil FG,Mamelak Mdoi
10.1016/0016-5085(90)90982-7subject
Has Abstractpub_date
1990-09-01 00:00:00pages
860-2issue
3eissn
0016-5085issn
1528-0012pii
0016-5085(90)90982-7journal_volume
99pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract::Electronic (video) endoscopes are a significant new development in gastroenterology, offering the potential of enhanced teaching and permanent storage of pictorial data. The primary concern of gastroenterologists is the resolution and color performance of these instruments, as these parameters have important bearings ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::The efficacy of cimetidine (1.6 g per day) was evaluated using a double blind placebo-controlled trial in 24 patients with moderate or severe peptic reflux esophagitis. The results show that cimetidine is superior to placebo when using endoscopic and histological criteria. Improved patient symptomatology and lower ant...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND & AIMS:Although different brands of fecal immunochemical tests (FITs) are used for colorectal cancer (CRC) screening, few studies have compared their accuracy in detecting advanced neoplasia. METHODS:We performed a large prospective cohort study within the Dutch national CRC screening program to evaluate 2 ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2018.07.021
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND & AIMS:Postcolonoscopy colorectal cancer (PCCRC) is CRC diagnosed after a colonoscopy in which no cancer was found. A consensus article from the World Endoscopy Organization (WEO) proposed an approach for investigating and categorizing PCCRCs detected within 4 years of a colonoscopy. We aimed to identify cas...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2019.12.031
更新日期:2020-04-01 00:00:00
abstract::Chronic liver diseases (CLDs), due to chronic hepatitis C; hepatitis B; nonalcoholic fatty liver diseases (NAFLD); and alcoholic liver disease, are a leading cause of morbidity and mortality globally. Early identification of patients with cirrhosis at high risk of progression to liver-related complications may facilit...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2017.03.016
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND & AIMS:Ferroportin disease is characterized by iron overload. It has an autosomal-dominant pattern of inheritance and has been associated with mutations in the SLC40A1 gene, which encodes the cellular iron exporter ferroportin. Since the first description in 2001, about 30 mutations have been reported; the h...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.12.049
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND & AIMS:This longitudinal study investigated the interactions and roles of hepatitis B virus (HBV) genotypes, pre-S deletions, and core promoter and precore mutations on the progression of liver disease in hepatitis B e antigen (HBeAg)-negative patients. METHODS:A total of 141 HBeAg-negative patients without...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.09.002
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND & AIMS:Tumor necrosis factor alpha (TNF-alpha) release plays a pivotal role in the pathogenesis of liver injury induced by lipopolysaccharide (LPS) administration in D-galactosamine (GalN)-sensitized mice. Interleukin (IL) 10 is an anti-inflammatory cytokine that inhibits TNF-alpha synthesis and release both...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v111.pm8780580
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND & AIMS:We have previously shown that patients with irritable bowel syndrome (IBS) have impaired transit of intestinal gas loads. Because abnormal gas retention can be experimentally reproduced in healthy subjects by pharmacological inhibition of gut motility, we hypothesized that impaired gas transit and ret...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/gast.2002.33658
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND & AIMS:Helicobacter pylori-negative idiopathic ulcers are increasingly recognized. The secular trend and long-term outcome of this condition are unknown. METHODS:We prospectively studied consecutive patients with bleeding gastroduodenal ulcers from January to December 2000. The incidence and etiology of ulc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.03.026
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND & AIMS:Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair gene mutations that define this syndrome and result in microsatellite instability (MSI). The carcinogenic path...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1053/j.gastro.2010.01.035
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND & AIMS:The effects of leukotriene (LT) D(4) on intestinal epithelial cells govern events that are involved in cell survival and colon cancer, notably increased expression of cyclooxygenase (COX)-2 and enhanced production of prostaglandin E(2). We investigated possible correlations between distribution of the...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2003.50011
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND/AIMS:The neuropeptide somatostatin exerts multiple functions in the gastrointestinal tract and may also play a regulatory role in inflammatory bowel disease, as several other neuropeptides do, e.g., substance P or calcitonin gene-related peptide. Therefore, the expression of somatostatin receptors was evalua...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90754-4
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND & AIMS:We investigated the expression of estrogen receptor (ER) alpha and beta subtypes in cholangiocytes of normal and bile duct-ligated (BDL) rats and evaluated the role and mechanisms of estrogens in the modulation of cholangiocyte proliferation. METHODS:ER-alpha and ER-beta were analyzed by immunohistoc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.20184
更新日期:2000-12-01 00:00:00
abstract::Exposure of isolated gastric mucosal surface cells to NH4+ results in acidification of cells as determined by a fluorescent dye technique using acridine orange. The resulting intracellular pH gradient is maintained when cells are suspended in either buffered HCO3- -free Ringer's or choline chloride solution. Cells sus...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
abstract::Frequent occurrence of post-transfusion hepatitis continues despite screening for Australia antigen in blood before transfusion and elimination of commercial donor sources. The majority of these cases appears unrelated to hepatitis B virus. Preoperative, acute, and convalescent serra were screened for evidence of hepa...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-12-01 00:00:00
abstract:BACKGROUND & AIMS:An increased duodenal expression of the iron transporters, divalent-metal-transporter-1, and ferroportin is observed in patients with iron deficiency or hereditary hemochromatosis. Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transpor...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)01063-1
更新日期:2003-09-01 00:00:00
abstract::Sepsis following the placement of a transjugular intrahepatic portosystemic shunt (TIPS) has been reported in up to 10% of cases. This report describes an unusual case of polymicrobial gram-negative sepsis after placement of TIPS associated with a cholangiographically documented fistulous connection between the biliar...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v111.pm8898650
更新日期:1996-11-01 00:00:00
abstract::In order to discover the effect of bile acid synthesis on cholesterol secretion into the bile, 7 rhesus monkeys were studied at various stable interruptions of the enterohepatic circulation of bile acids. In 4 animals, 2.5 and 7.5% interruptions were compared; 2.5 and 15% interruptions were compared in 5 animals. Ther...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND & AIMS:p16(INK4a) is a cell cycle inhibitor and a major tumor-suppressor protein, but the regulation of p16(INK4a) is poorly understood and the physiologic settings in which it exerts its antiproliferative effects are unknown. A role for p16(INK4a) in intestinal neoplasia is suggested by the observation that...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.17952
更新日期:2000-10-01 00:00:00
abstract::Increasing evidence has emerged that supports an important intersection between 3 fundamental cell biologic pathways in the pathogenesis of inflammatory bowel disease. These include the intersection between autophagy, as revealed by the original identification of ATG16L1 and IRGM as major genetic risk factors for Croh...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2011.02.048
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND & AIMS:Although bone marrow (BM) is known as a primary lymphoid organ, it also is known to harbor memory T cells, suggesting that this compartment is a preferential site for migration and/or selective retention of memory T cells. We here report the existence and the potential ability to induce colitis of the...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.10.035
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND & AIMS:Nitric oxide is a major inhibitory neurotransmitter in the enteric nervous system. Loss or dysfunction of nitrinergic neurons is associated with serious disruptions of motility, intractable symptoms, and long-term suffering. The aim of this study was to evaluate the effect of intrapyloric transplantat...
journal_title:Gastroenterology
pub_type: 评论,杂志文章
doi:10.1053/j.gastro.2005.08.055
更新日期:2005-12-01 00:00:00
abstract::Patients with chronic nausea and vomiting frequently present challenging diagnostic and therapeutic problems. In such patients, gastroparesis of unknown cause, or "idiopathic" gastroparesis, may be the only objective finding. Two middle-aged women with nausea, vomiting, and weight loss of 10 and 26 kg over 6 and 18 mo...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)91255-5
更新日期:1990-07-01 00:00:00
abstract::Chlorpromazine (CPZ) is a long recognized cause of jaundice, but the mechanism by which this agent produces icteric liver disease is not well defined. This study examined some effects of CPZ administration on bilirubin metabolism and biliary secretion in the rat. Acute CPZ treatment (25 mg per kg intravenously) produc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND & AIMS:Alcohol abuse causes half of all deaths from cirrhosis in the West, but few tools are available for noninvasive diagnosis of alcoholic liver disease. We evaluated 2 elastography techniques for diagnosis of alcoholic fibrosis and cirrhosis; liver biopsy with Ishak score and collagen-proportionate area ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2015.09.040
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND & AIMS:Gastrin stimulation of the type 2 cholecystokinin (CCK(2)) receptor results in ECL cell proliferation and histamine secretion. This report describes the effects of targeted disruption of the CCK(2) receptor gene on ECL cell morphology and function. METHODS:The ECL cells in the oxyntic mucosa of CCK(2...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.34746
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND & AIMS:The lipocalin superfamily, including the mouse and human homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin, show great functional diversity including roles in olfaction, transportation, and prostaglandin synthesis in mammals. Their potential role in maintaining gastrointestinal mucos...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.05.051
更新日期:2006-09-01 00:00:00
abstract::Pharmacologic and surgical procedures were used to define the neurohumoral pathways that mediate stress-induced changes in gastrointestinal transit in the rat. Physical restraint (a validated stressor) resulted in significant inhibition of gastric emptying and small bowel transit but in stimulation of large bowel tran...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)91439-x
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND & AIMS:Canalicular secretion of bile acids is stimulated by tauroursodesoxycholate (TUDC). This study investigates the underlying mechanisms. METHODS:TUDC effects on mitogen-activated protein (MAP) kinases, taurocholate (TC) excretion, proteolysis, and the localization of the bile salt export pump (Bsep) we...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.26262
更新日期:2001-08-01 00:00:00