Prokinetic effects in patients with intestinal gas retention.


BACKGROUND & AIMS:We have previously shown that patients with irritable bowel syndrome (IBS) have impaired transit of intestinal gas loads. Because abnormal gas retention can be experimentally reproduced in healthy subjects by pharmacological inhibition of gut motility, we hypothesized that impaired gas transit and retention can be reciprocally corrected by pharmacologically stimulating intestinal propulsion. METHODS:In 28 patients with abdominal bloating (14 IBS, 14 functional bloating) and in 14 healthy subjects, gas evacuation and perception of jejunal gas infusion (12 mL/min) were measured. After 2 hours, in 20 patients we tested the effect of intravenous neostigmine (0.5 mg) vs. intravenous saline administered blindly and randomly at a 1-hour interval. RESULTS:After 2 hours of gas infusion, patients with IBS and functional bloating alike exhibited significant gas retention (418 +/- 86 mL), abdominal symptoms (2.7 +/- 0.5 score), and objective distention (8 +/- 2 mm girth increment), in contrast to healthy controls, who experienced none (46 +/- 102 mL retention, 0.4 +/- 0.3 symptom score, and 3 +/- 1 mm distention; P < 0.05 for all). Neostigmine produced immediate clearance of gas retained within the gut (603 +/- 53 mL/30 minutes vs. 273 +/- 59 mL/30 minutes after saline; P < 0.05) and by 1 hour reduced gas retention (by 373 +/- 57 mL), abdominal symptoms (by 1.1 +/- 0.5 score), and distention (by 6 +/- 1 mm; P < 0.05 for all), whereas intravenous saline produced no effects. CONCLUSIONS:In patients with intestinal gas retention, pharmacological stimulation of intestinal propulsion improves gas transit, abdominal symptoms, and distention.






Caldarella MP,Serra J,Azpiroz F,Malagelada JR





Has Abstract


2002-06-01 00:00:00














  • Na+/H+ exchange in isolated hamster enterocytes. Its major role in intracellular pH regulation.

    abstract::The intracellular pH (pHi) of isolated hamster intestinal cells was determined with three techniques: the null-point method with digitonin, the distribution of the weak acid 5,5-dimethyloxazolidine-2,4-dione, and the trapped fluorescent indicator 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. In physiologic saline, ...


    pub_type: 杂志文章


    authors: Goré J,Hoinard C

    更新日期:1989-10-01 00:00:00

  • Macroamylase in the pleural fluid of a patient with lymphoma.

    abstract::A patient with a macroamylase in pleural fluid is described. A diagnosis of recurrent pleural effusion due to chronic relapsing pancreatitis had been made on the basis of hyperamylasemia, high pleural fluid amylase, and abdominal pain. The amylase in the pleural fluid as well as the serum was ultimately characterized ...


    pub_type: 杂志文章


    authors: Zimmerman HM,Bank S,Buch P,Katzka I,Lendvai S

    更新日期:1983-07-01 00:00:00

  • Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers.

    abstract:BACKGROUND & AIMS:The ratio of liver size to body weight (hepatostat) is tightly controlled, but little is known about how the physiologic functions of the liver help determine its size. Livers of mice repopulated with human hepatocytes (humanized livers) grow to larger than normal; the human hepatocytes do not recogni...


    pub_type: 杂志文章


    authors: Naugler WE,Tarlow BD,Fedorov LM,Taylor M,Pelz C,Li B,Darnell J,Grompe M

    更新日期:2015-09-01 00:00:00

  • Pentane clearance from inspired air by the rat: dependence on the liver.

    abstract::Pentane, a volatile hydrocarbon, is cleared from inspired air by the rat. We have studied this clearance to learn whether or not it is a function of the liver. Rats were put individually into airtight chambers which contained CO2 absorbent and were connected to an O2 reservoir. Pentane was injected into each chamber a...


    pub_type: 杂志文章


    authors: Burk RJ,Ludden TM,Lane JM

    更新日期:1983-01-01 00:00:00

  • Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system.

    abstract:BACKGROUND & AIMS:In the intestines, Toll-like receptor 2 (TLR2) mediates immune responses to pathogens and regulates epithelial barrier function; polymorphisms in TLR2 have been associated with inflammatory bowel disease phenotype. We assessed the effects of TLR2 signaling on the enteric nervous system (ENS) in mice. ...


    pub_type: 杂志文章


    authors: Brun P,Giron MC,Qesari M,Porzionato A,Caputi V,Zoppellaro C,Banzato S,Grillo AR,Spagnol L,De Caro R,Pizzuti D,Barbieri V,Rosato A,Sturniolo GC,Martines D,Zaninotto G,Palù G,Castagliuolo I

    更新日期:2013-12-01 00:00:00

  • Plasma arginine vasopressin response to oral, gastric, and intravenous water load in patients with cirrhosis.

    abstract:BACKGROUND/AIMS:Hepatic osmoreceptors are sensitive to changes in portal blood osmolality and cause variations in plasma antidiuretic hormone and water diuresis, which prevent major systemic osmotic changes. Insensitivity of hepatic osmoreceptors might contribute to maintaining increased plasma levels of antidiuretic h...


    pub_type: 杂志文章


    authors: Castellano G,Solis-Herruzo JA,Gonzalez A,Morillas JD,Moreno D,Muñoz T,Larrodera L

    更新日期:1994-03-01 00:00:00

  • Ursodeoxycholic acid and cholesterol induce enterohepatic cycling of bilirubin in rodents.

    abstract:BACKGROUND & AIMS:Oral administration of ursodeoxycholic acid (UDCA) and cholesterol causes bile salt malabsorption; the former by competition for and the latter by down-regulation of ileal bile acid transporters. Because ileectomy in rats induces enterohepatic cycling of bilirubin, the hypothesis that dietary steroids...


    pub_type: 杂志文章


    authors: Méndez-Sánchez N,Brink MA,Paigen B,Carey MC

    更新日期:1998-09-01 00:00:00

  • Esophageal ulceration activates keratinocyte growth factor and its receptor in rats: implications for ulcer healing.

    abstract:BACKGROUND & AIMS:Cellular and molecular mechanisms of esophageal ulcer healing remain unexplored. We studied the sequential cellular events and the expression of keratinocyte growth factor (KGF) and its receptor (KGF-R) during the healing of experimental esophageal ulcers. METHODS:Esophageal ulcers were produced in r...


    pub_type: 杂志文章


    authors: Baatar D,Kawanaka H,Szabo IL,Pai R,Jones MK,Kitano S,Tarnawski AS

    更新日期:2002-02-01 00:00:00

  • Sustained remission after corticosteroid therapy of severe hepatitis B surface antigen-negative chronic active hepatitis.

    abstract::To determine the frequency of a sustained remission and to assess the long-term prognosis of relapse and retreatment, 66 patients with severe hepatitis B surface antigen-negative chronic active hepatitis and prolonged follow-up after initial corticosteroid withdrawal (mean, 10 +/- 0.4 yr) were evaluated. Selection of ...


    pub_type: 杂志文章


    authors: Czaja AJ,Beaver SJ,Shiels MT

    更新日期:1987-01-01 00:00:00

  • Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells.

    abstract:BACKGROUND & AIMS:MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p...


    pub_type: 杂志文章


    authors: Almeida MI,Nicoloso MS,Zeng L,Ivan C,Spizzo R,Gafà R,Xiao L,Zhang X,Vannini I,Fanini F,Fabbri M,Lanza G,Reis RM,Zweidler-McKay PA,Calin GA

    更新日期:2012-04-01 00:00:00

  • Symptomatic hepatic disease in cystic fibrosis: incidence, course, and outcome of portal systemic hunting.

    abstract::Fifteen (2.2%) of 693 patients with cystic fibrosis seen over an 18-year period developed clinical hepatic disease. In 13 patients all symptoms were secondary to portal hypertension. Ten had hypersplenism and 6 had variceal bleeding, including 3 who developed both conditions. All 5 patients who survived the initial ep...


    pub_type: 杂志文章


    authors: Stern RC,Stevens DP,Boat TF,Doershuk CF,Izant RJ Jr,Matthews LW

    更新日期:1976-05-01 00:00:00

  • Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: a new approach.

    abstract:BACKGROUND & AIMS:We have reported that contrast echocardiography is a sensitive screening test for the hepatopulmonary syndrome (HPS). However, contrast echocardiography lacks specificity because many cirrhotic patients have positive study results with normal arterial blood gases and therefore do not fulfill criteria ...


    pub_type: 杂志文章


    authors: Abrams GA,Nanda NC,Dubovsky EV,Krowka MJ,Fallon MB

    更新日期:1998-02-01 00:00:00

  • Efficacy of entecavir with or without tenofovir disoproxil fumarate for nucleos(t)ide-naïve patients with chronic hepatitis B.

    abstract:BACKGROUND & AIMS:Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are potent antiviral agents that might have additive or synergistic antiviral activity in treatment of patients with chronic hepatitis B (CHB). We compared the efficacy and safety of ETV monotherapy with those of a combination of ETV and TDF. ME...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Lok AS,Trinh H,Carosi G,Akarca US,Gadano A,Habersetzer F,Sievert W,Wong D,Lovegren M,Cohen D,Llamoso C

    更新日期:2012-09-01 00:00:00

  • Sex and acquired cofactors determine phenotypes of ferroportin disease.

    abstract:BACKGROUND & AIMS:Ferroportin disease is characterized by iron overload. It has an autosomal-dominant pattern of inheritance and has been associated with mutations in the SLC40A1 gene, which encodes the cellular iron exporter ferroportin. Since the first description in 2001, about 30 mutations have been reported; the h...


    pub_type: 杂志文章


    authors: Le Lan C,Mosser A,Ropert M,Detivaud L,Loustaud-Ratti V,Vital-Durand D,Roget L,Bardou-Jacquet E,Turlin B,David V,Loréal O,Deugnier Y,Brissot P,Jouanolle AM

    更新日期:2011-04-01 00:00:00

  • NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis.

    abstract:BACKGROUND & AIMS:HuR is a RNA-binding factor whose expression is commonly upregulated in some human tumor types. We explored the molecular mechanism underlying HuR elevation and its role in gastric cancer tumorigenesis. METHODS:HuR expression and subcellular localization were determined by polymerase chain reaction, ...


    pub_type: 杂志文章


    authors: Kang MJ,Ryu BK,Lee MG,Han J,Lee JH,Ha TK,Byun DS,Chae KS,Lee BH,Chun HS,Lee KY,Kim HJ,Chi SG

    更新日期:2008-12-01 00:00:00

  • NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis.

    abstract:BACKGROUND & AIMS:Pancreatitis starts with primarily sterile local inflammation that induces systemic inflammatory response syndrome, followed by compensatory anti-inflammatory response syndrome (CARS). We investigated the mechanisms of these processes in mice and human serum. METHODS:We induced severe acute pancreati...


    pub_type: 杂志文章


    authors: Sendler M,van den Brandt C,Glaubitz J,Wilden A,Golchert J,Weiss FU,Homuth G,De Freitas Chama LL,Mishra N,Mahajan UM,Bossaller L,Völker U,Bröker BM,Mayerle J,Lerch MM

    更新日期:2020-01-01 00:00:00

  • Tumor Necrosis Factor-producing T-regulatory Cells Are Associated With Severe Liver Injury in Patients With Acute Hepatitis A.

    abstract:BACKGROUND AND AIMS:CD4+CD25+Foxp3+ T-regulatory (Treg) cells control immune responses and maintain immune homeostasis. However, under inflammatory conditions, Treg cells produce cytokines that promote inflammation. We investigated production of tumor necrosis factor (TNF) by Treg cells in patients with acute hepatitis...


    pub_type: 杂志文章


    authors: Choi YS,Jung MK,Lee J,Choi SJ,Choi SH,Lee HW,Lee JJ,Kim HJ,Ahn SH,Lee DH,Kim W,Park SH,Huh JR,Kim HP,Park JY,Shin EC

    更新日期:2018-03-01 00:00:00

  • Immunocytochemical localization of human intrinsic factor: the nonstimulated stomach.

    abstract::Human intrinsic factor (IF) is found on the surface of parietal cells at the light microscopic level by immunofluorescence, but there is no direct evidence that IF is synthesized in and secreted from this cell. In order to provide this evidence, IF was localized at the ultrastructural level in human stomach, using an ...


    pub_type: 杂志文章


    authors: Levine JS,Nakane PK,Allen RH

    更新日期:1980-09-01 00:00:00

  • Diagnostics of inflammatory bowel disease.

    abstract::The diagnosis of inflammatory bowel disease (IBD) with its 2 main subforms, Crohn's disease and ulcerative colitis, is based on clinical, endoscopic, radiologic, and histologic criteria. This paradigm remains unchanged despite the advent of new molecular technologies for the examination of serum proteins and genetic s...


    pub_type: 杂志文章,评审


    authors: Nikolaus S,Schreiber S

    更新日期:2007-11-01 00:00:00

  • High-dose oral erythromycin decreased the incidence of parenteral nutrition-associated cholestasis in preterm infants.

    abstract:BACKGROUND & AIMS:Feeding intolerance because of functional gastrointestinal dysmotility and parenteral nutrition-associated cholestasis (PNAC) are common problems in preterm, very-low-birth-weight (VLBW) infants. This double-blind, randomized, placebo-controlled study aimed to assess the effectiveness of "high-dose" o...


    pub_type: 杂志文章,随机对照试验


    authors: Ng PC,Lee CH,Wong SP,Lam HS,Liu FY,So KW,Lee CY,Fok TF

    更新日期:2007-05-01 00:00:00

  • Effect of systemic pH on models of altered ileal transport in the rat.

    abstract::Decreases in arterial pH markedly increase sodium, chloride, and water absorption in the normal ileum and can reverse ongoing cholera toxin-induced secretion. In the current study we examined whether these effects of pH are evident in other models of ileal secretion, and in a model of increased absorption. Rats were a...


    pub_type: 杂志文章


    authors: Charney AN,Ingrassia PM,Thaler SM,Keane MG

    更新日期:1989-02-01 00:00:00

  • Large paraesophageal varices on endosonography predict recurrence of esophageal varices and rebleeding.

    abstract:BACKGROUND & AIMS:Recurrence of varices and rebleeding after endoscopic therapy is very common. Data on the prediction of recurrent varices after initial obliteration by endoscopic therapy are few. The aim of this study was to correlate the presence and the size of paraesophageal varices (PEVs) in patients after endosc...


    pub_type: 杂志文章


    authors: Leung VK,Sung JJ,Ahuja AT,Tumala IE,Lee YT,Lau JY,Chung SC

    更新日期:1997-06-01 00:00:00

  • Measurement of serum acetaminophen-protein adducts in patients with acute liver failure.

    abstract:BACKGROUND & AIMS:Acetaminophen toxicity is the most common cause of acute liver failure (ALF) in the United States and Great Britain, but may be underrecognized in certain settings. Acetaminophen-protein adducts are specific biomarkers of drug-related toxicity in animal models and can be measured in tissue or blood sa...


    pub_type: 杂志文章


    authors: Davern TJ 2nd,James LP,Hinson JA,Polson J,Larson AM,Fontana RJ,Lalani E,Munoz S,Shakil AO,Lee WM,Acute Liver Failure Study Group.

    更新日期:2006-03-01 00:00:00

  • Factors influencing the eradication of Helicobacter pylori with triple therapy.

    abstract::Helicobacter pylori infection has been associated with gastritis, duodenal ulcer, gastric ulcer, and the epidemic form of gastric carcinoma. Eradication of H. pylori infection has proven to be difficult. Recently, combinations of antimicrobial drugs have been shown to eradicate greater than 50% of infections; however,...


    pub_type: 杂志文章


    authors: Graham DY,Lew GM,Malaty HM,Evans DG,Evans DJ Jr,Klein PD,Alpert LC,Genta RM

    更新日期:1992-02-01 00:00:00

  • Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency.

    abstract:BACKGROUND & AIMS:Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair gene mutations that define this syndrome and result in microsatellite instability (MSI). The carcinogenic path...


    pub_type: 杂志文章,多中心研究


    authors: Goel A,Xicola RM,Nguyen TP,Doyle BJ,Sohn VR,Bandipalliam P,Rozek LS,Reyes J,Cordero C,Balaguer F,Castells A,Jover R,Andreu M,Syngal S,Boland CR,Llor X

    更新日期:2010-05-01 00:00:00

  • Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease.

    abstract:BACKGROUND & AIMS:Crohn's disease (CD) is an immunologically mediated inflammatory disease of the gastrointestinal tract. Due to a high morbidity and/or an increase in mortality in refractory cases, a new treatment approach is needed. In theory, maximum immune ablation by autologous hematopoietic stem cell transplantat...


    pub_type: 临床试验,杂志文章


    authors: Oyama Y,Craig RM,Traynor AE,Quigley K,Statkute L,Halverson A,Brush M,Verda L,Kowalska B,Krosnjar N,Kletzel M,Whitington PF,Burt RK

    更新日期:2005-03-01 00:00:00

  • Notch signaling is required for exocrine regeneration after acute pancreatitis.

    abstract:BACKGROUND & AIMS:The mechanisms for tissue regeneration and renewal after acute pancreatitis are not well understood but may involve activation of Notch signaling. To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling i...


    pub_type: 杂志文章


    authors: Siveke JT,Lubeseder-Martellato C,Lee M,Mazur PK,Nakhai H,Radtke F,Schmid RM

    更新日期:2008-02-01 00:00:00

  • Fata eosinophilic enteritis.

    abstract::A patient is reported with eosinophilic enteritis of the jejunum with fatal evolution. Surgical resection was considered impossible and medical treatment with corticosteroids, elemental diet, parenteral nutrition, and antimicrobials to combat the intestinal bacterial overgrowth failed to control the disease. The destr...


    pub_type: 杂志文章


    authors: Tytgat GN,Grijm R,Dekker W,Den Hartog NA

    更新日期:1976-09-01 00:00:00

  • Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat.

    abstract:BACKGROUND:Capsaicin-sensitive neurons contain various peptides including calcitonin gene-related peptide. This study examines (1) whether calcitonin gene-related peptide is involved in capsaicin-induced gastroprotection and (2) whether nitric oxide and prostaglandin are required for calcitonin gene-related peptide to ...


    pub_type: 杂志文章


    authors: Lambrecht N,Burchert M,Respondek M,Müller KM,Peskar BM

    更新日期:1993-05-01 00:00:00

  • The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis.

    abstract:BACKGROUND & AIMS:The mechanism by which sulindac causes regression of adenomas in patients with familial adenomatous polyposis (FAP) is unclear. Conflicting data on the drug's effects on colorectal epithelial proliferation have been reported. An alternative mechanism, and one not previously studied, is via induction o...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pasricha PJ,Bedi A,O'Connor K,Rashid A,Akhtar AJ,Zahurak ML,Piantadosi S,Hamilton SR,Giardiello FM

    更新日期:1995-09-01 00:00:00