Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis.

abstract：BACKGROUND:Somatostatin inhibits pancreatic exocrine secretion in intact animals but not in vitro, suggesting an indirect effect. The present study examined the influence of extrapancreatic nerves and intrapancreatic cholinergic activity on somatostatin-induced inhibition of pancreatic exocrine secretion in conscious d...

journal_title：Gastroenterology

authors： Kuvshinoff BW,Brodish RJ,James L,McFadden DW,Fink AS

更新日期：1993-08-01 00:00:00

abstract：:Pharmacologic and surgical procedures were used to define the neurohumoral pathways that mediate stress-induced changes in gastrointestinal transit in the rat. Physical restraint (a validated stressor) resulted in significant inhibition of gastric emptying and small bowel transit but in stimulation of large bowel tran...

journal_title：Gastroenterology

authors： Lenz HJ

更新日期：1989-07-01 00:00:00

abstract：:Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842...

journal_title：Gastroenterology

authors： Carvajal-Carmona LG,Zauber AG,Jones AM,Howarth K,Wang J,Cheng T,APC Trial Collaborators.,APPROVe Trial Collaborators.,CORGI Study Collaborators.,Colon Cancer Family Registry Collaborators.,CGEMS Collaborators.,Riddell R,Lanas A,

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND & AIMS:Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the pancreas during pancreatitis may contribute to such activation. METHODS:To cause experimental pancreatitis, rats and mice were treated with ...

journal_title：Gastroenterology

authors： Gukovskaya AS,Vaquero E,Zaninovic V,Gorelick FS,Lusis AJ,Brennan ML,Holland S,Pandol SJ

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND & AIMS:Entecavir is a novel and selective nucleoside analogue with potent activity against hepatitis B virus (HBV). METHODS:In a 24-week, double-blind, randomized, multicenter, phase II clinical trial, the safety and efficacy of entecavir (0.01 mg/day, 0.1 mg/day, or 0.5 mg/day orally) were compared with la...

journal_title：Gastroenterology

authors： Lai CL,Rosmawati M,Lao J,Van Vlierberghe H,Anderson FH,Thomas N,Dehertogh D

更新日期：2002-12-01 00:00:00

abstract：:We have previously shown that in pregnancy fasting gallbladder volume is increased and emptying after a small volume liquid meal is incomplete. In this study we measured gallbladder volume throughout day and night in healthy women ingesting regular meals. Pregnant women, postpartum women, contraceptive-steroid users, ...

journal_title：Gastroenterology

authors： Everson GT,McKinley C,Lawson M,Johnson M,Kern F Jr

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND & AIMS:Dysbiosis of the intestinal microbiota has been associated with development of allergies in infants. However, it is not clear what microbes might contribute to this process. We investigated what microbe(s) might be involved in analyses of infant twins and mice. METHODS:We studied fecal specimens pros...

journal_title：Gastroenterology

authors： Chua HH,Chou HC,Tung YL,Chiang BL,Liao CC,Liu HH,Ni YH

更新日期：2018-01-01 00:00:00

abstract：:Helicobacter pylori infects the stomach of half of the human population worldwide and causes chronic active gastritis, which can lead to peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The host immune response to the infection is ineffective, because the bacterium persists...

journal_title：Gastroenterology

authors： Wilson KT,Crabtree JE

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND & AIMS:Acute-on-chronic liver failure (ACLF) develops in patients with chronic liver disease and has high mortality. Mobilization of bone marrow-derived stem cells with granulocyte colony-stimulating factor (G-CSF) could promote hepatic regeneration. METHODS:Consecutive patients with ACLF were randomly assi...

journal_title：Gastroenterology

authors： Garg V,Garg H,Khan A,Trehanpati N,Kumar A,Sharma BC,Sakhuja P,Sarin SK

更新日期：2012-03-01 00:00:00

abstract：:The burden of disease consequent to hepatitis C virus (HCV) infection has been well described and is expected to increase dramatically over the next decade. Current approved antiviral therapies are effective in eradicating the virus in approximately 50% of infected patients. However, pegylated interferon and ribavirin...

journal_title：Gastroenterology

authors： Pawlotsky JM,Chevaliez S,McHutchison JG

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hirschsprung disease is caused by failure of enteric neural crest cells (ENCCs) to fully colonize the bowel, leading to bowel obstruction and megacolon. Heterozygous mutations in the coding region of the RET gene cause a severe form of Hirschsprung disease (total colonic aganglionosis). However, 80% o...

journal_title：Gastroenterology

authors： Lai FP,Lau ST,Wong JK,Gui H,Wang RX,Zhou T,Lai WH,Tse HF,Tam PK,Garcia-Barcelo MM,Ngan ES

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND & AIMS:There are intra- and interobserver variations in endoscopic assessment of ulcerative colitis (UC) and biopsies are often collected for histologic evaluation. We sought to develop a deep neural network system for consistent, objective, and real-time analysis of endoscopic images from patients with UC. ...

journal_title：Gastroenterology

authors： Takenaka K,Ohtsuka K,Fujii T,Negi M,Suzuki K,Shimizu H,Oshima S,Akiyama S,Motobayashi M,Nagahori M,Saito E,Matsuoka K,Watanabe M

更新日期：2020-06-01 00:00:00

abstract：:Lamins have important roles in nuclear structure and cell signaling. Several diseases are associated with mutations in the lamin A/C gene (LMNA in humans). Patients with familial partial lipodystrophy caused by LMNA mutations develop pancreatitis, but lamin function in the pancreas and how these mutations affect pancr...

journal_title：Gastroenterology

authors： Elenbaas JS,Bragazzi Cunha J,Azuero-Dajud R,Nelson B,Oral EA,Williams JA,Stewart CL,Omary MB

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND & AIMS:Although bacterial bowel flora may be one of the contributing factors in the pathogenesis of chronic mucosal inflammation, antibiotic treatment has no established role in ulcerative colitis. The aim of the study was to evaluate the role of ciprofloxacin in the induction and maintenance of remission in...

journal_title：Gastroenterology

authors： Turunen UM,Färkkilä MA,Hakala K,Seppälä K,Sivonen A,Ogren M,Vuoristo M,Valtonen VV,Miettinen TA

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND & AIMS:Sex hormones have been reported to modulate visceral hypersensitivity (VH). Estrogen regulates neurons not only by binding to estrogen receptors (ERalpha and ERbeta) to initiate transcription but also via the G-protein coupled receptor GPR30, which binds and rapidly mediates actions of estrogen. We ex...

journal_title：Gastroenterology

authors： Lu CL,Hsieh JC,Dun NJ,Oprea TI,Wang PS,Luo JC,Lin HC,Chang FY,Lee SD

更新日期：2009-09-01 00:00:00

abstract：:In the rat, gastric histamine is stored mainly in the enterochromaffinlike cells. Gastrin releases histamine from these cells, and long-term hypergastrinemia results in hyperplasia. The effect of sustained hypergastrinemia on histamine-depleted enterochromaffinlike cells was studied by measuring histidine decarboxylas...

journal_title：Gastroenterology

authors： Andersson K,Håkanson R,Mattsson H,Ryberg B,Sundler F

更新日期：1992-09-01 00:00:00

abstract：:To estimate vascular changes in chronic liver disease, we quantitated intrahepatic arteriovenous and portal-systemic shunts in 12 patients with cirrhosis and arteriovenous shunts alone in 4 patients with cirrhosis. An index was obtained for intrahepatic arteriovenous shunts by instilling technetium 99m-macroaggregated...

journal_title：Gastroenterology

authors： Ohnishi K,Chin N,Sugita S,Saito M,Tanaka H,Terabayashi H,Saito M,Iida S,Nomura F,Okuda K

更新日期：1987-07-01 00:00:00

abstract：:The ability of hypnosis to both stimulate and inhibit gastric acid secretion in highly hypnotizable healthy volunteers was examined in two studies. In the first, after basal acid secretion was measured, subjects were hypnotized and instructed to imagine all aspects of eating a series of delicious meals. Acid output ro...

journal_title：Gastroenterology

authors： Klein KB,Spiegel D

更新日期：1989-06-01 00:00:00

abstract：:Sweden has one of the highest incidences of gallstone disease in the Western world. It is therefore important to characterize the mechanisms responsible for the formation of cholesterol gallstones in this population. In the present study, we have determined the kinetics of the two primary bile acids, cholic acid and c...

journal_title：Gastroenterology

authors： Nilsell K,Angelin B,Liljeqvist L,Einarsson K

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND & AIMS:Previous studies have indicated that serotonin-3-receptor antagonists might have a sex-specific effect in patients with irritable bowel syndrome with diarrhea (IBS-D). Alosetron has been approved for the treatment of only women, and ramosetron has been approved for the treatment for only men. We perfo...

journal_title：Gastroenterology

authors： Fukudo S,Kinoshita Y,Okumura T,Ida M,Akiho H,Nakashima Y,Nishida A,Haruma K

更新日期：2016-02-01 00:00:00

abstract：:Gastroenterologists frequently encounter pelvic floor disorders, which affect 10% to 15% of the population. The anorectum is a complex organ that collaborates with the pelvic floor muscles to preserve fecal continence and enable defecation. A careful clinical assessment is critical for the diagnosis and management of ...

journal_title：Gastroenterology

authors： Bharucha AE,Rao SS

更新日期：2014-01-01 00:00:00

abstract：:Isolation of a spiral-shaped bacterium closely related to Helicobacter pylori from the cat stomach made it possible to investigate new small animal models of gastric infection. Pure cultures of this bacterium, provisionally named "Helicobacter felis," were fed to germ-free mice. The organism colonized the stomach in l...

journal_title：Gastroenterology

authors： Lee A,Fox JG,Otto G,Murphy J

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND & AIMS:The ubiquitous cross-linking enzyme tissue transglutaminase (TG2) has been implicated in irreversible collagen stabilization in liver fibrosis, although functional evidence is lacking. We studied the contribution of TG2 to hepatic fibrotic matrix stability, as well as liver fibrosis progression and re...

journal_title：Gastroenterology

authors： Popov Y,Sverdlov DY,Sharma AK,Bhaskar KR,Li S,Freitag TL,Lee J,Dieterich W,Melino G,Schuppan D

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND & AIMS:The emergence of oxyntic atrophy and metaplastic cell lineages in response to chronic Helicobacter pylori infection predisposes to gastric neoplasia. We have described a trefoil factor family 2 (TFF2; spasmolytic polypeptide) expressing metaplasia (SPEM) associated with gastric neoplasia in both roden...

journal_title：Gastroenterology

authors： Nomura S,Baxter T,Yamaguchi H,Leys C,Vartapetian AB,Fox JG,Lee JR,Wang TC,Goldenring JR

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:There is a significant interobserver and intraobserver variation in grading dysplasia in Barrett's metaplasia. New markers are needed to optimize the assessment of potential risk of cancer development in these patients. The aim of this study is to explore the use of p53 as a marker of neoplastic progression ...

journal_title：Gastroenterology

authors： Younes M,Lebovitz RM,Lechago LV,Lechago J

更新日期：1993-12-01 00:00:00

abstract：:This study investigated the relationships of the serum markers of fibrogenesis and basement membrane formation to the clinical and morphological severity of alcoholic liver disease and to the degree of alcohol abuse. The concentrations of the aminoterminal propeptide of type III collagen, type IV collagen, and laminin...

journal_title：Gastroenterology

authors： Niemelä O,Risteli J,Blake JE,Risteli L,Compton KV,Orrego H

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND & AIMS:The long-term outcomes of patients treated for autoimmune hepatitis (AIH) are considered to be good. However, follow-up data beyond 10 years are limited and confined to tertiary referral centers. We assessed long-term outcomes and determinants of outcome in patients with AIH from a nontransplant cente...

journal_title：Gastroenterology

authors： Hoeroldt B,McFarlane E,Dube A,Basumani P,Karajeh M,Campbell MJ,Gleeson D

更新日期：2011-06-01 00:00:00

abstract：:Prior studies confirm the increased incidence of carcinoma of the colon in chronic ulcerative colitis. The authors reviewed clinical and histologic data retrospectively in 23 patients with colon carcinoma and chronic ulcerative colitis. Twenty-two of these patients had dysplasia of colonic epithelium remote from the c...

journal_title：Gastroenterology

authors： Nugent FW,Haggit RC,Colcher H,Kutteruf GC

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND & AIMS:Early growth response gene-1 (Egr-1) is an important inflammatory transcription factor. We hypothesize that leukocyte-derived Egr-1 plays a key inflammatory role in causing postoperative ileus. METHODS:Wild-type, Egr-1 knockout, and chimera mice (constructed by irradiation followed by injection with ...

journal_title：Gastroenterology

authors： Schmidt J,Stoffels B,Moore BA,Chanthaphavong RS,Mazie AR,Buchholz BM,Bauer AJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND & AIMS:Our aim was to investigate the relationship between alcohol consumption and iron overload, iron deficiency, or iron deficiency anemia in the U.S. population. METHODS:Adult participants of the Third National Health and Nutrition Examination Survey who did not consume alcohol (n = 8839) were compared w...

journal_title：Gastroenterology

authors： Ioannou GN,Dominitz JA,Weiss NS,Heagerty PJ,Kowdley KV

更新日期：2004-05-01 00:00:00