Proinflammatory role of leukocyte-derived Egr-1 in the development of murine postoperative ileus.

abstract：BACKGROUND & AIMS:Empirical therapy has been proposed for initial management of dyspepsia. The aim of this study was to evaluate initial endoscopy, empirical therapy, and testing for Helicobacter pylori in the management of patients with a new onset of dyspepsia. METHODS:Decision analysis was used to compare the direc...

journal_title：Gastroenterology

authors： Silverstein MD,Petterson T,Talley NJ

更新日期：1996-01-01 00:00:00

abstract：:We have examined the T-cell functional capabilities of human intestinal mononuclear cells isolated from surgically obtained normal and inflammatory bowel disease intestinal specimens. Intestinal mononuclear cells have T cells present which respond to the mitogenic lectins E-PHA, Con A, and PWM and to foreign cell-surf...

journal_title：Gastroenterology

authors： MacDermott RP,Bragdon MJ,Jenkins KM,Franklin GO,Shedlofsky S,Kodner IJ

更新日期：1981-04-01 00:00:00

abstract：:Histologic or ultrastructural evidence of the ability of sucralfate to protect the gastric mucosa against ethanol injury is lacking. Therefore we analyzed morphologic and functional changes in the mucosa of 120 rats receiving, intragastrically, 2 ml of either sucralfate 500 mg/kg body wt or a control solution and 1 h ...

journal_title：Gastroenterology

authors： Hollander D,Tarnawski A,Krause WJ,Gergely H

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic osmoreceptors are sensitive to changes in portal blood osmolality and cause variations in plasma antidiuretic hormone and water diuresis, which prevent major systemic osmotic changes. Insensitivity of hepatic osmoreceptors might contribute to maintaining increased plasma levels of antidiuretic h...

journal_title：Gastroenterology

authors： Castellano G,Solis-Herruzo JA,Gonzalez A,Morillas JD,Moreno D,Muñoz T,Larrodera L

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND & AIMS:Despite many advances in our understanding of Crohn's disease, the course of the disease in any given patient remains unpredictable. There is little agreement as to which factors increase a patient's risk of early postoperative recurrence. We have attempted to identify predictors of early recurrence a...

journal_title：Gastroenterology

authors： Lautenbach E,Berlin JA,Lichtenstein GR

更新日期：1998-08-01 00:00:00

abstract：:The prevalence of delta-markers among 71 patients with fulminant B viral hepatitis was found to be 33.8%. The majority of the patients with delta-markers showed serologic evidence of simultaneous acute delta-infection and B viral infection. Only 5 of the 24 patients with serologic markers of acute delta-infection in t...

journal_title：Gastroenterology

authors： Govindarajan S,Chin KP,Redeker AG,Peters RL

更新日期：1984-06-01 00:00:00

abstract：:The role of central (supraspinal and spinal) and peripheral alpha-adrenoceptors in the regulation of gastrointestinal propulsion in the mouse was studied using clonidine, an alpha 2-adrenoceptor agonist. Clonidine produced a dose-dependent inhibition of propulsion when given intracerebroventricularly, intrathecally, o...

journal_title：Gastroenterology

authors： Jiang Q,Sheldon RJ,Porreca F

更新日期：1988-11-01 00:00:00

abstract：:The effect of furosemide on secretin-stimulated pancreatic secretion was examined in 12 normal subjects using a perfusion method to quantitate pancreatic output. During continuous secretin infusion (0.9 U per kg per hr), secretory volume rose to a steady state level of 32.5 +/- 10.2 ml per min. When a bolus injection ...

journal_title：Gastroenterology

authors： Thomas FB,Sinar D,Caldwell JH,Mekhjian HS,Falko JM

更新日期：1977-08-01 00:00:00

abstract：:In humans and most other species, a decline in pH of gallbladder contents occurs during the concentration of bile. Recent in vitro studies in rabbit, guinea pig, and Necturus gallbladders have strongly suggested mucosal H+ secretion during sodium reabsorption, presumably representing a Na+/H+ exchange. The present in ...

journal_title：Gastroenterology

authors： Rege RV,Moore EW

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND & AIMS:In human and canine colon, both slow (slow waves, 2-8/min) and fast (myenteric potential oscillations [MPOs]; 16-20/min) electrical rhythms in the smooth muscle originate at the submucosal and myenteric borders, respectively. We used Ca(2+) imaging to investigate whether interstitial cells of Cajal (I...

journal_title：Gastroenterology

authors： Lee HT,Hennig GW,Park KJ,Bayguinov PO,Ward SM,Sanders KM,Smith TK

更新日期：2009-06-01 00:00:00

abstract：:Endosonography was performed preoperatively in 33 patients with common bile duct carcinoma and in 43 patients with carcinoma of the common hepatic duct and its bifurcation. The results were correlated with the histology of resected specimens according to the new (1987) TNM (tumor, node, metastasis) classification. End...

journal_title：Gastroenterology

authors： Tio TL,Cheng J,Wijers OB,Sars PR,Tytgat GN

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND & AIMS:Cost-effectiveness of colorectal cancer screening will be maximized by selecting the widest screening intervals that effectively prevent cancer mortality. However, data on the incidence of neoplasia in persons with no abnormal findings on initial examination are limited. The aim of this study was to d...

journal_title：Gastroenterology

authors： Rex DK,Cummings OW,Helper DJ,Nowak TV,McGill JM,Chiao GZ,Kwo PY,Gottlieb KT,Ikenberry SO,Gress FG,Lehman GA,Born LJ

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND & AIMS:We have shown that addition of gum arabic (GA) to a 90 mmol/L sodium-111 mmol/L glucose oral rehydration solution (ORS) enhances its effectiveness for water and electrolyte absorption in normal rats. The present study extends these observations on GA in ORS to two rat models of diarrheal disease. MET...

journal_title：Gastroenterology

authors： Wapnir RA,Wingertzahn MA,Moyse J,Teichberg S

更新日期：1997-06-01 00:00:00

abstract：:The goal of this study was to identify the structural and compositional features of human gallstones that influence in vitro gallstone dissolution in the cholesterol solvent monooctanoin. Gallstones were obtained from 86 consecutive patients who had at least three morphologically similar stones. One stone from each pa...

journal_title：Gastroenterology

authors： Smith BF

更新日期：1987-07-01 00:00:00

abstract：:In dispersed acini prepared from guinea pig pancreas, ethanol inhibited the increase in amylase secretion caused by cholecystokinin, carbachol, secretin, or vasoactive intestinal peptide. Ethanol did not alter binding of [125I] vasoactive intestinal peptide to pancreatic acinar cells or the inhibition of binding cause...

journal_title：Gastroenterology

authors： Uhlemann ER,Robberecht P,Gardner JD

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND & AIMS:In the enteric nervous system, neurotransmitters initiate changes in calcium (Ca(2+) responses) in glia, but it is not clear how this process affects intestinal function. We investigated whether Ca(2+)-mediated responses in enteric glia are required to maintain gastrointestinal function. METHODS:We u...

journal_title：Gastroenterology

authors： McClain J,Grubišić V,Fried D,Gomez-Suarez RA,Leinninger GM,Sévigny J,Parpura V,Gulbransen BD

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND & AIMS:Senescence prevents cellular transformation. We investigated whether vascular endothelial growth factor (VEGF) signaling via its receptor, VEGFR2, regulates senescence and proliferation of tumor cells in mice with colitis-associated cancer (CAC). METHODS:CAC was induced in VEGFR2(ΔIEC) mice, which do...

journal_title：Gastroenterology

authors： Foersch S,Sperka T,Lindner C,Taut A,Rudolph KL,Breier G,Boxberger F,Rau TT,Hartmann A,Stürzl M,Wittkopf N,Haep L,Wirtz S,Neurath MF,Waldner MJ

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND & AIMS:Electroneutral NaCl absorption across small intestine contributes importantly to systemic fluid balance. Disturbances in this process occur in both obstructive and diarrheal diseases, eg, cystic fibrosis, secretory diarrhea. NaCl absorption involves coupling of Cl(-)/HCO(3)(-) exchanger(s) primarily w...

journal_title：Gastroenterology

authors： Walker NM,Simpson JE,Yen PF,Gill RK,Rigsby EV,Brazill JM,Dudeja PK,Schweinfest CW,Clarke LL

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND & AIMS:Helicobacter pylori-negative idiopathic ulcers are increasingly recognized. The secular trend and long-term outcome of this condition are unknown. METHODS:We prospectively studied consecutive patients with bleeding gastroduodenal ulcers from January to December 2000. The incidence and etiology of ulc...

journal_title：Gastroenterology

authors： Hung LC,Ching JY,Sung JJ,To KF,Hui AJ,Wong VW,Leong RW,Chan HL,Wu JC,Leung WK,Lee YT,Chung SC,Chan FK

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND & AIMS:Carcinogenesis in Barrett's esophagus (BE) is associated with an increased expression of cyclooxygenase (COX) 2. However, there has been no direct evidence that inhibition of COX-2 prevents cancer in BE. We studied the effect of MF-Tricyclic, a selective COX-2 inhibitor, on the development of BE and a...

journal_title：Gastroenterology

authors： Buttar NS,Wang KK,Leontovich O,Westcott JY,Pacifico RJ,Anderson MA,Krishnadath KK,Lutzke LS,Burgart LJ

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND & AIMS:An increased duodenal expression of the iron transporters, divalent-metal-transporter-1, and ferroportin is observed in patients with iron deficiency or hereditary hemochromatosis. Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transpor...

journal_title：Gastroenterology

authors： Zoller H,Theurl I,Koch RO,McKie AT,Vogel W,Weiss G

更新日期：2003-09-01 00:00:00

abstract：:Spontaneous bacterial peritonitis in decompensated cirrhotic patients develops when bacteria invade preexising ascites. It is probable that other transudates such as pleural effusions can be afected in a similar manner. This paper describes a cirrhotic patient with long-standing pleural effusion in whom Escherichia co...

journal_title：Gastroenterology

authors： Flaum MA

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND & AIMS:The characteristics of colonic circular smooth muscle slow waves are altered during inflammation. The aim of this study was to examine whether inflammation modulates the open-state probability of Ca2+-activated K+ (KCa) channels in these cells to contribute to these alterations. METHODS:The experimen...

journal_title：Gastroenterology

authors： Lu G,Mazet B,Sun C,Qian X,Johnson CP,Adams MB,Roman RJ,Sarna SK

更新日期：1999-04-01 00:00:00

abstract：:In the anesthetized ferret jejunum, the role of extrinsic and intrinsic nerves in the relationship between intestinal motor activity and transmural potential difference (PD) was studied. In the vagally intact ferret and after sympathetic blockade, spontaneous bursts of jejunal motor activity were associated with fluct...

journal_title：Gastroenterology

authors： Greenwood B,Davison JS

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND & AIMS:During hepatic fibrogenesis, the hepatic extracellular matrix changes to fibrillar collagens types I and III, and cirrhosis is believed to produce an irreversible scar. In this study, we investigated whether gene delivery of human matrix metalloproteinase-1, which degrades collagens types I and type I...

journal_title：Gastroenterology

authors： Iimuro Y,Nishio T,Morimoto T,Nitta T,Stefanovic B,Choi SK,Brenner DA,Yamaoka Y

更新日期：2003-02-01 00:00:00

abstract：:Using in vivo and in vitro techniques, the mechanism by which intestinal mucosa obtains glutamine from luminal oligopeptides was investigated in humans. The rate of hydrolysis by mucosal brush border membrane was more than threefold greater for alanylglutamine than for glycylglutamine. Despite this difference, rates o...

journal_title：Gastroenterology

authors： Minami H,Morse EL,Adibi SA

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND & AIMS:Early metastasis is a hallmark of pancreatic ductal adenocarcinoma and responsible for >90% of pancreatic cancer death. Because little is known about the biology and genetics of the metastatic process, we desired to elucidate molecular pathways mediating pancreatic cancer metastasis in vivo by an unbi...

journal_title：Gastroenterology

authors： von Burstin J,Eser S,Paul MC,Seidler B,Brandl M,Messer M,von Werder A,Schmidt A,Mages J,Pagel P,Schnieke A,Schmid RM,Schneider G,Saur D

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Factors associated with the development and malignant progression of Barrett's esophagus are poorly understood. Gastrin is a mitogen capable of inducing growth in normal and malignant gastrointestinal mucosa. It is unknown whether gastrin can influence cellular events in the esophagus in Barrett's. ...

journal_title：Gastroenterology

authors： Haigh CR,Attwood SE,Thompson DG,Jankowski JA,Kirton CM,Pritchard DM,Varro A,Dimaline R

更新日期：2003-03-01 00:00:00

abstract：:The pancreatic secretion of 6 normal human volunteers was collected by endoscopic cannulation of the main pancreatic duct. The appearance of newly synthesized proteins was monitored at 1-min intervals after labeling with [75Se]methionine. The minimum transit time of these proteins from their site of synthesis to the a...

journal_title：Gastroenterology

authors： Robberecht P,Cremer M,Christophe J

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND & AIMS:Common germline genetic variation in the 3' region of myosin IXB (MYO9B) has been associated recently with susceptibility to celiac disease, with a hypothesis that MYO9B variants might influence intestinal permeability. These findings suggested the current study investigating a possible further role f...

journal_title：Gastroenterology

authors： van Bodegraven AA,Curley CR,Hunt KA,Monsuur AJ,Linskens RK,Onnie CM,Crusius JB,Annese V,Latiano A,Silverberg MS,Bitton A,Fisher SA,Steinhart AH,Forbes A,Sanderson J,Prescott NJ,Strachan DP,Playford RJ,Mathew CG,Wijm

更新日期：2006-12-01 00:00:00