Abstract：
:Using in vivo and in vitro techniques, the mechanism by which intestinal mucosa obtains glutamine from luminal oligopeptides was investigated in humans. The rate of hydrolysis by mucosal brush border membrane was more than threefold greater for alanylglutamine than for glycylglutamine. Despite this difference, rates of dipeptide and amino acid disappearance during intestinal perfusion were greater from test solutions containing glycylglutamine than alanylglutamine. Furthermore, rates of intraluminal appearance of products of hydrolysis during the infusion of two dipeptides were similar and less than 5% of the disappearance rate of the parent dipeptide. In contrast to free glutamine, uptake of peptide-bound glutamine by brush border membrane vesicles was not inhibited by deletion of sodium or addition of free amino acids to the incubation medium but was inhibited by other oligopeptides and stimulated by a proton gradient. Inhibition constants for the saturable uptake of glycylglutamine and alanylglutamine by vesicles were not significantly different, suggesting similar affinities for the peptide transporter. It is concluded that in human intestine the predominant mechanism for assimilation of glutamine-dipeptides is absorption as intact dipeptide rather than hydrolysis.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Minami H,Morse EL,Adibi SAdoi
10.1016/0016-5085(92)91088-lkeywords:
subject
Has Abstractpub_date
1992-07-01 00:00:00pages
3-11issue
1eissn
0016-5085issn
1528-0012pii
0016-5085(92)91088-Ljournal_volume
103pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：:This study was conducted to determine whether short-term (1.75 h) luminal glucose perfusion increases the mucosal protein synthesis rate in rat small intestine. A luminal perfusate containing 56 mM glucose was compared with a control perfusate containing mannitol in two jejunal segments constructed in the same animal....
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:We studied the influence of morphine on intestinal secretion induced by three different secretogogues in an attempt to elucidate the mechanism for its antisecretory activity. In rabbit ileal mucosa in vitro morphine (10(-4) M) did not influence the electrical response to the subsequent administration of prostaglandin ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1982-02-01 00:00:00
abstract：:The present study was undertaken to identify the different amino acid transport pathways present in the human small intestine during the early gestational period. The uptake time courses of neutral (L-leucine, L-alanine, L-methionine), acidic (L-glutamic and D-aspartic acids), basic (L-lysine), and imino (L-proline) a...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90664-7
更新日期：1991-06-01 00:00:00
abstract：:Biofeedback has been advocated as first-line therapy for patients whose symptoms of mild to moderate fecal incontinence have not responded to simple dietary advice or medication. Three main modalities have been described: (1) use of an intra-anal electromyographic sensor, a probe to measure intra-anal pressure, or per...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2003.10.058
更新日期：2004-01-01 00:00:00
abstract：:Radioactive lithocholate was administered intravenously to female rhesus monkeys with an exteriorized enterohepatic circulation, and the chemical form of biliary radioactivity was defined by thin layer chromatography. Most radioactivity was excreted in bile in the form of unsulfated conjugates (77%), indicating impair...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-06-01 00:00:00
abstract：BACKGROUND & AIMS:Host cell lipid rafts form a scaffold required for replication of hepatitis C virus (HCV). Serine palmitoyltransferases (SPTs) produce sphingolipids, which are essential components of the lipid rafts that associate with HCV nonstructural proteins. Prevention of the de novo synthesis of sphingolipids b...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2013.06.012
更新日期：2013-10-01 00:00:00
abstract：:This study is an examination of the association between Crohn's disease and psychiatric illness using careful gastrointestinal evaluation, a structured psychiatric interview of known reliability and validity, and explicit diagnostic criteria for psychiatric illness. A proband sample of 50 subjects with Crohn's disease...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：:Altered gallbladder motility could predispose to, or result from, gallstone formation and could also explain the alleged relief of biliary colic seen during bile acid therapy. Therefore, in 14 controls, 25 patients with radiolucent gallstones, and 14 patients with radiopaque gallstones, we used two techniques to measu...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：BACKGROUND & AIMS:Hepatic bile salt secretion is an essential function of vertebrate liver. Rat and mouse bile salt export pump (Bsep) are adenosine triphosphate (ATP)-dependent bile salt transporters. Mutations in human BSEP were identified as the cause of progressive familial intrahepatic cholestasis type 2. BSEP pro...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2002.36587
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND & AIMS:Leptin production has been reported in the rat and in human stomach. It initiates intestinal nutrient absorption. In this study, we analyzed the effect of vagal stimulation on leptin release in the human stomach. METHODS:We studied the secretion of gastric acid and leptin on stimulation with insulin ...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章
doi：10.1053/gast.2002.31385
更新日期：2002-02-01 00:00:00
abstract：:In this review, we speculate about future therapeutic approaches for inflammatory bowel diseases (IBDs), focusing on the need for better preclinical and clinical models and approaches beyond small molecules and systemically administered biologics. We offer ideas to change clinical trial programs and to use immunologic...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2011.02.014
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND & AIMS:An increased duodenal expression of the iron transporters, divalent-metal-transporter-1, and ferroportin is observed in patients with iron deficiency or hereditary hemochromatosis. Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transpor...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(03)01063-1
更新日期：2003-09-01 00:00:00
abstract：:A patient is described with Campylobacter enteritis complicated by massive lower gastrointestinal bleeding from multiple mucosal ulcers in the terminal ileum and at the ileocecal valve. Repeated stool cultures and antibiotic therapy may be indicated in certain patients to diminish the morbidity arising from what may s...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1980-10-01 00:00:00
abstract：BACKGROUND/AIMS:The pathways underlying rectal hypersensitivity to balloon distention in patients with irritable bowel syndrome (IBS) are not known. The aim of this study was to characterize the involvement of sacral and thoracolumbar afferents in the perception of rectal distention. METHODS:Rectal balloon distention ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(94)90809-5
更新日期：1994-12-01 00:00:00
abstract：:To study the relationship between gallstone disease (cholelithiasis and cholecystectomy) and cancer, a case-control study was performed in two Swedish hospitals comparing the prevalence of gallstone disease discovered at necropsy in 1422 subjects who died of cancer and 1205 subjects who did not die of cancer. Gallston...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：:By speeding the fragmentation of meat, peptic digestion might accelerate gastric emptying. To examine this possibility, mongrel dogs prepared with chronic duodenal fistulas were fed steak and 99mTc-labeled chicken liver, measuring 99mTc in all chyme exiting from the stomach out the duodenal fistula allowed quantitatio...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1980-08-01 00:00:00
abstract：BACKGROUND & AIMS:Cancer progression/metastases and embryonic development share many properties including cellular plasticity, dynamic cell motility, and integral interaction with the microenvironment. We hypothesized that the heterogeneous nature of hepatocellular carcinoma (HCC), in part, may be owing to the presence...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2008.12.004
更新日期：2009-03-01 00:00:00
abstract：:The leukocyte migration inhibition test has been used to investigate cellular immune responses to antigens in a protein fraction (BPF) of normal human gallbladder bile in patients with a variety of intra- and extrahepatic diseases. Inhibition of leukocyte migration in the presence of BPF was observed in 30 (81%) of 37...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
abstract：:This study correlates duodenal bile acid delivery with motility of the sphincter of Oddi during the fasting state. Dogs were prepared with a functional cholecystectomy, a duodenal cannula for direct vision cannulation of the common bile duct, and 12 bipolar electrodes serosally implanted from stomach to terminal ileum...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：BACKGROUND & AIMS:Chronic hepatitis C virus (HCV) infection is a major burden on individuals and health care systems. The Extension for Community Healthcare Outcomes (Project ECHO) enables primary care providers to deliver best-practice care for complex conditions to underserved populations. The US Congress passed the ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.10.016
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND & AIMS:Genetic and epigenetic alterations contribute to the pathogenesis of colorectal cancer (CRC). There is considerable molecular heterogeneity among colorectal tumors, which appears to arise as polyps progress to cancer. This heterogeneity results in different pathways to tumorigenesis. Although epigenet...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2014.04.039
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND & AIMS:Idiopathic inflammatory bowel disease (IBD) is associated with bone loss in more than 30% of cases. Nevertheless, the pathogenesis of the bone loss is uncertain. The aim of this study was to investigate the bone loss and underlying mechanisms using an animal model of IBD. METHODS:Severe colitis was i...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1996.v111.pm8898640
更新日期：1996-11-01 00:00:00
abstract：BACKGROUND & AIMS:Gastroesophageal reflux typically occurs after meals. During dual gastric and esophageal pH monitoring, we observed that postprandial refluxate was often more acidic than the gastric contents. This study aimed to investigate this phenomenon. METHODS:Dual gastric and esophageal pH tracings were analyz...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2001.27997
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND & AIMS:Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the pancreas during pancreatitis may contribute to such activation. METHODS:To cause experimental pancreatitis, rats and mice were treated with ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2002.32409
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND & AIMS:Germline mutations in one of four mismatch repair genes have been found in the majority of families with hereditary nonpolyposis colorectal cancer (HNPCC), but only in a small part of families with atypical HNPCC. The recently cloned EXO1 gene might be involved in the pathogenesis of HNPCC because the...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2001.25117
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:The mucosal response to intestinal resection has been extensively studied; little is known of the motor response. Our aim was to evaluate motility in the intestinal remnant following distal resection. METHODS:Motor activity, duodenocecal transit, nutrition, and absorption were studied over a 3-month period ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(93)90897-l
更新日期：1993-09-01 00:00:00
abstract：:Serial studies of plasma lipids and lipoproteins were performed in 4 patients with acute alcoholic liver disease characterized by a massive fatty liver and laboratory evidence of intrahepatic cholestasis. There were striking alterations in the plasma lipoprotein electrophoretic patterns characterized by the absence of...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression. The tumor suppressor miRNA let-7a has been reported to be inhibited posttranscriptionally in embryonic stem cells and in human cancers. Microtubule-associated kinase DCAMKL-1 is a putative intestinal stem cell marker that is express...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2009.05.004
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND & AIMS:Although dextran sodium sulfate (DSS)-induced colitis is a commonly used model of colonic injury, the mechanism of this model is not understood. The aim of this study was to determine the contribution of prostaglandins to the mechanism of DSS-induced epithelial injury. METHODS:Mice were treated with ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(98)70259-8
更新日期：1998-10-01 00:00:00
abstract：:Frequent occurrence of post-transfusion hepatitis continues despite screening for Australia antigen in blood before transfusion and elimination of commercial donor sources. The majority of these cases appears unrelated to hepatitis B virus. Preoperative, acute, and convalescent serra were screened for evidence of hepa...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-12-01 00:00:00
