Prostaglandins prevent decreased epithelial cell proliferation associated with dextran sodium sulfate injury in mice.

abstract：:Ursodeoxycholic acid, the 7 beta-hydroxy epimer of chenodeoxycholic acid, is more hydrophilic and less hepatotoxic than chenodeoxycholic acid. Because "lagodeoxycholic acid," the 12 beta-hydroxy epimer of deoxycholic acid, is also more hydrophilic than deoxycholic acid, it was hypothesized that it should also be less ...

journal_title：Gastroenterology

authors： Schmassmann A,Angellotti MA,Clerici C,Hofmann AF,Ton-Nu HT,Schteingart CD,Marcus SN,Hagey LR,Rossi SS,Aigner A

更新日期：1990-10-01 00:00:00

abstract：:To clarify the intracellular distribution of myosin in normal rat hepatocytes and its alterations in phal-loidin-treated rat hepatocytes as a morphologic basis for the dysfunction of microfilaments, we performed indirect immunofluorescence using monospecific antibody raised against rat hepatocyte myosin. Cryostat rat ...

journal_title：Gastroenterology

authors： Yasuura S,Ueno T,Watanabe S,Hirose M,Namihisa T

更新日期：1989-10-01 00:00:00

abstract：:Five carboxyl-terminal fragments of secretin ranging in size from 6 to 21 amino acid residues were tested for pancreatic secretory activity in the rat. None of the fragments displayed activity when given alone but each displayed significant activity when given after secretin. This apparent activity was shown to be the...

journal_title：Gastroenterology

authors： Bitar KN,Zfass AM,Makhlouf GM

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND & AIMS:To screen the genetic variants in cyclooxygenase-2 (COX-2), and evaluate their effects on COX-2 expression and risk of gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, Shangdong Province, an area of China, a high-risk area of GC. METHODS:Genotypes were d...

journal_title：Gastroenterology

authors： Liu F,Pan K,Zhang X,Zhang Y,Zhang L,Ma J,Dong C,Shen L,Li J,Deng D,Lin D,You W

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND & AIMS:An increased duodenal expression of the iron transporters, divalent-metal-transporter-1, and ferroportin is observed in patients with iron deficiency or hereditary hemochromatosis. Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transpor...

journal_title：Gastroenterology

authors： Zoller H,Theurl I,Koch RO,McKie AT,Vogel W,Weiss G

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND & AIMS:New serologic markers of inflammatory bowel disease may be useful for differentiating between Crohn's disease and ulcerative colitis and for disease stratification. We profiled sugar-binding antibodies to identify novel antiglycan antibodies that may be associated with inflammatory bowel disease. MET...

journal_title：Gastroenterology

authors： Dotan I,Fishman S,Dgani Y,Schwartz M,Karban A,Lerner A,Weishauss O,Spector L,Shtevi A,Altstock RT,Dotan N,Halpern Z

更新日期：2006-08-01 00:00:00

abstract：:Although long-term parenteral nutrition is lifesaving in patients with intestinal failure, it is expensive and associated with serious complications such as catheter sepsis, venous occlusions, and liver failure and severely impairs the quality of life in the short bowel patients. Therefore, treatments that increase th...

journal_title：Gastroenterology

authors： Jeppesen PB

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND & AIMS:In the absence of a genetic test, diagnostic criteria for hereditary hemochromatosis have been imprecise. The identification of the HFE gene and the C282Y mutation allow definition of expression of this disease and reassessment of diagnostic criteria. The aim of this study was to analyze the concordan...

journal_title：Gastroenterology

authors： Crawford DH,Jazwinska EC,Cullen LM,Powell LW

更新日期：1998-05-01 00:00:00

abstract：:The cause of Ménétrier's disease is unknown, although allergic, autoimmune, and infectious, particularly viral, causes have been postulated. This case report describes a 3-year-old child with Ménétrier's disease in whom evidence of acute cytomegalovirus (CMV) infection was found. To our knowledge, this is the first ca...

journal_title：Gastroenterology

authors： Eisenstat DD,Griffiths AM,Cutz E,Petric M,Drumm B

更新日期：1995-08-01 00:00:00

abstract：:Polycystic liver diseases (PLD) are inherited disorders of the biliary epithelium, caused by genetic defects in proteins associated with intracellular organelles, mainly the endoplasmic reticulum and the cilium. PLD are characterized by the formation and progressive enlargement of multiple cysts scattered throughout t...

journal_title：Gastroenterology

authors： Strazzabosco M,Somlo S

更新日期：2011-06-01 00:00:00

abstract：:Intracellular recording methods were used to study the effects of morphine on electrical behavior of myenteric neurons in cat small intestine. Two general categories of myenteric ganglion cells were found. AH/Type 2 neurons and relatively high resting membrane potentials, low input resistances, spikes only at the onse...

journal_title：Gastroenterology

authors： Wood JD

更新日期：1980-12-01 00:00:00

abstract：:Water and electrolyte transport were determined in rat ileum and colon using the single-pass perfusion technique. Intraperitoneal dopamine caused prompt stimulation of both ileal and colonic water absorption. The dopamine effect was mediated by both specific dopamine and alpha 2-adrenergic receptors. Haloperidol, a sp...

journal_title：Gastroenterology

authors： Donowitz M,Elta G,Battisti L,Fogel R,Label-Schwartz E

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND & AIMS:Improving methods for early detection of gastric cancer could reduce mortality. Measurements of serum pepsinogen levels have been used for screening in Japan without satisfactory levels of sensitivity or specificity. Trefoil factor family (TFF) proteins (TFF1, TFF2, and TFF3) are small and stable mole...

journal_title：Gastroenterology

authors： Aikou S,Ohmoto Y,Gunji T,Matsuhashi N,Ohtsu H,Miura H,Kubota K,Yamagata Y,Seto Y,Nakajima A,Goldenring JR,Kaminishi M,Nomura S

更新日期：2011-09-01 00:00:00

abstract：:We have used measurements of intestinal epithelial cell kinetics and counts of intraepithelial lymphocytes and mucosal mast cells to measure small intestinal mucosal changes during the proliferative and recovery phases of graft-vs.-host reaction in neonatal mice. Unirradiated (CBA x BALB/c)F1 mice were injected with p...

journal_title：Gastroenterology

authors： Mowat AM,Ferguson A

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND & AIMS:Proinflammatory cytokines alter function in enteric nerves, but little is known about underlying mechanisms. This study was designed to investigate the roles of prostanoids and of macrophage-like cells in cytokine-induced suppression of [3H]norepinephrine release from rat myenteric plexus. METHODS:Th...

journal_title：Gastroenterology

authors： Rühl A,Berezin I,Collins SM

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND & AIMS:Individuals with human immunodeficiency virus (HIV) infection frequently also are infected with hepatitis C virus (HCV) (co-infection), but little is known about its effects on the progression of HIV-associated disease. We aimed to determine the effects of co-infection on mortality from HIV and/or acq...

journal_title：Gastroenterology

authors： van der Helm J,Geskus R,Sabin C,Meyer L,Del Amo J,Chêne G,Dorrucci M,Muga R,Porter K,Prins M,CASCADE Collaboration in EuroCoord.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND & AIMS:The effect of hepatitis C viral (HCV) infection on patient and allograft survival after orthotopic liver transplantation is controversial. Hepatitis C recurrence after transplant is inevitable, but studies to date have not found a survival difference between recipients with and without HCV. METHODS:U...

journal_title：Gastroenterology

authors： Forman LM,Lewis JD,Berlin JA,Feldman HI,Lucey MR

更新日期：2002-04-01 00:00:00

abstract：:Several compounds, in particular bile acids, undergo enterohepatic circulation (EHC). Limited data are available on the pathophysiologic aspects of this circulation. In the present study we describe a surgical technique in rats that allows a long-term, reversible interruption of the EHC and monitoring of peripheral bl...

journal_title：Gastroenterology

authors： Kuipers F,Havinga R,Bosschieter H,Toorop GP,Hindriks FR,Vonk RJ

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Autoimmune responses against colonic epithelium may play a role in the development of colonic inflammation associated with ulcerative colitis (UC). In this study, we established and characterized B-cell lines and clones that produced anticolon antibody from inflamed colonic mucosa of UC subjects. M...

journal_title：Gastroenterology

authors： Inoue N,Watanabe M,Sato T,Okazawa A,Yamazaki M,Kanai T,Ogata H,Iwao Y,Ishii H,Hibi T

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND & AIMS:The duodenum is a cystic fibrosis transmembrane conductance regulator (CFTR)-expressing epithelium with high bicarbonate secretory capacity. We aimed to define the role of CFTR in human duodenal epithelial bicarbonate secretion in normal (NL) subjects and patients with cystic fibrosis (CF). METHODS:E...

journal_title：Gastroenterology

authors： Pratha VS,Hogan DL,Martensson BA,Bernard J,Zhou R,Isenberg JI

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND/AIMS:Capillarization of the hepatic sinusoid occurs in alcoholic liver disease. Because endothelial cell proliferation is relevant to capillarization, we used the intragastric feeding rat model to evaluate the relationship between pathological liver injury and endothelial cell proliferation. METHODS:Male Wi...

journal_title：Gastroenterology

authors： Nanji AA,Tahan SR,Wei Y,Sadrzadeh SM

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND & AIMS:Platelet-activating factor (PAF) is increased during relapse of ulcerative colitis. In animal models of experimental colitis, specific inhibition of PAF has reduced inflammation. The aim of this study was to evaluate the efficacy and safety of the PAF antagonist SR27417A in moderately active UC. METH...

journal_title：Gastroenterology

authors： Stack WA,Jenkins D,Vivet P,Hawkey CJ

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND & AIMS:Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis. Although highly expressed in liver, several studies have reported TfR2 expression in other tissues. To determine the contribution of liver expressed...

journal_title：Gastroenterology

authors： Wallace DF,Summerville L,Subramaniam VN

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND & AIMS:Prostaglandin-endoperoxide synthase (Ptgs)2 is an enzyme involved in prostaglandin production during the response to mucosal damage. Its expression is regulated, in part, by messenger RNA (mRNA)-binding proteins that control the stability of Ptgs2 mRNA. We used a precise system of colonic injury and r...

journal_title：Gastroenterology

authors： Manieri NA,Drylewicz MR,Miyoshi H,Stappenbeck TS

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p...

journal_title：Gastroenterology

authors： Almeida MI,Nicoloso MS,Zeng L,Ivan C,Spizzo R,Gafà R,Xiao L,Zhang X,Vannini I,Fanini F,Fabbri M,Lanza G,Reis RM,Zweidler-McKay PA,Calin GA

更新日期：2012-04-01 00:00:00

abstract：:Raised plasma carcinoembryonic antigen (CEA) levels were found in over 90% of 71 patients with chronic liver disease and 50% of 16 patients with acute liver damage. Levels increasing chronicity and clinical severity of disease. In individual patients, the plasma CEA level fluctuated with the clinical condition. Persis...

journal_title：Gastroenterology

authors： Bullen AW,Losowsky MS,Carter S,Patel S,Neville AM

更新日期：1977-10-01 00:00:00

abstract：:A prospective and randomized study was performed comparing pneumatic forceful dilatation and surgical esophagomyotomy as primary treatment of patients with achalasia of the esophagus. Eighteen dilated and 20 operated patients were studied before and after treatment with 1 patient lost. Clinical, radiologic, and manome...

journal_title：Gastroenterology

authors： Csendes A,Velasco N,Braghetto I,Henriquez A

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Prolonged lamivudine therapy is associated with treatment-resistant YMDD mutant hepatitis B virus (HBV). We evaluated the efficacy and safety of adding adefovir dipivoxil to lamivudine in 135 patients with chronic hepatitis B (CHB) and YMDD mutant HBV. METHODS:Ninety-five patients with compensated ...

journal_title：Gastroenterology

authors： Perrillo R,Hann HW,Mutimer D,Willems B,Leung N,Lee WM,Moorat A,Gardner S,Woessner M,Bourne E,Brosgart CL,Schiff E

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND & AIMS:Our aim was to investigate the relationship between alcohol consumption and iron overload, iron deficiency, or iron deficiency anemia in the U.S. population. METHODS:Adult participants of the Third National Health and Nutrition Examination Survey who did not consume alcohol (n = 8839) were compared w...

journal_title：Gastroenterology

authors： Ioannou GN,Dominitz JA,Weiss NS,Heagerty PJ,Kowdley KV

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regula...

journal_title：Gastroenterology

authors： Garuti C,Tian Y,Montosi G,Sabelli M,Corradini E,Graf R,Ventura P,Vegetti A,Clavien PA,Pietrangelo A

更新日期：2010-07-01 00:00:00