Involvement of eicosanoids and macrophage-like cells in cytokine-mediated changes in rat myenteric nerves.

abstract：:Isolation of a spiral-shaped bacterium closely related to Helicobacter pylori from the cat stomach made it possible to investigate new small animal models of gastric infection. Pure cultures of this bacterium, provisionally named "Helicobacter felis," were fed to germ-free mice. The organism colonized the stomach in l...

journal_title：Gastroenterology

authors： Lee A,Fox JG,Otto G,Murphy J

更新日期：1990-11-01 00:00:00

abstract：:Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is influenced by the local colonic environment and the patient's genetic background. Consolidating the knowledge of genetic and epigenetic events that occur with initiation, progression, and metastasis of sporadic CRC has identified so...

journal_title：Gastroenterology

authors： Carethers JM,Jung BH

更新日期：2015-10-01 00:00:00

abstract：:A combination of approaches has begun to elucidate the mechanisms of gastrointestinal development. This review describes progress over the last 20 years in understanding human gastrointestinal development, including data from both human and experimental animal studies that address molecular mechanisms. Rapid progress ...

journal_title：Gastroenterology

authors： Montgomery RK,Mulberg AE,Grand RJ

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND & AIMS:The majority of patients with Helicobacter pylori infection have autoantibodies cross-reacting with gastric antigens. In this study, the relation between autoantibody status, histopathology of body mucosa, and antigenic profile of H. pylori was investigated. METHODS:One hundred patients were examined...

journal_title：Gastroenterology

authors： Negrini R,Savio A,Poiesi C,Appelmelk BJ,Buffoli F,Paterlini A,Cesari P,Graffeo M,Vaira D,Franzin G

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND & AIMS:Interferon-free direct-acting antiviral (DAA) therapies are effective in patients with hepatitis C virus-induced cryoglobulinemia vasculitis (HCV-CV). We analyzed blood samples from patients with HCV-CV before and after DAA therapy to determine mechanisms of these drugs and their effects on cellular i...

journal_title：Gastroenterology

authors： Comarmond C,Garrido M,Pol S,Desbois AC,Costopoulos M,Le Garff-Tavernier M,Si Ahmed SN,Alric L,Fontaine H,Bellier B,Maciejewski A,Rosenzwajg M,Klatzmann D,Musset L,Poynard T,Cacoub P,Saadoun D

更新日期：2017-06-01 00:00:00

abstract：:In order to discover the effect of bile acid synthesis on cholesterol secretion into the bile, 7 rhesus monkeys were studied at various stable interruptions of the enterohepatic circulation of bile acids. In 4 animals, 2.5 and 7.5% interruptions were compared; 2.5 and 15% interruptions were compared in 5 animals. Ther...

journal_title：Gastroenterology

authors： Strasberg SM,Petrunka CN,Ilson RG

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND & AIMS:Nitric oxide is a major inhibitory neurotransmitter in the enteric nervous system. Loss or dysfunction of nitrinergic neurons is associated with serious disruptions of motility, intractable symptoms, and long-term suffering. The aim of this study was to evaluate the effect of intrapyloric transplantat...

journal_title：Gastroenterology

authors： Micci MA,Kahrig KM,Simmons RS,Sarna SK,Espejo-Navarro MR,Pasricha PJ

更新日期：2005-12-01 00:00:00

abstract：DESCRIPTION:Thanks to ready access to hydrogen breath testing, small intestinal bacterial overgrowth (SIBO) is now commonly diagnosed among individuals presenting with a variety of gastrointestinal and even nongastrointestinal symptoms and is increasingly implicated in lay press and media in the causation of a diverse ...

journal_title：Gastroenterology

authors： Quigley EMM,Murray JA,Pimentel M

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Autoimmune responses against colonic epithelium may play a role in the development of colonic inflammation associated with ulcerative colitis (UC). In this study, we established and characterized B-cell lines and clones that produced anticolon antibody from inflamed colonic mucosa of UC subjects. M...

journal_title：Gastroenterology

authors： Inoue N,Watanabe M,Sato T,Okazawa A,Yamazaki M,Kanai T,Ogata H,Iwao Y,Ishii H,Hibi T

更新日期：2001-07-01 00:00:00

abstract：:To look for possible HLA linkage in familial Crohn's disease, HLA haplotype segregation patterns were determined in 70 members of five kindreds, each having 2 or more patients with Crohn's disease (total number: 13 with Crohn's disease, 1 with ulcerative colitis). Concordant segregation of HLA haplotypes and disease w...

journal_title：Gastroenterology

authors： Eade OE,Moulton C,MacPherson BR,Andre-Ukena SS,Albertini RJ,Beeken WL

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND & AIMS:No controlled trial has examined the clinical efficacy of antibiotics in small bowel bacterial overgrowth. METHODS:Ten patients with bacterial overgrowth-related diarrhea underwent the following five 7-day treatment periods: untreated (control period), then placebo, and subsequently, in random order ...

journal_title：Gastroenterology

authors： Attar A,Flourié B,Rambaud JC,Franchisseur C,Ruszniewski P,Bouhnik Y

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND & AIMS:The NOD2 gene, which is strongly associated with susceptibility to Crohn's disease (CD) of the terminal ileum, interacts with bacterial lipopolysaccharide (LPS), inducing cellular activation. However, the mechanisms by which NOD2 mutations cause terminal ileitis are unknown, and NOD2 is expressed most...

journal_title：Gastroenterology

authors： Lala S,Ogura Y,Osborne C,Hor SY,Bromfield A,Davies S,Ogunbiyi O,Nuñez G,Keshav S

更新日期：2003-07-01 00:00:00

abstract：:This study was undertaken to determine the pathogenesis of muscle atrophy that frequently accompanies liver disease. Hepatic injury was induced in rats by giving weekly intragastric doses of carbon tetrachloride (CCl4) in combination with phenobarbital in the drinking water. Muscle protein catabolism was assessed duri...

journal_title：Gastroenterology

authors： Weber FL Jr,Macechko PT,Kelson SR,Karajiannis E,Hassan MO

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The chemokines CCL19 and CCL21 bind CCR7, which is involved in the organization of secondary lymphoid tissue and is expressed during chronic tissue inflammation. We investigated the expression of CCL21 and CCR7 in chronic hepatitis C. The effects of CCL21 on hepatic stellate cells (HSCs) were also s...

journal_title：Gastroenterology

authors： Bonacchi A,Petrai I,Defranco RM,Lazzeri E,Annunziato F,Efsen E,Cosmi L,Romagnani P,Milani S,Failli P,Batignani G,Liotta F,Laffi G,Pinzani M,Gentilini P,Marra F

更新日期：2003-10-01 00:00:00

abstract：:A randomized, controlled trial was conducted to investigate the ability of indomethacin and chloroquine to reduce intestinal secretion in 29 adult patients with severe cholera. All patients received intravenous infusion to restore fluid balance, but no antibiotics were given. Patients treated with oral indomethacin (t...

journal_title：Gastroenterology

authors： Rabbani GH,Butler T

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND & AIMS:The maintenance of the intestinal mucosal barrier may be energy dependent. Tacrolimus is a potent immunosuppressive drug that decreases mitochondrial adenosine triphosphate production and increases intestinal permeability in animals. METHODS:Twelve liver graft recipients receiving tacrolimus, 9 healt...

journal_title：Gastroenterology

authors： Gabe SM,Bjarnason I,Tolou-Ghamari Z,Tredger JM,Johnson PG,Barclay GR,Williams R,Silk DB

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND & AIMS:Host genetic factors are likely to contribute to the variable course of hepatic fibrosis in response to chronic liver injury. Similarly, the fibrotic response differs among inbred mouse strains after challenge with CCl(4). Our aim was to identify unknown susceptibility loci for hepatic fibrosis in a c...

journal_title：Gastroenterology

authors： Hillebrandt S,Goos C,Matern S,Lammert F

更新日期：2002-12-01 00:00:00

abstract：:This study was designed to investigate the location, specificity, and significance of antibody-containing cells in the liver. After intestinal administration of cholera toxin, high numbers of specific antibody-containing cells appeared in the liver during the early priming period and after boosting. In contrast, a sig...

journal_title：Gastroenterology

authors： Altorfer J,Hardesty SJ,Scott JH,Jones AL

更新日期：1987-09-01 00:00:00

abstract：:Previous investigations demonstrated that S-adenosyl-L-methionine suppresses the cholestatic effect of ethynylestradiol and reduces the irreversible binding of the estrogen to rat liver microsomes, probably favoring ethynylestradiol transformation into its methyl-derivatives. Since it is not known whether SAMe also pr...

journal_title：Gastroenterology

authors： Stramentinoli G,Di Padova C,Gualano M,Rovagnati P,Galli-Kienle M

更新日期：1981-01-01 00:00:00

abstract：:Intestinal microbiota are involved in the pathogenesis of Crohn's disease, ulcerative colitis, and pouchitis. We review the mechanisms by which these gut bacteria, fungi, and viruses mediate mucosal homeostasis via their composite genes (metagenome) and metabolic products (metabolome). We explain how alterations to th...

journal_title：Gastroenterology

authors： Sartor RB,Wu GD

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND & AIMS:Maintenance of acid-base homeostasis is required for normal physiology, metabolism, and development. It is not clear how cell death is activated in response to changes in pH. We performed a screen to identify agents that induce cell death in a pH-dependent manner (we call this alkaliptosis) in pancrea...

journal_title：Gastroenterology

authors： Song X,Zhu S,Xie Y,Liu J,Sun L,Zeng D,Wang P,Ma X,Kroemer G,Bartlett DL,Billiar TR,Lotze MT,Zeh HJ,Kang R,Tang D

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND & AIMS:Although a significant amount of regenerating gene (REG) Ialpha protein is present not only in normal gastric mucosa but also in gastric cancer tissues, its pathophysiologic role in gastric cancer development remains unclear. We investigated REG Ialpha protein expression in early gastric cancers, and ...

journal_title：Gastroenterology

authors： Sekikawa A,Fukui H,Fujii S,Takeda J,Nanakin A,Hisatsune H,Seno H,Takasawa S,Okamoto H,Fujimori T,Chiba T

更新日期：2005-03-01 00:00:00

abstract：:The distribution of sigma and phencyclindine binding sites in the gastrointestinal tract of the guinea pig was studied by autoradiography after in vitro incubation of tissue slices with (+)3H-SKF 10,047 and 3H-1-1-[(2-thienyl)cyclohexyl] piperidine to locate sigma and phencyclidine receptors, respectively. A dense dis...

journal_title：Gastroenterology

authors： Roman F,Pascaud X,Chomette G,Bueno L,Junien JL

更新日期：1989-07-01 00:00:00

abstract：:Low residue, chemically defined diets containing all essential nutrients in a readily assimilated form, require minimal digestion and are almost entirely absorbed in the upper gastrointestinal tract. Within the past decade, these diets have been reported to provide nutritional support in a variety of clinical situatio...

journal_title：Gastroenterology

authors： Young EA,Heuler N,Russell P,Weser E

更新日期：1975-12-01 00:00:00

abstract：:Pancreatic blood flow and its relationship to pancreatic interstitial pressure were investigated in a model of chronic pancreatitis in cats using a hydrogen gas-clearance technique with an intraductal electrode. The intraductal technique correlated well with blood flow measurements made using gamma-labeled microsphere...

journal_title：Gastroenterology

authors： Reber HA,Karanjia ND,Alvarez C,Widdison AL,Leung FW,Ashley SW,Lutrin FJ

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:The role of cytotoxicity mediated by peripheral blood mononuclear cells for colonic epithelial cells in inflammatory bowel disease (IBD) is still controversial. To clarify it, we studied major histocompatibility antigen (MHC)-restricted T cell-mediated cytotoxicity (CTL). METHODS:Cytotoxicity was measured b...

journal_title：Gastroenterology

authors： Okazaki K,Morita M,Nishimori I,Sano S,Toyonaga M,Nakazawa Y,Yamamoto Y,Yamamoto Y

更新日期：1993-02-01 00:00:00

abstract：:Twenty-seven carriers of the hepatitis B surface antigen who underwent liver transplantation in Italy and Belgium for terminal Hepatitis delta virus (HDV) cirrhosis were investigated. In 22 of the patients, HDV infection recurred. Two patients died of coexisting HDV and hepatitis B virus (HBV) reactivation. Four patie...

journal_title：Gastroenterology

authors： Ottobrelli A,Marzano A,Smedile A,Recchia S,Salizzoni M,Cornu C,Lamy ME,Otte JB,De Hemptinne B,Geubel A

更新日期：1991-12-01 00:00:00

abstract：:In humans and most other species, a decline in pH of gallbladder contents occurs during the concentration of bile. Recent in vitro studies in rabbit, guinea pig, and Necturus gallbladders have strongly suggested mucosal H+ secretion during sodium reabsorption, presumably representing a Na+/H+ exchange. The present in ...

journal_title：Gastroenterology

authors： Rege RV,Moore EW

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is often associated with hepatitis B virus (HBV) infection. Cells of most HBV-related HCCs contain HBV-DNA fragments that do not encode entire HBV antigens. We investigated whether these integrated HBV-DNA fragments encode epitopes that are recognized by T cells and whet...

journal_title：Gastroenterology

authors： Tan AT,Yang N,Lee Krishnamoorthy T,Oei V,Chua A,Zhao X,Tan HS,Chia A,Le Bert N,Low D,Tan HK,Kumar R,Irani FG,Ho ZZ,Zhang Q,Guccione E,Wai LE,Koh S,Hwang W,Chow WC,Bertoletti A

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND & AIMS:Human primary liver cancer is classified into biologically distinct subgroups based on cellular origin. Liver cancer stem cells (CSCs) have been recently described. We investigated the ability of distinct lineages of hepatic cells to become liver CSCs and the phenotypic and genetic heterogeneity of pr...

journal_title：Gastroenterology

authors： Holczbauer Á,Factor VM,Andersen JB,Marquardt JU,Kleiner DE,Raggi C,Kitade M,Seo D,Akita H,Durkin ME,Thorgeirsson SS

更新日期：2013-07-01 00:00:00