Abstract:
:Five carboxyl-terminal fragments of secretin ranging in size from 6 to 21 amino acid residues were tested for pancreatic secretory activity in the rat. None of the fragments displayed activity when given alone but each displayed significant activity when given after secretin. This apparent activity was shown to be the result of displacement of secretin bound to the walls of the injection catheter. The activity was abolished by dissolving secretin in 2% bovine serum albumin. The finding emphasizes the ease with which secretin can bind to plastic surfaces and consequently the need to reevaluate previous dose-response studies and the caution required in the design of future studies.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Bitar KN,Zfass AM,Makhlouf GMsubject
Has Abstractpub_date
1978-12-01 00:00:00pages
1080-2issue
6eissn
0016-5085issn
1528-0012pii
S0016508578002504journal_volume
75pub_type
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