当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Pentane clearance from inspired air by the rat: dependence on the liver.

Pentane clearance from inspired air by the rat: dependence on the liver.

Abstract：

:Pentane, a volatile hydrocarbon, is cleared from inspired air by the rat. We have studied this clearance to learn whether or not it is a function of the liver. Rats were put individually into airtight chambers which contained CO2 absorbent and were connected to an O2 reservoir. Pentane was injected into each chamber and chamber atmosphere was assayed frequently for pentane over 6 h by gas chromatography. Semilog plots of pentane concentration had a rapid distribution phase and a log-linear terminal elimination phase. A chamber clearance value in milliliters at atmosphere cleared per minute per kilogram rat weight was calculated. Nephrectomy had no effect on pentane clearance. Liver injury by thioacetamide (5 mmol/kg) or by CCl4 (75 or 125 microliters/100 g) was associated with a marked decrease in pentane clearance, indicating a major role for the liver in pentane elimination. Treatment of rats with inducers or inhibitors of the hepatic microsomal cytochrome P450 system did not affect their ability to clear pentane. However, administration of ethanol or 4-methyl-pyrazole diminished pentane clearance, suggesting that alcohol dehydrogenase may be involved in pentane metabolism. These findings demonstrate that pentane clearance is a liver function.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Burk RJ,Ludden TM,Lane JM

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

138-42

issue

1

eissn

0016-5085

issn

1528-0012

pii

S0016508583000074

journal_volume

84

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy.

    abstract：BACKGROUND & AIMS:Patients with colorectal tumors with microsatellite instability (MSI) have better prognoses than patients with tumors without MSI, but have a poor response to 5-fluorouracil–based chemotherapy. A dominant-negative form of heat shock protein (HSP)110 (HSP110DE9) expressed by cancer cells with MSI, via ...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1053/j.gastro.2013.10.054

    authors： Collura A,Lagrange A,Svrcek M,Marisa L,Buhard O,Guilloux A,Wanherdrick K,Dorard C,Taieb A,Saget A,Loh M,Soong R,Zeps N,Platell C,Mews A,Iacopetta B,De Thonel A,Seigneuric R,Marcion G,Chapusot C,Lepage C,Bouvier

    更新日期：2014-02-01 00:00:00

  • Propranolol inhibits adenylate cyclase and secretion stimulated by deoxycholic acid in the rabbit colon.

    abstract：:Bile acids cause diarrhea by inducing colonic secretion, probably mediated through the cyclic AMP system. The aim was to determine the effects of an adenylate cyclase inhibitor, propranolol, on deoxycholic acid (DCA) stimulation of net secretion and the cyclic AMP system in the colon. In each of 30 New Zealand white r...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Conley D,Coyne M,Chung A,Bonorris G,Schoenfield L

    更新日期：1976-07-01 00:00:00

  • Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society.

    abstract：:Adenomatous polyps are the most common neoplastic findings discovered in people who undergo colorectal screening or who have a diagnostic work-up for symptoms. It was common practice in the 1970s for these patients to have annual follow-up surveillance examinations to detect additional new adenomas and missed synchron...

    journal_title：Gastroenterology

    pub_type： 杂志文章,实务指引,评审

    doi：10.1053/j.gastro.2006.03.012

    authors： Winawer SJ,Zauber AG,Fletcher RH,Stillman JS,O'Brien MJ,Levin B,Smith RA,Lieberman DA,Burt RW,Levin TR,Bond JH,Brooks D,Byers T,Hyman N,Kirk L,Thorson A,Simmang C,Johnson D,Rex DK,US Multi-Society Task Force on Colo

    更新日期：2006-05-01 00:00:00

  • Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers.

    abstract：BACKGROUND & AIMS:Colorectal cancers (CRC) associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome display high-level microsatellite instability (MSI-H) as a consequence of mismatch repair deficiency. HNPCC-associated CRC frequently show features of a pronounced immune response, most likely resul...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1053/j.gastro.2008.01.015

    authors： Schwitalle Y,Kloor M,Eiermann S,Linnebacher M,Kienle P,Knaebel HP,Tariverdian M,Benner A,von Knebel Doeberitz M

    更新日期：2008-04-01 00:00:00

  • Association Between Psychological Distress and Liver Disease Mortality: A Meta-analysis of Individual Study Participants.

    abstract：BACKGROUND & AIMS:Risk factors for cardiovascular disease, such as obesity and hypertension, have been associated with nonalcoholic fatty liver disease. Psychological distress (symptoms of anxiety and depression) is a risk factor for cardiovascular disease, so it might also be associated, directly or indirectly, with l...

    journal_title：Gastroenterology

    pub_type： 杂志文章,meta分析

    doi：10.1053/j.gastro.2015.02.004

    authors： Russ TC,Kivimäki M,Morling JR,Starr JM,Stamatakis E,Batty GD

    更新日期：2015-05-01 00:00:00

  • Ability of human colonic epithelium to express the 4F2 antigen, the common acute lymphoblastic leukemia antigen, and the transferrin receptor. Studies in inflammatory bowel disease and after in vitro exposure to different stimuli.

    abstract：:We investigated the ability of isolated human colonic epithelial cells to express the common acute lymphoblastic leukemia antigen (CALLA), the transferrin receptor, and the 4F2 antigen in response to different types of stimuli. The expression of these markers was assessed by immunofluorescence using monoclonal antibod...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)90387-9

    authors： Fais S,Pallone F

    更新日期：1989-12-01 00:00:00

  • Pancreatic secretory activity of secretin5-27 and substituted analogues.

    abstract：:The effect of secretin5-27 and four substituted analogues (9 Gln-secretin5-27, 15-Asn-secretin5-27, 9-Gln-15-Asn-secretin5-27, and 15-Lys-secretin5-27) on pancreatic secretion in the rat and guinea pig was examined. Secretin5-27 retained significant pancreatic secretory activity in both species. Its efficacy (intrinsi...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Makhlouf GM,Bodanszky M,Fink ML,Schebalin M

    更新日期：1978-08-01 00:00:00

  • Ingestion of corrosive acids. Spectrum of injury to upper gastrointestinal tract and natural history.

    abstract：:We have prospectively evaluated 41 patients who ingested acid for location, extent, severity, and outcome of the injury to the upper gastrointestinal tract. The injury was assessed within 36 h of acid intake by endoscopy or surgery, or at autopsy. Symptoms and signs were unreliable in predicting the extent and severit...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Zargar SA,Kochhar R,Nagi B,Mehta S,Mehta SK

    更新日期：1989-09-01 00:00:00

  • Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.

    abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is often associated with hepatitis B virus (HBV) infection. Cells of most HBV-related HCCs contain HBV-DNA fragments that do not encode entire HBV antigens. We investigated whether these integrated HBV-DNA fragments encode epitopes that are recognized by T cells and whet...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2019.01.251

    authors： Tan AT,Yang N,Lee Krishnamoorthy T,Oei V,Chua A,Zhao X,Tan HS,Chia A,Le Bert N,Low D,Tan HK,Kumar R,Irani FG,Ho ZZ,Zhang Q,Guccione E,Wai LE,Koh S,Hwang W,Chow WC,Bertoletti A

    更新日期：2019-05-01 00:00:00

  • T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells.

    abstract：BACKGROUND & AIMS:Intestinal epithelial cells release antigen-presenting vesicles (exosomes) bearing major histocompatibility complex class II/peptide complexes stimulating specific immune responses in vivo. To characterize further the role of human epithelial exosomes in antigen presentation, their capacity to load an...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2007.02.043

    authors： Mallegol J,Van Niel G,Lebreton C,Lepelletier Y,Candalh C,Dugave C,Heath JK,Raposo G,Cerf-Bensussan N,Heyman M

    更新日期：2007-05-01 00:00:00

  • Intestinal vessels express a high density of somatostatin receptors in human inflammatory bowel disease.

    abstract：BACKGROUND/AIMS:The neuropeptide somatostatin exerts multiple functions in the gastrointestinal tract and may also play a regulatory role in inflammatory bowel disease, as several other neuropeptides do, e.g., substance P or calcitonin gene-related peptide. Therefore, the expression of somatostatin receptors was evalua...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(94)90754-4

    authors： Reubi JC,Mazzucchelli L,Laissue JA

    更新日期：1994-04-01 00:00:00

  • Lactococcus lactis Subspecies cremoris Elicits Protection Against Metabolic Changes Induced by a Western-Style Diet.

    abstract：BACKGROUND & AIMS:A Western-style diet, which is high in fat and sugar, can cause significant dyslipidemia and nonalcoholic fatty liver disease; the diet has an especially strong effect in women, regardless of total calorie intake. Dietary supplementation with beneficial microbes might reduce the detrimental effects of...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2020.03.010

    authors： Naudin CR,Maner-Smith K,Owens JA,Wynn GM,Robinson BS,Matthews JD,Reedy AR,Luo L,Wolfarth AA,Darby TM,Ortlund EA,Jones RM

    更新日期：2020-08-01 00:00:00

  • Implementation of on-site screening sigmoidoscopy positively influences utilization by primary care providers.

    abstract：BACKGROUND & AIMS:Sigmoidoscopy is an effective screening strategy for colorectal cancer that is not widely used by primary care providers. The aim of this study was to assess the impact of "academic detailing" in the form of an outreach educational seminar combined with implementation of on-site sigmoidoscopy services...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1053/gast.1999.0029900304

    authors： Schroy PC,Heeren T,Bliss CM,Pincus J,Wilson S,Prout M

    更新日期：1999-08-01 00:00:00

  • Colonic and small intestinal alkaline phosphatase. A histochemical and biochemical study.

    abstract：:Colonic and intestinal alkaline phosphatase were studied histoenzymatically and biochemically in normal mucosae from eight hemicolectomy specimens. Histochemically, the most intense reaction was found in the small intestine, followed by vascular endothelium and colonic epithelium, respectively. The reaction was strong...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Lev R,Griffiths WC

    更新日期：1982-06-01 00:00:00

  • alpha-1-antitrypsin deficiency in liver disease: the extent of the problem.

    abstract：:A prospective screening program was undertaken at the Royal Free Hospital, London, to ascertain the incidence of alpha-1-antitrypsin (AAT) deficiency in patients with liver disease. Quantitative determinations of serum alpha-1-antitrypsin were performed on 469 patients with hepatobiliary disease and 98 subjects with n...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Fisher RL,Taylor L,Sherlock S

    更新日期：1976-10-01 00:00:00

  • American gastroenterological association institute medical position statement on the use of gastrointestinal medications in pregnancy.

    abstract：:This document presents the official recommendations of the American Gastroenterological Association (AGA) Institute on "Use of Gastrointestinal Medications in Pregnancy." It was approved by the Clinical Practice and Economics Committee on February 22, 2006, and by the AGA Institute Governing Board on April 20, 2006. ...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2006.04.048

    authors： Mahadevan U,Kane S

    更新日期：2006-07-01 00:00:00

  • Abnormal gallbladder emptying in a subgroup of patients with gallstones.

    abstract：:Gallbladder stasis has been implicated in gallstone formation. Gallbladder filling and emptying were quantitated by computer-assisted cholescintigraphy in 41 normal subjects versus 26 patients with gallstones. Gallbladder contraction was induced by low-dose (1.2 U/kg . h) cholecystokinin infusion. Gallstone patients e...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(85)90152-0

    authors： Pomeranz IS,Shaffer EA

    更新日期：1985-03-01 00:00:00

  • Fulminant B viral hepatitis: role of delta agent.

    abstract：:The prevalence of delta-markers among 71 patients with fulminant B viral hepatitis was found to be 33.8%. The majority of the patients with delta-markers showed serologic evidence of simultaneous acute delta-infection and B viral infection. Only 5 of the 24 patients with serologic markers of acute delta-infection in t...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Govindarajan S,Chin KP,Redeker AG,Peters RL

    更新日期：1984-06-01 00:00:00

  • Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22.

    abstract：BACKGROUND & AIMS:The aim of this study was to evaluate the role of known colorectal adenoma and carcinoma susceptibility genes and to locate a novel susceptibility gene in an Ashkenazi family (SM1311) with dominantly inherited predisposition to colorectal adenomas and carcinomas. METHODS:Clinicopathologic and family ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(99)70061-2

    authors： Tomlinson I,Rahman N,Frayling I,Mangion J,Barfoot R,Hamoudi R,Seal S,Northover J,Thomas HJ,Neale K,Hodgson S,Talbot I,Houlston R,Stratton MR

    更新日期：1999-04-01 00:00:00

  • Stimulation of pancreatic secretion of water and electrolytes by furosemide.

    abstract：:The effect of furosemide on secretin-stimulated pancreatic secretion was examined in 12 normal subjects using a perfusion method to quantitate pancreatic output. During continuous secretin infusion (0.9 U per kg per hr), secretory volume rose to a steady state level of 32.5 +/- 10.2 ml per min. When a bolus injection ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Thomas FB,Sinar D,Caldwell JH,Mekhjian HS,Falko JM

    更新日期：1977-08-01 00:00:00

  • Erythromycin accelerates gastric emptying by inducing antral contractions and improved gastroduodenal coordination.

    abstract：:Erythromycin has been shown to act as a motilin agonist by binding to motilin receptors on gastrointestinal smooth muscle and to improve the severely impaired gastric emptying in patients with diabetic gastroparesis. To elucidate the motor pattern that accounts for this accelerated emptying, the effect of 200 mg eryth...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0016-5085(92)90164-t

    authors： Annese V,Janssens J,Vantrappen G,Tack J,Peeters TL,Willemse P,Van Cutsem E

    更新日期：1992-03-01 00:00:00

  • The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair.

    abstract：BACKGROUND & AIMS:Dkk1 is a secreted antagonist of the Wnt/β-catenin signaling pathway. It is induced by inflammatory cytokines during colitis and exacerbates tissue damage by promoting apoptosis of epithelial cells. However, little is known about the physiologic role of Dkk1 in normal intestinal homeostasis and during...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2011.03.043

    authors： Koch S,Nava P,Addis C,Kim W,Denning TL,Li L,Parkos CA,Nusrat A

    更新日期：2011-07-01 00:00:00

  • REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer.

    abstract：BACKGROUND & AIMS:Although a significant amount of regenerating gene (REG) Ialpha protein is present not only in normal gastric mucosa but also in gastric cancer tissues, its pathophysiologic role in gastric cancer development remains unclear. We investigated REG Ialpha protein expression in early gastric cancers, and ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2004.12.045

    authors： Sekikawa A,Fukui H,Fujii S,Takeda J,Nanakin A,Hisatsune H,Seno H,Takasawa S,Okamoto H,Fujimori T,Chiba T

    更新日期：2005-03-01 00:00:00

  • Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome.

    abstract：BACKGROUND & AIMS:Hereditary colorectal cancer is associated most commonly with the hereditary nonpolyposis colorectal cancer or familial adenomatous polyposis syndromes. We investigated the prevalence of early onset colorectal cancer and the frequency of p53 germline mutations in 64 families from a Li-Fraumeni syndrom...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2005.10.014

    authors： Wong P,Verselis SJ,Garber JE,Schneider K,DiGianni L,Stockwell DH,Li FP,Syngal S

    更新日期：2006-01-01 00:00:00

  • Human mucosal T-cell cytotoxicity.

    abstract：:Non-major histocompatibility complex-restricted cytotoxicity triggered by antibodies to the CD3 component of the human T-cell receptor complex is thought to be an indirect measure of in vivo primed cytotoxic T-cell activity. We have used this technique to examine the lytic activity of freshly isolated T cells from non...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(88)90554-9

    authors： Shanahan F,Deem R,Nayersina R,Leman B,Targan S

    更新日期：1988-04-01 00:00:00

  • Alterations in vesicle transport and cell polarity in rat hepatocytes subjected to mechanical or chemical cholestasis.

    abstract：BACKGROUND & AIMS:The molecular mechanisms that contribute to the cholestatic condition in hepatocytes are poorly defined. It has been postulated that a disruption of normal vesicle-based protein trafficking may lead to alterations in hepatocyte polarity. METHODS:To determine if vesicle motility is reduced by cholesta...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.28652

    authors： Török NJ,Larusso EM,McNiven MA

    更新日期：2001-11-01 00:00:00

  • Radioembolization results in longer time-to-progression and reduced toxicity compared with chemoembolization in patients with hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:Chemoembolization is one of several standards of care treatment for hepatocellular carcinoma (HCC). Radioembolization with Yttrium-90 microspheres is a novel, transarterial approach to radiation therapy. We performed a comparative effectiveness analysis of these therapies in patients with HCC. METHOD...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.10.049

    authors： Salem R,Lewandowski RJ,Kulik L,Wang E,Riaz A,Ryu RK,Sato KT,Gupta R,Nikolaidis P,Miller FH,Yaghmai V,Ibrahim SM,Senthilnathan S,Baker T,Gates VL,Atassi B,Newman S,Memon K,Chen R,Vogelzang RL,Nemcek AA,Resnick SA

    更新日期：2011-02-01 00:00:00

  • Guaran effect on rat intestinal absorption. A perfusion study.

    abstract：:Among the components of dietary fiber, the soluble polysaccharides, primarily guaran and pectin, have been found to impair intestinal absorption. Little is known, however, about the mechanism of this effect. The direct action of guaran on small intestinal absorption was evaluated by a single-pass perfusion technique. ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Elsenhans B,Zenker D,Caspary WF

    更新日期：1984-04-01 00:00:00

  • Benign recurrent intrahepatic cholestasis: treatment with S-adenosylmethionine.

    abstract：:S-Adenosylmethionine (800 mg i.v. per day) was used to treat two brothers and a brother and sister from each of two kindreds with benign recurrent intrahepatic cholestasis. Symptoms, routine tests of liver function, concentrations of total bile acids, and the oral clearances of [11,12-2H]chenodeoxycholic acid and [24-...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(89)80024-1

    authors： Everson GT,Ahnen D,Harper PC,Krawitt EL

    更新日期：1989-05-01 00:00:00

  • Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E.

    abstract：BACKGROUND & AIMS:Confocal laser endomicroscopy (CLE) is a technique that permits real-time detection and quantification of changes in intestinal tissues and cells, including increases in intraepithelial lymphocytes and fluid extravasation through epithelial leaks. Using CLE analysis of patients with irritable bowel sy...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2019.03.046

    authors： Fritscher-Ravens A,Pflaum T,Mösinger M,Ruchay Z,Röcken C,Milla PJ,Das M,Böttner M,Wedel T,Schuppan D

    更新日期：2019-07-01 00:00:00