Rotaviruses: from pathogenesis to vaccination.

abstract：BACKGROUND & AIMS:We previously isolated a monoclonal antibody against a Necturus gallbladder epitope that blocks native adenosine 3',5'-cyclic monophosphate (cAMP)-dependent chloride channels in intestine, gallbladder, urinary bladder, and airway epithelia in various animals. METHODS:Using this antibody, we purified ...

journal_title：Gastroenterology

authors： Finn AL,Kuzhikandathil EV,Oxford GS,Itoh-Lindstrom Y

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND & AIMS:Based on experimental and epidemiologic studies, we investigated whether coffee and caffeine consumption reduced the risk of elevated alanine aminotransferase (ALT) activity in persons at high risk for liver injury in a national, population-based study. METHODS:Participants were 5944 adults in the Th...

journal_title：Gastroenterology

authors： Ruhl CE,Everhart JE

更新日期：2005-01-01 00:00:00

abstract：:The purpose of this study was to determine whether gamma-hydroxybutyrate provides protection against intestinal ischemia/reperfusion injury and to compare its effect with that of allopurinol and vitamin E. Thirty minutes of total regional ischemia, followed by 3 hours of reperfusion, produced intestinal damage that wa...

journal_title：Gastroenterology

authors： Boyd AJ,Sherman IA,Saibil FG,Mamelak M

更新日期：1990-09-01 00:00:00

abstract：:Spinal cord stimulation is an increasingly popular form of pain treatment. An electrode positioned on the dorsal aspect of the spinal cord at the level of the nerve roots from the painful area stimulates the spinal cord. Current from the electrode is supplied by a pulse generator in the lower anterior abdominal wall. ...

journal_title：Gastroenterology

authors： Kemler MA,Barendse GA,Van Kleef M

更新日期：1999-07-01 00:00:00

abstract：:A case of a 41-year-old man with diarrhea, hypoalbuminemia, and cryptogenic cirrhosis with features of portal hypertension is described. Protein-losing enteropathy was confirmed by analysis of whole-gut lavage fluid, and intestinal inflammation and infection were excluded. Distal duodenal biopsy specimens showed evide...

journal_title：Gastroenterology

authors： Stanley AJ,Gilmour HM,Ghosh S,Ferguson A,McGilchrist AJ

更新日期：1996-12-01 00:00:00

abstract：:A multicenter study was conducted on 173 patients with active, endoscopically proven duodenal ulcers (158 men, 15 women). They were randomly assigned, in a double-blind manner, to two groups: those receiving placebo capsules (91 patients) and those receiving capsules containing 100 microgram of 15(R)-15-methyl prostag...

journal_title：Gastroenterology

authors： Vantrappen G,Janssens J,Popiela T,Kulig J,Tytgat GN,Huibregtse K,Lambert R,Pauchard JP,Robert A

更新日期：1982-08-01 00:00:00

abstract：:An animal model for giardiasis was developed using Giardia muris in Swiss albino mice. Intraesophageal inoculation of G. muris cysts caused a reproducible pattern of infection, with trophozoite and cyst counts reaching a maximum on days 5 to 14 after cyst inoculation and thereafter showing a progressive decline. Spont...

journal_title：Gastroenterology

authors： Roberts-Thomson IC,Stevens DP,Mahmoud AA,Warren KS

更新日期：1976-07-01 00:00:00

abstract：:In a series of in vitro studies, both the soluble (plasmatic) coagulation system and the cellular (platelet-mediated) aspect of coagulation were shown to be extremely sensitive to relatively minor increases in hydrogen ion concentration. All studies became abnormal at pH 6.8. At pH 6.4, assays of the intrinsic and ext...

journal_title：Gastroenterology

authors： Green FW Jr,Kaplan MM,Curtis LE,Levine PH

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND & AIMS:The majority of patients with Helicobacter pylori infection have autoantibodies cross-reacting with gastric antigens. In this study, the relation between autoantibody status, histopathology of body mucosa, and antigenic profile of H. pylori was investigated. METHODS:One hundred patients were examined...

journal_title：Gastroenterology

authors： Negrini R,Savio A,Poiesi C,Appelmelk BJ,Buffoli F,Paterlini A,Cesari P,Graffeo M,Vaira D,Franzin G

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Over 60 studies have addressed the hypothesis that the risk of colorectal cancer is increased following cholecystectomy; these studies have yielded inconsistent findings. The aim of the present study was to quantitatively summarize the results from the collective studies. METHODS:A meta-analysis of the publ...

journal_title：Gastroenterology

authors： Giovannucci E,Colditz GA,Stampfer MJ

更新日期：1993-07-01 00:00:00

abstract：:Chlorpromazine (CPZ) is a long recognized cause of jaundice, but the mechanism by which this agent produces icteric liver disease is not well defined. This study examined some effects of CPZ administration on bilirubin metabolism and biliary secretion in the rat. Acute CPZ treatment (25 mg per kg intravenously) produc...

journal_title：Gastroenterology

authors： Knodell RG

更新日期：1975-10-01 00:00:00

abstract：:The purpose of the study was to determine (a) the frequency and cause of mortality in patients with chronic pancreatitis; (b) the cumulative survival rates corrected by comparison of patients with a matched French population; and (c) the factors associated with mortality by a unidimensional and multidimensional analys...

journal_title：Gastroenterology

authors： Levy P,Milan C,Pignon JP,Baetz A,Bernades P

更新日期：1989-04-01 00:00:00

abstract：:The importance of cholecystectomy as a risk factor for colorectal cancer was analyzed in an historical cohort study covering 16,773 cases during 11-14 years completed after operation. The observed number of colorectal cancers (130) was lower than the expected 153.5 [relative risk (RR) = 0.85]. For cancer of the colon,...

journal_title：Gastroenterology

authors： Adami HO,Meirik O,Gustavsson S,Nyrén O,Krusemo UB

更新日期：1983-10-01 00:00:00

abstract：:In this review, we compared the outcome of 25 studies of experimentally induced pancreatitis in animals with 13 studies of human acute pancreatitis in which the same therapeutic agents were used (aprotinin, glucagon, 5-fluorouracil, somatostatin, peritoneal lavage). Whereas 81% of the animal studies had a positive out...

journal_title：Gastroenterology

authors： Steinberg WM,Schlesselman SE

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND & AIMS:This study attempts to elucidate a part of the genetic predisposition to the sporadic invasive ductal adenocarcinoma of the pancreas focusing on the genes implicated in the gene-environment interactions in carcinogenesis. METHODS:First, 227 single nucleotide polymorphisms (SNPs) of 46 genes were geno...

journal_title：Gastroenterology

authors： Ohnami S,Sato Y,Yoshimura K,Ohnami S,Sakamoto H,Aoki K,Ueno H,Ikeda M,Morizane C,Shimada K,Sakamoto Y,Esaki M,Saito I,Hirose H,Saito D,Sugimura H,Kosuge T,Okusaka T,Yoshida T

更新日期：2008-08-01 00:00:00

abstract：:The ability of hypnosis to both stimulate and inhibit gastric acid secretion in highly hypnotizable healthy volunteers was examined in two studies. In the first, after basal acid secretion was measured, subjects were hypnotized and instructed to imagine all aspects of eating a series of delicious meals. Acid output ro...

journal_title：Gastroenterology

authors： Klein KB,Spiegel D

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND & AIMS:Studies of hepatitis C virus (HCV) infection, immunopathogenesis, and resulting liver diseases have been hampered by the lack of a small animal model. We developed humanized mice with human immune system and liver tissues to improve the studies of hepatitis C virus pathogenesis and treatment. METHODS...

journal_title：Gastroenterology

authors： Washburn ML,Bility MT,Zhang L,Kovalev GI,Buntzman A,Frelinger JA,Barry W,Ploss A,Rice CM,Su L

更新日期：2011-04-01 00:00:00

abstract：:It has been suggested that the lower esophageal sphincter (LES) plays an important role in preventing gastroesophageal reflux. This study was designed to determine if abolition of the LES alone is sufficient to induce gastroesophageal reflux and esophagitis. Studies were performed in the Australian brush-tailed possum...

journal_title：Gastroenterology

authors： De Carle DJ

更新日期：1975-09-01 00:00:00

abstract：:The transport of folic acid was investigated in organ-cultured endoscopic biopsy specimens of intestinal mucosa from normal subjects. In the proximal small intestine at pH 5.5 and 6.5, [3H]folic acid accumulated to concentrations 2.64- and 2.17-fold higher than those of the medium, respectively, but at pH 7.5 the conc...

journal_title：Gastroenterology

authors： Zimmerman J

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:To date, the potential effects of free radicals on the activities of intestinal brush-border membrane enzymes have received little attention. Therefore, we conducted a series of experiments to examine the effects of free radicals on various enzymatic activities of rat small intestinal brush-border membranes....

journal_title：Gastroenterology

authors： Dudeja PK,Brasitus TA

更新日期：1993-08-01 00:00:00

abstract：:The effect of deoxycholate ingestion, 750 mg per day, on bile acid kinetics, biliary bile acid composition, and biliary lipid secretion was studied in 7 healthy volunteers. Bile acid kinetics were measured by isotope dilution, and hourly outputs of bile acid, cholesterol, and phospholipid were quantitated by a duodena...

journal_title：Gastroenterology

authors： LaRusso NF,Szczepanik PA,Hofmann AF

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Earlier studies have suggested that patients with hemochromatosis have poor post-transplantation survival. We aimed to compare patients with hemochromatosis to those with other causes of liver disease with regard to post-transplantation survival. METHODS:We compared the post-transplant survival of ...

journal_title：Gastroenterology

authors： Yu L,Ioannou GN

更新日期：2007-08-01 00:00:00

abstract：:Using in vivo and in vitro techniques, the mechanism by which intestinal mucosa obtains glutamine from luminal oligopeptides was investigated in humans. The rate of hydrolysis by mucosal brush border membrane was more than threefold greater for alanylglutamine than for glycylglutamine. Despite this difference, rates o...

journal_title：Gastroenterology

authors： Minami H,Morse EL,Adibi SA

更新日期：1992-07-01 00:00:00

abstract：:A patient with a macroamylase in pleural fluid is described. A diagnosis of recurrent pleural effusion due to chronic relapsing pancreatitis had been made on the basis of hyperamylasemia, high pleural fluid amylase, and abdominal pain. The amylase in the pleural fluid as well as the serum was ultimately characterized ...

journal_title：Gastroenterology

authors： Zimmerman HM,Bank S,Buch P,Katzka I,Lendvai S

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND & AIMS:There is no clear and point for the response to treatment of gastrointestinal human cytomegalovirus (HCMV) disease. HCMV-DNA quantitation on gastrointestinal biopsy specimens has proven its value for the diagnosis of gastrointestinal HCMV disease in patients with acquired immunodeficiency syndrome (AI...

journal_title：Gastroenterology

authors： Cotte L,Drouet E,Bailly F,Vitozzi S,Denoyel G,Trepo C

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND & AIMS:Substance P, a member of the tachykinin family, is a prosecretory neuropeptide distributed widely throughout the enteric nervous system. Implicated in inflammatory states, its role in enterotoxigenic water and electrolyte secretion is unclear. We assessed the effect of substance P antagonists and neur...

journal_title：Gastroenterology

authors： Turvill JL,Connor P,Farthing MJ

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND & AIMS:Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair gene mutations that define this syndrome and result in microsatellite instability (MSI). The carcinogenic path...

journal_title：Gastroenterology

authors： Goel A,Xicola RM,Nguyen TP,Doyle BJ,Sohn VR,Bandipalliam P,Rozek LS,Reyes J,Cordero C,Balaguer F,Castells A,Jover R,Andreu M,Syngal S,Boland CR,Llor X

更新日期：2010-05-01 00:00:00

abstract：:Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is typically characterized by episodic fever, myalgia, skin rash, conjunctivitis, and abdominal cramps. Recently, mutations in the TNFRSF1A gene on chromosome 12p13 encoding tumor necrosis factor receptor type 1 have been linked to this autoinflammato...

journal_title：Gastroenterology

authors： Haas SL,Lohse P,Schmitt WH,Hildenbrand R,Karaorman M,Singer MV,Böcker U

更新日期：2006-01-01 00:00:00

abstract：:One hundred Chinese patients who received induction cytotoxic therapy for malignant lymphoma were prospectively studied to determine the incidence, morbidity, mortality, and predisposing factors for reactivation of hepatitis B virus replication during cytotoxic therapy. In 18 (67%) hepatitis B surface antigen-positive...

journal_title：Gastroenterology

authors： Lok AS,Liang RH,Chiu EK,Wong KL,Chan TK,Todd D

更新日期：1991-01-01 00:00:00

abstract：:A 14-yr-old girl presented with long-standing symptoms of partial gastric outlet obstruction due to an antral mucosal diaphragm that had a central aperture of 4-5 mm. The literature of this congenital malformation is reviewed with respect to diagnostic criteria and feasibility of endoscopic transection. The procedure ...

journal_title：Gastroenterology

authors： Berr F,Rienmueller R,Sauerbruch T

更新日期：1985-11-01 00:00:00