Experimental gastroesophageal reflux in the Australian brush-tailed possum.

abstract：BACKGROUND:Malnutrition is common in alcoholic cirrhosis. Bedside nutritional assessment techniques may be unreliable in patients with chronic liver disease. The aim of this study was to quantify changes in body composition and compare methods for measuring body composition in alcoholic cirrhosis. METHODS:Thirty-eight...

journal_title：Gastroenterology

authors： Prijatmoko D,Strauss BJ,Lambert JR,Sievert W,Stroud DB,Wahlqvist ML,Katz B,Colman J,Jones P,Korman MG

更新日期：1993-12-01 00:00:00

abstract：:Decreases in arterial pH markedly increase sodium, chloride, and water absorption in the normal ileum and can reverse ongoing cholera toxin-induced secretion. In the current study we examined whether these effects of pH are evident in other models of ileal secretion, and in a model of increased absorption. Rats were a...

journal_title：Gastroenterology

authors： Charney AN,Ingrassia PM,Thaler SM,Keane MG

更新日期：1989-02-01 00:00:00

abstract：:Thirty-five 1-day-old Pekin-Aylesbury ducks were inoculated intravenously or intraperitoneally with duck hepatitis B virus, and the time-course of infection was examined by Southern-blot, dot-blot, and in situ hybridization and by immunohistochemistry. Randomly scattered single infected hepatocytes were first seen on ...

journal_title：Gastroenterology

authors： Jilbert AR,Freiman JS,Burrell CJ,Holmes M,Gowans EJ,Rowland R,Hall P,Cossart YE

更新日期：1988-11-01 00:00:00

abstract：:The purpose of this study was to determine whether gamma-hydroxybutyrate provides protection against intestinal ischemia/reperfusion injury and to compare its effect with that of allopurinol and vitamin E. Thirty minutes of total regional ischemia, followed by 3 hours of reperfusion, produced intestinal damage that wa...

journal_title：Gastroenterology

authors： Boyd AJ,Sherman IA,Saibil FG,Mamelak M

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND & AIMS:beta3 Adrenoceptor (beta3-AR) is expressed on adipocytes and enteric neurons. GW427353 is a human selective beta3-AR agonist with visceral analgesic effects. Some of its effects may involve release of somatostatin (SST) and actions on enteric neurons. The aim of this study was to investigate the mode ...

journal_title：Gastroenterology

authors： Schemann M,Hafsi N,Michel K,Kober OI,Wollmann J,Li Q,Zeller F,Langer R,Lee K,Cellek S

更新日期：2010-01-01 00:00:00

abstract：:Two patients developed local gangrene after subcutaneous infiltration of vasopressin (Pitressin, Parke, Davis & Company, Detroit, Mich.) utilized for the control of bleeding from esophageal varices. In the 1st patient, ischemic gangrene resulted in transmetatarsal amputation and also necessitated skin grafts on the fo...

journal_title：Gastroenterology

authors： Greenwald RA,Rheingold OJ,Chiprut RO,Rogers AI

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND & AIMS:In human and canine colon, both slow (slow waves, 2-8/min) and fast (myenteric potential oscillations [MPOs]; 16-20/min) electrical rhythms in the smooth muscle originate at the submucosal and myenteric borders, respectively. We used Ca(2+) imaging to investigate whether interstitial cells of Cajal (I...

journal_title：Gastroenterology

authors： Lee HT,Hennig GW,Park KJ,Bayguinov PO,Ward SM,Sanders KM,Smith TK

更新日期：2009-06-01 00:00:00

abstract：:Abdominal cramps and urgent defecation are common side effects of clinical doses of arginine vasopressin, indicating that the drug may have stimulating effects on colonic motor activity. Four strain-gauge transducers were implanted on the colon in six monkeys. A blood flow probe was fixed on the inferior mesenteric ar...

journal_title：Gastroenterology

authors： Zhu YR,Cowles VE,Herranz ES,Schulte WJ,Condon RE

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary epithelial cells are the target of numerous immune-mediated liver diseases, yet their role in pathogenesis remains unclear because of difficulties in obtaining pure preparations. The aim of this study was to establish pure clones of immortalized murine intrahepatic biliary epithelial cells. M...

journal_title：Gastroenterology

authors： Paradis K,Le ON,Russo P,St-Cyr M,Fournier H,Bu D

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND & AIMS:The characteristics of colonic circular smooth muscle slow waves are altered during inflammation. The aim of this study was to examine whether inflammation modulates the open-state probability of Ca2+-activated K+ (KCa) channels in these cells to contribute to these alterations. METHODS:The experimen...

journal_title：Gastroenterology

authors： Lu G,Mazet B,Sun C,Qian X,Johnson CP,Adams MB,Roman RJ,Sarna SK

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND & AIMS:Activated pancreatic stellate cells have recently been implicated in pancreatic fibrogenesis. This study examined the role of pancreatic stellate cells in alcoholic pancreatic fibrosis by determining whether these cells are activated by ethanol itself and, if so, whether such activation is caused by t...

journal_title：Gastroenterology

authors： Apte MV,Phillips PA,Fahmy RG,Darby SJ,Rodgers SC,McCaughan GW,Korsten MA,Pirola RC,Naidoo D,Wilson JS

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive and metastatic disease for which conventional treatments are of limited efficacy. A number of agents in development are potential anti-invasive and antimetastatic agents, including the Src kinase inhibitor dasatinib. The aim of this study wa...

journal_title：Gastroenterology

authors： Morton JP,Karim SA,Graham K,Timpson P,Jamieson N,Athineos D,Doyle B,McKay C,Heung MY,Oien KA,Frame MC,Evans TR,Sansom OJ,Brunton VG

更新日期：2010-07-01 00:00:00

abstract：:To clarify the intracellular distribution of myosin in normal rat hepatocytes and its alterations in phal-loidin-treated rat hepatocytes as a morphologic basis for the dysfunction of microfilaments, we performed indirect immunofluorescence using monospecific antibody raised against rat hepatocyte myosin. Cryostat rat ...

journal_title：Gastroenterology

authors： Yasuura S,Ueno T,Watanabe S,Hirose M,Namihisa T

更新日期：1989-10-01 00:00:00

abstract：:The effect of secretin5-27 and four substituted analogues (9 Gln-secretin5-27, 15-Asn-secretin5-27, 9-Gln-15-Asn-secretin5-27, and 15-Lys-secretin5-27) on pancreatic secretion in the rat and guinea pig was examined. Secretin5-27 retained significant pancreatic secretory activity in both species. Its efficacy (intrinsi...

journal_title：Gastroenterology

authors： Makhlouf GM,Bodanszky M,Fink ML,Schebalin M

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND & AIMS:The risk of colorectal neoplasms among siblings of patients with advanced adenomas is not clear. We determined the prevalence of advanced adenomas in the siblings of patients with advanced adenomas and compared it with that of siblings of individuals without these lesions. METHODS:In a blinded, cross...

journal_title：Gastroenterology

authors： Ng SC,Lau JY,Chan FK,Suen BY,Tse YK,Hui AJ,Leung-Ki EL,Ching JY,Chan AW,Wong MC,Ng SS,To KF,Wu JC,Sung JJ

更新日期：2016-03-01 00:00:00

abstract：:The goal of this study was to identify the structural and compositional features of human gallstones that influence in vitro gallstone dissolution in the cholesterol solvent monooctanoin. Gallstones were obtained from 86 consecutive patients who had at least three morphologically similar stones. One stone from each pa...

journal_title：Gastroenterology

authors： Smith BF

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:There is a significant interobserver and intraobserver variation in grading dysplasia in Barrett's metaplasia. New markers are needed to optimize the assessment of potential risk of cancer development in these patients. The aim of this study is to explore the use of p53 as a marker of neoplastic progression ...

journal_title：Gastroenterology

authors： Younes M,Lebovitz RM,Lechago LV,Lechago J

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic steatosis is frequent in chronic hepatitis C. Several mechanisms might be implicated, including metabolic cofactors and direct viral effects on intracellular lipid pathways. In a transgenic mouse model, hepatitis C virus (HCV) was shown to inhibit microsomal triglyceride transfer protein (MTP)...

journal_title：Gastroenterology

authors： Mirandola S,Realdon S,Iqbal J,Gerotto M,Dal Pero F,Bortoletto G,Marcolongo M,Vario A,Datz C,Hussain MM,Alberti A

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND & AIMS:Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by dense tissue eosinophilia; it is refractory to proton pump inhibitor therapy. EoE affects all age groups but most frequently individuals between 20 and 50 years of age. Topical corticosteroids are effect...

journal_title：Gastroenterology

authors： Straumann A,Conus S,Degen L,Felder S,Kummer M,Engel H,Bussmann C,Beglinger C,Schoepfer A,Simon HU

更新日期：2010-11-01 00:00:00

abstract：:Biofeedback has been advocated as first-line therapy for patients whose symptoms of mild to moderate fecal incontinence have not responded to simple dietary advice or medication. Three main modalities have been described: (1) use of an intra-anal electromyographic sensor, a probe to measure intra-anal pressure, or per...

journal_title：Gastroenterology

authors： Norton C

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND & AIMS:Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Elevated 5-HT levels are associated with diarrheal conditions such as irritable bowel syndrome and enteric infections. Whether alteration in SERT activity contributes to the...

journal_title：Gastroenterology

authors： Esmaili A,Nazir SF,Borthakur A,Yu D,Turner JR,Saksena S,Singla A,Hecht GA,Alrefai WA,Gill RK

更新日期：2009-12-01 00:00:00

abstract：:Ileal Na+-dependent bile acid transport was quantified in vitro as the uptake of 3H-taurocholate into brush-border membrane vesicles. Vesicles were prepared from ileal biopsies of 158 patients placed in 10 diagnostic categories. Active bile acid transport (expressed as picomoles taurocholate uptake per milligram brush...

journal_title：Gastroenterology

authors： van Tilburg AJ,de Rooij FW,van Blankenstein M,van den Berg JW,Bosman-Jacobs EP

更新日期：1990-01-01 00:00:00

abstract：:The effect of experimental bypass on the intestinal epithelium of the rat was investigated from 2 to 360 days after creating a Thiry-Vella fistula. Within 7 to 14 days the number of cells per villus column and, to a lesser degree, the number of cells per crypt column decreased and subsequently these values remained co...

journal_title：Gastroenterology

authors： Rijke RP,Plaisier HM,de Ruiter H,Galjaard H

更新日期：1977-05-01 00:00:00

abstract：:The effects of a variety of substances influencing the initiation of cyclic motor events at the gastroduodenal junction were studied in conscious sheep. A significant and long-lasting decrease in the frequency of cyclic events from approximately 100 min to 30-40 min was elicited by the intraduodenal bulb administratio...

journal_title：Gastroenterology

authors： Ruckebusch Y

更新日期：1984-11-01 00:00:00

abstract：:Intracellular microelectrodes were used to evaluate electrical properties of the cell membranes in Necturus antral mucosa during exposure to luminal acid alone (pH 4) or to 5 mmol/L aspirin [acetylsalicylic acid (ASA)] in the presence of luminal acid. When nutrient solutions were buffered by HCO3- (pH 7.3), ASA modera...

journal_title：Gastroenterology

authors： Soybel DI,Davis MB,West AB

更新日期：1992-11-01 00:00:00

abstract：:The origin and neoplastic potential of gastric epithelial polyps remains an area of great interest, and treatment choices are a topic of controversy. This report describes a patient diagnosed with three concurrent hyperplastic gastric polyps that were studied for genetic alterations. The polyps were investigated for a...

journal_title：Gastroenterology

authors： Dijkhuizen SM,Entius MM,Clement MJ,Polak MM,Van den Berg FM,Craanen ME,Slebos RJ,Offerhaus GJ

更新日期：1997-02-01 00:00:00

abstract：:The cause of Ménétrier's disease is unknown, although allergic, autoimmune, and infectious, particularly viral, causes have been postulated. This case report describes a 3-year-old child with Ménétrier's disease in whom evidence of acute cytomegalovirus (CMV) infection was found. To our knowledge, this is the first ca...

journal_title：Gastroenterology

authors： Eisenstat DD,Griffiths AM,Cutz E,Petric M,Drumm B

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND & AIMS:Sjögren's syndrome and autoimmune pancreatitis are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. Nonobese diabetic/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren's syndrome and chronic pancreatitis and MRL/Mp mice are models of autoi...

journal_title：Gastroenterology

authors： Zeng M,Szymczak M,Ahuja M,Zheng C,Yin H,Swaim W,Chiorini JA,Bridges RJ,Muallem S

更新日期：2017-10-01 00:00:00

abstract：:The effect of continuous intraduodenal enteral nutrition on gastric pH was compared with the effects of fasting and of parenteral and standard nutrition control regimens containing equal amounts of carbohydrate, protein, and lipid. Eleven healthy volunteers underwent four 24-hour intragastric pH-metry studies; serum g...

journal_title：Gastroenterology

authors： Armstrong D,Castiglione F,Emde C,Cilluffo T,Duroux P,Koerfer J,Temler E,Lamers CB,Jansens JB,Blum AL

更新日期：1992-05-01 00:00:00

abstract：:Glycine protects renal tubule cells from cell death during adenosine triphosphate (ATP) depletion. Although the liver plays a key role in glycine metabolism, information is lacking regarding the effects of glycine on lethal hepatocellular injury. Thus, the aim of this study was to determine the potential cytoprotectiv...

journal_title：Gastroenterology

authors： Dickson RC,Bronk SF,Gores GJ

更新日期：1992-06-01 00:00:00