Abstract:
:Decreases in arterial pH markedly increase sodium, chloride, and water absorption in the normal ileum and can reverse ongoing cholera toxin-induced secretion. In the current study we examined whether these effects of pH are evident in other models of ileal secretion, and in a model of increased absorption. Rats were anesthetized and transport was measured in ileal loops during respiratory acidosis and alkalosis. Decreases in arterial pH increased absorption equally in control loops and in adjacent loops perfused with a Ringer's solution containing ST toxin (cyclic guanosine monophosphate-mediated secretion), hypertonic mannitol (passive, osmotically mediated secretion), or glucose. Decreases in arterial pH increased absorption in a similar way in loops exposed to cholera toxin (cyclic adenosine monophosphate-mediated secretion) that were then perfused with glucose-Ringer's solution. Alterations in arterial and luminal pH did not affect glucose absorption. These results suggest that the effect of arterial pH on ileal absorption occurs by a mechanism that is independent of these various means of altering transport.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Charney AN,Ingrassia PM,Thaler SM,Keane MGdoi
10.1016/0016-5085(89)91556-4subject
Has Abstractpub_date
1989-02-01 00:00:00pages
331-8issue
2 Pt 1eissn
0016-5085issn
1528-0012pii
0016-5085(89)91556-4journal_volume
96pub_type
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