Abstract：
BACKGROUND & AIMS:The characteristics of colonic circular smooth muscle slow waves are altered during inflammation. The aim of this study was to examine whether inflammation modulates the open-state probability of Ca2+-activated K+ (KCa) channels in these cells to contribute to these alterations. METHODS:The experiments were performed on freshly dissociated single smooth muscle cells from the canine colon using standard patch clamp methods. Inflammation was induced by mucosal exposure to ethanol and acetic acid. RESULTS:Inflammation decreased the open-state probability of large-conductance KCa (BK) channels in the cell-attached and excised inside-out configurations. The voltage sensitivity of the channels was also reduced during inflammation. Inflammation had no significant effect on the large, medium, and small conductances or the unitary current levels of channel openings. However, it decreased the maximum number of simultaneous channel openings. The channels were Ca2+-dependent and were blocked by tetraethylammonium and charybdotoxin in normal and inflamed cells. CONCLUSIONS:Inflammation decreases the open-state probability of BK channels. This may partially reverse the decrease in duration and amplitude of slow waves and depolarization of membrane potential seen in inflammation.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Lu G,Mazet B,Sun C,Qian X,Johnson CP,Adams MB,Roman RJ,Sarna SKdoi
10.1016/s0016-5085(99)70071-5keywords:
subject
Has Abstractpub_date
1999-04-01 00:00:00pages
884-92issue
4eissn
0016-5085issn
1528-0012pii
S0016508599006368journal_volume
116pub_type
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