Pancreatic secretory activity of secretin5-27 and substituted analogues.

abstract：:Canine jejunal epithelial cells were isolated and maintained in short-term culture to study cholecystokinin (CCK) release. Sequential digestion of jejunal mucosa with collagenase and ethylenediaminetetraacetic acid was followed by counterflow elutriation to enrich CCK-containing cells. After 40 hours in culture on col...

journal_title：Gastroenterology

authors： Koop I,Buchan AM

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND & AIMS:A previous 4-week trial of telbivudine in patients with chronic hepatitis B indicated marked antiviral effects with good tolerability, leading to the present 1-year phase 2b trial. METHODS:This randomized, double-blind, multicenter trial evaluated the efficacy and safety of telbivudine 400 or 600 mg/...

journal_title：Gastroenterology

authors： Lai CL,Leung N,Teo EK,Tong M,Wong F,Hann HW,Han S,Poynard T,Myers M,Chao G,Lloyd D,Brown NA,Telbivudine Phase II Investigator Group.

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND & AIMS:Methionine adenosyltransferase (MAT) catalyzes S-adenosylmethionine biosynthesis. Two genes (MAT1A and MAT2A) encode for the catalytic subunit of MAT, while a third gene (MAT2beta) encodes for a regulatory subunit that modulates the activity of MAT2A-encoded isoenzyme. We uncovered multiple splicing v...

journal_title：Gastroenterology

authors： Yang H,Ara AI,Magilnick N,Xia M,Ramani K,Chen H,Lee TD,Mato JM,Lu SC

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND & AIMS:Previous studies indicated that the peptide neurotensin (NT) stimulates Cl(-) secretion in animal small intestinal mucosa in vitro. In this study, we investigated whether NT causes Cl(-) secretion in human colonic mucosa and examined the mechanism of this response. METHODS:Human mucosal preparations ...

journal_title：Gastroenterology

authors： Riegler M,Castagliuolo I,Wang C,Wlk M,Sogukoglu T,Wenzl E,Matthews JB,Pothoulakis C

更新日期：2000-08-01 00:00:00

abstract：DESCRIPTION:The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update is to review the available evidence and best practice advice statements regarding the use of endoscopic therapies in treating patients with non-variceal upper gastrointestinal bleeding. METHODS:This expert...

journal_title：Gastroenterology

authors： Mullady DK,Wang AY,Waschke KA

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND & AIMS:Conflicting results have been published concerning the effects of different opioid-receptor agonists against visceral noxious stimulation. The introduction of colorectal distention facilitates research in this field. The aim of this study was to examine intrathecally administered opioid agonists again...

journal_title：Gastroenterology

authors： Borgbjerg FM,Frigast C,Madsen JB,Mikkelsen LF

更新日期：1996-01-01 00:00:00

abstract：:To characterize gastric mucosal perfusion in cirrhotic patients with portal hypertensive gastropathy, 34 cirrhotics with this lesion and 24 noncirrhotics were studied by reflectance spectrophotometry and laser-Doppler flowmetry during endoscopy. A significant correlation was observed between the hemoglobin content of ...

journal_title：Gastroenterology

authors： Panés J,Bordas JM,Piqué JM,Bosch J,García-Pagán JC,Feu F,Casadevall M,Terés J,Rodés J

更新日期：1992-12-01 00:00:00

abstract：:The effects of some newly developed tachykinin antagonists that are selective for the neurokinin (NK)-1 (L 668,169) or the NK-2 (MEN 10,207, L 659,877 and R 396) tachykinin receptor on the cholinergic and noncholinergic contraction and on the nonadrenergic noncholinergic relaxation produced by electrical field stimula...

journal_title：Gastroenterology

authors： Maggi CA,Giuliani S,Patacchini R,Santicioli P,Theodorsson E,Barbanti G,Turini D,Giachetti A

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND & AIMS:Iron overload may cause or contribute to hepatic injury and fibrosis. Mutations in the HFE gene may influence development or progression of chronic liver disease by increasing iron stores or modulating immune responses. The aim of this work was to assess the influence of HFE mutations and serum and he...

journal_title：Gastroenterology

authors： Bonkovsky HL,Naishadham D,Lambrecht RW,Chung RT,Hoefs JC,Nash SR,Rogers TE,Banner BF,Sterling RK,Donovan JA,Fontana RJ,Di Bisceglie AM,Ghany MG,Morishima C,HALT-C Trial Group.

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND & AIMS:Early metastasis is a hallmark of pancreatic ductal adenocarcinoma and responsible for >90% of pancreatic cancer death. Because little is known about the biology and genetics of the metastatic process, we desired to elucidate molecular pathways mediating pancreatic cancer metastasis in vivo by an unbi...

journal_title：Gastroenterology

authors： von Burstin J,Eser S,Paul MC,Seidler B,Brandl M,Messer M,von Werder A,Schmidt A,Mages J,Pagel P,Schnieke A,Schmid RM,Schneider G,Saur D

更新日期：2009-07-01 00:00:00

abstract：:The prevalence of marginal zinc nutriture in several populations of people in this country and the lack of reports on the effect of marginal zinc nutriture in experimental animals prompted us to look at pancreatic acinar cell function and morphology in rats fed a zinc-deficient diet ad libitum: 4 and 50 ppm zinc-suppl...

journal_title：Gastroenterology

authors： Perez-Jimenez F,Bockman DE,Singh M

更新日期：1986-04-01 00:00:00

abstract：:Fifty consecutive patients with symptomatic endoscopically proven duodenal ulcer were randomized double-blind to Mylanta II or cimetidine treatment schedules. Smoking habits were noted, but patients were not advised to alter these. Healing was determined by reendoscopy at 6 wk. Eighty percent of patients on active cim...

journal_title：Gastroenterology

authors： Korman MG,Shaw RG,Hansky J,Schmidt GT,Stern AI

更新日期：1981-06-01 00:00:00

abstract：:Cell-mediated immunity is impaired during cholestasis, and there is evidence that bile acids play a role in this immune defect. Ursodeoxycholic acid (UDCA), which corrects the immunological abnormalities observed in primary biliary cirrhosis, could counter the detrimental effects of the endogenous bile acids. Accordin...

journal_title：Gastroenterology

authors： Calmus Y,Weill B,Ozier Y,Chéreau C,Houssin D,Poupon R

更新日期：1992-08-01 00:00:00

abstract：:To understand mechanisms of viral diarrhea further, we studied ileal ion transport in vitro in relation to mucosal changes and epithelial differentiation in transmissible gastroenteritis in piglets, an invasive viral enteritis thought to involve mainly proximal intestine. In infected pigs, at the height of diarrhea, s...

journal_title：Gastroenterology

authors： Shepherd RW,Gall DG,Butler DG,Hamilton JR

更新日期：1979-01-01 00:00:00

abstract：:A human colon cancer cell line, HCT-8, is shown to be an appropriate target cell for study of natural killer (NK) activity in man. In parallel experiments, effector cell characteristics for NK and antibody-dependent cellular cytotoxicity (ADCC) were found to be vested in a single lymphocyte subpopulation, which bore r...

journal_title：Gastroenterology

authors： Helms RA,Bull DM

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND & AIMS:The ubiquitous cross-linking enzyme tissue transglutaminase (TG2) has been implicated in irreversible collagen stabilization in liver fibrosis, although functional evidence is lacking. We studied the contribution of TG2 to hepatic fibrotic matrix stability, as well as liver fibrosis progression and re...

journal_title：Gastroenterology

authors： Popov Y,Sverdlov DY,Sharma AK,Bhaskar KR,Li S,Freitag TL,Lee J,Dieterich W,Melino G,Schuppan D

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND & AIMS:Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with constipation (IBS-C). Little is known about the mechanism by which linaclotide reduces abdominal pain in patients with IBS-C. METHODS:We determined t...

journal_title：Gastroenterology

authors： Castro J,Harrington AM,Hughes PA,Martin CM,Ge P,Shea CM,Jin H,Jacobson S,Hannig G,Mann E,Cohen MB,MacDougall JE,Lavins BJ,Kurtz CB,Silos-Santiago I,Johnston JM,Currie MG,Blackshaw LA,Brierley SM

更新日期：2013-12-01 00:00:00

abstract：:Regional differences in the esophageal distribution and clearance of refluxed gastric acid was studied in seven asymptomatic volunteers and seven patients with reflux esophagitis. Intraluminal pH was recorded for 3 postprandial hours from the distal, middle, and proximal esophagus on two separate occasions (with subje...

journal_title：Gastroenterology

authors： Shaker R,Dodds WJ,Helm JF,Kern MK,Hogan WJ

更新日期：1991-08-01 00:00:00

abstract：:We describe a novel "silvering" method to determine the surface area of nonspherical objects and have applied this method to human cholesterol gallstones. A standard curve is first constructed, using data obtained from the dissolution rates of silver-coated plastic spheres of known dimensions in unstirred thiosulfate-...

journal_title：Gastroenterology

authors： Park YH,Igimi H,Carey MC

更新日期：1982-11-01 00:00:00

abstract：:Sepsis, peritonitis, and gastroenteritis developed in a 45-yr-old homosexual man 1 day after ingestion of raw oysters. The patient had chronic active hepatitis and cirrhosis with hepatitis B virus and delta-infection. He also had persistent generalized lymphadenopathy associated with HTLV-III antibody positivity. Vibr...

journal_title：Gastroenterology

authors： Chin KP,Lowe MA,Tong MJ,Koehler AL

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND/AIMS:Gastrointestinal peptides and biogenic monoamines participate in the regulation of gastrointestinal functions. The aim of this study was to examine the influence of the microflora on the distribution of endocrine cells and on the release of gastrointestinal peptides. METHODS:A quantitative morphologica...

journal_title：Gastroenterology

authors： Uribe A,Alam M,Johansson O,Midtvedt T,Theodorsson E

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND & AIMS:Omeprazole is metabolized by cytochrome P450 (CYP2C19). The activity of this enzyme is polymorphic, with incidences of poor metabolizers (PMs), heterozygous extensive metabolizers (EMs), and homozygous EMs in white populations of 3%, 30%, and 67%, respectively. The importance of the CYP2C19 polymorphi...

journal_title：Gastroenterology

authors： Sagar M,Tybring G,Dahl ML,Bertilsson L,Seensalu R

更新日期：2000-09-01 00:00:00

abstract：:In vivo and in vitro ultrasonic characteristics of gallstones were compared with stone size and composition with the aim of understanding the basis for these features. In vivo and in vitro ultrasonic features of the same stone were identical. Acoustic shadowing was not due to stone type, radiodensity, or calcium conte...

journal_title：Gastroenterology

authors： Good LI,Edell SL,Soloway RD,Trotman BW,Mulhern C,Arger PA

更新日期：1979-08-01 00:00:00

abstract：:Radioactive lithocholate was administered intravenously to female rhesus monkeys with an exteriorized enterohepatic circulation, and the chemical form of biliary radioactivity was defined by thin layer chromatography. Most radioactivity was excreted in bile in the form of unsulfated conjugates (77%), indicating impair...

journal_title：Gastroenterology

authors： Gadacz TR,Allan RN,Mack E,Hofmann AF

更新日期：1976-06-01 00:00:00

abstract：:The effects of chronic mild restraint on the susceptibility of the rat gastric mucosa to ethanol or cold-restraint injury were studied. Gastric mucosas of animals subjected to chronic mild restraint exhibited less damage when bathed with 40% ethanol than those of control animals. This reduced damage was observed with ...

journal_title：Gastroenterology

authors： Wallace JL,Track NS,Cohen MM

更新日期：1983-08-01 00:00:00

abstract：:Three analogues of the carboxyl-terminal tricosapeptide of secretin (S5-27), one with glutamine replacing glutamic acid in position 9 (9-Gln-S5-27), a second with asparagine substituted for aspartic acid in position 15 (15-Asn-S5-27), and a third with both replacements (9-Gln-15-Asn-S5-27) were tested for their abilit...

journal_title：Gastroenterology

authors： Gardner JD,Conlon TP,Fink ML,Bodanszky M

更新日期：1976-12-01 00:00:00

abstract：:Serum group I pepsinogen (PG I) levels have been determined before and at intervals after the administration of betazole hydrochloride (Histalog) in 50 symptomatic postoperative patients, 20 with and 30 without recurrent ulcer, after either a vagotomy and gastric resection or a drainage procedure. In patients with rec...

journal_title：Gastroenterology

authors： Samloff IM,Secrist DM,Passaro E Jr

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND & AIMS:We recently showed that dietary supplementation with an analogue of 1alpha,25-dihydroxy-vitamin D3, 1alpha,25-dihydroxy-16-ene-23-yne-26,27 F6-vitamin D3 (RO24-5531), reduced the incidence of colonic tumors in rats treated with azoxymethane (AOM). The aim of this study was to determine whether alterat...

journal_title：Gastroenterology

authors： Wali RK,Bissonnette M,Khare S,Aquino B,Niedziela S,Sitrin M,Brasitus TA

更新日期：1996-07-01 00:00:00

abstract：:The relationship between renal tubular acidosis (RTA) and copper metabolism has been investigated in a group of 18 patients with primary biliary cirrhosis. RTA, considered when urinary pH remained above 5.4 after an oral load of ammonium chloride of 0.1 g/kg body wt, was found in 6 patients (33%). Plasma copper concen...

journal_title：Gastroenterology

authors： Parés A,Rimola A,Bruguera M,Mas E,Rodés J

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND & AIMS:The mammalian small intestine is lined by a highly specialized epithelium that functions in the digestion and absorption of nutrients. The molecular mechanisms that direct intestinal epithelial cell morphogenesis and terminal differentiation are poorly understood. We have previously identified Elf3 (E...

journal_title：Gastroenterology

authors： Ng AY,Waring P,Ristevski S,Wang C,Wilson T,Pritchard M,Hertzog P,Kola I

更新日期：2002-05-01 00:00:00