Regional esophageal distribution and clearance of refluxed gastric acid.

abstract：:A case of primary undifferentiated sarcoma of the liver in a 66-year-old woman is reported. The similarity of the presenting symptoms to those of a hepatic abscess is emphasized. The patient's response to palliative treatment by means of hepatic artery ligation and chemotherapy was excellent. We believe that this is t...

journal_title：Gastroenterology

authors： Tanner AR,Bolton PM,Powell LW

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Several studies suggest that statins prevent some cancers, with one study finding a 47% reduction in colorectal cancer risk after >or=5 years of regular use. METHODS:A nested case-control study was conducted within 454 general practices in the United Kingdom using the QRESEARCH database. Cases with...

journal_title：Gastroenterology

authors： Vinogradova Y,Hippisley-Cox J,Coupland C,Logan RF

更新日期：2007-08-01 00:00:00

abstract：:The human gut microbiome is a collection of bacteria, protozoa, fungi, and viruses that coexist in our bodies and are essential in protective, metabolic, and physiologic functions of human health. Gut dysbiosis has traditionally been linked to increased risk of infection, but imbalances within the intestinal microbial...

journal_title：Gastroenterology

authors： Haran JP,McCormick BA

更新日期：2021-01-01 00:00:00

abstract：:This report describes a 59-year-old woman, who, after an initial reaction to hydralazine, inadvertently took the drug again. She promptly developed symptoms of acute cholangitis--fever, right upper quadrant tenderness, obtundation, and hypotension. Cholecystectomy was performed and no obstruction or infection of the b...

journal_title：Gastroenterology

authors： Myers JL,Augur NA Jr

更新日期：1984-11-01 00:00:00

abstract：:Neuron specific enolase, the most acidic isoenzyme of the glycolytic enzyme enolase, was first believed to be present exclusively in central neurons. More recently, it has been found in peripheral autonomic nerves and in a number of endocrine cells. An immunocytochemical study was carried out concerning the distributi...

journal_title：Gastroenterology

authors： Bishop AE,Polak JM,Facer P,Ferri GL,Marangos PJ,Pearse AG

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND & AIMS:To elucidate the survival of the patients with unresectable hepatocellular carcinoma (HCC) who underwent transcatheter arterial lipiodol chemoembolization (TACE) and to analyze the factors affecting the survivals. METHODS:During the last 8 years, a nationwide prospective cohort study was performed in...

journal_title：Gastroenterology

authors： Takayasu K,Arii S,Ikai I,Omata M,Okita K,Ichida T,Matsuyama Y,Nakanuma Y,Kojiro M,Makuuchi M,Yamaoka Y,Liver Cancer Study Group of Japan.

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND & AIMS:The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS:Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structu...

journal_title：Gastroenterology

authors： Lerat H,Honda M,Beard MR,Loesch K,Sun J,Yang Y,Okuda M,Gosert R,Xiao SY,Weinman SA,Lemon SM

更新日期：2002-02-01 00:00:00

abstract：:Basal lower esophageal sphincter (LES) pressure was measured in 6 patients with the Zollinger-Ellison syndrome (ZES) and hypergastrinemia, and in 6 patients with duodenal ulcer and normogastrinemia. Basal LES pressure in ZES patients, 17.0 +/- 3.7 (mean +/- SE) mm Hg was similar to basal LES pressure in duodenal ulcer...

journal_title：Gastroenterology

authors： Snyder N,Hughes W

更新日期：1977-06-01 00:00:00

abstract：:To explore the metabolic aspects of chronic liver disease, diurnal changes of arterial ketone body ratio (acetoacetate/3-hydroxybutyrate), reflecting hepatic mitochondrial redox potential, were investigated in normal subjects, patients with chronic liver disease (Child's class A or B), and patients with hepatic failur...

journal_title：Gastroenterology

authors： Iwata S,Ozawa K,Shimahara Y,Mori K,Kobayashi N,Kumada K,Yamaoka Y

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) and hepatitis C virus (HCV) can be transmitted during administration of intravenous anesthesia when medication vials are used for multiple patients using incorrect technique. We investigated an outbreak of acute HBV and HCV infections among patients who received anesthesia duri...

journal_title：Gastroenterology

authors： Gutelius B,Perz JF,Parker MM,Hallack R,Stricof R,Clement EJ,Lin Y,Xia GL,Punsalang A,Eramo A,Layton M,Balter S

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:Several studies have reported that low doses of interferon can delay the development of hepatocellular carcinoma (HCC) and progression of chronic hepatitis C. We investigated the incidence of clinical events among participants of the Evaluation of PegIntron in Control of Hepatitis C Cirrhosis (EPIC)3 ...

journal_title：Gastroenterology

authors： Bruix J,Poynard T,Colombo M,Schiff E,Burak K,Heathcote EJ,Berg T,Poo JL,Mello CB,Guenther R,Niederau C,Terg R,Bedossa P,Boparai N,Griffel LH,Burroughs M,Brass CA,Albrecht JK,EPIC3 Study Group.

更新日期：2011-06-01 00:00:00

abstract：:The normal surface anatomy of rat hepatocytes, sinusoids, and bile canaliculi was examined by scanning electron microscopy following finger fracture of tissues that were perfused via the portal vein and fixed with 2.5% glutaraldehyde. These normal findings were contrasted with several models of cholestasis, including ...

journal_title：Gastroenterology

authors： Layden TJ,Schwarz,Boyer JL

更新日期：1975-09-01 00:00:00

abstract：:The efficacy of phenobarbital in altering biliary lipid composition in normal man was investigated by determining parameters of biliary lipid metabolism in 8 human subjects without biliary tract disease before and after oral phenobarbital administration at a dose of approximately 3 mg per kg per day for 25 to 54 days....

journal_title：Gastroenterology

authors： Ginsberg RL,Garnick MB

更新日期：1977-06-01 00:00:00

abstract：:Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is typically characterized by episodic fever, myalgia, skin rash, conjunctivitis, and abdominal cramps. Recently, mutations in the TNFRSF1A gene on chromosome 12p13 encoding tumor necrosis factor receptor type 1 have been linked to this autoinflammato...

journal_title：Gastroenterology

authors： Haas SL,Lohse P,Schmitt WH,Hildenbrand R,Karaorman M,Singer MV,Böcker U

更新日期：2006-01-01 00:00:00

abstract：:The histamine-storing enterochromaffinlike cells, which are numerous in the oxyntic mucosa of the rat stomach, are known to proliferate in response to long-lasting hypergastrinaemia. In addition, portacaval shunting, which is not associated with elevated serum gastrin, causes an increase in enterochromaffinlike cell d...

journal_title：Gastroenterology

authors： Axelson J,Ekelund M,Sundler F,Håkanson R

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND/AIMS:Cytokines are thought to be important in mediating tissue damage in inflammatory bowel disease (IBD). Many of the in vivo activities of tumor necrosis factor alpha (TNF-alpha) match the changes found in IBD, but its importance is controversial. METHODS:A sensitive, reverse hemolytic plaque assay was us...

journal_title：Gastroenterology

authors： Breese EJ,Michie CA,Nicholls SW,Murch SH,Williams CB,Domizio P,Walker-Smith JA,MacDonald TT

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with chronic hepatitis B virus (HBV) infection have a high risk for developing hepatocellular carcinoma (HCC). Patients with lower levels of hepatitis B surface antigen (HBsAg) have higher chances of losing HBsAg than those with high levels. However, little is known about whether higher level...

journal_title：Gastroenterology

authors： Tseng TC,Liu CJ,Yang HC,Su TH,Wang CC,Chen CL,Kuo SF,Liu CH,Chen PJ,Chen DS,Kao JH

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic glucuronidation is quantitatively the most important conjugation reaction by which an array of endogenous compounds and xenobiotics undergo biotransformation and detoxification. The active site of the uridine diphosphate (UDP) glucuronosyltransferases, which catalyze glucuronidation reactions, h...

journal_title：Gastroenterology

authors： Berg CL,Radominska A,Lester R,Gollan JL

更新日期：1995-01-01 00:00:00

abstract：:The existence of high- and low-affinity cholecystokinin (CCK)-A receptors on rodent pancreatic acini is well established. Until recently, CCK was believed to act directly on pancreatic acini to stimulate pancreatic secretion in both rodents and humans. However, conclusive evidence that human pancreatic acini lack func...

journal_title：Gastroenterology

authors： Owyang C,Logsdon CD

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND & AIMS:Abdominal bloating is a frequent complaint in irritable bowel syndrome (IBS), but its underlying mechanism remains uncertain. Our aim was to determine whether the abdominal wall, specifically its adaptation to intra-abdominal volumes, plays a role. METHODS:In 12 patients complaining of abdominal bloa...

journal_title：Gastroenterology

authors： Tremolaterra F,Villoria A,Azpiroz F,Serra J,Aguadé S,Malagelada JR

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND & AIMS:Cyclosporin A specifically suppresses hepatitis C virus (HCV) replication in vitro at clinically achievable concentrations. In this study, we investigated the mechanisms of action of cyclosporin A against HCV replication. METHODS:The in vitro effects of cyclosporin A on HCV replication were analyzed ...

journal_title：Gastroenterology

authors： Nakagawa M,Sakamoto N,Tanabe Y,Koyama T,Itsui Y,Takeda Y,Chen CH,Kakinuma S,Oooka S,Maekawa S,Enomoto N,Watanabe M

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND & AIMS:Nuclear factor of activated T cells transcription factors plays a central role in immunity by regulating the expression of multiple cytokines and other regulatory molecules, many of which have been heavily implicated in the pathogenesis of inflammatory bowel disease. However, few studies have directly...

journal_title：Gastroenterology

authors： Gerth AJ,Lin L,Neurath MF,Glimcher LH,Peng SL

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND & AIMS:Drug-induced cholestasis is a frequent form of acquired liver disease. To elucidate the molecular pathogenesis of drug-induced cholestasis, we investigated the effects of prototypic cholestatic drugs on the canalicular bile salt export pump (Bsep) of rat liver. METHODS:Vesicles were isolated from Bse...

journal_title：Gastroenterology

authors： Stieger B,Fattinger K,Madon J,Kullak-Ublick GA,Meier PJ

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND & AIMS:Bile secretion is regulated in part by adenosine 3',5'-cyclic monophosphate (cAMP) and cytosolic Ca2+ (Ca2+i). Hormone receptors that link to these second messengers are not uniformly distributed across the hepatic lobule, but both cAMP and Ca2+i cross gap junctions, so we tested whether gap junctiona...

journal_title：Gastroenterology

authors： Nathanson MH,Rios-Velez L,Burgstahler AD,Mennone A

更新日期：1999-05-01 00:00:00

abstract：:In dispersed acini prepared from guinea pig pancreas, ethanol inhibited the increase in amylase secretion caused by cholecystokinin, carbachol, secretin, or vasoactive intestinal peptide. Ethanol did not alter binding of [125I] vasoactive intestinal peptide to pancreatic acinar cells or the inhibition of binding cause...

journal_title：Gastroenterology

authors： Uhlemann ER,Robberecht P,Gardner JD

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND & AIMS:Calcitonin gene-related peptide (CGRP) protects the gastric mucosa against injurious stimuli in various experimental models. The underlying mechanism could be the increase in gastric mucosal blood flow (GMBF). A number of endogenous vasodilators exert their effects through the activation of adenosine ...

journal_title：Gastroenterology

authors： Doi K,Nagao T,Kawakubo K,Ibayashi S,Aoyagi K,Yano Y,Yamamoto C,Kanamoto K,Iida M,Sadoshima S,Fujishima M

更新日期：1998-01-01 00:00:00

abstract：:The purpose of this study was to determine whether gamma-hydroxybutyrate provides protection against intestinal ischemia/reperfusion injury and to compare its effect with that of allopurinol and vitamin E. Thirty minutes of total regional ischemia, followed by 3 hours of reperfusion, produced intestinal damage that wa...

journal_title：Gastroenterology

authors： Boyd AJ,Sherman IA,Saibil FG,Mamelak M

更新日期：1990-09-01 00:00:00

abstract：:Much of what is currently accepted on the natural history of Helicobacter pylori-induced gastritis and its relationship with gastric adenocarcinoma rests on the assumption that atrophic gastritis can be correctly identified and reproducibly recognized. Recently, several studies have indicated that pathologists have a ...

journal_title：Gastroenterology

authors： Genta RM

更新日期：1997-12-01 00:00:00

abstract：:Hepatic plasma flow was assessed with sorbitol (hepatic extraction = 0.96) at steady state. After infusion of 50 mg/min for 3 h, total and renal sorbitol clearances were calculated, and the extrarenal clearance was obtained by taking the difference between the two. In normal volunteers, the mean (+/- SD) extrarenal so...

journal_title：Gastroenterology

authors： Zeeh J,Lange H,Bosch J,Pohl S,Loesgen H,Eggers R,Navasa M,Chesta J,Bircher J

更新日期：1988-09-01 00:00:00

abstract：:Familial gastrointestinal stromal tumor (GIST) is a rare autosomal dominant genetic disorder associated with KIT germline mutations. In sporadic forms of the disease, somatic mutations target either KIT or PDGFRA genes. In a kindred in which 5 individuals had GIST, no germline mutation in KIT coding sequence has been ...

journal_title：Gastroenterology

authors： Chompret A,Kannengiesser C,Barrois M,Terrier P,Dahan P,Tursz T,Lenoir GM,Bressac-De Paillerets B

更新日期：2004-01-01 00:00:00