Basal and calcium-stimulated gastroesophageal sphincter pressure in patients with Zollinger-Ellison syndrome.


:Basal lower esophageal sphincter (LES) pressure was measured in 6 patients with the Zollinger-Ellison syndrome (ZES) and hypergastrinemia, and in 6 patients with duodenal ulcer and normogastrinemia. Basal LES pressure in ZES patients, 17.0 +/- 3.7 (mean +/- SE) mm Hg was similar to basal LES pressure in duodenal ulcer patients, 18.3 +/- 3.5 mm Hg (P greater than 0.10). LES pressure and serum gastrin concentration were not related in the ZES patients, r = 0.03, or in the duodenal ulcer patients, r = 0.20. Intravenous infusion of calcium gluconate in ZES patients produced a marked rise in serum gastrin concentration, delta = 1580 +/- 1110 pg per ml (P less than 0.001), and a moderate but significant rise in LES pressure, delta = 5.9 +/- 0.9 mm Hg (P less than 0.05). In duodenal ulcer patients calcium infusion produced only slight rises in gastrin concentration, delta = 10 +/- 12 pg per ml, and LES pressure, delta = 2.1 +/- 0.5 mm Hg, which were not significant (P greater than 0.10). This study suggests that basal LES pressure is not regulated by blood gastrin levels in the ZES. We interpret the calcium infusion study to show that the LES pressure in patients with ZES may respond to acute changes in endogenous gastrin levels.






Snyder N,Hughes W


Has Abstract


1977-06-01 00:00:00














  • Effect of colchicine on guinea pig intrinsic factor-vitamin B12 receptor.

    abstract::Colchicine can induce the malabsorption of vitamin B12 and other nutrients. Previous investigations have suggested but not proved that this malabsorption was due to a lesion in the ileal mucosa. Employing the receptor assay of M. Katz and B. A. Cooper (J Clin Invest 54:733-739, 1974), the authors have observed a dose-...


    pub_type: 杂志文章


    authors: Stopa EG,O'Brien R,Katz M

    更新日期:1979-02-01 00:00:00

  • Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology.

    abstract:BACKGROUND & AIMS:Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibroblast-rich desmoplastic stroma. Cancer-associated fibroblasts (CAFs) have been shown to display a high degree of interconvertible states including quiescent, inflammatory, and myofibroblastic phenotypes; however, the mechanisms by whic...


    pub_type: 杂志文章


    authors: Feldmann K,Maurer C,Peschke K,Teller S,Schuck K,Steiger K,Engleitner T,Öllinger R,Nomura A,Wirges N,Papargyriou A,Jahan Sarker RS,Ranjan RA,Dantes Z,Weichert W,Rustgi AK,Schmid RM,Rad R,Schneider G,Saur D,Reichert

    更新日期:2021-01-01 00:00:00

  • The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in rats.

    abstract:BACKGROUND & AIMS:Rats fed ethanol at a constant rate through a permanent intragastric cannula have a regular fluctuation in blood alcohol level (BAL) and urine alcohol level (UAL). The level of ethanol peaks every 6-10 days. The question is how the liver differs at the peaks and troughs of the UAL cycle. Hypoxic injur...


    pub_type: 杂志文章


    authors: Bardag-Gorce F,French BA,Li J,Riley NE,Yuan QX,Valinluck V,Fu P,Ingelman-Sundberg M,Yoon S,French SW

    更新日期:2002-07-01 00:00:00

  • IW-3718 Reduces Heartburn Severity in Patients With Refractory Gastroesophageal Reflux Disease in a Randomized Trial.

    abstract:BACKGROUND & AIMS:Refractory gastroesophageal reflux disease (GERD) reduces quality of life and creates significant financial burden on the health care system. Approximately 30% of patients with GERD who receive label-dose proton pump inhibitors (PPIs) still have symptoms. We performed a trial to evaluate the efficacy ...


    pub_type: 杂志文章


    authors: Vaezi MF,Fass R,Vakil N,Reasner DS,Mittleman RS,Hall M,Shao JZ,Chen Y,Lane L,Gates AM,Currie MG

    更新日期:2020-06-01 00:00:00

  • Approaches and Challenges to Management of Pediatric and Adult Patients With Eosinophilic Esophagitis.

    abstract::Treatment of eosinophilic esophagitis has progressed from elemental formula for children and esophageal dilation for adults to selective exclusion of food triggers and swallowed topical corticosteroids. Management guidelines are available from the American Gastroenterological Association and the Joint Task Force on Al...


    pub_type: 杂志文章,评审


    authors: Hirano I,Furuta GT

    更新日期:2020-03-01 00:00:00

  • Risk factors for early postoperative recurrence of Crohn's disease.

    abstract:BACKGROUND & AIMS:Despite many advances in our understanding of Crohn's disease, the course of the disease in any given patient remains unpredictable. There is little agreement as to which factors increase a patient's risk of early postoperative recurrence. We have attempted to identify predictors of early recurrence a...


    pub_type: 杂志文章


    authors: Lautenbach E,Berlin JA,Lichtenstein GR

    更新日期:1998-08-01 00:00:00

  • Pentane clearance from inspired air by the rat: dependence on the liver.

    abstract::Pentane, a volatile hydrocarbon, is cleared from inspired air by the rat. We have studied this clearance to learn whether or not it is a function of the liver. Rats were put individually into airtight chambers which contained CO2 absorbent and were connected to an O2 reservoir. Pentane was injected into each chamber a...


    pub_type: 杂志文章


    authors: Burk RJ,Ludden TM,Lane JM

    更新日期:1983-01-01 00:00:00

  • Biliary-shunt fistula following transjugular intrahepatic portosystemic shunt placement.

    abstract::Sepsis following the placement of a transjugular intrahepatic portosystemic shunt (TIPS) has been reported in up to 10% of cases. This report describes an unusual case of polymicrobial gram-negative sepsis after placement of TIPS associated with a cholangiographically documented fistulous connection between the biliar...


    pub_type: 杂志文章


    authors: Mallery S,Freeman ML,Peine CJ,Miller RP,Stanchfield WR

    更新日期:1996-11-01 00:00:00

  • Tropism for Spasmolytic Polypeptide-Expressing Metaplasia Allows Helicobacter pylori to Expand Its Intragastric Niche.

    abstract:BACKGROUND & AIMS:In patients with chronic Helicobacter pylori (H pylori) infection, parietal and chief cell atrophy in the gastric corpus, a process known as spasmolytic polypeptide-expressing metaplasia (SPEM), increases the risk for progression to cancer. The relation between H pylori and these metaplastic changes i...


    pub_type: 杂志文章


    authors: Sáenz JB,Vargas N,Mills JC

    更新日期:2019-01-01 00:00:00

  • Blockade of glucagon-like peptide 1 receptor corrects postprandial hypoglycemia after gastric bypass.

    abstract:BACKGROUND & AIMS:Postprandial glycemia excursions increase after gastric bypass surgery; this effect is even greater among patients with recurrent hypoglycemia. These patients also have increased postprandial levels of insulin and glucagon-like peptide 1 (GLP-1). We performed a clinical trial to determine the role of ...


    pub_type: 杂志文章


    authors: Salehi M,Gastaldelli A,D'Alessio DA

    更新日期:2014-03-01 00:00:00

  • In situ hybridization and immunohistochemical analysis of cytomegalovirus-associated ileal perforation.

    abstract::A patient with the acquired immunodeficiency syndrome (AIDS) with a cytomegalovirus (CMV) infection localized in the area of an ileal Kaposi sarcoma resulting in perforation is described. Because only one case of such an association of Kaposi sarcoma with CMV leading to perforation has been reported, the presence and ...


    pub_type: 杂志文章


    authors: Genta RM,Bleyzer I,Cate TR,Tandon AK,Yoffe B

    更新日期:1993-06-01 00:00:00

  • Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats.

    abstract:BACKGROUND & AIMS:We investigated the expression of estrogen receptor (ER) alpha and beta subtypes in cholangiocytes of normal and bile duct-ligated (BDL) rats and evaluated the role and mechanisms of estrogens in the modulation of cholangiocyte proliferation. METHODS:ER-alpha and ER-beta were analyzed by immunohistoc...


    pub_type: 杂志文章


    authors: Alvaro D,Alpini G,Onori P,Perego L,Svegliata Baroni G,Franchitto A,Baiocchi L,Glaser SS,Le Sage G,Folli F,Gaudio E

    更新日期:2000-12-01 00:00:00

  • CD8+CD28- regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice.

    abstract:BACKGROUND & AIMS:Immune responses to innocuous intestinal antigens appear tightly controlled by regulatory T lymphocytes. While CD4+ T lymphocytes have recently attracted the most attention, CD8+ regulatory T-cell populations are also believed to play an important role in control of mucosal immunity. However, CD8+ reg...


    pub_type: 杂志文章


    authors: Ménager-Marcq I,Pomié C,Romagnoli P,van Meerwijk JP

    更新日期:2006-12-01 00:00:00

  • Gastric ulcers in the fundic gland area.

    abstract::Gastric ulcers have been thought to occur only in the pyloric gland area. However, endoscopic examinations using the Congo red test showed that 18 of the ulcers examined (7.8%) were surrounded by an acid-secreting area, and so were in the fundic gland area. Histological examination of specimens obtained by gastrectomy...


    pub_type: 杂志文章


    authors: Tatsuta M,Okuda S

    更新日期:1976-07-01 00:00:00

  • Effects of ghrelin administration after total gastrectomy: a prospective, randomized, placebo-controlled phase II study.

    abstract:BACKGROUND & AIMS:Body weight (BW) loss and reduction of blood ghrelin level are commonly observed after total gastrectomy (TG). A prospective study was designed to elucidate whether exogenous ghrelin administration prevents postoperative BW loss by improving appetite and oral food intake in patients with gastric cance...


    pub_type: 杂志文章,随机对照试验


    authors: Adachi S,Takiguchi S,Okada K,Yamamoto K,Yamasaki M,Miyata H,Nakajima K,Fujiwara Y,Hosoda H,Kangawa K,Mori M,Doki Y

    更新日期:2010-04-01 00:00:00

  • Stimulation of gastric inhibitory polypeptide in normal and duodenal ulcer patients.

    abstract::To investigate the role of gastric inhibitory polypeptide (GIP), a potent inhibitor of gastric acid secretion, in the hypersecretion associated with duodenal ulcer, we compared the serum GIP concentrations in 11 healthy subjects and 16 duodenal ulcer patients after the stimulation of GIP release by a mixed meal. Fasti...


    pub_type: 杂志文章


    authors: Cataland S,O'Dorisio TM,Brooks R,Mekhjian HS

    更新日期:1977-07-01 00:00:00

  • Primary malignant melanoma of the gallbladder, metastatic to the common bile duct.

    abstract::A primary malignant melanoma of the gallbladder, metastatic to the common bile duct, is reported. Both tumor sites were first visualized by abdominal sonography. The presence of the common bile duct metastasis was confirmed by endoscopic retrograde cholangiopancreatography. Histologic evidence is presented that the pr...


    pub_type: 杂志文章


    authors: Verbanck JJ,Rutgeerts LJ,van Aelst FJ,Tytgat JH,Decoster JM,Noyez DN,Theunynck PJ,Geboes KJ

    更新日期:1986-07-01 00:00:00

  • Rat intestinal M cells contain acidic endosomal-lysosomal compartments and express class II major histocompatibility complex determinants.

    abstract:BACKGROUND:It is generally believed that M cells do not modify the antigens they transport from the intestinal lumen to underlying immunocompetent cells because it has been reported that M cells contain few elements of the lysosomal system. METHODS:We used specific cytochemical and immunocytochemical probes to examine...


    pub_type: 杂志文章


    authors: Allan CH,Mendrick DL,Trier JS

    更新日期:1993-03-01 00:00:00

  • Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation.

    abstract:BACKGROUND & AIMS:Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regula...


    pub_type: 杂志文章


    authors: Garuti C,Tian Y,Montosi G,Sabelli M,Corradini E,Graf R,Ventura P,Vegetti A,Clavien PA,Pietrangelo A

    更新日期:2010-07-01 00:00:00

  • Liver copper levels in intrahepatic cholestasis of childhood.

    abstract::Liver copper concentration was studied in four groups of age-matched patients and in 9 patients with Wilson's disease of comparable age. Neutron activation analysis of hepatic copper concentration revealed markedly elevated hepatic copper levels, comparable with those in Wilson's disease, in 13 of 15 patients (P less ...


    pub_type: 杂志文章


    authors: Evans J,Newman S,Sherlock S

    更新日期:1978-11-01 00:00:00

  • The association between hepatitis C infection and survival after orthotopic liver transplantation.

    abstract:BACKGROUND & AIMS:The effect of hepatitis C viral (HCV) infection on patient and allograft survival after orthotopic liver transplantation is controversial. Hepatitis C recurrence after transplant is inevitable, but studies to date have not found a survival difference between recipients with and without HCV. METHODS:U...


    pub_type: 杂志文章


    authors: Forman LM,Lewis JD,Berlin JA,Feldman HI,Lucey MR

    更新日期:2002-04-01 00:00:00

  • Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook.

    abstract::The community of microorganisms within the human gut (or microbiota) is critical to health and functions with a level of complexity comparable to that of an organ system. Alterations of this ecology (or dysbiosis) have been implicated in a number of disease states, and the prototypical example is Clostridium difficile...


    pub_type: 杂志文章,评审


    authors: Kelly CR,Kahn S,Kashyap P,Laine L,Rubin D,Atreja A,Moore T,Wu G

    更新日期:2015-07-01 00:00:00

  • Hydralazine-induced cholangitis.

    abstract::This report describes a 59-year-old woman, who, after an initial reaction to hydralazine, inadvertently took the drug again. She promptly developed symptoms of acute cholangitis--fever, right upper quadrant tenderness, obtundation, and hypotension. Cholecystectomy was performed and no obstruction or infection of the b...


    pub_type: 杂志文章


    authors: Myers JL,Augur NA Jr

    更新日期:1984-11-01 00:00:00

  • Gallstone dissolution in vitro using methyl tert-butyl ether: radiologic selection criteria.

    abstract::Methyl tert-butyl ether dissolves cholesterol gallbladder stones when infused through a percutaneous transhepatic catheter. All gallstones, however, contain noncholesterol components that are insoluble in lipid solvents and may be too large to be aspirated through a small catheter or flushed from the gallbladder. To i...


    pub_type: 杂志文章


    authors: Nelson PE,Moyer TP,Thistle JL

    更新日期:1990-05-01 00:00:00

  • Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis.

    abstract:BACKGROUND & AIMS:Long-term ursodeoxycholic acid (UDCA) therapy slows the progression of primary biliary cirrhosis. This study examined the effect of UDCA therapy on survival free of liver transplantation in a large group of patients. METHODS:Data from three clinical trials were combined in which patients with primary...


    pub_type: 杂志文章


    authors: Poupon RE,Lindor KD,Cauch-Dudek K,Dickson ER,Poupon R,Heathcote EJ

    更新日期:1997-09-01 00:00:00

  • Immunocytochemical localization of myosin in normal and phalloidin-treated rat hepatocytes.

    abstract::To clarify the intracellular distribution of myosin in normal rat hepatocytes and its alterations in phal-loidin-treated rat hepatocytes as a morphologic basis for the dysfunction of microfilaments, we performed indirect immunofluorescence using monospecific antibody raised against rat hepatocyte myosin. Cryostat rat ...


    pub_type: 杂志文章


    authors: Yasuura S,Ueno T,Watanabe S,Hirose M,Namihisa T

    更新日期:1989-10-01 00:00:00

  • Intestinal B-cell isotype response in relation to local bacterial load: evidence for immunoglobulin A subclass adaptation.

    abstract:BACKGROUND & AIMS:In experimental animals, the indigenous microbiota modulates mucosal immunity. In humans, such direct evidence is scarce. The aim of this study was to examine the effect of intestinal bacteria on the local immunoglobulin (Ig) response. METHODS:The numbers of IgA-, IgM-, and IgG-producing immunocytes ...


    pub_type: 杂志文章


    authors: Kett K,Baklien K,Bakken A,Kral JG,Fausa O,Brandtzaeg P

    更新日期:1995-09-01 00:00:00

  • Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis.

    abstract:BACKGROUND & AIMS:We have shown previously that cure of Helicobacter pylori infection leads to the disappearance of acid-neutralizing substances. Also, patients with ulcer after cure may gain weight. The aim of this study was to investigate whether cure of the infection increases the risk of reflux esophagitis. METHOD...


    pub_type: 临床试验,杂志文章


    authors: Labenz J,Blum AL,Bayerdörffer E,Meining A,Stolte M,Börsch G

    更新日期:1997-05-01 00:00:00

  • Advances in Use of Endoscopy, Radiology, and Biomarkers to Monitor Inflammatory Bowel Diseases.

    abstract::Crohn's disease and ulcerative colitis are heterogeneous inflammatory bowel diseases, and therapeutic requirements vary among patients. We have a limited capacity to predict disease progression for individual patients, therefore it is important that they are evaluated for the presence of active disease when symptoms a...


    pub_type: 杂志文章,评审


    authors: Panes J,Jairath V,Levesque BG

    更新日期:2017-02-01 00:00:00

  • p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation.

    abstract:BACKGROUND & AIMS:p16(INK4a) is a cell cycle inhibitor and a major tumor-suppressor protein, but the regulation of p16(INK4a) is poorly understood and the physiologic settings in which it exerts its antiproliferative effects are unknown. A role for p16(INK4a) in intestinal neoplasia is suggested by the observation that...


    pub_type: 杂志文章


    authors: Dai CY,Furth EE,Mick R,Koh J,Takayama T,Niitsu Y,Enders GH

    更新日期:2000-10-01 00:00:00