Ileal distention relaxes the canine colon: a model of megacolon?

abstract：BACKGROUND & AIMS:SMAD4 frequently is lost from colorectal cancers (CRCs), which is associated with the development of metastases and a poor prognosis. SMAD4 loss is believed to alter transforming growth factor β signaling to promote tumor progression. However, SMAD4 is also a central component of the bone morphogeneti...

journal_title：Gastroenterology

authors： Voorneveld PW,Kodach LL,Jacobs RJ,Liv N,Zonnevylle AC,Hoogenboom JP,Biemond I,Verspaget HW,Hommes DW,de Rooij K,van Noesel CJ,Morreau H,van Wezel T,Offerhaus GJ,van den Brink GR,Peppelenbosch MP,Ten Dijke P,Hardwick JC

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND & AIMS:In cirrhosis, increased amounts of circulating hormones such as angiotensin II may induce vascular tone changes and alter vascular smooth muscle cell (VSMC) function and growth. The aim of this study was to investigate the growth of aortic VSMCs from cirrhotic rats with or without the addition of angi...

journal_title：Gastroenterology

authors： Tazi KA,Moreau R,Cailmail S,Gadano A,Trombino C,Lebrec D

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND & AIMS:A variety of gastrointestinal motility disorders have been attributed to alterations of interstitial cells of Cajal and malformations of the enteric nervous system. This study evaluates both the distribution of interstitial cells of Cajal and the pathohistology of the enteric nervous system in 2 sever...

journal_title：Gastroenterology

authors： Wedel T,Spiegler J,Soellner S,Roblick UJ,Schiedeck TH,Bruch HP,Krammer HJ

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND & AIMS:The tumor necrosis factor (TNF)-alpha/TNF receptor system is critical for liver development because hepatocytes undergo apoptosis if the antiapoptotic cascades resulting in RelA NF-kappaB activation are not effective. Therefore, we studied the role of TNF-alpha in fulminant hepatic failure (FHF) and d...

journal_title：Gastroenterology

authors： Streetz K,Leifeld L,Grundmann D,Ramakers J,Eckert K,Spengler U,Brenner D,Manns M,Trautwein C

更新日期：2000-08-01 00:00:00

abstract：:Boron may be beneficial for bone growth and maintenance, central nervous system function, and the inflammatory response, and silicon may be beneficial for bone maintenance and wound healing. Fluoride is not an essential element but amounts provided by contamination may be beneficial for bone strength. Fluoride toxicit...

journal_title：Gastroenterology

authors： Nielsen FH

更新日期：2009-11-01 00:00:00

abstract：:Regional specific antibodies and chromatography were used to analyze the distributions and molecular forms of peptide histidine isoleucine (PHI) and vasoactive intestinal peptide (VIP) in the porcine intestine. Both peptides were present along the entire length of the intestine, the highest concentrations occurring in...

journal_title：Gastroenterology

authors： Yiangou Y,Christofides ND,Blank MA,Yanaihara N,Tatemoto K,Bishop AE,Polak JM,Bloom SR

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND & AIMS:Although bone marrow (BM) is known as a primary lymphoid organ, it also is known to harbor memory T cells, suggesting that this compartment is a preferential site for migration and/or selective retention of memory T cells. We here report the existence and the potential ability to induce colitis of the...

journal_title：Gastroenterology

authors： Nemoto Y,Kanai T,Makita S,Okamoto R,Totsuka T,Takeda K,Watanabe M

更新日期：2007-01-01 00:00:00

abstract：:Two female adolescents with cystic fibrosis were investigated by endoscopic retrograde cholangiography for recurrent abdominal pain. The cholangiogram of 1 patient demonstrated multiple irregular filling defects throughout the biliary tree representing thickened bile and mucus as well as stones. The cholangiogram of t...

journal_title：Gastroenterology

authors： Bass S,Connon JJ,Ho CS

更新日期：1983-06-01 00:00:00

abstract：:To examine the premise that exercise reduces the gastrointestinal transit time, we evaluated the effect of walking 4.5 km in an hour on mouth-to-cecum transit time. Twenty-three healthy volunteers, 9 men and 14 women, with an age range of 19-28 yr, were studied. After an overnight fast, the subjects ingested 10 g of l...

journal_title：Gastroenterology

authors： Meshkinpour H,Kemp C,Fairshter R

更新日期：1989-03-01 00:00:00

abstract：:Lower esophageal sphincter pressure, basal gastric pH, fasting plasma gastrin, and plasma concentrations of estrone, estradiol, and progesterone were measured in pregnant volunteers at 12, 24, and 36 weeks of gestation, and again at 1 to 4 weeks postpartum. In addition, basal and pentagastrin-stimulated acid secretory...

journal_title：Gastroenterology

authors： Van Thiel DH,Gavaler JS,Joshi SN,Sara RK,Stremple J

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with Barrett's esophagus (BE) show increased risk of developing esophageal adenocarcinoma and are routinely examined using upper endoscopy with biopsy to detect neoplastic changes. Angle-resolved low coherence interferometry (a/LCI) uses in vivo depth-resolved nuclear morphology measurements ...

journal_title：Gastroenterology

authors： Terry NG,Zhu Y,Rinehart MT,Brown WJ,Gebhart SC,Bright S,Carretta E,Ziefle CG,Panjehpour M,Galanko J,Madanick RD,Dellon ES,Trembath D,Bennett A,Goldblum JR,Overholt BF,Woosley JT,Shaheen NJ,Wax A

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND & AIMS:Both androgenic and estrogenic steroids have been implicated in the development and course of several liver diseases, including hepatocellular carcinoma. The aim of this study was to investigate temporal changes in hepatic estrogen and androgen receptors and hormone metabolism in a rat model of liver ...

journal_title：Gastroenterology

authors： Eagon PK,Elm MS,Epley MJ,Shinozuka H,Rao KN

更新日期：1996-04-01 00:00:00

abstract：:Colchicine can induce the malabsorption of vitamin B12 and other nutrients. Previous investigations have suggested but not proved that this malabsorption was due to a lesion in the ileal mucosa. Employing the receptor assay of M. Katz and B. A. Cooper (J Clin Invest 54:733-739, 1974), the authors have observed a dose-...

journal_title：Gastroenterology

authors： Stopa EG,O'Brien R,Katz M

更新日期：1979-02-01 00:00:00

abstract：:To determine the pattern of inheritance of lactase deficiency, we studied 104 American Indian and 2 white subjects in 19 families. Subjects were considered deficient in lactase if breath-hydrogen excretion exceeded 0.20 ml per min above fasting at 2 hr after a lactose load of 2 g per kg of body weight (maximum 50 g). ...

journal_title：Gastroenterology

authors： Newcomer AD,Gordon H,Thomas PJ,McGill DB

更新日期：1977-11-01 00:00:00

abstract：:We studied gallbladder bile flow before, during, and after cholesterol gallstone formation in the prairie dog using infusion cholescintigraphy with 99mTc-diethyl iminodiacetic acid. In 18 fasting animals partitioning of bile between gallbladder and intestine was determined every 15 min for 140 min, and gallbladder res...

journal_title：Gastroenterology

authors： Pellegrini CA,Ryan T,Broderick W,Way LW

更新日期：1986-01-01 00:00:00

abstract：:Behavioral economic approaches could increase uptake for colorectal cancer screening. We performed a randomized controlled trial of 2245 employees to determine whether an email containing a phone number for scheduling (control), an email with the active choice to opt in or opt out (active choice), or the active choice...

journal_title：Gastroenterology

authors： Mehta SJ,Feingold J,Vandertuyn M,Niewood T,Cox C,Doubeni CA,Volpp KG,Asch DA

更新日期：2017-11-01 00:00:00

abstract：:Women are underrepresented in gastroenterology. A questionnaire examined the training and career experiences of female members of the Canadian Association for Gastroenterology (CAG) and their male counterparts. A pretested questionnaire was mailed to the 50 female CAG and 100 age-matched male members. Descriptive anal...

journal_title：Gastroenterology

authors： Heathcote J,Cauch-Dudek K,Rhyne D

更新日期：1997-08-01 00:00:00

abstract：:Four Puerto Rican sisters had recurrent prolonged cholestasis of pregnancy without preexisting or intercurrent hepatic disorders. Available information was reviewed on the course, mechanism, and sequelae of prolonged recurrent cholestasis after 14 pregnancies in the 4 sisters. Etiologic, clinical, laboratory, radiolog...

journal_title：Gastroenterology

authors： Leevy CB,Koneru B,Klein KM

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND & AIMS:Little is known about substitutions that mediate resistance of hepatitis C virus (HCV) to direct-acting antivirals (DAAs), due to the small number of patients with treatment failure in approval studies. It is important to identify resistance patterns to select effective salvage treatments. METHODS:We...

journal_title：Gastroenterology

authors： Dietz J,Susser S,Vermehren J,Peiffer KH,Grammatikos G,Berger A,Ferenci P,Buti M,Müllhaupt B,Hunyady B,Hinrichsen H,Mauss S,Petersen J,Buggisch P,Felten G,Hüppe D,Knecht G,Lutz T,Schott E,Berg C,Spengler U,von Ha

更新日期：2018-03-01 00:00:00

abstract：:The effects of bile salts on energy metabolism and acid secretion were investigated in the amphibian gastric mucosa in vitro. Serosal exposure to deoxycholate (0.2-2 mM), cholate (2-8 mM), or taurocholate (4-80 mM), at pH 7.4, decreased acid secretion depending on the concentration and time of exposure. Mucosal applic...

journal_title：Gastroenterology

authors： Núñez D,Chacín J

更新日期：1989-01-01 00:00:00

abstract：:2-Camphanone is under clinical evaluation for alleviation of hemorrhoidal bleeding and inflammation. Reduced portal venous blood flow may distend, whereas improved portal venous blood flow may alleviate, hemorrhoidal vein distention. The effects of 2-camphanone on canine portal venous blood flow were investigated usin...

journal_title：Gastroenterology

authors： Xie JM,Greenberg SS,Longenecker G

更新日期：1992-02-01 00:00:00

abstract：:The effect of neuropeptide Y on the motor activity of the circular and longitudinal muscle of the guinea pig small intestine was investigated. Neuropeptide Y (0.3-30 nM) inhibited, in a concentration-dependent manner, the ascending enteric reflex contraction of the circular muscle; both the cholinergic and noncholiner...

journal_title：Gastroenterology

authors： Holzer P,Lippe IT,Barthó L,Saria A

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND & AIMS:Elevated hepatic iron concentration may affect the response to antiviral therapy in chronic hepatitis C. This study explored the contribution of genetic hemochromatosis to iron accumulation in chronic hepatitis C. METHODS:HFE mutations (C282Y and H63D) were assessed in 184 patients with chronic hepat...

journal_title：Gastroenterology

authors： Kazemi-Shirazi L,Datz C,Maier-Dobersberger T,Kaserer K,Hackl F,Polli C,Steindl PE,Penner E,Ferenci P

更新日期：1999-01-01 00:00:00

abstract：:Effects of opiates on intestinal motor activity and transport of water and electrolytes have been studied separately in previous investigations. The aim of these experiments was to evaluate simultaneously the effects of a synthetic opiate, loperamide, on motor activity and transport in the human intestine. Jejunal, il...

journal_title：Gastroenterology

authors： Kachel G,Ruppin H,Hagel J,Barina W,Meinhardt M,Domschke W

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:The anti-cancer effects of vegetables and fruit have been investigated extensively, but the association between vegetable and fruit consumption and risk of hepatocellular carcinoma (HCC) has not been quantified. We performed a meta-analysis of observational studies to clarify the association. METHODS...

journal_title：Gastroenterology

authors： Yang Y,Zhang D,Feng N,Chen G,Liu J,Chen G,Zhu Y

更新日期：2014-11-01 00:00:00

abstract：:The distribution of sigma and phencyclindine binding sites in the gastrointestinal tract of the guinea pig was studied by autoradiography after in vitro incubation of tissue slices with (+)3H-SKF 10,047 and 3H-1-1-[(2-thienyl)cyclohexyl] piperidine to locate sigma and phencyclidine receptors, respectively. A dense dis...

journal_title：Gastroenterology

authors： Roman F,Pascaud X,Chomette G,Bueno L,Junien JL

更新日期：1989-07-01 00:00:00

abstract：:Developmental aspects of the intestinal transport of biotin were examined in suckling (16 day old) and weanling (24 day old) rats using the everted sac technique. The results were compared with those of adult rats previously reported by us using the same intestinal preparation. Transport of biotin was linear for 20 mi...

journal_title：Gastroenterology

authors： Said HM,Redah R

更新日期：1988-01-01 00:00:00

abstract：:In dogs provided with Heidenhain pouch and gastric fistula, we studied the effect of near-total excision of the fundic mucosa of the main stomach on acid secretion and gastrin release. Fundic mucosal excision abolished the mean response of the gastric fistula and reduced its maximal response to pentagastrin and to his...

journal_title：Gastroenterology

authors： Soon-Shiong P,Debas HT

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND & AIMS:Synchronous activation of the Wnt signaling pathway, mostly because of loss of function of the APC tumor suppressor, and of the oncogenic KRAS-signaling pathway is very frequent in colorectal cancer and is associated with poor prognosis. METHODS:We have generated a compound transgenic mouse model, KR...

journal_title：Gastroenterology

authors： Janssen KP,Alberici P,Fsihi H,Gaspar C,Breukel C,Franken P,Rosty C,Abal M,El Marjou F,Smits R,Louvard D,Fodde R,Robine S

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND & AIMS:Therapy with interferon alfa (IFN-alpha) leads to remission of disease in one third of patients with chronic hepatitis B. The aim of this study was to better define the long-term prognosis of this outcome. METHODS:One hundred three patients with chronic hepatitis B who underwent IFN-alpha therapy in ...

journal_title：Gastroenterology

authors： Lau DT,Everhart J,Kleiner DE,Park Y,Vergalla J,Schmid P,Hoofnagle JH

更新日期：1997-11-01 00:00:00