Abstract:
BACKGROUND & AIMS:We performed a prospective, randomized, controlled study to compare the combination of esomeprazole and clopidogrel vs clopidogrel alone in preventing recurrent peptic ulcers in patients with atherosclerosis and a history of peptic ulcers. We also investigated the effects of esomeprazole on the antiplatelet action of clopidogrel. METHODS:From January 2008 to January 2010, long-term clopidogrel users with histories of peptic ulcers who did not have peptic ulcers at an initial endoscopy examination were assigned randomly to receive the combination of esomeprazole (20 mg/day, before breakfast) and clopidogrel (75 mg/day, at bedtime), or clopidogrel alone for 6 months. A follow-up endoscopy examination was performed at the end of the sixth month and whenever severe symptoms occurred. Platelet aggregation tests were performed on days 1 and 28 for 42 consecutive patients who participated in the pharmacodynamic study. RESULTS:The cumulative incidence of recurrent peptic ulcer during the 6-month period was 1.2% among patients given the combination of esomeprazole and clopidogrel (n = 83) and 11.0% among patients given clopidogrel alone (n = 82) (difference, 9.8%; 95% confidence interval, 2.6%-17.0%; P = .009). In the group given the combination therapy, there were no differences in the percentages of aggregated platelets on days 1 and 28 (31.0% ± 20.5% vs 30.1% ± 16.5%). CONCLUSIONS:Among patients with atherosclerosis and a history of peptic ulcers, the combination of esomeprazole and clopidogrel reduced recurrence of peptic ulcers, compared with clopidogrel alone. Esomeprazole does not influence the action of clopidogrel on platelet aggregation.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Hsu PI,Lai KH,Liu CPdoi
10.1053/j.gastro.2010.11.056subject
Has Abstractpub_date
2011-03-01 00:00:00pages
791-8issue
3eissn
0016-5085issn
1528-0012pii
S0016-5085(10)01747-6journal_volume
140pub_type
杂志文章,随机对照试验相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND & AIMS:Tobacco smoking has a complex effect on intestinal inflammation, being protective in ulcerative colitis, whereas it aggravates Crohn's disease. The beneficial effect of smoking has been attributed to nicotine, but the mechanisms underlying the adverse effect are still under investigation. The aim of t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(99)70346-x
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND & AIMS:Although restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) substantially reduces the risk of colorectal cancer in patients with inflammatory bowel disease (IBD), subsequent pouch neoplasia can develop. There are few data on the incidence of and risk factors for neoplasia, so there i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.09.047
更新日期:2014-01-01 00:00:00
abstract::Low residue, chemically defined diets containing all essential nutrients in a readily assimilated form, require minimal digestion and are almost entirely absorbed in the upper gastrointestinal tract. Within the past decade, these diets have been reported to provide nutritional support in a variety of clinical situatio...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:
更新日期:1975-12-01 00:00:00
abstract::Jejunal absorption of acetate, propionate, and butyrate--the three predominant short chain fatty acids (SCFA's) in small and large intestinal contents--was studied in 5 volunteer subjects. A triple-lumen perfusion technique was employed; the test solutions were isotonic and contained 0, 5, 10, 25, 40, or 50 mM of a SC...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND & AIMS:Defects in the epithelial tight junction (TJ) barrier contribute to development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) increases intestinal permeability in mice. We investigated microRNAs that are regulated by IL1B and their effects on expression of TJ proteins ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2020.06.038
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND & AIMS:The complications of diverticulosis cause considerable morbidity in the United States; health care expenditures for this disorder are estimated to be $2.5 billion per year. Many physicians and patients believe that a high-fiber diet and frequent bowel movements prevent the development of diverticulosi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.10.035
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND & AIMS:In colorectal adenoma and carcinoma, glutathione S-transferase-pi (GSTP1-1) is highly expressed. K-ras mutation is also known to occur frequently in colorectal adenoma and carcinoma, as well as in the putative precursor of adenoma, aberrant crypt foci (ACF). Further, forced expression of v-H-ras in ra...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.27982
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND & AIMS:Glutamine is an essential amino acid for rapidly dividing cells such as enterocytes. The progress of cancer is associated with a decrease of arterial and muscle glutamine concentrations. The aim of this study was to test whether increasing tumor loads affect gut intracellular glutamine handling, prote...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70226-9
更新日期:1997-01-01 00:00:00
abstract::Ursodeoxycholic acid, the 7 beta-hydroxy epimer of chenodeoxycholic acid, is more hydrophilic and less hepatotoxic than chenodeoxycholic acid. Because "lagodeoxycholic acid," the 12 beta-hydroxy epimer of deoxycholic acid, is also more hydrophilic than deoxycholic acid, it was hypothesized that it should also be less ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90630-j
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND & AIMS:Serine proteases are postulated to influence gastrointestinal function by stimulating protease-activated receptors (PARs). This study identified the effects on myenteric neurons of activating PARs and investigated underlying mechanisms of action. METHODS:Intracellular electrophysiologic methods were ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.36581
更新日期:2002-11-01 00:00:00
abstract::Mast cell/nerve associations have been recorded in several publications; however, the human gastrointestinal tract has received little attention. Accordingly, mucosal samples from small bowel, appendix, and large bowel were studied. Combined histochemical/immunocytochemical techniques revealed that the proportion of m...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)90627-6
更新日期:1989-09-01 00:00:00
abstract::Approximately 5% of the world's human population have an increased risk for developing liver cancer and cirrhosis as a direct consequence of chronic infection with the hepatitis B virus (HBV). Antiviral chemotherapy remains the only option for controlling infection in these individuals, for whom the current licensed h...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1016/s0016-5085(00)70008-4
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND & AIMS:The goal of the study was to facilitate fat balance measurements with an appropriate intestinal marker for the transit of dietary fat and thereby eliminate the need for complete diet and fecal collections. METHODS:Dietary fat containing 5% sucrose polybehenate was fed in a semisynthetic diet to rats ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2004.04.007
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND & AIMS:Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is a challenge to determine a patient's prognosis. We aimed to identify new prognostic markers of patients with HCC treated by liver resection. METHODS:We collected 314 HCC samples from patients at Bordeaux (1998-200...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.03.051
更新日期:2013-07-01 00:00:00
abstract::The case of a 21-yr-old man, who died in cachexia after 2 yr of intermittent abdominal pain, bouts of diarrhea, and anorexia, is reported. Laboratory tests performed shortly before death disclosed signs of malabsorption. Radiologic examination of the gastrointestinal tract showed a coarse mucosal relief in the upper j...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1979-10-01 00:00:00
abstract:BACKGROUND & AIMS:We assessed the influence of genetic variants in the hepatitis B virus (HBV) core, which is a principal immunologic target, on the progression to hepatocellular carcinoma (HCC) in a cohort of 4841 male HBV carriers followed up for 16 years. METHODS:First, baseline sera from 116 HCC cases and 154 cont...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.07.063
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND & AIMS:Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Elevated 5-HT levels are associated with diarrheal conditions such as irritable bowel syndrome and enteric infections. Whether alteration in SERT activity contributes to the...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.09.002
更新日期:2009-12-01 00:00:00
abstract::A 62-year-old man with rheumatoid arthritis developed jaundice while taking piroxicam. A full evaluation including ultrasound, computerized tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic cholestasis. The patient's jaundice and all other liver function abnormalities nor...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1016/0016-5085(91)90417-j
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND & AIMS:Caco-2 cells have been used extensively to elucidate events involved in intestinal cell proliferation and differentiation. Because individual isoforms of protein kinase C (PKC) and p21waf1, a cyclin-dependent kinase inhibitor, may regulate these processes, their role(s) on the growth and differentiati...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(98)70533-5
更新日期:1998-03-01 00:00:00
abstract::Liver copper concentration was studied in four groups of age-matched patients and in 9 patients with Wilson's disease of comparable age. Neutron activation analysis of hepatic copper concentration revealed markedly elevated hepatic copper levels, comparable with those in Wilson's disease, in 13 of 15 patients (P less ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract::Frequent occurrence of post-transfusion hepatitis continues despite screening for Australia antigen in blood before transfusion and elimination of commercial donor sources. The majority of these cases appears unrelated to hepatitis B virus. Preoperative, acute, and convalescent serra were screened for evidence of hepa...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-12-01 00:00:00
abstract::We performed 92 computed tomography-guided percutaneous needle aspirations of pancreatic inflammatory masses in 60 patients suspected of harboring pancreatic infection. Thirty-six patients (60%) were found by Gram stain and culture to have a total of 41 separate episodes of pancreatic infection. Among 42 aspirates jud...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90261-7
更新日期:1987-12-01 00:00:00
abstract::Interstitial pneumonitis is an uncommon complication of low-dose methotrexate therapy in patients with psoriasis but occurs in 3%-5% of patients with rheumatoid arthritis. We found a higher incidence of interstitial pneumonitis in patients with primary biliary cirrhosis (14%) and describe its clinical manifestations, ...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1016/0016-5085(94)90085-x
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND & AIMS:In several rat infection experiments, we have shown that dietary calcium inhibits intestinal colonization and translocation of invasive salmonella. The aim of the present study was to find out whether calcium is also protective against enterotoxigenic Escherichia coli (ETEC) infection. This was first ...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1016/s0016-5085(03)00884-9
更新日期:2003-08-01 00:00:00
abstract::Characteristics of a macroamylase that was considered not to be formed by the binding of normal amylase to immunoglobulins were studied. The macroamylase was reversibly dissociated into apparently normal amylase by treating the macroamylasemic serum with guanidine hydrochloride. Concanavalin A precipitated a large por...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND & AIMS:Gastroesophageal reflux typically occurs after meals. During dual gastric and esophageal pH monitoring, we observed that postprandial refluxate was often more acidic than the gastric contents. This study aimed to investigate this phenomenon. METHODS:Dual gastric and esophageal pH tracings were analyz...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.27997
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Celiac disease is a prevalent disorder characterized by a chronic intestinal inflammation driven by HLA-DQ2 or -DQ8-restricted T cells specific for ingested wheat gluten peptides. The dominant T-cell responses are to epitopes that cluster within a stable 33mer fragment formed by physiologic digestio...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2004.11.003
更新日期:2005-02-01 00:00:00
abstract::The mechanism of action of Senokot, a widely used laxative, has not been established. Senokot was given orally to rats 8-14 h before intestinal water and electrolyte transport were studied. Senokot significantly decreased colonic and jejunal water absorption measured in vivo by the single-pass perfusion technique. The...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND & AIMS:Sigmoidoscopy is an effective screening strategy for colorectal cancer that is not widely used by primary care providers. The aim of this study was to assess the impact of "academic detailing" in the form of an outreach educational seminar combined with implementation of on-site sigmoidoscopy services...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1053/gast.1999.0029900304
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND & AIMS:beta3 Adrenoceptor (beta3-AR) is expressed on adipocytes and enteric neurons. GW427353 is a human selective beta3-AR agonist with visceral analgesic effects. Some of its effects may involve release of somatostatin (SST) and actions on enteric neurons. The aim of this study was to investigate the mode ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.09.046
更新日期:2010-01-01 00:00:00