Abstract:
:We compared the inhibition of food-stimulated gastric acid secretion and changes in serum concentrations of immunoreactive gastric inhibitory polypeptide and gastrin caused by: (a) duodenal perfusion of oleic acid, and (b) intravenous infusion of pure, natural, porcine gastric inhibitory, polypeptide in dogs with gastric fistula and pancreatic fistula. A rate of duodenal perfusion of oleic acid (12 ml/hr) which gave near maximal pancreatic protein response was chosen. This dose of oleic acid caused complete suppression of acid response to a meal of liver extract (300 ml of a 15% solution) while elevating serum immunoreactive gastric inhibitory polypeptide modestly. By contrast, intravenous administration of gastric inhibitory polypeptide that raised serum immunoreactive gastric inhibitory polypeptide several fold caused only 40% inhibition of acid response to the same meal. Other effects of duodenal perfusion of oleic acid were exaggeration of pancreatic protein secretion and significant inhibition of gastrin release in response to the meal. Exogenous administration of gastric inhibitory polypeptide, on the other hand, was without significant effect on these responses. These results suggest that, in the innervated dog stomach, the enterogastrone action of fat is not primarily mediated by gastric inhibitory polypeptide.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Yamagishi T,Debas HTsubject
Has Abstractpub_date
1980-05-01 00:00:00pages
931-6issue
5 Pt 1eissn
0016-5085issn
1528-0012pii
S0016508580000790journal_volume
78pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND & AIMS:According to the National Center for Health Statistics (NCHS), chronic liver disease and cirrhosis is the 12(th) leading cause of death in the United States. However, this single descriptor might not adequately enumerate all deaths from liver disease. The aim of our study was to update data on liver m...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.04.005
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND & AIMS:Macrophage migration inhibitory factor (MIF) inhibits macrophage migration and has pleiotropic activities on immune and inflammatory responses, cell growth, and glucose metabolism. MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators imp...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.31891
更新日期:2002-03-01 00:00:00
abstract::This study is an examination of the association between Crohn's disease and psychiatric illness using careful gastrointestinal evaluation, a structured psychiatric interview of known reliability and validity, and explicit diagnostic criteria for psychiatric illness. A proband sample of 50 subjects with Crohn's disease...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND & AIMS:The evaluation of patients with chronic watery diarrhea represents a diagnostic challenge for clinicians because organic causes, including inflammatory bowel disease, microscopic colitis, and chronic infection, must be differentiated from functional diarrhea and diarrhea-predominant irritable bowel sy...
journal_title:Gastroenterology
pub_type: 杂志文章,实务指引,评审
doi:10.1053/j.gastro.2019.06.014
更新日期:2019-09-01 00:00:00
abstract::Rotaviruses cause life-threatening gastroenteritis in children worldwide; the enormous disease burden has focused efforts to develop vaccines and led to the discovery of novel mechanisms of gastrointestinal virus pathogenesis and host responses to infection. Two live-attenuated vaccines for gastroenteritis (Rotateq [M...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2009.02.076
更新日期:2009-05-01 00:00:00
abstract::The case of a woman with protoporphyria who developed liver failure and underwent liver transplantation is described. During the pretransplant episode of liver failure she developed quadriparesis that rapidly progressed after transplantation to a severe polyneuropathy. Following transplantation she also developed a se...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(91)90680-j
更新日期:1991-06-01 00:00:00
abstract::There is increasing evidence that ingested diet-borne components are involved in the pathogenesis of disorders such as inflammatory bowel diseases, atherosclerosis, and type 2 diabetes. Nutrients can have short- and long-term effects in shaping the composition of the microbiota. Western diets (enriched in fat, phospha...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2014.12.036
更新日期:2015-05-01 00:00:00
abstract::Helicobacter pylori infects the stomach of half of the human population worldwide and causes chronic active gastritis, which can lead to peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The host immune response to the infection is ineffective, because the bacterium persists...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2007.05.008
更新日期:2007-07-01 00:00:00
abstract::The purpose of this study was to determine the utility of jejunal manometry in evaluating patients having partial small intestinal obstruction or the pseudoobstruction syndrome. We studied 10 healthy volunteers, 9 patients with documented mechanical obstruction, and 3 patients with chronic intestinal pseudoobstruction...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-12-01 00:00:00
abstract::The human lower esophageal sphincter (LES) is believed to be innervated by nonadrenergic, noncholinergic inhibitory nerves, and cholinergic excitatory nerves. In idiopathic achalasia, LES relaxation is abnormal because the inhibitory nerves to the sphincter are either absent or functionally impaired. The integrity of ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90869-3
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND & AIMS:We have previously shown that patients with irritable bowel syndrome (IBS) have impaired transit of intestinal gas loads. Because abnormal gas retention can be experimentally reproduced in healthy subjects by pharmacological inhibition of gut motility, we hypothesized that impaired gas transit and ret...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/gast.2002.33658
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND & AIMS:In searching for effects of acetaminophen (APAP) on hepatocytes downstream of its metabolism that may participate in hepatotoxicity, we examined the role of stress kinases. METHODS:Mouse hepatocytes and C57BL/6 mice were administered a toxic dose of APAP with or without SP600125, a chemical c-jun N-t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.03.045
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND & AIMS:Epithelial cells of the small intestine migrate to the tip of the villus at which they are shed. It is not understood how the intestinal barrier is maintained during this high cell turnover. The aim of this study was to use high-resolution in vivo light microscopy to investigate the mechanism of epith...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.06.015
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND & AIMS:Induction of heat-shock protein 72 is associated with enhanced tolerance to subsequent nonthermal stresses. This study evaluated whether induction of heat-shock protein 72 protects against intestinal ischemia/reperfusion injury. METHODS:Groups of nonheated and heated rats underwent sham operation, 30...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90339-9
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND & AIMS:Math1 (Atoh1) is a basic helix-loop-helix transcription factor important for intestinal secretory cell differentiation. We hypothesized that Math1 is important in cell fate commitment, and therefore mediates proliferative homeostasis and the adaptive response following intestinal resection in the adul...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.03.047
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND & AIMS:Gastroesophageal reflux typically occurs after meals. During dual gastric and esophageal pH monitoring, we observed that postprandial refluxate was often more acidic than the gastric contents. This study aimed to investigate this phenomenon. METHODS:Dual gastric and esophageal pH tracings were analyz...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.27997
更新日期:2001-10-01 00:00:00
abstract::Noninvasive imaging modalities may suggest the diagnosis of Budd-Chiari syndrome but they are rarely diagnostic. Inferior vena cavography, hepatic venography, and liver biopsy, alone or in combination, are usually necessary for definitive diagnosis. Because of its excellent depiction of blood vessels as regions of abs...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(86)80029-4
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND & AIMS:The effects of leukotriene (LT) D(4) on intestinal epithelial cells govern events that are involved in cell survival and colon cancer, notably increased expression of cyclooxygenase (COX)-2 and enhanced production of prostaglandin E(2). We investigated possible correlations between distribution of the...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2003.50011
更新日期:2003-01-01 00:00:00
abstract::Obstruction of the common bile duct can now be relieved by endoscopic electrosurgery. This report describes our experience with 267 patients. In 192 of 222 patients with choledocholithiasis all calculi were evacuated by endoscopic papillotomy (EP). The remaining patients had EP because of papillary stenosis. Complicat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND & AIMS:Parenteral methotrexate is an effective treatment for patients with Crohn's disease, but has never been adequately evaluated in patients with ulcerative colitis (UC). We conducted a randomized controlled trial to determine its safety and efficacy in patients with steroid-dependent UC. METHODS:We perf...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1053/j.gastro.2015.10.050
更新日期:2016-02-01 00:00:00
abstract::In ilea of spontaneously infested guinea pigs, we examined the interface between the plasma membranes of cryptosporidia and absorptive cells using thin section and freeze fracture techniques. Initially, cryptosporidia invaginate microvilli, and the resulting redundant folds of membrane envelop the protozoan, thereby i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)91112-1
更新日期:1986-03-01 00:00:00
abstract::The growth rate of 31 asymptomatic hepatocellular carcinomas (diameter less than or equal to 5 cm) discovered in 28 patients by a prospective screening program was determined by real-time ultrasonography over 36-860 days. Except for one tumor that shrank on follow-up, the doubling time ranged from 29 to 398 days, with...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90324-5
更新日期:1985-08-01 00:00:00
abstract::To study the relationship between gallstone disease (cholelithiasis and cholecystectomy) and cancer, a case-control study was performed in two Swedish hospitals comparing the prevalence of gallstone disease discovered at necropsy in 1422 subjects who died of cancer and 1205 subjects who did not die of cancer. Gallston...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND & AIMS:To elucidate the survival of the patients with unresectable hepatocellular carcinoma (HCC) who underwent transcatheter arterial lipiodol chemoembolization (TACE) and to analyze the factors affecting the survivals. METHODS:During the last 8 years, a nationwide prospective cohort study was performed in...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.05.021
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND & AIMS:Differences in genetic background may play a role in the development of ulcerative colitis (UC)-related neoplasia. Loss of heterozygosity (LOH) of APC has been reported in human UC-associated neoplasia. To investigate the role of genetic differences in UC-associated neoplasia, we compared differences ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.29609
更新日期:2001-12-01 00:00:00
abstract::A pancreatic somatostatinoma metastatized to the liver was detected in a 70-yr-old woman presenting with chronic diarrhea, steatorrhea, pancreatic insufficiency, diabetes mellitus, and achlorhydria. At immunocytochemistry, most tumor cells stored both somatostatin and calcitoninlike substances. Chromatography of acid ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::The possibility that chronic uremia renders the gastric mucosa more susceptible to acid injury was investigated. A rat model of chronic renal failure was induced by subtotal nephrectomy. [H+] back-diffusion across the mucosa, following intragastric perfusion of 0.15N HCl or 15% ethanol in 0.15N HCl, was significantly ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)91432-4
更新日期:1992-12-01 00:00:00
abstract::The symptoms of urgency, diarrhea, and abdominal discomfort are exaggerated after a meal in inflammatory disorders of the colon, such as ulcerative colitis. The possible motor correlates of these symptoms were investigated in a model of acute colitis in six dogs. Each dog was instrumented with seven strain gauge trans...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(91)90389-3
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND & AIMS:Because current therapies for chronic hepatitis C virus (HCV) infections are suboptimal and associated with severe side effects, novel treatment options are needed. A small animal model has recently been developed to study HCV infections. To examine the usefulness of this human liver-urokinase-type pl...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.07.007
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND & AIMS:The cyclic adenosine monophosphate (cAMP) and Ca(2+) signaling pathways synergize to regulate many physiological functions. However, little is known about the mechanisms by which these pathways interact. We investigated the synergy between these signaling pathways in mouse pancreatic and salivary glan...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.03.047
更新日期:2013-07-01 00:00:00