Morphologic and physiologic studies of canine ileal enteroglucagon-containing cells in short-term culture.

abstract：BACKGROUND & AIMS:The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic activity of MIF has been described in several cancer models. Therefore, we investigated the expression and function of MIF during the early stages of intestinal ...

journal_title：Gastroenterology

authors： Wilson JM,Coletta PL,Cuthbert RJ,Scott N,MacLennan K,Hawcroft G,Leng L,Lubetsky JB,Jin KK,Lolis E,Medina F,Brieva JA,Poulsom R,Markham AF,Bucala R,Hull MA

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND & AIMS:According to the National Center for Health Statistics (NCHS), chronic liver disease and cirrhosis is the 12(th) leading cause of death in the United States. However, this single descriptor might not adequately enumerate all deaths from liver disease. The aim of our study was to update data on liver m...

journal_title：Gastroenterology

authors： Asrani SK,Larson JJ,Yawn B,Therneau TM,Kim WR

更新日期：2013-08-01 00:00:00

abstract：:This study correlates duodenal bile acid delivery with motility of the sphincter of Oddi during the fasting state. Dogs were prepared with a functional cholecystectomy, a duodenal cannula for direct vision cannulation of the common bile duct, and 12 bipolar electrodes serosally implanted from stomach to terminal ileum...

journal_title：Gastroenterology

authors： Scott RB,Strasberg SM,El-Sharkawy TY,Diamant NE

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND & AIMS:The risk for colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) could have changed over time, with changes in treatment options. We studied CRC risk in a nationwide cohort of 47,374 Danish patients with IBD over a 30-year period. METHODS:We determined relative risk (RR) values ...

journal_title：Gastroenterology

authors： Jess T,Simonsen J,Jørgensen KT,Pedersen BV,Nielsen NM,Frisch M

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND & AIMS:Host genetic factors are likely to contribute to the variable course of hepatic fibrosis in response to chronic liver injury. Similarly, the fibrotic response differs among inbred mouse strains after challenge with CCl(4). Our aim was to identify unknown susceptibility loci for hepatic fibrosis in a c...

journal_title：Gastroenterology

authors： Hillebrandt S,Goos C,Matern S,Lammert F

更新日期：2002-12-01 00:00:00

abstract：:Histologic or ultrastructural evidence of the ability of sucralfate to protect the gastric mucosa against ethanol injury is lacking. Therefore we analyzed morphologic and functional changes in the mucosa of 120 rats receiving, intragastrically, 2 ml of either sucralfate 500 mg/kg body wt or a control solution and 1 h ...

journal_title：Gastroenterology

authors： Hollander D,Tarnawski A,Krause WJ,Gergely H

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND & AIMS:New serologic markers of inflammatory bowel disease may be useful for differentiating between Crohn's disease and ulcerative colitis and for disease stratification. We profiled sugar-binding antibodies to identify novel antiglycan antibodies that may be associated with inflammatory bowel disease. MET...

journal_title：Gastroenterology

authors： Dotan I,Fishman S,Dgani Y,Schwartz M,Karban A,Lerner A,Weishauss O,Spector L,Shtevi A,Altstock RT,Dotan N,Halpern Z

更新日期：2006-08-01 00:00:00

abstract：:Initially, scintigraphy was established as a valid method for detecting and quantitating enterogastric reflux. A new, tubeless technique for the measurement of enterogastric reflux was developed. 99mTc bound to [(2,6 dimethylphenylcarbamoylmethyl) iminodiacetic acid] (5 mCi) was administered intravenously to visualize...

journal_title：Gastroenterology

authors： Tolin RD,Malmud LS,Stelzer F,Menin R,Makler PT Jr,Applegate G,Fisher RS

更新日期：1979-11-01 00:00:00

abstract：DESCRIPTION:Thanks to ready access to hydrogen breath testing, small intestinal bacterial overgrowth (SIBO) is now commonly diagnosed among individuals presenting with a variety of gastrointestinal and even nongastrointestinal symptoms and is increasingly implicated in lay press and media in the causation of a diverse ...

journal_title：Gastroenterology

authors： Quigley EMM,Murray JA,Pimentel M

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND & AIMS:Postcolonoscopy colorectal cancer (PCCRC) is CRC diagnosed after a colonoscopy in which no cancer was found. A consensus article from the World Endoscopy Organization (WEO) proposed an approach for investigating and categorizing PCCRCs detected within 4 years of a colonoscopy. We aimed to identify cas...

journal_title：Gastroenterology

authors： Anderson R,Burr NE,Valori R

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND & AIMS:We investigated the expression of estrogen receptor (ER) alpha and beta subtypes in cholangiocytes of normal and bile duct-ligated (BDL) rats and evaluated the role and mechanisms of estrogens in the modulation of cholangiocyte proliferation. METHODS:ER-alpha and ER-beta were analyzed by immunohistoc...

journal_title：Gastroenterology

authors： Alvaro D,Alpini G,Onori P,Perego L,Svegliata Baroni G,Franchitto A,Baiocchi L,Glaser SS,Le Sage G,Folli F,Gaudio E

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND & AIMS:Adenomatous polyps are by definition dysplastic and pathologically indistinguishable from the dysplasia-associated lesion or mass (DALM) described in 1981. Yet, adenomatous polyps in noncolitic colons are usually removed definitively endoscopically, whereas DALMs are regarded as harbingers of colon ca...

journal_title：Gastroenterology

authors： Rubin PH,Friedman S,Harpaz N,Goldstein E,Weiser J,Schiller J,Waye JD,Present DH

更新日期：1999-12-01 00:00:00

abstract：:Helicobacter pylori has recently been implicated as an etiologic agent of gastroduodenal disorders. Comparing the antibody to H. pylori in the sera of patients with that of normal controls by Western blot analysis, a unique antibody was detected in the sera of patients, which reacted with the 25-kilodalton antigen of ...

journal_title：Gastroenterology

authors： Sugiyama T,Imai K,Yoshida H,Takayama Y,Yabana T,Yokota K,Oguma K,Yachi A

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:The interactions among pre-S deletion, precore (PC) mutation, and basal core promoter (BCP) mutation in various stages of chronic hepatitis B virus (HBV) infection remain unclear and were thus investigated in this study. METHODS:The sequences of the pre-S region and the BCP (A1762T, G1764A) and PC (G...

journal_title：Gastroenterology

authors： Chen BF,Liu CJ,Jow GM,Chen PJ,Kao JH,Chen DS

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with previous stomach and terminal ileum resections are often treated with intramuscular vitamin B12 injections. Disadvantages are, on a worldwide scale, the frequent need for medical personnel to administer injections and the sometimes painful way of application. This study was designed to i...

journal_title：Gastroenterology

authors： Slot WB,Merkus FW,Van Deventer SJ,Tytgat GN

更新日期：1997-08-01 00:00:00

abstract：:To clarify the intracellular distribution of myosin in normal rat hepatocytes and its alterations in phal-loidin-treated rat hepatocytes as a morphologic basis for the dysfunction of microfilaments, we performed indirect immunofluorescence using monospecific antibody raised against rat hepatocyte myosin. Cryostat rat ...

journal_title：Gastroenterology

authors： Yasuura S,Ueno T,Watanabe S,Hirose M,Namihisa T

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic stress is associated with visceral hyperalgesia in functional gastrointestinal disorders. We investigated whether corticosterone plays a role in chronic psychological stress-induced visceral hyperalgesia. METHODS:Male rats were subjected to 1-hour water avoidance (WA) stress or subcutaneous c...

journal_title：Gastroenterology

authors： Hong S,Zheng G,Wu X,Snider NT,Owyang C,Wiley JW

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that invades surrounding structures and metastasizes rapidly. Although inflammation is associated with tumor formation and progression, little is known about the mechanisms of this connection. We investigate the effects of interleukin...

journal_title：Gastroenterology

authors： Perusina Lanfranca M,Zhang Y,Girgis A,Kasselman S,Lazarus J,Kryczek I,Delrosario L,Rhim A,Koneva L,Sartor M,Sun L,Halbrook C,Nathan H,Shi J,Crawford HC,Pasca di Magliano M,Zou W,Frankel TL

更新日期：2020-04-01 00:00:00

abstract：:The onset, course, and regression of the biochemical and structural alterations associated with pancreatitis induced by various doses of caerulein were studied in the mouse. In addition, the protective effect of secretin was compared with that of the cholecystokinin-receptor antagonists proglumide and benzotript. Subc...

journal_title：Gastroenterology

authors： Niederau C,Ferrell LD,Grendell JH

更新日期：1985-05-01 00:00:00

abstract：:Mast cell/nerve associations have been recorded in several publications; however, the human gastrointestinal tract has received little attention. Accordingly, mucosal samples from small bowel, appendix, and large bowel were studied. Combined histochemical/immunocytochemical techniques revealed that the proportion of m...

journal_title：Gastroenterology

authors： Stead RH,Dixon MF,Bramwell NH,Riddell RH,Bienenstock J

更新日期：1989-09-01 00:00:00

abstract：:We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for d...

journal_title：Gastroenterology

authors： Dedhia PH,Bertaux-Skeirik N,Zavros Y,Spence JR

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND & AIMS:The enteric nervous system (ENS) coordinates essential intestinal functions through the concerted action of diverse enteric neurons (ENs). However, integrated molecular knowledge of EN subtypes is lacking. To compare human and mouse ENs, we transcriptionally profiled healthy ENS from adult humans and ...

journal_title：Gastroenterology

authors： May-Zhang AA,Tycksen E,Southard-Smith AN,Deal KK,Benthal JT,Buehler DP,Adam M,Simmons AJ,Monaghan JR,Matlock BK,Flaherty DK,Potter SS,Lau KS,Southard-Smith EM

更新日期：2020-09-30 00:00:00

abstract：:A case of a 41-year-old man with diarrhea, hypoalbuminemia, and cryptogenic cirrhosis with features of portal hypertension is described. Protein-losing enteropathy was confirmed by analysis of whole-gut lavage fluid, and intestinal inflammation and infection were excluded. Distal duodenal biopsy specimens showed evide...

journal_title：Gastroenterology

authors： Stanley AJ,Gilmour HM,Ghosh S,Ferguson A,McGilchrist AJ

更新日期：1996-12-01 00:00:00

abstract：:The clinical case is presented of a 16-yr-old patient with thoracoabdominal duplication that communicated with the main pancreatic duct and the right pleural cavity and resulted in pancreaticopleural fistula. Although abdominal duplications communicating with the pancreas have been described before, to our knowledge, ...

journal_title：Gastroenterology

authors： Fitzgibbons RJ Jr,Nugent FW,Ellis FH Jr,Braasch JW,Scholz FJ

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic hepatitis C virus infection activates an intrahepatic immune response, leading to increased expression of interferon (IFN)-stimulated genes and activation of natural killer (NK) cells-the most prevalent innate immune cell in the liver. We investigated whether the elimination of hepatitis C vir...

journal_title：Gastroenterology

authors： Serti E,Chepa-Lotrea X,Kim YJ,Keane M,Fryzek N,Liang TJ,Ghany M,Rehermann B

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND & AIMS:High-level coffee consumption has been associated with reduced progression of pre-existing liver diseases and lower risk of hepatocellular carcinoma. However, its relationship with therapy for hepatitis C virus infection has not been evaluated. METHODS:Patients (n=885) from the lead-in phase of the H...

journal_title：Gastroenterology

authors： Freedman ND,Curto TM,Lindsay KL,Wright EC,Sinha R,Everhart JE,HALT-C TRIAL GROUP.

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:T helper (Th) 17 cells that express the retinoid-related orphan receptor (ROR) γt contribute to the development of colitis in mice, yet are found in normal and inflamed intestine. We investigated their development and functions in intestines of mice. METHODS:We analyzed intestinal Th17 cells in healt...

journal_title：Gastroenterology

authors： Ono Y,Kanai T,Sujino T,Nemoto Y,Kanai Y,Mikami Y,Hayashi A,Matsumoto A,Takaishi H,Ogata H,Matsuoka K,Hisamatsu T,Watanabe M,Hibi T

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND & AIMS:Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis. Although highly expressed in liver, several studies have reported TfR2 expression in other tissues. To determine the contribution of liver expressed...

journal_title：Gastroenterology

authors： Wallace DF,Summerville L,Subramaniam VN

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND & AIMS:We have reported that contrast echocardiography is a sensitive screening test for the hepatopulmonary syndrome (HPS). However, contrast echocardiography lacks specificity because many cirrhotic patients have positive study results with normal arterial blood gases and therefore do not fulfill criteria ...

journal_title：Gastroenterology

authors： Abrams GA,Nanda NC,Dubovsky EV,Krowka MJ,Fallon MB

更新日期：1998-02-01 00:00:00

abstract：:Acute, acute recurrent, and chronic forms of pancreatitis have been increasingly diagnosed in children in the past 2 decades. Risk factors in the pediatric group are broad and appear to be strikingly different compared with the adult cohort. However, the disease burden and impact on quality of life are surprisingly si...

journal_title：Gastroenterology

authors： Uc A,Husain SZ

更新日期：2019-05-01 00:00:00