Mast cells are closely apposed to nerves in the human gastrointestinal mucosa.

Abstract:

:Mast cell/nerve associations have been recorded in several publications; however, the human gastrointestinal tract has received little attention. Accordingly, mucosal samples from small bowel, appendix, and large bowel were studied. Combined histochemical/immunocytochemical techniques revealed that the proportion of mast cells apposed to nerves ranged from 47.08% +/- 6.10% to 77.66% +/- 4.26%. The highest incidence of contact was observed in the appendix; where the apparent nerve density was also greater than in the large or small bowel. Electron-microscopic studies revealed many mast cells adjacent to nerve fibers and membrane-to-membrane contact between axonlike processes and mast cells. Often, these processes were dilated, as were axons in adjacent nerve fibers. These data provide a microanatomic basis for potential communication between nerves and mast cells in the human gastrointestinal mucosa. This may be of physiologic significance in the normal individual and important in disease processes, such as inflammation and fibrosis.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Stead RH,Dixon MF,Bramwell NH,Riddell RH,Bienenstock J

doi

10.1016/0016-5085(89)90627-6

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

575-85

issue

3

eissn

0016-5085

issn

1528-0012

pii

0016-5085(89)90627-6

journal_volume

97

pub_type

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