Abstract：
BACKGROUND & AIMS:We have reported that contrast echocardiography is a sensitive screening test for the hepatopulmonary syndrome (HPS). However, contrast echocardiography lacks specificity because many cirrhotic patients have positive study results with normal arterial blood gases and therefore do not fulfill criteria for HPS. The aim of this study was to assess the role of macroaggregated albumin lung perfusion scans (MAA scans) in the diagnosis of HPS. METHODS:MAA scans were performed in 25 patients with HPS, 25 cirrhotic patients without HPS, and 15 hypoxemic subjects with intrinsic lung disease alone. An MAA shunt fraction was calculated from brain and lung counts. RESULTS:MAA scan results were positive in 21 of 25 patients with HPS and negative in all controls. All 21 patients with positive MAA scans had PO2 values of <60 mm Hg. There was a strong inverse correlation between the degree of the MAA shunt fraction and arterial hypoxemia (r = -0.726). CONCLUSIONS:A positive MAA scan result in cirrhosis is specific for the presence of moderate to severe HPS. We speculate that MAA scans may be particularly useful in evaluating the contribution of HPS to the hypoxemia in cirrhotic patients with intrinsic lung disease.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Abrams GA,Nanda NC,Dubovsky EV,Krowka MJ,Fallon MBdoi
10.1016/s0016-5085(98)70481-0subject
Has Abstractpub_date
1998-02-01 00:00:00pages
305-10issue
2eissn
0016-5085issn
1528-0012pii
S0016508598001231journal_volume
114pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：:Cellular protooncogenes such as c-myc and c-Ha-ras may play important roles in the control of regeneration of the stomach. In this study, in situ hybridization histochemistry and immunohistochemistry were used to determine how these protooncogenes and the corresponding oncoproteins are expressed at the cellular level ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(90)91085-k
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND & AIMS:Prior thermal stress induces heat shock protein 70 (HSP70) expression in the pancreas and protects against secretagogue-induced pancreatitis, but it is not clear that this thermal stress-induced protection is actually mediated by HSP70 since thermal stress may have other, non-HSP related, effects. ME...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2002.30314
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND & AIMS:Intestinal myofibroblasts are known to respond to inflammatory signals and may play a role in Crohn's disease-associated fibrosis. However, putative involvement by myofibroblasts in innate immune responses as part of intestinal host defense has not been characterized. We therefore analyzed expression ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(03)00403-7
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND & AIMS:The mechanism(s) by which sucralfate heals duodenal ulcers remains unclear. The aim of this study was to determine the effect of sucralfate on Helicobacter pylori infection and on the accompanying hypersecretion of gastric acid the infection induces in patients with duodenal ulcer. METHODS:Basal and ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1996.v110.pm8608880
更新日期：1996-03-01 00:00:00
abstract：:We are delighted to introduce a new and simple format in the references section of the articles we publish in Gastroenterology that highlights joint first authors of citations. We believe this is an important step to acknowledging equal contribution to published work as research becomes increasingly team-oriented and ...
journal_title：Gastroenterology
pub_type： 社论
doi：10.1053/j.gastro.2012.08.009
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND & AIMS:Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor (EGF) receptor signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the recep...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.07.008
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND & AIMS:Advanced cirrhosis is associated with impaired leukocyte function, but the mechanism underlying this host defense alteration is unknown. The aim of this study was to investigate the lipoxygenase pathway of arachidonic acid metabolism and its influence in leukocyte trafficking in patients with cirrhosi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(98)70376-2
更新日期：1998-07-01 00:00:00
abstract：:In 6 anesthetized dogs receiving 400 pmoles kg-1 hr-1 of natural human little gastrin intravenously, blood samples for radioimmunoassay of gastrin were taken repeatedly from a carotid artery, jugular vein, femoral vein, renal vein, and mesenteric vein. The calculated removal of gastrin in a single passage through thes...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:In the rat, gastric histamine is stored mainly in the enterochromaffinlike cells. Gastrin releases histamine from these cells, and long-term hypergastrinemia results in hyperplasia. The effect of sustained hypergastrinemia on histamine-depleted enterochromaffinlike cells was studied by measuring histidine decarboxylas...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)90023-r
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND & AIMS:Activation of Fas or tumor necrosis factor receptor 1 (TNF-R1) on hepatocytes leads to apoptosis, which requires mitochondria activation. The pro-death Bcl-2 family protein, Bid, mediates this pathway by inducing mitochondrial releases of cytochrome c and other apoptotic factors. How Bid activates mit...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(03)01066-7
更新日期：2003-09-01 00:00:00
abstract：:This study was conducted to determine whether short-term (1.75 h) luminal glucose perfusion increases the mucosal protein synthesis rate in rat small intestine. A luminal perfusate containing 56 mM glucose was compared with a control perfusate containing mannitol in two jejunal segments constructed in the same animal....
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND:Active transport of conjugated bile acids by ileal enterocytes is a key mechanism for conservation of the bile acid pool. Experiments were performed to determine whether such transport is regulated by substrate load. METHODS:Using anesthetized biliary fistula guinea pigs or rats, the ileum was perfused with...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(93)90833-x
更新日期：1993-01-01 00:00:00
abstract：:The purpose of this study was to develop an in vitro model of the proximal colon that would permit investigation of the function of colonic bacteria. Five continuous cultures of fecal bacteria were maintained anaerobically in steady state for at least 21 days in a medium simulating ileostomy effluent. The pH was maint...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(85)90017-4
更新日期：1985-06-01 00:00:00
abstract：BACKGROUND & AIMS:Few data are available on the potential role of T lymphocytes in experimental acute pancreatitis. The aim of this study was to characterize their role in the inflammatory cascade of acute pancreatitis. METHODS:To type this issue, acute pancreatitis was induced by repeated injections of cerulein in nu...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(00)70265-4
更新日期：2000-03-01 00:00:00
abstract：:A 62-year-old man with rheumatoid arthritis developed jaundice while taking piroxicam. A full evaluation including ultrasound, computerized tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic cholestasis. The patient's jaundice and all other liver function abnormalities nor...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1016/0016-5085(91)90417-j
更新日期：1991-12-01 00:00:00
abstract：BACKGROUND & AIMS:Patients affected by familial adenomatous polyposis (FAP) are at increased risk of developing duodenal adenomas. In this study, cell proliferation of duodenal mucosa was analyzed to detect kinetic abnormalities related to cancer risk. METHODS:Duodenal biopsy specimens were collected in three groups o...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1997.v113.pm9322510
更新日期：1997-10-01 00:00:00
abstract：:The onset, course, and regression of the biochemical and structural alterations associated with pancreatitis induced by various doses of caerulein were studied in the mouse. In addition, the protective effect of secretin was compared with that of the cholecystokinin-receptor antagonists proglumide and benzotript. Subc...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(85)80079-2
更新日期：1985-05-01 00:00:00
abstract：BACKGROUND & AIMS:Induction of colitis in mice by administration of oxazolone is mediated by T-helper (Th) 2 cells and has features of human ulcerative colitis. We investigated whether activation of interleukin (IL)-4Rα on T and B cells determines their effector functions and mediates oxazolone-induced colitis. METHOD...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.09.044
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND & AIMS:The effects of trypsin on pancreatic ductal epithelial cells (PDECs) vary among species and depend on the localization of proteinase-activated receptor 2 (PAR-2). We compared PAR-2 localization in human and guinea-pig PDECs, and used isolated guinea pig ducts to study the effects of trypsin and a PAR-...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.08.039
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND & AIMS:Ischemia and reperfusion injury are common causes of oxidative tissue damage associated with many liver diseases and hepatic surgery. The Wnt-β-catenin signaling pathway is an important regulator of hepatic development, regeneration, and carcinogenesis. However, the role of Wnt signaling in the hepato...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.04.051
更新日期：2011-08-01 00:00:00
abstract：:Glycine protects renal tubule cells from cell death during adenosine triphosphate (ATP) depletion. Although the liver plays a key role in glycine metabolism, information is lacking regarding the effects of glycine on lethal hepatocellular injury. Thus, the aim of this study was to determine the potential cytoprotectiv...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)90338-y
更新日期：1992-06-01 00:00:00
abstract：:The aims of our prospective study were to determine the development and natural history of esophageal varices and variceal bleeding in patients with primary biliary cirrhosis. As part of a controlled clinical study, 265 patients with primary biliary cirrhosis who did not have esophageal varices at entry were followed ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(89)90526-x
更新日期：1989-06-01 00:00:00
abstract：:Colchicine treatment was used in this randomized placebo-controlled trial in patients with severe acute alcoholic hepatitis [serum bilirubin greater than or equal to 5 mg/dL (85.5 mumol/L) mean, 17.5 +/- 7.5 mg/dL (299.25 +/- 128.25 mumol/L)]. Hospitalization mortality and morbidity and the effect on biochemical test ...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0016-5085(90)90973-5
更新日期：1990-09-01 00:00:00
abstract：BACKGROUND & AIMS:Activated pancreatic stellate cells have recently been implicated in pancreatic fibrogenesis. This study examined the role of pancreatic stellate cells in alcoholic pancreatic fibrosis by determining whether these cells are activated by ethanol itself and, if so, whether such activation is caused by t...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(00)70148-x
更新日期：2000-04-01 00:00:00
abstract：:A numerically important group of patients with functional gastrointestinal disorders have chronic symptoms that can be attributed to the gastroduodenal region. Based on the consensus opinion of an international panel of clinical investigators who reviewed the available evidence, a classification of the functional gast...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2005.11.059
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND & AIMS:The early detection of colorectal cancer is desired because this cancer can be cured surgically if diagnosed early. The purpose of the present study was to determine the feasibility of a new methodology for isolating colonocytes from naturally evacuated feces, followed by cytology or molecular biology...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2005.10.007
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND & AIMS:Acetaminophen toxicity is the most common cause of acute liver failure (ALF) in the United States and Great Britain, but may be underrecognized in certain settings. Acetaminophen-protein adducts are specific biomarkers of drug-related toxicity in animal models and can be measured in tissue or blood sa...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2006.01.033
更新日期：2006-03-01 00:00:00
abstract：:Lamins have important roles in nuclear structure and cell signaling. Several diseases are associated with mutations in the lamin A/C gene (LMNA in humans). Patients with familial partial lipodystrophy caused by LMNA mutations develop pancreatitis, but lamin function in the pancreas and how these mutations affect pancr...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2018.01.024
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND & AIMS:Previous studies have indicated that serotonin-3-receptor antagonists might have a sex-specific effect in patients with irritable bowel syndrome with diarrhea (IBS-D). Alosetron has been approved for the treatment of only women, and ramosetron has been approved for the treatment for only men. We perfo...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1053/j.gastro.2015.10.047
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND/AIMS:Familial adenomatous polyposis is caused by germline mutation of the adenomatous polyposis coli (APC) gene. Affected individuals develop hundreds of colorectal adenomas at young age and can have extracolonic lesions. METHODS:This study evaluated the phenotype of 74 patients with familial adenomatous po...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(94)90408-1
更新日期：1994-06-01 00:00:00
