Organoid Models of Human Gastrointestinal Development and Disease.

Abstract:

:We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for decades in GI research. Organoids are derived from primary tissues and have the capacity for long-term growth. They contain varying levels of cellular complexity and physiological similarity to native organ systems. We review the latest discoveries from studies of tissue-derived and pluripotent stem cell-derived intestinal, gastric, esophageal, liver, and pancreatic organoids. These studies have provided important insights into GI development, tissue homeostasis, and disease and might be used to develop personalized medicines.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Dedhia PH,Bertaux-Skeirik N,Zavros Y,Spence JR

doi

10.1053/j.gastro.2015.12.042

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

1098-1112

issue

5

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(16)00042-1

journal_volume

150

pub_type

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