Abstract:
:We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for decades in GI research. Organoids are derived from primary tissues and have the capacity for long-term growth. They contain varying levels of cellular complexity and physiological similarity to native organ systems. We review the latest discoveries from studies of tissue-derived and pluripotent stem cell-derived intestinal, gastric, esophageal, liver, and pancreatic organoids. These studies have provided important insights into GI development, tissue homeostasis, and disease and might be used to develop personalized medicines.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Dedhia PH,Bertaux-Skeirik N,Zavros Y,Spence JRdoi
10.1053/j.gastro.2015.12.042subject
Has Abstractpub_date
2016-05-01 00:00:00pages
1098-1112issue
5eissn
0016-5085issn
1528-0012pii
S0016-5085(16)00042-1journal_volume
150pub_type
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