Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease.

abstract：BACKGROUND & AIMS:Deoxycholate (DC) has proapoptotic and tumorigenic effects in different cell types of the gastrointestinal tract. Exposure of BHK-21 (stromal) cells to DC induces Ca(2+) entry at the plasma membrane, which affects intracellular Ca(2+) signaling. We assessed whether DC-induced increases in [Ca(2+)] can...

journal_title：Gastroenterology

authors： Gerbino A,Ranieri M,Lupo S,Caroppo R,Debellis L,Maiellaro I,Caratozzolo MF,Lopez F,Colella M

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND & AIMS:Long non-coding RNAs (lncRNAs) are expressed in tissue-specific pattern, but it is not clear how these are regulated. We aimed to identify squamous cell carcinoma (SCC)-specific lncRNAs and investigate mechanisms that control their expression and function. METHODS:We studied expression patterns and f...

journal_title：Gastroenterology

authors： Xie JJ,Jiang YY,Jiang Y,Li CQ,Lim MC,An O,Mayakonda A,Ding LW,Long L,Sun C,Lin LH,Chen L,Wu JY,Wu ZY,Cao Q,Fang WK,Yang W,Soukiasian H,Meltzer SJ,Yang H,Fullwood M,Xu LY,Li EM,Lin DC,Koeffler HP

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND & AIMS:Keratins 8 and 18 (K8/K18) provide anti-apoptotic functions upon liver injury. The cytoprotective function of keratins explains the overrepresentation of K8/K18 variants in patients with cirrhosis. However, K8/K18 variant-associated susceptibility to acute liver injury, which is well-described in anim...

journal_title：Gastroenterology

authors： Strnad P,Zhou Q,Hanada S,Lazzeroni LC,Zhong BH,So P,Davern TJ,Lee WM,Acute Liver Failure Study Group.,Omary MB

更新日期：2010-09-01 00:00:00

abstract：:A 61-yr-old woman was found to have multicentric hepatocellular carcinoma associated with clinical hyperthyroidism. Marked elevations in serum thyroid-stimulating hormone, T4, T3, and free T4 were documented. These values increased with tumor progression. It is postulated that this patient's hepatoma produced a substa...

journal_title：Gastroenterology

authors： Helzberg JH,McPhee MS,Zarling EJ,Lukert BP

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND/AIMS:Helicobacter felis colonizes the gastric mucosa of rodents. Preliminary studies showed differences in the distribution of the organism in different parts of the stomach that seemed related to the secretory capacity of the mucosa. The aim of this study was to determine the localization of H. felis in the...

journal_title：Gastroenterology

authors： Danon SJ,O'Rourke JL,Moss ND,Lee A

更新日期：1995-05-01 00:00:00

abstract：:We report a patient with severe peptic ulcer disease and a right ovarian mass that was found to be a gastrin-producing cystadenocarcinoma. Gastrin production by the tumor was stimulated by secretin and inhibited by the long-acting somatostatin analogue SMS 201-995. Following resection of the tumor, serum gastrin level...

journal_title：Gastroenterology

authors： Heyd J,Livni N,Herbet D,Mor-Yosef S,Glaser B

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND & AIMS:Trinitrobenzene sulfonic acid (TNBS)-induced colitis is a T-helper 1 (Th1) T cell-mediated inflammation that is rapidly reversed by administration of anti-interleukin (IL) 12. This study sought to define the mechanism of this curative effect. METHODS:Cells and tissue from mice with TNBS colitis recei...

journal_title：Gastroenterology

authors： Fuss IJ,Marth T,Neurath MF,Pearlstein GR,Jain A,Strober W

更新日期：1999-11-01 00:00:00

abstract：:Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and pyroptosis, a form of phagocyte cell death induced by bacterial pathogens. Members of the Nod-like receptor family (including Nlrp1, Nlrp3, and...

journal_title：Gastroenterology

authors： Chen GY,Núñez G

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND/AIMS:Growth factors and their receptors play a role in healing ulcers of the rat. Somatostatin is a putative growth factor in the gastric mucosa with multiple functions mediated by specific receptors. Therefore, the distribution of somatostatin receptors was evaluated in the gastric mucosa of healing ulcers....

journal_title：Gastroenterology

authors： Reubi JC,Waser B,Schmassmann A,Halter F

更新日期：1994-08-01 00:00:00

abstract：:The effect of experimental bypass on the intestinal epithelium of the rat was investigated from 2 to 360 days after creating a Thiry-Vella fistula. Within 7 to 14 days the number of cells per villus column and, to a lesser degree, the number of cells per crypt column decreased and subsequently these values remained co...

journal_title：Gastroenterology

authors： Rijke RP,Plaisier HM,de Ruiter H,Galjaard H

更新日期：1977-05-01 00:00:00

abstract：:Neuron specific enolase, the most acidic isoenzyme of the glycolytic enzyme enolase, was first believed to be present exclusively in central neurons. More recently, it has been found in peripheral autonomic nerves and in a number of endocrine cells. An immunocytochemical study was carried out concerning the distributi...

journal_title：Gastroenterology

authors： Bishop AE,Polak JM,Facer P,Ferri GL,Marangos PJ,Pearse AG

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND/AIMS:Human colonic epithelium produces large amounts of mucin. The aim of this study was to examine mucin biosynthesis in the human colon. METHODS:Human colonic mucin was isolated using CsCl density gradients, and polyclonal antiserum was raised. Biosynthesis of colonic mucins was studied by labeling coloni...

journal_title：Gastroenterology

authors： Tytgat KM,Büller HA,Opdam FJ,Kim YS,Einerhand AW,Dekker J

更新日期：1994-11-01 00:00:00

abstract：:Two infants under 3 mo of age who presented with obstructive jaundice secondary to cholelithiasis are reported. Neither infant had any congenital anatomic abnormality of the biliary tract leading to stasis, yet both had cultures of gallbladder bile that grew abundant bacteria. In both, recovery of gallbladder bile and...

journal_title：Gastroenterology

authors： Treem WR,Malet PF,Gourley GR,Hyams JS

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND & AIMS:There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to compare de novo lipogenesis and fatty acid flux between subjects with NAFLD and those without, matched for metabolic factors (controls). METHODS:W...

journal_title：Gastroenterology

authors： Lambert JE,Ramos-Roman MA,Browning JD,Parks EJ

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND & AIMS:Manganese (Mn) deposition could be responsible for the T(1)-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional specificity of the Mn increases as well as their relationship to portal-systemic shunting or hepatobili...

journal_title：Gastroenterology

authors： Rose C,Butterworth RF,Zayed J,Normandin L,Todd K,Michalak A,Spahr L,Huet PM,Pomier-Layrargues G

更新日期：1999-09-01 00:00:00

abstract：:Excretion of hydrogen in breath commonly persists despite an overnight fast. Although elevation of hydrogen concentration above the fasting value after administration of a test sugar is evidence of malabsorption, the significance of the fasting value itself is unknown. We determined the normal limits of fasting breath...

journal_title：Gastroenterology

authors： Perman JA,Modler S,Barr RG,Rosenthal P

更新日期：1984-12-01 00:00:00

abstract：:Polycystic liver diseases (PLD) are inherited disorders of the biliary epithelium, caused by genetic defects in proteins associated with intracellular organelles, mainly the endoplasmic reticulum and the cilium. PLD are characterized by the formation and progressive enlargement of multiple cysts scattered throughout t...

journal_title：Gastroenterology

authors： Strazzabosco M,Somlo S

更新日期：2011-06-01 00:00:00

abstract：:This document presents the official recommendations of the American Gastroenterological Association (AGA) Institute on "Use of Gastrointestinal Medications in Pregnancy." It was approved by the Clinical Practice and Economics Committee on February 22, 2006, and by the AGA Institute Governing Board on April 20, 2006. ...

journal_title：Gastroenterology

authors： Mahadevan U,Kane S

更新日期：2006-07-01 00:00:00

abstract：:The incidence of celiac disease is increasing, partly because of improved recognition of, and testing for, the disease. The rise in incidence is also due to a real increase of this immune-based disorder, independent of disease detection. The reasons for this true rise in recent decades are unknown but may be related t...

journal_title：Gastroenterology

authors： Lebwohl B,Rubio-Tapia A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND & AIMS:Cyclooxygenase 2 (COX-2)-specific inhibitors (coxibs) decrease gastrointestinal (GI) events in controlled trials, but results in clinical practice are unknown. We assessed GI-related resource use and costs in patients switching from chronic nonsteroidal anti-inflammatory drug (NSAID) therapy to chroni...

journal_title：Gastroenterology

authors： Laine L,Wogen J,Yu H

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND & AIMS:In several rat infection experiments, we have shown that dietary calcium inhibits intestinal colonization and translocation of invasive salmonella. The aim of the present study was to find out whether calcium is also protective against enterotoxigenic Escherichia coli (ETEC) infection. This was first ...

journal_title：Gastroenterology

authors： Bovee-Oudenhoven IM,Lettink-Wissink ML,Van Doesburg W,Witteman BJ,Van Der Meer R

更新日期：2003-08-01 00:00:00

abstract：:A case of acute hypervitaminosis A complicating viral hepatitis is reported. Twenty days after presenting with hepatitis B, a 42-yr-old vegetarian developed acute hypervitaminosis A in the absence of recent, massive exposure to the vitamin. Findings included headache, confusion, skin desquamation, and hypercalcemia. P...

journal_title：Gastroenterology

authors： Hatoff DE,Gertler SL,Miyai K,Parker BA,Weiss JB

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:The clonality of hepatocellular carcinoma is still controversial. To evaluate the clonality of this cancer, mostly small multiple hepatocellular carcinomas of 18 patients were analyzed by DNA fingerprinting. METHODS:DNA from the liver tissues was digested with HinfI. After gel electrophoresis, in gel-hybrid...

journal_title：Gastroenterology

authors： Sheu JC,Huang GT,Chou HC,Lee PH,Wang JT,Lee HS,Chen DS

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND & AIMS:Unlike adult antral cells, feline newborn antral cells are unable to contract in response to agonists in the absence of extracellular calcium or in response to exogenous inositol 1,4,5-triphosphate (IP3) after permeabilization. Changes in intracellular pathways that are associated with these differenc...

journal_title：Gastroenterology

authors： Hillemeier AC,Deutsch DE,Bitar KN

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis C virus (HCV) infection is a leading cause of end-stage liver disease. Interferon-α (IFNα) is an important component of anti-HCV therapy; it up-regulates transcription of IFN-stimulated genes, many of which have been investigated for their antiviral effects. However, all of the genes require...

journal_title：Gastroenterology

authors： Fusco DN,Brisac C,John SP,Huang YW,Chin CR,Xie T,Zhao H,Jilg N,Zhang L,Chevaliez S,Wambua D,Lin W,Peng L,Chung RT,Brass AL

更新日期：2013-06-01 00:00:00

abstract：:Methylbenzylnitrosamine is an esophageal-specific carcinogen in the rat, and the incidence of methylbenzylnitrosamine-induced esophageal carcinoma is increased by dietary zinc deficiency. Methylbenzylnitrosamine requires activation by cytochrome P-450 to be mutagenic; the present study examined the role of dietary zin...

journal_title：Gastroenterology

authors： Barch DH,Fox CC,Rosche WA,Rundhaugen LM,Wrighton SA

更新日期：1992-09-01 00:00:00

abstract：:This report describes a 59-year-old woman, who, after an initial reaction to hydralazine, inadvertently took the drug again. She promptly developed symptoms of acute cholangitis--fever, right upper quadrant tenderness, obtundation, and hypotension. Cholecystectomy was performed and no obstruction or infection of the b...

journal_title：Gastroenterology

authors： Myers JL,Augur NA Jr

更新日期：1984-11-01 00:00:00

abstract：:In sickle cell anemia the shortened survival of red blood cells presents the liver with an augmented load of bilirubin for hepatic clearance. To determine the effects of this excessive bilirubin load on the microsomal conjugating enzyme, hepatic bilirubin UDP-glucuronyltransferase, levels of this enzyme were measured ...

journal_title：Gastroenterology

authors： Maddrey WC,Cukier JO,Maglalang AC,Boitnott JK,Odell GB

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND & AIMS:Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with adverse events in observational studies. We aimed to confirm these findings in an adequately powered randomized trial. METHODS:...

journal_title：Gastroenterology

authors： Moayyedi P,Eikelboom JW,Bosch J,Connolly SJ,Dyal L,Shestakovska O,Leong D,Anand SS,Störk S,Branch KRH,Bhatt DL,Verhamme PB,O'Donnell M,Maggioni AP,Lonn EM,Piegas LS,Ertl G,Keltai M,Bruns NC,Muehlhofer E,Dagenais G

更新日期：2019-09-01 00:00:00

abstract：:The ability of hypnosis to both stimulate and inhibit gastric acid secretion in highly hypnotizable healthy volunteers was examined in two studies. In the first, after basal acid secretion was measured, subjects were hypnotized and instructed to imagine all aspects of eating a series of delicious meals. Acid output ro...

journal_title：Gastroenterology

authors： Klein KB,Spiegel D

更新日期：1989-06-01 00:00:00