American gastroenterological association institute medical position statement on the use of gastrointestinal medications in pregnancy.

abstract：:Although nocturnal acid secretion has been emphasized in the pathophysiology and treatment of duodenal ulcer, its importance in gastric ulcer disease has been questioned. To explore this area, this multicenter U.S. trial compared the effect of a once-daily nighttime dose of H2-receptor antagonist with placebo on the h...

journal_title：Gastroenterology

authors： McCullough AJ,Graham DY,Knuff TE,Lanza FL,Levenson HL,Lyon DT,Munsell WP,Perozza J,Roufail WM,Sinar DR

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:The duodenum is a cystic fibrosis transmembrane conductance regulator (CFTR)-expressing epithelium with high bicarbonate secretory capacity. We aimed to define the role of CFTR in human duodenal epithelial bicarbonate secretion in normal (NL) subjects and patients with cystic fibrosis (CF). METHODS:E...

journal_title：Gastroenterology

authors： Pratha VS,Hogan DL,Martensson BA,Bernard J,Zhou R,Isenberg JI

更新日期：2000-06-01 00:00:00

abstract：:Morphologic and physiologic experiments in rodents have demonstrated differences between jejunal and ileal fat absorption. Compared with the rat jejunum, absorbed lipid particles within rat ileal absorptive cells are larger and exit at a slower rate. To evaluate the relevance of these observations to humans, we studie...

journal_title：Gastroenterology

authors： Surawicz CM,Levine DS,Saunders DR,Rubin CE

更新日期：1988-06-01 00:00:00

abstract：:Twenty-one of 52 patients with regional enteritis had low serum zinc concentrations on initial testing. Fourteen of 31 patients followed longitudinally had low serum zinc concentrations. Two patients are presented as case reports who developed acrodermatitis skin lesions that responded to zinc therapy. Hypogonadism, g...

journal_title：Gastroenterology

authors： McClain C,Soutor C,Zieve L

更新日期：1980-02-01 00:00:00

abstract：:Data collected by nine population-based tumor registries participating in the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute were analyzed to characterize the epidemiology of noncarcinoid adenocarcinomas of the colon and rectum in young adults. Tumors diagnosed in persons under 40...

journal_title：Gastroenterology

authors： Griffin PM,Liff JM,Greenberg RS,Clark WS

更新日期：1991-04-01 00:00:00

abstract：:In order to assess the efficacy of cimetidine in patients with endoscopically anastomotic ulcer after partial gastrectomy, 21 such patients entered a double-blind prospective clinical trial. At endoscopy after 4 wk of treatment, 8 of 12 patients treated with 1 g of cimetidine daily compared with 1 of 9 patients who re...

journal_title：Gastroenterology

authors： Festen HP,Lamers CB,Driessen WM,Van Tongeren JH

更新日期：1979-07-01 00:00:00

abstract：:Serum group I pepsinogen (PG I) levels have been determined before and at intervals after the administration of betazole hydrochloride (Histalog) in 50 symptomatic postoperative patients, 20 with and 30 without recurrent ulcer, after either a vagotomy and gastric resection or a drainage procedure. In patients with rec...

journal_title：Gastroenterology

authors： Samloff IM,Secrist DM,Passaro E Jr

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND & AIMS:We have few population-level data on the performance of endoscopic retrograde cholangiopancreatography (ERCP) in the United States. We investigated the numbers of unplanned hospital encounters (UHEs), patient and facility factors associated with UHEs, and variation in quality and outcomes in the perfo...

journal_title：Gastroenterology

authors： Huang RJ,Barakat MT,Girotra M,Lee JS,Banerjee S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals. The aim of this study was to examine the influences of age at dia...

journal_title：Gastroenterology

authors： Polito JM 2nd,Childs B,Mellits ED,Tokayer AZ,Harris ML,Bayless TM

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND/AIMS:The survival rate for hepatocellular carcinoma after hepatectomy remains unsatisfactorily low because of the high recurrence rate. The purpose of this study was to elucidate predictive factors for postoperative recurrence of hepatocellular carcinoma. METHODS:Univariate analysis and a multiple regressio...

journal_title：Gastroenterology

authors： Okada S,Shimada K,Yamamoto J,Takayama T,Kosuge T,Yamasaki S,Sakamoto M,Hirohashi S

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND & AIMS:The accurate identification of inactive (serum HBV-DNA persistently

journal_title：Gastroenterology

authors： Brunetto MR,Oliveri F,Colombatto P,Moriconi F,Ciccorossi P,Coco B,Romagnoli V,Cherubini B,Moscato G,Maina AM,Cavallone D,Bonino F

更新日期：2010-08-01 00:00:00

abstract：:Cholinergic innervation in the aganglionic bowel of the piebald lethal mouse model of Hirschsprung's disease was investigated by analysis of muscarinic acetylcholine receptors before and after administration of hexamethonium. After hexamethonium administration in the normal rectum, the maximum specific binding (Bmax) ...

journal_title：Gastroenterology

authors： Ueki S,Okamoto E,Kuwata K,Toyosaka A,Nagai K

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND & AIMS:The liver has high regenerative potential. We attempted to establish a novel culture system for extensive expansion of fetal mouse hepatic stem/progenitor cells and to characterize cultured cells. METHODS:Hepatic spheroids collected from 6-day floating cultures were cultured on collagen-coated dishes...

journal_title：Gastroenterology

authors： Tsuchiya A,Heike T,Fujino H,Shiota M,Umeda K,Yoshimoto M,Matsuda Y,Ichida T,Aoyagi Y,Nakahata T

更新日期：2005-06-01 00:00:00

abstract：:Abdominal cramps and urgent defecation are common side effects of clinical doses of arginine vasopressin, indicating that the drug may have stimulating effects on colonic motor activity. Four strain-gauge transducers were implanted on the colon in six monkeys. A blood flow probe was fixed on the inferior mesenteric ar...

journal_title：Gastroenterology

authors： Zhu YR,Cowles VE,Herranz ES,Schulte WJ,Condon RE

更新日期：1992-03-01 00:00:00

abstract：:The fibrinolytic activity of blood draining from the stomachs of patients with gastroduodenal disease has been compared with the fibrinolytic activity of blood in the systemic venous circulation and with the blood draining from normal stomachs. Gastric venous blood from normal and diseased stomachs contains greater am...

journal_title：Gastroenterology

authors： O'Brien TE,Hadley H,Irving MH

更新日期：1979-03-01 00:00:00

abstract：BACKGROUND & AIMS:Omeprazole is metabolized by cytochrome P450 (CYP2C19). The activity of this enzyme is polymorphic, with incidences of poor metabolizers (PMs), heterozygous extensive metabolizers (EMs), and homozygous EMs in white populations of 3%, 30%, and 67%, respectively. The importance of the CYP2C19 polymorphi...

journal_title：Gastroenterology

authors： Sagar M,Tybring G,Dahl ML,Bertilsson L,Seensalu R

更新日期：2000-09-01 00:00:00

abstract：:To study the peripheral effect of somatostatin in dogs a tiny Silastic catheter was implanted in an almost terminal branch of the mesenteric artery, providing blood supply to a jejunal segment of 5-10 cm. In 4 dogs one catheter was implanted, perfusing a small bowel segment about 60 cm below the angle of Treitz; in 3 ...

journal_title：Gastroenterology

authors： Hostein J,Janssens J,Vantrappen G,Peeters TL,Vandeweerd M,Leman G

更新日期：1984-11-01 00:00:00

abstract：:Because approximately 80% of reported patients with somatostatinomas have gallstones, this study was performed to determine the effects of exogenous somatostatin on gallbladder emptying responses to liquid and solid meals, direct cholinergic stimulation by bethanechol, indirect cholinergic stimulation by sham feeding,...

journal_title：Gastroenterology

authors： Fisher RS,Rock E,Levin G,Malmud L

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND & AIMS:Although a significant amount of regenerating gene (REG) Ialpha protein is present not only in normal gastric mucosa but also in gastric cancer tissues, its pathophysiologic role in gastric cancer development remains unclear. We investigated REG Ialpha protein expression in early gastric cancers, and ...

journal_title：Gastroenterology

authors： Sekikawa A,Fukui H,Fujii S,Takeda J,Nanakin A,Hisatsune H,Seno H,Takasawa S,Okamoto H,Fujimori T,Chiba T

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND & AIMS:A 3-dimensional (3D) culture system for immortalized human hepatocytes (HuS-E/2 cells) recently was shown to support the lifecycle of blood-borne hepatitis C virus (HCV). We used this system to identify proteins that are active during the HCV lifecycle under 3D culture conditions. METHODS:We compared...

journal_title：Gastroenterology

authors： Abe Y,Aly HH,Hiraga N,Imamura M,Wakita T,Shimotohno K,Chayama K,Hijikata M

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND & AIMS:Congenital tufting enteropathy (CTE) is a rare autosomal recessive diarrheal disorder presenting in the neonatal period. CTE is characterized by intestinal epithelial cell dysplasia leading to severe malabsorption and significant morbidity and mortality. The pathogenesis and genetics of this disorder ...

journal_title：Gastroenterology

authors： Sivagnanam M,Mueller JL,Lee H,Chen Z,Nelson SF,Turner D,Zlotkin SH,Pencharz PB,Ngan BY,Libiger O,Schork NJ,Lavine JE,Taylor S,Newbury RO,Kolodner RD,Hoffman HM

更新日期：2008-08-01 00:00:00

abstract：:In neurogenic fecal incontinence there is denervation of the external anal sphincter and pelvic floor muscles but the role of the internal anal sphincter is incompletely understood. We have evaluated the internal anal sphincter in 6 patients with neurogenic incontinence undergoing postanal repair and in 7 control subj...

journal_title：Gastroenterology

authors： Lubowski DZ,Nicholls RJ,Burleigh DE,Swash M

更新日期：1988-10-01 00:00:00

abstract：:Individuals who deny alcohol consumption may develop liver injury that histologically resembles the liver injury found in alcoholic patients. To determine whether any clinical or histologic features distinguish alcoholic and nonalcoholic subjects with "alcohollike" liver injury, the clinical records and liver biopsy s...

journal_title：Gastroenterology

authors： Diehl AM,Goodman Z,Ishak KG

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND & AIMS:Coffee is one of the most widely consumed beverages worldwide. Epidemiologic data indicate that coffee consumption protects against the progression of chronic liver disease and development of hepatocellular carcinoma and diabetes, but the mechanisms are not clear. UDP glucuronosyltransferases (UGT1A) ...

journal_title：Gastroenterology

authors： Kalthoff S,Ehmer U,Freiberg N,Manns MP,Strassburg CP

更新日期：2010-11-01 00:00:00

abstract：:Lower esophageal sphincter pressure, basal gastric pH, fasting plasma gastrin, and plasma concentrations of estrone, estradiol, and progesterone were measured in pregnant volunteers at 12, 24, and 36 weeks of gestation, and again at 1 to 4 weeks postpartum. In addition, basal and pentagastrin-stimulated acid secretory...

journal_title：Gastroenterology

authors： Van Thiel DH,Gavaler JS,Joshi SN,Sara RK,Stremple J

更新日期：1977-04-01 00:00:00

abstract：DESCRIPTION:This expert review was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership. The intent is to evaluate the current data on mechanism of altered coagulation in pat...

journal_title：Gastroenterology

authors： O'Leary JG,Greenberg CS,Patton HM,Caldwell SH

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic activity of MIF has been described in several cancer models. Therefore, we investigated the expression and function of MIF during the early stages of intestinal ...

journal_title：Gastroenterology

authors： Wilson JM,Coletta PL,Cuthbert RJ,Scott N,MacLennan K,Hawcroft G,Leng L,Lubetsky JB,Jin KK,Lolis E,Medina F,Brieva JA,Poulsom R,Markham AF,Bucala R,Hull MA

更新日期：2005-11-01 00:00:00

abstract：:Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease...

journal_title：Gastroenterology

authors： Gukovskaya AS,Gukovsky I,Algül H,Habtezion A

更新日期：2017-11-01 00:00:00

abstract：:Regional differences in the esophageal distribution and clearance of refluxed gastric acid was studied in seven asymptomatic volunteers and seven patients with reflux esophagitis. Intraluminal pH was recorded for 3 postprandial hours from the distal, middle, and proximal esophagus on two separate occasions (with subje...

journal_title：Gastroenterology

authors： Shaker R,Dodds WJ,Helm JF,Kern MK,Hogan WJ

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND & AIMS:Activating transcription factor 4 (ATF4) regulates genes involved in the inflammatory response, amino acid metabolism, autophagy, and endoplasmic reticulum stress. We investigated whether its activity is altered in patients with inflammatory bowel diseases (IBDs) and mice with enterocolitis. METHODS:...

journal_title：Gastroenterology

authors： Hu X,Deng J,Yu T,Chen S,Ge Y,Zhou Z,Guo Y,Ying H,Zhai Q,Chen Y,Yuan F,Niu Y,Shu W,Chen H,Ma C,Liu Z,Guo F

更新日期：2019-03-01 00:00:00