Abstract:
:We report a patient with severe peptic ulcer disease and a right ovarian mass that was found to be a gastrin-producing cystadenocarcinoma. Gastrin production by the tumor was stimulated by secretin and inhibited by the long-acting somatostatin analogue SMS 201-995. Following resection of the tumor, serum gastrin levels and the gastrin response to secretin returned to normal. Histologic examination, including Alcian blue staining for mucin and immunoperoxidase staining for gastrin, revealed gastrin at the base and mucin at the apex of the tumor cells. This report demonstrates secretin stimulation and somatostatin inhibition of gastrin secretion from a cell that is apparently not of endocrine origin.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Heyd J,Livni N,Herbet D,Mor-Yosef S,Glaser Bdoi
10.1016/0016-5085(89)90084-xsubject
Has Abstractpub_date
1989-08-01 00:00:00pages
464-7issue
2eissn
0016-5085issn
1528-0012pii
0016-5085(89)90084-Xjournal_volume
97pub_type
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